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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：P42566 New Search
10PDB entries
11Biological assembly
11chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
1C07 STRUCTURE OF THE THIRD EPS15 HOMOLOGY DOMAIN OF HUMAN EPS15 Deposited 1999-07-14 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 217–311（95 aa） Fragment：EPS15 HOMOLOGY (EH) DOMAIN 3
Not recorded CA CALCIUM ION × 1 SOLUTION NMR
NMR measurement conditions pH 7.8；298 K；Ionic strength (raw mmCIF value) 100mM KCL, 2mM CACL2, 2mM NAN3；Pressure AMBIENT
NMR sample composition 0.5-1MM EH3; 20MM D-TRIS, 100MM KCL, 2MM CACL2, 2MM NAN3, 0.1MM D-DTT; 95% H2O, 5% D2O
Resolution not provided
1EH2 STRUCTURE OF THE SECOND EPS15 HOMOLOGY DOMAIN OF HUMAN EPS15, NMR, 20 STRUCTURES Deposited 1998-07-10 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 121–218（98 aa） Fragment：EPS15 HOMOLOGY (EH) DOMAIN 2, RESIDUES 121-218
Not recorded CA CALCIUM ION × 1 SOLUTION NMR
NMR measurement conditions pH 7；298 K；Ionic strength (raw mmCIF value) 120 MILLIMOLAR；Pressure ATMOSPHERIC
NMR sample composition H2O AND D2O
Resolution not provided
1F8H STRUCTURE OF THE SECOND EPS15 HOMOLOGY DOMAIN OF HUMAN EPS15 IN COMPLEX WITH PTGSSSTNPFR Deposited 2000-06-30 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 121–215（95 aa） Fragment：RESIDUES 121-218 OF HUMAN EPS15
Not recorded CA CALCIUM ION × 1 SOLUTION NMR
NMR measurement conditions pH 7；298 K；Ionic strength (raw mmCIF value) 0.15；Pressure ambient
NMR measurement conditions pH 7；298 K；Ionic strength (raw mmCIF value) 0.15；Pressure ambient
NMR measurement conditions pH 7；298 K；Ionic strength (raw mmCIF value) 0.15；Pressure ambient
NMR measurement conditions pH 7；298 K；Ionic strength (raw mmCIF value) 0.15；Pressure ambient
NMR sample composition 1 mM {15N}-EH2 and 5 mM peptide, 20 mM perdeuterated Tris, 100 mM potassium chloride, 1 mM perdeuterated DTT, 1 mM sodium azide 2 mM calcium chloride | 10%/90% D2O/H2O
NMR sample composition 1 mM {15N}-EH2 and 5 mM peptide, 20 mM perdeuterated Tris, 100 mM potassium chloride, 1 mM perdeuterated DTT, 1 mM sodium azide 2 mM calcium chloride | 99.999% D2O
NMR sample composition 0.2 mM {15N}-EH2 and 5 mM peptide, 20 mM perdeuterated Tris, 100 mM potassium chloride, 1 mM perdeuterated DTT, 1 mM sodium azide 2 mM calcium chloride | 10%/90% D2O/H2O
NMR sample composition 0.2 mM {15N}-EH2 and 5 mM peptide, 20 mM perdeuterated Tris, 100 mM potassium chloride, 1 mM perdeuterated DTT, 1 mM sodium azide 2 mM calcium chloride | 10%/90% D2O/H2O
Resolution not provided
1FF1 STRUCTURE OF THE SECOND EPS15 HOMOLOGY DOMAIN OF HUMAN EPS15 IN COMPLEX WITH PTGSSSTNPFL Deposited 2000-07-24 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 121–215（95 aa） Fragment：SECOND EH DOMAIN
Not recorded CA CALCIUM ION × 1 SOLUTION NMR
NMR measurement conditions pH 7；298 K；Ionic strength (raw mmCIF value) 0.15；Pressure AMBIENT
NMR sample composition 1 MM {15N}-EH2 AND 5 MM PEPTIDE, 20 MM PERDEUTERATED TRIS, 100 MM POTASSIUM CHLORIDE, 1 MM PERDEUTERATED DTT, 1 MM SODIUM AZIDE, 2 MM CALCIUM CHLORIDE | 90% H2O/10% D2O
NMR sample composition 1 MM {15N}-EH2 AND 5 MM PEPTIDE, 20 MM PERDEUTERATED TRIS, 100 MM POTASSIUM CHLORIDE, 1 MM PERDEUTERATED DTT, 1 MM SODIUM AZIDE, 2 MM CALCIUM CHLORIDE | 100% D2O
Resolution not provided
