当前蛋白身份：P37023
重新检索
差异标签只比较当前检索结果；所有PDB和assembly原始记录仍分别保留。
相关结构差异明细
一行代表一个 PDB 条目中的一个 biological assembly；同一蛋白的多个单体会分别列出。
| PDB 条目 | Assembly / 聚集状态 | 构建体 | 突变与修饰 | 配体、离子与非聚合物 | 实验方法 | 实验环境 | 结构质量 |
|---|---|---|---|---|---|---|---|
| 2LCR NMR Structure of Alk1 extracellular domain 提交 2011-05-06 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
22–118（97 aa）
片段：Extracellular domain residues 22-118
|
未记录 | 未记录非水小分子 | SOLUTION NMR |
NMR测量条件
pH 5.5；305 K；压力 ambient
NMR样品组成
0.5 mM [U-100% 15N] Alk1, 25 mM sodium phosphate, 0.02 % sodium azide, 95% H2O/5% D2O | 95% H2O/5% D2O
NMR样品组成
0.5 mM [U-100% 13C; U-100% 15N] Alk1, 25 mM sodium phosphate, 0.02 % sodium azide, 95% H2O/5% D2O | 95% H2O/5% D2O
NMR样品组成
0.5 mM [U-100% 13C; U-100% 15N] Alk1, 25 mM sodium phosphate, 0.02 % sodium azide, 5mg/mL mg Pf1 phage, 95% H2O/5% D2O | 95% H2O/5% D2O
|
分辨率未提供 |
| 3MY0 Crystal structure of the ACVRL1 (ALK1) kinase domain bound to LDN-193189 提交 2010-05-08 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
195–497（303 aa）
片段：kinase domain (UNP residue 195-497)
|
未记录 | LDN 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；pH 7.5；293.15 K；16% PEG 3350, 0.2M Na/K PO4, 5% ethylene glycol, 2% glycerol, pH 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 293.15K
|
分辨率 2.65 Å R-free 0.247 |
| 3MY0 Crystal structure of the ACVRL1 (ALK1) kinase domain bound to LDN-193189 提交 2010-05-08 | Assembly 10 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 J
195–497（303 aa）
片段：kinase domain (UNP residue 195-497)
|
未记录 | LDN 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；pH 7.5；293.15 K；16% PEG 3350, 0.2M Na/K PO4, 5% ethylene glycol, 2% glycerol, pH 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 293.15K
|
分辨率 2.65 Å R-free 0.247 |
| 3MY0 Crystal structure of the ACVRL1 (ALK1) kinase domain bound to LDN-193189 提交 2010-05-08 | Assembly 11 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 K
195–497（303 aa）
片段：kinase domain (UNP residue 195-497)
|
未记录 | LDN 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；pH 7.5；293.15 K；16% PEG 3350, 0.2M Na/K PO4, 5% ethylene glycol, 2% glycerol, pH 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 293.15K
|
分辨率 2.65 Å R-free 0.247 |
| 3MY0 Crystal structure of the ACVRL1 (ALK1) kinase domain bound to LDN-193189 提交 2010-05-08 | Assembly 12 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 L
195–497（303 aa）
片段：kinase domain (UNP residue 195-497)
|
未记录 | LDN 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；pH 7.5；293.15 K；16% PEG 3350, 0.2M Na/K PO4, 5% ethylene glycol, 2% glycerol, pH 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 293.15K
|
分辨率 2.65 Å R-free 0.247 |
| 3MY0 Crystal structure of the ACVRL1 (ALK1) kinase domain bound to LDN-193189 提交 2010-05-08 | Assembly 13 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 M
195–497（303 aa）
片段：kinase domain (UNP residue 195-497)
|
未记录 | LDN 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；pH 7.5；293.15 K；16% PEG 3350, 0.2M Na/K PO4, 5% ethylene glycol, 2% glycerol, pH 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 293.15K
|
分辨率 2.65 Å R-free 0.247 |
| 3MY0 Crystal structure of the ACVRL1 (ALK1) kinase domain bound to LDN-193189 提交 2010-05-08 | Assembly 14 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 N
195–497（303 aa）
片段：kinase domain (UNP residue 195-497)
|
