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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：P35414 New Search
34PDB entries
34Biological assembly
51chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
2LOT AR55 solubilised in SDS micelles Deposited 2012-01-27 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–55（55 aa） Fragment：UNP residues 1-55
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 5；310 K
NMR sample composition 0.8 mM [U-99% 13C; U-99% 15N] AR55, 96 mM [U-99% 2H] SDS, 20 mM sodium acetate, 1 mM sodium azide, 1 mM DSS, 10 mM [U-99% 2H] DTT, 95% H2O/5% D2O | 95% H2O/5% D2O
Resolution not provided
2LOU AR55 solubilised in DPC micelles Deposited 2012-01-27 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–55（55 aa） Fragment：UNP residues 1-55
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 4；310 K
NMR sample composition 1 mM [U-99% 13C; U-99% 15N] AR55, 150 mM [U-99% 2H] DPC, 20 mM sodium acetate, 1 mM sodium azide, 1 mM DSS, 10 mM [U-99% 2H] DTT, 95% H2O/5% D2O | 95% H2O/5% D2O
Resolution not provided
2LOV AR55 solubilised in LPPG micelles Deposited 2012-01-27 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–55（55 aa） Fragment：UNP residues 1-55
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 5；310 K
NMR sample composition 0.56 mM [U-99% 13C; U-99% 15N] AR55, 72 mM LPPG, 20 mM [U-2H] sodium acetate, 1 mM sodium azide, 1 mM DSS, 10 mM [U-99% 2H] DTT, 95% H2O/5% D2O | 95% H2O/5% D2O
Resolution not provided
2LOW Solution structure of AR55 in 50% HFIP Deposited 2012-01-27 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–55（55 aa） Fragment：UNP residues 1-55
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions 310 K
NMR sample composition .9 mM [U-99% 13C; U-99% 15N] AR55, 50 % [U-99% 2H] hexafluoroisopropanol, 1 mM DSS, 5 mM [U-99% 2H] DTT, 40 % H2O, 10 % [U-99% 2H] D2O, 50% Hexafluoroisopropanol/40% H2O /10% D2O | 50% Hexafluoroisopropanol/40% H2O /10% D2O
Resolution not provided
5VBL Structure of apelin receptor in complex with agonist peptide Deposited 2017-03-29 Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 7–229（223 aa） Fragment：UNP residues 7-229, UNP residues 1-54, UNP residues 243-330
Chain B 243–330（88 aa） Fragment：UNP residues 7-229, UNP residues 1-54, UNP residues 243-330
Mutation：V117A, T177N,W261K, C325L, C326M Mutation：V117A, T177N,W261K, C325L, C326M ZN ZINC ION × 1 OLC (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate × 1 X-RAY DIFFRACTION
X-ray crystallization conditions LIPIDIC CUBIC PHASE；293 K；100mM MES pH 6.1, 26% PEG500 DME, 125mM MgCl2, 100mM NaCl, 500uM AMG3054
Resolution 2.60 Å R-free 0.256
6KNM Apelin receptor in complex with single domain antibody Deposited 2019-08-06 Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 7–229（223 aa）
Chain B 243–330（88 aa）
Mutation：V117A, T177N,W261K, C325L, C326M,V117A, T177N,W261K, C325L, C326M,V117A, T177N,W261K, C325L, C326M Mutation：V117A, T177N,W261K, C325L, C326M,V117A, T177N,W261K, C325L, C326M,V117A, T177N,W261K, C325L, C326M ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions LIPIDIC CUBIC PHASE；293 K；100 mM MES pH 6.1, 26% PEG500 DME, 125 mM MgCl2, 100 mM NaCl
Resolution 3.20 Å R-free 0.305
7SUS Crystal structure of Apelin receptor in complex with small molecule Deposited 2021-11-18 Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 7–229（223 aa）
Chain A 243–330（88 aa）
Mutation：V117A,E174C,T177N,M217C,I250C,C325L,C326M Mutation：V117A,E174C,T177N,M217C,I250C,C325L,C326M ZN ZINC ION × 1 8EH (1R,2S)-N-[4-(2,6-dimethoxyphenyl)-5-(6-methylpyridin-2-yl)-1,2,4-triazol-3-yl]-1-(5-methylpyrimidin-2-yl)-1-oxidanyl-propane-2-sulfonamide × 1 OLC (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate × 1 X-RAY DIFFRACTION
X-ray crystallization conditions LIPIDIC CUBIC PHASE；293 K；100 mM MES pH 6.1, 26% PEG500 DME, 125 mM MgCl2, 100 mM NaCl
Resolution 2.70 Å R-free 0.274
7W0L Cryo-EM structure of a dimeric GPCR-Gi complex with small molecule Deposited 2021-11-18 Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain Q 2–330（329 aa）
