当前蛋白身份：P31226
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差异标签只比较当前检索结果；所有PDB和assembly原始记录仍分别保留。
相关结构差异明细
一行代表一个 PDB 条目中的一个 biological assembly；同一蛋白的多个单体会分别列出。
| PDB 条目 | Assembly / 聚集状态 | 构建体 | 突变与修饰 | 配体、离子与非聚合物 | 实验方法 | 实验环境 | 结构质量 |
|---|---|---|---|---|---|---|---|
| 6O0D Saxiphilin Apo structure 提交 2019-02-16 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
1–844（844 aa）
|
未记录 | 未记录非水小分子 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；277.15 K；0.1 M sodium cacodylate pH 6.5, 5% PEG 8000, and 40% 2-methyl-2,4-pentanediol (MPD)
|
分辨率 2.50 Å R-free 0.253 |
| 6O0D Saxiphilin Apo structure 提交 2019-02-16 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
1–844（844 aa）
|
未记录 | 未记录非水小分子 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；277.15 K；0.1 M sodium cacodylate pH 6.5, 5% PEG 8000, and 40% 2-methyl-2,4-pentanediol (MPD)
|
分辨率 2.50 Å R-free 0.253 |
| 6O0E Saxiphilin:STX complex, soaking 提交 2019-02-16 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
1–844（844 aa）
|
未记录 | 9SL [(3aS,4R,10aS)-2,6-diamino-10,10-dihydroxy-3a,4,9,10-tetrahydro-3H,8H-pyrrolo[1,2-c]purin-4-yl]methyl carbamate × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277.15 K；0.1 M sodium cacodylate pH 6.5, 5% PEG 8000, and 40% 2-methyl-2,4-pentanediol (MPD). 1mM final concentration of STX was added during soaking
|
分辨率 2.50 Å R-free 0.262 |
| 6O0E Saxiphilin:STX complex, soaking 提交 2019-02-16 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
1–844（844 aa）
|
未记录 | 9SL [(3aS,4R,10aS)-2,6-diamino-10,10-dihydroxy-3a,4,9,10-tetrahydro-3H,8H-pyrrolo[1,2-c]purin-4-yl]methyl carbamate × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277.15 K；0.1 M sodium cacodylate pH 6.5, 5% PEG 8000, and 40% 2-methyl-2,4-pentanediol (MPD). 1mM final concentration of STX was added during soaking
|
分辨率 2.50 Å R-free 0.262 |
| 6O0F Saxiphilin:STX complex, co-crystal 提交 2019-02-16 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
1–844（844 aa）
|
未记录 | 9SL [(3aS,4R,10aS)-2,6-diamino-10,10-dihydroxy-3a,4,9,10-tetrahydro-3H,8H-pyrrolo[1,2-c]purin-4-yl]methyl carbamate × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；277.15 K；0.1 M sodium cacodylate pH 6.5, 5% PEG 8000, and 40% 2-methyl-2,4-pentanediol (MPD). STX: Saxiphilin molar ratio 1:1.1
|
分辨率 2.12 Å R-free 0.259 |
| 6O0F Saxiphilin:STX complex, co-crystal 提交 2019-02-16 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
1–844（844 aa）
|
未记录 | 9SL [(3aS,4R,10aS)-2,6-diamino-10,10-dihydroxy-3a,4,9,10-tetrahydro-3H,8H-pyrrolo[1,2-c]purin-4-yl]methyl carbamate × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；277.15 K；0.1 M sodium cacodylate pH 6.5, 5% PEG 8000, and 40% 2-methyl-2,4-pentanediol (MPD). STX: Saxiphilin molar ratio 1:1.1
|
分辨率 2.12 Å R-free 0.259 |
| 8D6P Rana catesbeiana saxiphilin mutant - Y558A 提交 2022-06-06 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
1–844（844 aa）
|
突变：Y558A | 未记录非水小分子 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277.15 K；0.08-0.2 M sodium cacodylate, pH 6.5, 5% PEG8000, 33% MPD
|
分辨率 2.60 Å R-free 0.264 |
| 8D6P Rana catesbeiana saxiphilin mutant - Y558A 提交 2022-06-06 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
1–844（844 aa）
|