未记录 | LDN 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；pH 7.5；293.15 K；16% PEG 3350, 0.2M Na/K PO4, 5% ethylene glycol, 2% glycerol, pH 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 293.15K
|
分辨率 2.65 Å R-free 0.247 |
| 3MY0 Crystal structure of the ACVRL1 (ALK1) kinase domain bound to LDN-193189 提交 2010-05-08 | Assembly 15 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 O
195–497（303 aa）
片段：kinase domain (UNP residue 195-497)
|
未记录 | LDN 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；pH 7.5；293.15 K；16% PEG 3350, 0.2M Na/K PO4, 5% ethylene glycol, 2% glycerol, pH 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 293.15K
|
分辨率 2.65 Å R-free 0.247 |
| 3MY0 Crystal structure of the ACVRL1 (ALK1) kinase domain bound to LDN-193189 提交 2010-05-08 | Assembly 16 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 P
195–497（303 aa）
片段：kinase domain (UNP residue 195-497)
|
未记录 | LDN 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；pH 7.5；293.15 K；16% PEG 3350, 0.2M Na/K PO4, 5% ethylene glycol, 2% glycerol, pH 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 293.15K
|
分辨率 2.65 Å R-free 0.247 |
| 3MY0 Crystal structure of the ACVRL1 (ALK1) kinase domain bound to LDN-193189 提交 2010-05-08 | Assembly 17 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 Q
195–497（303 aa）
片段：kinase domain (UNP residue 195-497)
|
未记录 | LDN 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；pH 7.5；293.15 K；16% PEG 3350, 0.2M Na/K PO4, 5% ethylene glycol, 2% glycerol, pH 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 293.15K
|
分辨率 2.65 Å R-free 0.247 |
| 3MY0 Crystal structure of the ACVRL1 (ALK1) kinase domain bound to LDN-193189 提交 2010-05-08 | Assembly 18 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 R
195–497（303 aa）
片段：kinase domain (UNP residue 195-497)
|
未记录 | LDN 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；pH 7.5；293.15 K；16% PEG 3350, 0.2M Na/K PO4, 5% ethylene glycol, 2% glycerol, pH 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 293.15K
|
分辨率 2.65 Å R-free 0.247 |
| 3MY0 Crystal structure of the ACVRL1 (ALK1) kinase domain bound to LDN-193189 提交 2010-05-08 | Assembly 19 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 S
195–497（303 aa）
片段：kinase domain (UNP residue 195-497)
|
未记录 | LDN 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；pH 7.5；293.15 K；16% PEG 3350, 0.2M Na/K PO4, 5% ethylene glycol, 2% glycerol, pH 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 293.15K
|
分辨率 2.65 Å R-free 0.247 |
| 3MY0 Crystal structure of the ACVRL1 (ALK1) kinase domain bound to LDN-193189 提交 2010-05-08 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
195–497（303 aa）
片段：kinase domain (UNP residue 195-497)
|
未记录 | LDN 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；pH 7.5；293.15 K；16% PEG 3350, 0.2M Na/K PO4, 5% ethylene glycol, 2% glycerol, pH 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 293.15K
|
分辨率 2.65 Å R-free 0.247 |
| 3MY0 Crystal structure of the ACVRL1 (ALK1) kinase domain bound to LDN-193189 提交 2010-05-08 | Assembly 20 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 T
195–497（303 aa）
片段：kinase domain (UNP residue 195-497)
|
未记录 | LDN 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；pH 7.5；293.15 K；16% PEG 3350, 0.2M Na/K PO4, 5% ethylene glycol, 2% glycerol, pH 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 293.15K
|
分辨率 2.65 Å R-free 0.247 |
| 3MY0 Crystal structure of the ACVRL1 (ALK1) kinase domain bound to LDN-193189 提交 2010-05-08 | Assembly 21 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 U