Chain R 2–330（329 aa）
Not recorded 8EH (1R,2S)-N-[4-(2,6-dimethoxyphenyl)-5-(6-methylpyridin-2-yl)-1,2,4-triazol-3-yl]-1-(5-methylpyrimidin-2-yl)-1-oxidanyl-propane-2-sulfonamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.57 Å
7W0M Cryo-EM structure of a monomeric GPCR-Gi complex with small molecule Deposited 2021-11-18 Assembly 1 Insufficient information Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count
Chain R 2–330（329 aa）
Not recorded 8EH (1R,2S)-N-[4-(2,6-dimethoxyphenyl)-5-(6-methylpyridin-2-yl)-1,2,4-triazol-3-yl]-1-(5-methylpyrimidin-2-yl)-1-oxidanyl-propane-2-sulfonamide × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.71 Å
7W0N Cryo-EM structure of a dimeric GPCR-Gi complex with peptide Deposited 2021-11-18 Assembly 1 Insufficient information Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain Q 2–330（329 aa）
Chain R 2–330（329 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.21 Å
7W0O Cryo-EM structure of a monomeric GPCR-Gi complex with peptide Deposited 2021-11-18 Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain R 2–330（329 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.78 Å
7W0P Cryo-EM structure of a GPCR-Gi complex with peptide Deposited 2021-11-18 Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain R 2–330（329 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.16 Å
8S4D Crystal structure of a peptidergic GPCR in complex with a small synthetic G protein-biased agonist Deposited 2024-02-21 Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 7–229（223 aa）
Chain A 235–324（90 aa）
Mutation：T87V,N112A,T177N,T207M,F214L,I224A,S298A,C325L,C326M Mutation：T87V,N112A,T177N,T207M,F214L,I224A,S298A,C325L,C326M A1D5N (3~{S})-5-methyl-3-[[1-pentan-3-yl-2-(thiophen-2-ylmethyl)benzimidazol-5-yl]carbonylamino]hexanoic acid × 1 OLA OLEIC ACID × 6 1PE PENTAETHYLENE GLYCOL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions LIPIDIC CUBIC PHASE；pH 4.75；293 K；25 to 35 % polyethylene glycol (PEG) 400, 100 mM sodium citrate, pH 4.75, and 150 mM of ammonium phosphate or ammonium acetate
Resolution 2.58 Å R-free 0.275
8XQE Cryo-EM structure of human dimeric APJR-Gi complex with apelin-13. Deposited 2024-01-05 Assembly 1 Insufficient information Heteromer；Protein × 7 PDB declaration: heptameric（7） Consistent with protein count
Chain Q 1–330（330 aa）
Chain R 1–330（330 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.48 Å
8XQF Cryo-EM structure of human monomeric APJR-Gi complex with apelin-13. Deposited 2024-01-05 Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain R 1–330（330 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.13 Å
8XQI Cryo-EM structure of human dimeric Apelin receptor. Deposited 2024-01-05 Assembly 1 Insufficient information Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 1–330（330 aa）
Chain B 1–330（330 aa）
Not recorded CLR CHOLESTEROL × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.25 Å
8XQJ Cryo-EM structure of human dimeric APJR complex with antagonistic antibody Deposited 2024-01-05 Assembly 1 Insufficient information Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain C 1–330（330 aa）
Chain D 1–330（330 aa）
Not recorded CLR CHOLESTEROL × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.95 Å
8XZF Cryo-EM structure of the WN561-bound human APLNR-Gi complex Deposited 2024-01-21 Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain R 1–380（380 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.00 Å
8XZG Cryo-EM structure of the [Pyr1]-apelin-13-bound human APLNR-Gi complex Deposited 2024-01-21 Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count
Chain R 1–380（380 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.20 Å
8XZH Cryo-EM structure of the MM07-bound human APLNR-Gi complex Deposited 2024-01-21 Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain R 1–380（380 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.60 Å
8XZI Cryo-EM structure of the CMF-019-bound human APLNR-Gi complex Deposited 2024-01-21 Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count