突变：Y558A | 未记录非水小分子 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277.15 K；0.08-0.2 M sodium cacodylate, pH 6.5, 5% PEG8000, 33% MPD
|
分辨率 2.60 Å R-free 0.264 |
| 8D6Q Rana catesbeiana saxiphilin mutant - Y558I 提交 2022-06-06 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
1–844（844 aa）
|
突变：Y558I | 未记录非水小分子 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；277.15 K；0.08-0.2 M sodium cacodylate, pH 6.5, 5% PEG8000, 27% MPD
|
分辨率 2.70 Å R-free 0.272 |
| 8D6Q Rana catesbeiana saxiphilin mutant - Y558I 提交 2022-06-06 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
1–844（844 aa）
|
突变：Y558I | 未记录非水小分子 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；277.15 K；0.08-0.2 M sodium cacodylate, pH 6.5, 5% PEG8000, 27% MPD
|
分辨率 2.70 Å R-free 0.272 |
| 8D6S Rana catesbeiana saxiphilin mutant - Y558A:STX (co-crystal) 提交 2022-06-06 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
1–844（844 aa）
|
突变：Y558A | 9SL [(3aS,4R,10aS)-2,6-diamino-10,10-dihydroxy-3a,4,9,10-tetrahydro-3H,8H-pyrrolo[1,2-c]purin-4-yl]methyl carbamate × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；277.15 K；0.08-0.2 M sodium cacodylate, pH 6.5, 5% PEG8000, 33% MPD, STX:Saxiphilin molar ratio 1.1:1
|
分辨率 2.60 Å R-free 0.262 |
| 8D6S Rana catesbeiana saxiphilin mutant - Y558A:STX (co-crystal) 提交 2022-06-06 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
1–844（844 aa）
|
突变：Y558A | 9SL [(3aS,4R,10aS)-2,6-diamino-10,10-dihydroxy-3a,4,9,10-tetrahydro-3H,8H-pyrrolo[1,2-c]purin-4-yl]methyl carbamate × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；277.15 K；0.08-0.2 M sodium cacodylate, pH 6.5, 5% PEG8000, 33% MPD, STX:Saxiphilin molar ratio 1.1:1
|
分辨率 2.60 Å R-free 0.262 |
| 8D6T Rana catesbeiana saxiphilin mutant - Y558I:STX (co-crystal) 提交 2022-06-06 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
1–844（844 aa）
|
突变：Y558I | 9SL [(3aS,4R,10aS)-2,6-diamino-10,10-dihydroxy-3a,4,9,10-tetrahydro-3H,8H-pyrrolo[1,2-c]purin-4-yl]methyl carbamate × 1 CAC CACODYLATE ION × 3 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；277.15 K；0.08-0.2 M sodium cacodylate, pH 6.5, 5% PEG8000, 27% MPD, STX:Saxiphilin molar ratio 1.1:1
|
分辨率 2.15 Å R-free 0.234 |
| 8D6T Rana catesbeiana saxiphilin mutant - Y558I:STX (co-crystal) 提交 2022-06-06 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
1–844（844 aa）
|
突变：Y558I | 9SL [(3aS,4R,10aS)-2,6-diamino-10,10-dihydroxy-3a,4,9,10-tetrahydro-3H,8H-pyrrolo[1,2-c]purin-4-yl]methyl carbamate × 1 CAC CACODYLATE ION × 3 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；277.15 K；0.08-0.2 M sodium cacodylate, pH 6.5, 5% PEG8000, 27% MPD, STX:Saxiphilin molar ratio 1.1:1
|
分辨率 2.15 Å R-free 0.234 |
| 8D6U Rana catesbeiana saxiphilin:F-STX (soaked) 提交 2022-06-06 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
1–844（844 aa）
|
未记录 | QDX (2P)-4-({6-[({[(3aS,4R,7R,10aS)-2,6-diamino-10,10-dihydroxy-3a,4,9,10-tetrahydro-3H,8H-pyrrolo[1,2-c]purin-4-yl]methoxy}carbonyl)amino]hexyl}carbamoyl)-2-{[4aP,9(9a)P]-6-hydroxy-3-oxo-3H-xanthen-9-yl}benzoic acid × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；277.15 K；0.11-0.2 M sodium cacodylate, pH 6.5, 5% PEG8000, 33% MPD, 1 mM (final concentration) F-STX was added during soaking
|
分辨率 2.65 Å R-free 0.266 |