195–497（303 aa）
片段：kinase domain (UNP residue 195-497)
|
未记录 | LDN 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；pH 7.5；293.15 K；16% PEG 3350, 0.2M Na/K PO4, 5% ethylene glycol, 2% glycerol, pH 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 293.15K
|
分辨率 2.65 Å R-free 0.247 |
| 3MY0 Crystal structure of the ACVRL1 (ALK1) kinase domain bound to LDN-193189 提交 2010-05-08 | Assembly 22 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 V
195–497（303 aa）
片段：kinase domain (UNP residue 195-497)
|
未记录 | LDN 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；pH 7.5；293.15 K；16% PEG 3350, 0.2M Na/K PO4, 5% ethylene glycol, 2% glycerol, pH 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 293.15K
|
分辨率 2.65 Å R-free 0.247 |
| 3MY0 Crystal structure of the ACVRL1 (ALK1) kinase domain bound to LDN-193189 提交 2010-05-08 | Assembly 23 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 W
195–497（303 aa）
片段：kinase domain (UNP residue 195-497)
|
未记录 | LDN 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；pH 7.5；293.15 K；16% PEG 3350, 0.2M Na/K PO4, 5% ethylene glycol, 2% glycerol, pH 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 293.15K
|
分辨率 2.65 Å R-free 0.247 |
| 3MY0 Crystal structure of the ACVRL1 (ALK1) kinase domain bound to LDN-193189 提交 2010-05-08 | Assembly 24 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 X
195–497（303 aa）
片段：kinase domain (UNP residue 195-497)
|
未记录 | LDN 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；pH 7.5；293.15 K；16% PEG 3350, 0.2M Na/K PO4, 5% ethylene glycol, 2% glycerol, pH 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 293.15K
|
分辨率 2.65 Å R-free 0.247 |
| 3MY0 Crystal structure of the ACVRL1 (ALK1) kinase domain bound to LDN-193189 提交 2010-05-08 | Assembly 3 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 C
195–497（303 aa）
片段：kinase domain (UNP residue 195-497)
|
未记录 | LDN 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；pH 7.5；293.15 K；16% PEG 3350, 0.2M Na/K PO4, 5% ethylene glycol, 2% glycerol, pH 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 293.15K
|
分辨率 2.65 Å R-free 0.247 |
| 3MY0 Crystal structure of the ACVRL1 (ALK1) kinase domain bound to LDN-193189 提交 2010-05-08 | Assembly 4 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 D
195–497（303 aa）
片段：kinase domain (UNP residue 195-497)
|
未记录 | LDN 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；pH 7.5；293.15 K；16% PEG 3350, 0.2M Na/K PO4, 5% ethylene glycol, 2% glycerol, pH 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 293.15K
|
分辨率 2.65 Å R-free 0.247 |
| 3MY0 Crystal structure of the ACVRL1 (ALK1) kinase domain bound to LDN-193189 提交 2010-05-08 | Assembly 5 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 E
195–497（303 aa）
片段：kinase domain (UNP residue 195-497)
|
未记录 | LDN 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；pH 7.5；293.15 K；16% PEG 3350, 0.2M Na/K PO4, 5% ethylene glycol, 2% glycerol, pH 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 293.15K
|
分辨率 2.65 Å R-free 0.247 |
| 3MY0 Crystal structure of the ACVRL1 (ALK1) kinase domain bound to LDN-193189 提交 2010-05-08 | Assembly 6 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 F
195–497（303 aa）
片段：kinase domain (UNP residue 195-497)
|
未记录 | LDN 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；pH 7.5；293.15 K；16% PEG 3350, 0.2M Na/K PO4, 5% ethylene glycol, 2% glycerol, pH 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 293.15K