Chain R 1–380（380 aa）
Not recorded A1D5N (3~{S})-5-methyl-3-[[1-pentan-3-yl-2-(thiophen-2-ylmethyl)benzimidazol-5-yl]carbonylamino]hexanoic acid × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.70 Å
8XZJ Cryo-EM structure of the WN353-bound human APLNR-Gi complex Deposited 2024-01-21 Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain R 1–380（380 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.00 Å
8Z74 Cryo-EM structure of APJR complex with agonistic antibody Deposited 2024-04-19 Assembly 1 Insufficient information Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain C 2–330（329 aa）
Chain D 2–330（329 aa）
Not recorded CLR CHOLESTEROL × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.01 Å
8Z7J Cryo-EM structure of APJR-Gi complex with agonistic antibody Deposited 2024-04-20 Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain R 2–330（329 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.12 Å
9JH3 CMF-019 with APLNR-Gi complex Deposited 2024-09-08 Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count
Chain R 1–380（380 aa）
Not recorded A1D5N (3~{S})-5-methyl-3-[[1-pentan-3-yl-2-(thiophen-2-ylmethyl)benzimidazol-5-yl]carbonylamino]hexanoic acid × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.93 Å
9LQT Cryo-EM structure of the Apo-state APLNR homodimer Deposited 2025-01-28 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 1–380（380 aa）
Chain B 1–380（380 aa）
Not recorded PCF 1,2-DIACYL-SN-GLYCERO-3-PHOSHOCHOLINE × 2 CLR CHOLESTEROL × 16 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.60 Å
9LQU Cryo-EM structure of the JN241-9-bound state 1a of APLNR homodimer Deposited 2025-01-28 Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–380（380 aa）
Chain B 1–380（380 aa）
Not recorded CLR CHOLESTEROL × 16 PCF 1,2-DIACYL-SN-GLYCERO-3-PHOSHOCHOLINE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.70 Å
9LQW Cryo-EM structure of the JN241-9-bound state 1b of APLNR homodimer Deposited 2025-01-28 Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–380（380 aa）
Chain B 1–380（380 aa）
Not recorded PCF 1,2-DIACYL-SN-GLYCERO-3-PHOSHOCHOLINE × 2 CLR CHOLESTEROL × 16 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.70 Å
9LQX Cryo-EM structure of the JN241-9-bound state 1c of APLNR homodimer Deposited 2025-01-28 Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–380（380 aa）
Chain B 1–380（380 aa）
Not recorded CLR CHOLESTEROL × 16 PCF 1,2-DIACYL-SN-GLYCERO-3-PHOSHOCHOLINE × 3 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.70 Å
9LQY Cryo-EM structure of the AMG986-bound state 2a of APLNR homodimer Deposited 2025-01-28 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 1–380（380 aa）
Chain B 1–380（380 aa）
Not recorded PCF 1,2-DIACYL-SN-GLYCERO-3-PHOSHOCHOLINE × 2 A1EK3 Azelaprag × 2 CLR CHOLESTEROL × 16 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.40 Å
9LQZ Cryo-EM structure of the AMG986-bound state 2b of APLNR homodimer Deposited 2025-01-28 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 1–380（380 aa）
Chain B 1–380（380 aa）
Not recorded A1EK3 Azelaprag × 2 PCF 1,2-DIACYL-SN-GLYCERO-3-PHOSHOCHOLINE × 2 CLR CHOLESTEROL × 16 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.60 Å
9LR1 Cryo-EM structure of the JN241-9-bound APLNR monomer-Gi complex Deposited 2025-01-28 Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain R 1–380（380 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.50 Å
9LR2 Cryo-EM structure of the JN241-9-bound APLNR dimer-Gi complex Deposited 2025-01-28 Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain Q 1–380（380 aa）
Chain R 1–380（380 aa）
Not recorded PCF 1,2-DIACYL-SN-GLYCERO-3-PHOSHOCHOLINE × 2 CLR CHOLESTEROL × 14 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
9LR3 Cryo-EM structure of the AMG986-bound APLNR monomer-Gi complex Deposited 2025-01-28 Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count
Chain R 1–380（380 aa）
Not recorded A1EK3 Azelaprag × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.80 Å

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.