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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：P23246 New Search
13PDB entries
19Biological assembly
27chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
4WII HUMAN SPLICING FACTOR, CONSTRUCT 3 Deposited 2014-09-26 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 276–535（260 aa） Fragment：UNP RESIDUES 276-535
Chain B 276–535（260 aa） Fragment：UNP RESIDUES 276-535
Not recorded SO4 SULFATE ION × 1 EDO 1,2-ETHANEDIOL × 8 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；293 K；1.9 M AMMONIUM SULFATE, 0.1 M TRIS, 20% ETHYLENE GLYCOL (V/V), PH 8.5, VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 293K
Resolution 2.05 Å R-free 0.235
4WIJ HUMAN SPLICING FACTOR, CONSTRUCT 1 Deposited 2014-09-26 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 276–598（323 aa） Fragment：UNP RESIDUES 276-598
Chain B 276–598（323 aa） Fragment：UNP RESIDUES 276-598
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7；293 K；26% (V/V) 1,4 DIOXANE, 0.05M MOPS, 50 MM MAGNESIUM CHLORIDE HEXAHYDRATE, 1 MM SPERMINE, PH 7.0, VAPOR DIFFUSION, SITTING DROP, TEMPERATURE 293K
Resolution 3.49 Å R-free 0.335
4WIK HUMAN SPLICING FACTOR, CONSTRUCT 2 Deposited 2014-09-26 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 369–598（230 aa） Fragment：UNP RESIDUES 369-598
Chain B 369–598（230 aa） Fragment：UNP RESIDUES 369-598
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；0.2 M SODIUM PHOSPHATE DIBASIC DIHYDRATE, 22% (W/V) POLYETHYLENE GLYCOL 3350, VAPOR DIFFUSION, SITTING DROP, TEMPERATURE 293K
Resolution 3.00 Å R-free 0.291
5WPA Structure of human SFPQ/PSPC1 heterodimer Deposited 2017-08-04 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 276–535（260 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；25% PEG3350, 0.05 M MES, pH 5.5, 0.2 M sodium chloride, 3% aminohexanoic acid
Resolution 2.29 Å R-free 0.272
6NCQ The dimerization domain of human SFPQ in space group C2221 Deposited 2018-12-12 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 276–535（260 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M Tris-HCl (pH 8,5), 35-40% (v/v) MPD
Resolution 1.90 Å R-free 0.243
6OWJ Zn-mediated polymerization of human SFPQ Deposited 2019-05-10 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 276–535（260 aa） Fragment：UNP residues 276-535
Chain B 276–535（260 aa） Fragment：UNP residues 276-535
Not recorded ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；14% PEG4000, 0.2 M calcium chloride, 0.1 M MES, pH 6.0
Resolution 1.94 Å R-free 0.218
6WMZ Crystal structure of human SFPQ/NONO complex Deposited 2020-04-22 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 214–598（385 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；0.1 M Tris-HCl (pH 8.5), 0.2 M ammonium sulfate, 19% PEG 3350
Resolution 2.85 Å R-free 0.283
6WMZ Crystal structure of human SFPQ/NONO complex Deposited 2020-04-22 Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain C 214–598（385 aa）
Not recorded SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；0.1 M Tris-HCl (pH 8.5), 0.2 M ammonium sulfate, 19% PEG 3350
Resolution 2.85 Å R-free 0.283
7LRQ Crystal structure of human SFPQ/NONO heterodimer, conserved DBHS region Deposited 2021-02-17 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 276–535（260 aa）
Not recorded CL CHLORIDE ION × 5 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；22.5% PEG3350, 0.4 M MgCl2, 0.1 M HEPES pH 7.5
Resolution 2.30 Å R-free 0.299
7LRU Crystal structure of SFPQ-NONO-SFPQ chimeric protein homodimer Deposited 2021-02-17 Assembly 1 Insufficient information Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 276–452（177 aa）
Chain B 505–535（31 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；15%(v/v) Jeffamine ED-2003, 10% EtOH
Resolution 1.60 Å R-free 0.256
7PU5 Structure of SFPQ-NONO complex Deposited 2021-09-28 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 277–535（259 aa）
Not recorded MG MAGNESIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；277 K；25 mM Tris-HCl pH8.5, 14-16 % PEG 8K, 20 % w/v
Resolution 3.00 Å R-free 0.255
7PU5 Structure of SFPQ-NONO complex Deposited 2021-09-28 Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain D 277–535（259 aa）
Not recorded MG MAGNESIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；277 K；25 mM Tris-HCl pH8.5, 14-16 % PEG 8K, 20 % w/v
Resolution 3.00 Å R-free 0.255
7PU5 Structure of SFPQ-NONO complex Deposited 2021-09-28 Assembly 3 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain F 277–535（259 aa）
Not recorded MG MAGNESIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；277 K；25 mM Tris-HCl pH8.5, 14-16 % PEG 8K, 20 % w/v
Resolution 3.00 Å R-free 0.255
7PU5 Structure of SFPQ-NONO complex Deposited 2021-09-28 Assembly 4 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain H 277–535（259 aa）
Not recorded MG MAGNESIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；277 K；25 mM Tris-HCl pH8.5, 14-16 % PEG 8K, 20 % w/v
Resolution 3.00 Å R-free 0.255
7PU5 Structure of SFPQ-NONO complex Deposited 2021-09-28 Assembly 5 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain J 277–535（259 aa）
Not recorded MG MAGNESIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；277 K；25 mM Tris-HCl pH8.5, 14-16 % PEG 8K, 20 % w/v
Resolution 3.00 Å R-free 0.255
7PU5 Structure of SFPQ-NONO complex Deposited 2021-09-28 Assembly 6 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain L 277–535（259 aa）
Not recorded MG MAGNESIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；277 K；25 mM Tris-HCl pH8.5, 14-16 % PEG 8K, 20 % w/v
Resolution 3.00 Å R-free 0.255
7SP0 Crystal structure of human SFPQ L534I mutant in complex with zinc Deposited 2021-11-01 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 276–535（260 aa）
Chain B 276–535（260 aa）
Mutation：L534I Mutation：L534I ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；12% PEG4000, 0.2 M CALCIUM CHLORIDE, 0.1 M MES, PH 6.0
Resolution 1.83 Å R-free 0.216
7UJ1 Crystal structure of PSF-RNA complex Deposited 2022-03-30 Assembly 1 Protein–RNA Homooligomer；Protein × 2 PDB declaration: tetrameric（4） Consistent with all polymers
Chain A 214–598（385 aa）
Chain B 214–598（385 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；295 K；0.1M Tris-HCl, pH 8.5, 5mM MgCl2, 1mM DTT, 26% SOKALAN CP 42.
Resolution 3.50 Å R-free 0.241
7UK1 Complex Structure of Human Polypyrimidine Splicing Factor (PSF/SFPQ) with Murine Virus-like 30S Transcript-1 (VS30-1) Reveals Cooperative Binding of RNA Deposited 2022-03-31 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 214–598（385 aa）
Chain B 214–598（385 aa）
Not recorded MG MAGNESIUM ION × 5 X-RAY DIFFRACTION
X-ray crystallization conditions EVAPORATION；pH 7；285.15 K；0.1 M MgCl2, 0.1 M HEPES pH 7.0, 15% (w/v),PEG4000, or 15% (w/v) PEG3500, or 20% PEG2000MME
Resolution 2.70 Å R-free 0.291

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.