|
分辨率 2.65 Å R-free 0.247 |
| 3MY0 Crystal structure of the ACVRL1 (ALK1) kinase domain bound to LDN-193189 提交 2010-05-08 | Assembly 7 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 G
195–497（303 aa）
片段：kinase domain (UNP residue 195-497)
|
未记录 | LDN 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；pH 7.5；293.15 K；16% PEG 3350, 0.2M Na/K PO4, 5% ethylene glycol, 2% glycerol, pH 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 293.15K
|
分辨率 2.65 Å R-free 0.247 |
| 3MY0 Crystal structure of the ACVRL1 (ALK1) kinase domain bound to LDN-193189 提交 2010-05-08 | Assembly 8 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 H
195–497（303 aa）
片段：kinase domain (UNP residue 195-497)
|
未记录 | LDN 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；pH 7.5；293.15 K；16% PEG 3350, 0.2M Na/K PO4, 5% ethylene glycol, 2% glycerol, pH 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 293.15K
|
分辨率 2.65 Å R-free 0.247 |
| 3MY0 Crystal structure of the ACVRL1 (ALK1) kinase domain bound to LDN-193189 提交 2010-05-08 | Assembly 9 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 I
195–497（303 aa）
片段：kinase domain (UNP residue 195-497)
|
未记录 | LDN 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；pH 7.5；293.15 K；16% PEG 3350, 0.2M Na/K PO4, 5% ethylene glycol, 2% glycerol, pH 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 293.15K
|
分辨率 2.65 Å R-free 0.247 |
| 4FAO Specificity and Structure of a high affinity Activin-like 1 (ALK1) signaling complex 提交 2012-05-22 | Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 6 PDB 声明：hexameric（6） 与蛋白数一致 |
链 C
22–118（97 aa）
片段：Extracellular domain
链 D
22–118（97 aa）
片段：Extracellular domain
|
未记录 | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 NA SODIUM ION × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION；pH 6.5；293 K；20% PEG 3350, 0.2 M sodium malonate, 0.1 M Bis-Tris propane, pH 6.5, vapor diffusion, temperature 293K
|
分辨率 3.36 Å R-free 0.261 |
| 4FAO Specificity and Structure of a high affinity Activin-like 1 (ALK1) signaling complex 提交 2012-05-22 | Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 6 PDB 声明：hexameric（6） 与蛋白数一致 |
链 I
22–118（97 aa）
片段：Extracellular domain
链 J
22–118（97 aa）
片段：Extracellular domain
|
未记录 | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 NA SODIUM ION × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION；pH 6.5；293 K；20% PEG 3350, 0.2 M sodium malonate, 0.1 M Bis-Tris propane, pH 6.5, vapor diffusion, temperature 293K
|
分辨率 3.36 Å R-free 0.261 |
| 4FAO Specificity and Structure of a high affinity Activin-like 1 (ALK1) signaling complex 提交 2012-05-22 | Assembly 3 蛋白异源复合物 异源复合物；蛋白 × 6 PDB 声明：hexameric（6） 与蛋白数一致 |
链 O
22–118（97 aa）
片段：Extracellular domain
链 P
22–118（97 aa）
片段：Extracellular domain
|
未记录 | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 NA SODIUM ION × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION；pH 6.5；293 K；20% PEG 3350, 0.2 M sodium malonate, 0.1 M Bis-Tris propane, pH 6.5, vapor diffusion, temperature 293K
|
分辨率 3.36 Å R-free 0.261 |
| 4FAO Specificity and Structure of a high affinity Activin-like 1 (ALK1) signaling complex 提交 2012-05-22 | Assembly 4 蛋白异源复合物 异源复合物；蛋白 × 6 PDB 声明：hexameric（6） 与蛋白数一致 |
链 U
22–118（97 aa）
片段：Extracellular domain
链 V
22–118（97 aa）
片段：Extracellular domain
|