2JXC Structure of the EPS15-EH2 Stonin2 Complex Deposited 2007-11-12 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 121–215（95 aa） Fragment：EH 2 domain
Not recorded CA CALCIUM ION × 1 SOLUTION NMR
NMR measurement conditions pH 7；295 K；Ionic strength (raw mmCIF value) 0.1；Pressure ambient
NMR sample composition 0.5-1 mM [U-99% 13C; U-99% 15N] EH2, 0.5-1 mM Stonin peptide, 2 mM CA, 93% H2O/7% D2O | 93% H2O/7% D2O
NMR sample composition 0.5-1 mM EH2, 0.5-1 mM [U-99% 13C; U-99% 15N] Stonin peptide, 2 mM CA, 93% H2O/7% D2O | 93% H2O/7% D2O
NMR sample composition 0.5-1 mM [U-99% 13C; U-99% 15N] EH2, 0.5-1 mM Stonin peptide, 2 mM CA, 100% D2O | 100% D2O
NMR sample composition 0.5-1 mM EH2, 0.5-1 mM [U-99% 13C; U-99% 15N] Stonin peptide, 2 mM CA, 100% D2O | 100% D2O
NMR sample composition 0.6 mM EH2, 0.6 mM Stonin peptide, 2 mM CA, 100% D2O | 100% D2O
Resolution not provided
4RH5 Crystal structure of PTPN3 (PTPH1) in complex with Eps15 pTyr849 peptide Deposited 2014-10-01 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 846–854（9 aa） Fragment：PTYR849 peptide (UNP RESIDUES 846-854)
Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；0.1M Tris-HCl, 21% PEG 8000, pH 8.5, VAPOR DIFFUSION, SITTING DROP, temperature 293K
Resolution 1.60 Å R-free 0.203
4RH9 Crystal structure of PTPN3 (PTPH1) H812F, M883G mutant in complex with Eps15 pTyr849 peptide Deposited 2014-10-01 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 846–854（9 aa） Fragment：pTyr849 peptide (UNP RESIDUES 846-854)
Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；0.1M Tris-HCl, 21% PEG 8000, 5% glycerol, pH 8.5, VAPOR DIFFUSION, SITTING DROP, temperature 293K
Resolution 1.60 Å R-free 0.226
4RHG Crystal structure of PTPN3 (PTPH1) D811E, C842S mutant in complex with Eps15 pTyr849 peptide Deposited 2014-10-02 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 846–854（9 aa） Fragment：pTyr849 peptide (UNP RESIDUES 846-854)
Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；0.1M Tris-HCl, 21% PEG 8000, 5% glycerol, pH 8.5, VAPOR DIFFUSION, SITTING DROP, temperature 293K
Resolution 1.58 Å R-free 0.209
4S0G Crystal structure of PTPN3 (PTPH1) in complex with Eps15 pTyr849 P850V peptide Deposited 2014-12-31 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 846–854（9 aa） Fragment：Phosphotyrosine 849 peptide, UNP residues 846-854
Mutation：P850V Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；0.1M Tris-HCl, 26% PEG 8000, pH 8.5, VAPOR DIFFUSION, SITTING DROP, temperature 293K
Resolution 1.72 Å R-free 0.229
5JP2 Fcho1 Mu homology domain (Danio Rerio) with bound Eps15 peptide Deposited 2016-05-03 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain E 615–637（23 aa） Fragment：UNP Residues 615-637
Not recorded ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；289 K；100 mM Bis-Tris propane pH, 6.0, 200 mM sodium citrate, 22% PEG 3350 and 10 mM DTT Crystals were cryopretetcted in 22% glycerol before flash cooling
Resolution 2.40 Å R-free 0.234
5JP2 Fcho1 Mu homology domain (Danio Rerio) with bound Eps15 peptide Deposited 2016-05-03 Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain F 615–637（23 aa） Fragment：UNP Residues 615-637
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；289 K；100 mM Bis-Tris propane pH, 6.0, 200 mM sodium citrate, 22% PEG 3350 and 10 mM DTT Crystals were cryopretetcted in 22% glycerol before flash cooling
Resolution 2.40 Å R-free 0.234

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.