| 8D6U Rana catesbeiana saxiphilin:F-STX (soaked) 提交 2022-06-06 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
1–844（844 aa）
|
未记录 | QDX (2P)-4-({6-[({[(3aS,4R,7R,10aS)-2,6-diamino-10,10-dihydroxy-3a,4,9,10-tetrahydro-3H,8H-pyrrolo[1,2-c]purin-4-yl]methoxy}carbonyl)amino]hexyl}carbamoyl)-2-{[4aP,9(9a)P]-6-hydroxy-3-oxo-3H-xanthen-9-yl}benzoic acid × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；277.15 K；0.11-0.2 M sodium cacodylate, pH 6.5, 5% PEG8000, 33% MPD, 1 mM (final concentration) F-STX was added during soaking
|
分辨率 2.65 Å R-free 0.266 |
| 9YAR Rana catesbeiana saxiphilin:STX-C13-OBz (co-crystal) 提交 2025-09-16 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
1–844（844 aa）
|
未记录 | A1CTG [(2Z,3aS,4R,6Z,7R,10aS)-10,10-dihydroxy-2,6-diiminooctahydro-1H,8H-pyrrolo[1,2-c]purin-4-yl]methyl benzoate × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277.15 K；0.08-0.2 M sodium cacodylate, pH 6.5, 5% PEG8000, 27% MPD, STX-C13-OBz:Saxiphilin molar ratio 1.1:1
|
分辨率 2.40 Å R-free 0.278 |
| 9YAR Rana catesbeiana saxiphilin:STX-C13-OBz (co-crystal) 提交 2025-09-16 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
1–844（844 aa）
|
未记录 | A1CTG [(2Z,3aS,4R,6Z,7R,10aS)-10,10-dihydroxy-2,6-diiminooctahydro-1H,8H-pyrrolo[1,2-c]purin-4-yl]methyl benzoate × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277.15 K；0.08-0.2 M sodium cacodylate, pH 6.5, 5% PEG8000, 27% MPD, STX-C13-OBz:Saxiphilin molar ratio 1.1:1
|
分辨率 2.40 Å R-free 0.278 |
| 9YAS Rana catesbeiana saxiphilin mutant - Y558A:STX-C13-OBz (co-crystal) 提交 2025-09-16 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
1–844（844 aa）
|
突变：Y558A | A1CTG [(2Z,3aS,4R,6Z,7R,10aS)-10,10-dihydroxy-2,6-diiminooctahydro-1H,8H-pyrrolo[1,2-c]purin-4-yl]methyl benzoate × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277.15 K；0.08-0.2 M sodium cacodylate, pH 6.5, 5% PEG8000, 33% MPD, STX-C13-OBz:Saxiphilin molar ratio 1.1:1
|
分辨率 2.45 Å R-free 0.284 |
| 9YAS Rana catesbeiana saxiphilin mutant - Y558A:STX-C13-OBz (co-crystal) 提交 2025-09-16 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
1–844（844 aa）
|
突变：Y558A | A1CTG [(2Z,3aS,4R,6Z,7R,10aS)-10,10-dihydroxy-2,6-diiminooctahydro-1H,8H-pyrrolo[1,2-c]purin-4-yl]methyl benzoate × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277.15 K；0.08-0.2 M sodium cacodylate, pH 6.5, 5% PEG8000, 33% MPD, STX-C13-OBz:Saxiphilin molar ratio 1.1:1
|
分辨率 2.45 Å R-free 0.284 |
| 9YAT Rana catesbeiana saxiphilin mutant - T563A 提交 2025-09-16 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
1–844（844 aa）
|
突变：T563A | 未记录非水小分子 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277.15 K；0.08-0.2 M sodium cacodylate, pH 6.5, 5% PEG8000, 33% MPD
|
分辨率 2.50 Å R-free 0.246 |
| 9YAT Rana catesbeiana saxiphilin mutant - T563A 提交 2025-09-16 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
1–844（844 aa）
|
突变：T563A | 未记录非水小分子 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277.15 K；0.08-0.2 M sodium cacodylate, pH 6.5, 5% PEG8000, 33% MPD
|
分辨率 2.50 Å R-free 0.246 |
| 9YAV Rana catesbeiana saxiphilin mutant - F561A 提交 2025-09-16 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
1–844（844 aa）
|
突变：F561A | 未记录非水小分子 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277.15 K；0.08-0.2 M sodium cacodylate, pH 6.5, 5% PEG8000, 33% MPD
|