未记录 | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 NA SODIUM ION × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION；pH 6.5；293 K；20% PEG 3350, 0.2 M sodium malonate, 0.1 M Bis-Tris propane, pH 6.5, vapor diffusion, temperature 293K
|
分辨率 3.36 Å R-free 0.261 |
| 4FAO Specificity and Structure of a high affinity Activin-like 1 (ALK1) signaling complex 提交 2012-05-22 | Assembly 5 蛋白异源复合物 异源复合物；蛋白 × 6 PDB 声明：hexameric（6） 与蛋白数一致 |
链 c
22–118（97 aa）
片段：Extracellular domain
链 d
22–118（97 aa）
片段：Extracellular domain
|
未记录 | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 NA SODIUM ION × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION；pH 6.5；293 K；20% PEG 3350, 0.2 M sodium malonate, 0.1 M Bis-Tris propane, pH 6.5, vapor diffusion, temperature 293K
|
分辨率 3.36 Å R-free 0.261 |
| 4FAO Specificity and Structure of a high affinity Activin-like 1 (ALK1) signaling complex 提交 2012-05-22 | Assembly 6 蛋白异源复合物 异源复合物；蛋白 × 6 PDB 声明：hexameric（6） 与蛋白数一致 |
链 i
22–118（97 aa）
片段：Extracellular domain
链 j
22–118（97 aa）
片段：Extracellular domain
|
未记录 | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 NA SODIUM ION × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION；pH 6.5；293 K；20% PEG 3350, 0.2 M sodium malonate, 0.1 M Bis-Tris propane, pH 6.5, vapor diffusion, temperature 293K
|
分辨率 3.36 Å R-free 0.261 |
| 6SF1 Bone morphogenetic protein 10 (BMP10) complexed with extracellular domain of activin receptor-like kinase 1 (ALK1). 提交 2019-07-30 | Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 4 PDB 声明：tetrameric（4） 与蛋白数一致 |
链 A
21–118（98 aa）
|
未记录 | NI NICKEL (II) ION × 10 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；295 K；17% PEG 3350, 0.175 M NH4I, 0.1 M HEPES pH 7.8
|
分辨率 2.80 Å R-free 0.279 |
| 6SF2 Ternary complex of human bone morphogenetic protein 9 (BMP9) growth factor domain, its prodomain and extracellular domain of activin receptor-like kinase 1 (ALK1). 提交 2019-07-31 | Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 6 PDB 声明：hexameric（6） 与蛋白数一致 |
链 A
21–118（98 aa）
链 D
21–118（98 aa）
|
未记录 | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；295 K；0.14 M potassium sodium tartrate, 14% PEG 3350
|
分辨率 3.30 Å R-free 0.274 |
| 6SF3 Bone morphogenetic protein 10 (BMP10) in complex with extracellular domain of activin receptor-like kinase 1 (ALK1) at 2.3 Angstrom 提交 2019-07-31 | Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 4 PDB 声明：tetrameric（4） 与蛋白数一致 |
链 A
21–118（98 aa）
|
未记录 | 未记录非水小分子 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 8.5；295 K；0.07 M Amino acids (0.014 M DL-Glutamic acids monohydrate; 0.014 M DL-Alanine; 0.014 M Glycine; 0.014 M DL-Lysine monohydrochloride; 0.014 M DL-Serine), 0.07 M Buffer System 3 (0.07 M Tris(base)/BICINE), 35% Precipitant Mix 4 (9% v/v MPD, 9% w/v PEG 1000, 9% w/ PEG3350)
|
分辨率 2.30 Å R-free 0.243 |
| 7PPC Ternary signalling complex of BMP10 bound to ALK1 and BMPRII 提交 2021-09-13 | Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 6 PDB 声明：hexameric（6） 与蛋白数一致 |
链 E
22–118（97 aa）
链 F
22–118（97 aa）
|
未记录 | 未记录非水小分子 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；294.15 K；20% PEG 3350
0.2 M Calcium acetate hydrate
|
分辨率 3.60 Å R-free 0.282 |
| 7PPC Ternary signalling complex of BMP10 bound to ALK1 and BMPRII 提交 2021-09-13 | Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 6 PDB 声明：hexameric（6） 与蛋白数一致 |
链 G
22–118（97 aa）
链 H
22–118（97 aa）
|
未记录 | 未记录非水小分子 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；294.15 K；20% PEG 3350
0.2 M Calcium acetate hydrate
|
分辨率 3.60 Å R-free 0.282 |