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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：P24385 New Search
10PDB entries
11Biological assembly
11chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
2W96 Crystal Structure of CDK4 in complex with a D-type cyclin Deposited 2009-01-21 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 1–271（271 aa）
Not recorded GOL GLYCEROL × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.30 Å R-free 0.259
2W99 Crystal Structure of CDK4 in complex with a D-type cyclin Deposited 2009-01-22 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 1–271（271 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.80 Å R-free 0.270
2W9F Crystal Structure of CDK4 in complex with a D-type cyclin Deposited 2009-01-23 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 1–271（271 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.85 Å R-free 0.300
2W9Z Crystal Structure of CDK4 in complex with a D-type cyclin Deposited 2009-01-30 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 16–271（256 aa） Fragment：RESIDUES 16-271
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.45 Å R-free 0.272
6P8E Crystal structure of CDK4 in complex with CyclinD1 and P27 Deposited 2019-06-07 Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain A 19–267（249 aa）
Not recorded MG MAGNESIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions MICROBATCH；295 K；100mM Tris (7.0) 200mM MgCl2 25%PEG 8000
Resolution 2.30 Å R-free 0.222
6P8F Crystal structure of CDK4 in complex with CyclinD1 and P27 Deposited 2019-06-07 Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain A 19–267（249 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7；295 K；100mM Tris (7.0) 17% PEG 3350 100 mM CaCl2 10 mM MgCl2
Resolution 2.89 Å R-free 0.242
6P8G Crystal structure of CDK4 in complex with CyclinD1 and P27 Deposited 2019-06-07 Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain A 19–267（249 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions MICROBATCH；295 K；100mM Tris (7.0) 200mM MgCl2 10% PEG 8000
Resolution 2.80 Å R-free 0.275
6P8H Crystal structure of CDK4 in complex with CyclinD1 and P21 Deposited 2019-06-07 Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain A 19–267（249 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions MICROBATCH；pH 7；295 K；100mM Tris (7.0), 10% PEG 8000 200mM MgCl2
Resolution 3.19 Å R-free 0.258
9CSK Crystal structure of CDK4 cyclin D1 in complex with atirmociclib Deposited 2024-07-24 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 16–271（256 aa）
Not recorded A1AZ4 Atirmociclib × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；294.15 K；Salt: 0.1 M DL-Malic acid Polymer: 12.4642857143 %w/v PEG 3350 Buffer: 0.1 M HEPES (pH 6.91) Additive: 10mM DTT [protein] 6mg/ml
Resolution 2.25 Å R-free 0.270
9CSK Crystal structure of CDK4 cyclin D1 in complex with atirmociclib Deposited 2024-07-24 Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain C 16–271（256 aa）
Not recorded A1AZ4 Atirmociclib × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；294.15 K；Salt: 0.1 M DL-Malic acid Polymer: 12.4642857143 %w/v PEG 3350 Buffer: 0.1 M HEPES (pH 6.91) Additive: 10mM DTT [protein] 6mg/ml
Resolution 2.25 Å R-free 0.270
9IVD Cryo-EM structure of CyclinD1 bound AMBRA1-DDB1 Deposited 2024-07-23 Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain E 1–295（295 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.55 Å

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.