分辨率 2.23 Å R-free 0.244 |
| 9YAV Rana catesbeiana saxiphilin mutant - F561A 提交 2025-09-16 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
1–844（844 aa）
|
突变：F561A | 未记录非水小分子 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277.15 K；0.08-0.2 M sodium cacodylate, pH 6.5, 5% PEG8000, 33% MPD
|
分辨率 2.23 Å R-free 0.244 |
| 9YBD Rana catesbeiana saxiphilin mutant - F561A:STX-C13-OBz (co-crystal) 提交 2025-09-17 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
1–844（844 aa）
|
突变：F561A | A1CTG [(2Z,3aS,4R,6Z,7R,10aS)-10,10-dihydroxy-2,6-diiminooctahydro-1H,8H-pyrrolo[1,2-c]purin-4-yl]methyl benzoate × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277.15 K；0.08-0.2 M sodium cacodylate, pH 6.5, 5% PEG8000, 33% MPD, STX-C13-OBz:Saxiphilin molar ratio 1.1:1
|
分辨率 2.40 Å R-free 0.258 |
| 9YBD Rana catesbeiana saxiphilin mutant - F561A:STX-C13-OBz (co-crystal) 提交 2025-09-17 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
1–844（844 aa）
|
突变：F561A | A1CTG [(2Z,3aS,4R,6Z,7R,10aS)-10,10-dihydroxy-2,6-diiminooctahydro-1H,8H-pyrrolo[1,2-c]purin-4-yl]methyl benzoate × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277.15 K；0.08-0.2 M sodium cacodylate, pH 6.5, 5% PEG8000, 33% MPD, STX-C13-OBz:Saxiphilin molar ratio 1.1:1
|
分辨率 2.40 Å R-free 0.258 |
| 9YBE Rana catesbeiana saxiphilin mutant - F561A:STX (co-crystal) 提交 2025-09-17 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
1–844（844 aa）
|
突变：F561A | 9SL [(3aS,4R,10aS)-2,6-diamino-10,10-dihydroxy-3a,4,9,10-tetrahydro-3H,8H-pyrrolo[1,2-c]purin-4-yl]methyl carbamate × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277.15 K；0.08-0.2 M sodium cacodylate, pH 6.5, 5% PEG8000, 33% MPD, STX:Saxiphilin molar ratio 1.1:1
|
分辨率 2.35 Å R-free 0.274 |
| 9YBE Rana catesbeiana saxiphilin mutant - F561A:STX (co-crystal) 提交 2025-09-17 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
1–844（844 aa）
|
突变：F561A | 9SL [(3aS,4R,10aS)-2,6-diamino-10,10-dihydroxy-3a,4,9,10-tetrahydro-3H,8H-pyrrolo[1,2-c]purin-4-yl]methyl carbamate × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277.15 K；0.08-0.2 M sodium cacodylate, pH 6.5, 5% PEG8000, 33% MPD, STX:Saxiphilin molar ratio 1.1:1
|
分辨率 2.35 Å R-free 0.274 |
| 9YBF Rana catesbeiana saxiphilin mutant - T563A:STX-C13-OBz (co-crystal) 提交 2025-09-17 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
1–844（844 aa）
|
突变：T563A | A1CTG [(2Z,3aS,4R,6Z,7R,10aS)-10,10-dihydroxy-2,6-diiminooctahydro-1H,8H-pyrrolo[1,2-c]purin-4-yl]methyl benzoate × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277.15 K；0.08-0.2 M sodium cacodylate, pH 6.5, 5% PEG8000, 33% MPD, STX-C13-OBz:Saxiphilin molar ratio 1.1:1
|
分辨率 2.45 Å R-free 0.263 |
| 9YBF Rana catesbeiana saxiphilin mutant - T563A:STX-C13-OBz (co-crystal) 提交 2025-09-17 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
1–844（844 aa）
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突变：T563A | A1CTG [(2Z,3aS,4R,6Z,7R,10aS)-10,10-dihydroxy-2,6-diiminooctahydro-1H,8H-pyrrolo[1,2-c]purin-4-yl]methyl benzoate × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277.15 K；0.08-0.2 M sodium cacodylate, pH 6.5, 5% PEG8000, 33% MPD, STX-C13-OBz:Saxiphilin molar ratio 1.1:1
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分辨率 2.45 Å R-free 0.263 |