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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：P43681 New Search
12PDB entries
12Biological assembly
48chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
2LLY NMR structures of the transmembrane domains of the nAChR a4 subunit Deposited 2011-11-18 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 240–339（100 aa） Fragment：Helical transmembrane region, residues 242-339 and residues 598-625
Chain A 598–626（29 aa） Fragment：Helical transmembrane region, residues 242-339 and residues 598-625
Mutation：R240E, R241E, L301S, I303S, L305S, R336E, M626E Mutation：R240E, R241E, L301S, I303S, L305S, R336E, M626E No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 4.65；318 K；Pressure ambient
NMR sample composition 0.25 mM [U-100% 13C; U-100% 15N] protein, 5 mM sodium acetate, 1.5 % LDAO, 10 mM sodium chloride, 5 % [U-100% 2H] D2O, 0.1 mM DSS, 10 mM sodium chloride, 20 mM beta-mercaptoethanol, 95% H2O/5% D2O | 95% H2O/5% D2O
Resolution not provided
5KXI X-ray structure of the human Alpha4Beta2 nicotinic receptor Deposited 2016-07-20 Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count
Chain A 27–364（338 aa） Fragment：UNP residues 27-364, 586-627,UNP residues 27-364, 586-627
Chain A 586–627（42 aa） Fragment：UNP residues 27-364, 586-627,UNP residues 27-364, 586-627
Chain D 27–364（338 aa） Fragment：UNP residues 27-364, 586-627,UNP residues 27-364, 586-627
Chain D 586–627（42 aa） Fragment：UNP residues 27-364, 586-627,UNP residues 27-364, 586-627
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5 NCT (S)-3-(1-METHYLPYRROLIDIN-2-YL)PYRIDINE × 2 NA SODIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；287.15 K；0.05 M ADA pH 6.8, 12.5% PEG 1500 and 10% PEG 1000
Resolution 3.94 Å R-free 0.307
6CNJ Structure of the 2alpha3beta stiochiometry of the human Alpha4Beta2 nicotinic receptor Deposited 2018-03-08 Assembly 1 Other combination Heteromer；Protein × 11 PDB declaration: undecameric（11） Consistent with protein count
Chain A 27–364（338 aa）
Chain A 586–627（42 aa）
Chain D 27–364（338 aa）
Chain D 586–627（42 aa）
Mutation：Glu-Arg linker was inserted in the MX-M4 junction, between Phe559-Ser560 in the alpha4 subunit Mutation：Glu-Arg linker was inserted in the MX-M4 junction, between Phe559-Ser560 in the alpha4 subunit Mutation：Glu-Arg linker was inserted in the MX-M4 junction, between Phe559-Ser560 in the alpha4 subunit Mutation：Glu-Arg linker was inserted in the MX-M4 junction, between Phe559-Ser560 in the alpha4 subunit NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 NCT (S)-3-(1-METHYLPYRROLIDIN-2-YL)PYRIDINE × 2 Y01 CHOLESTEROL HEMISUCCINATE × 10 NA SODIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE；4 second blot time
Resolution 3.70 Å
6CNK Structure of the 3alpha2beta stiochiometry of the human Alpha4Beta2 nicotinic receptor Deposited 2018-03-08 Assembly 1 Other combination Heteromer；Protein × 9 PDB declaration: nonameric（9） Consistent with protein count
Chain A 27–364（338 aa）
Chain A 586–627（42 aa）
Chain B 27–364（338 aa）
Chain B 586–627（42 aa）
Chain D 27–364（338 aa）
Chain D 586–627（42 aa）
Mutation：;Glu-Arg linker was inserted in the MX-M4 junction, between Phe559-Ser560 in the alpha4 subunit,Glu-Arg linker was inserted in the MX-M4 junction, between Phe559-Ser560 in the alpha4 subunit ; Mutation：;Glu-Arg linker was inserted in the MX-M4 junction, between Phe559-Ser560 in the alpha4 subunit,Glu-Arg linker was inserted in the MX-M4 junction, between Phe559-Ser560 in the alpha4 subunit ; Mutation：;Glu-Arg linker was inserted in the MX-M4 junction, between Phe559-Ser560 in the alpha4 subunit,Glu-Arg linker was inserted in the MX-M4 junction, between Phe559-Ser560 in the alpha4 subunit ; Mutation：;Glu-Arg linker was inserted in the MX-M4 junction, between Phe559-Ser560 in the alpha4 subunit,Glu-Arg linker was inserted in the MX-M4 junction, between Phe559-Ser560 in the alpha4 subunit ; Mutation：;Glu-Arg linker was inserted in the MX-M4 junction, between Phe559-Ser560 in the alpha4 subunit,Glu-Arg linker was inserted in the MX-M4 junction, between Phe559-Ser560 in the alpha4 subunit ; Mutation：;Glu-Arg linker was inserted in the MX-M4 junction, between Phe559-Ser560 in the alpha4 subunit,Glu-Arg linker was inserted in the MX-M4 junction, between Phe559-Ser560 in the alpha4 subunit ; NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 Y01 CHOLESTEROL HEMISUCCINATE × 10 NA SODIUM ION × 1 NCT (S)-3-(1-METHYLPYRROLIDIN-2-YL)PYRIDINE × 3 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE；4 second blot time
Resolution 3.90 Å
6UR8 CryoEM structure of human alpha4beta2 nicotinic acetylcholine receptor in complex with varenicline Deposited 2019-10-22 Assembly 1 Insufficient information Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count
Chain A 27–364（338 aa）
Chain A 589–627（39 aa）
Chain D 27–364（338 aa）
Chain D 589–627（39 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 8 QMR VARENICLINE × 2 BMA beta-D-mannopyranose × 3 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.71 Å
6USF CryoEM structure of human alpha4beta2 nicotinic acetylcholine receptor with varenicline in complex with anti-BRIL synthetic antibody BAK5 Deposited 2019-10-26 Assembly 1 Insufficient information Heteromer；Protein × 9 PDB declaration: nonameric（9） Consistent with protein count
Chain A 27–358（332 aa）
Chain A 589–627（39 aa）
Chain D 27–358（332 aa）
Chain D 589–627（39 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 QMR VARENICLINE × 2 BMA beta-D-mannopyranose × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.87 Å
8SSZ The 2alpha3beta stoichiometry of full-length human alpha4beta2 nicotinic acetylcholine receptor in complex with acetylcholine and calcium Deposited 2023-05-09 Assembly 1 Other combination Heteromer；Protein × 11 PDB declaration: undecameric（11） Consistent with protein count
Chain A 27–627（601 aa）
Chain D 27–627（601 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 6 ACH ACETYLCHOLINE × 2 CA CALCIUM ION × 2 NA SODIUM ION × 1 OCT N-OCTANE × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.64 Å
8ST0 The 2alpha3beta stoichiometry of full-length human alpha4beta2 nicotinic acetylcholine receptor in complex with acetylcholine Deposited 2023-05-09 Assembly 1 Other combination Heteromer；Protein × 11 PDB declaration: undecameric（11） Consistent with protein count
Chain A 27–627（601 aa）
Chain D 27–627（601 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 ACH ACETYLCHOLINE × 2 OCT N-OCTANE × 1 NA SODIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.40 Å
8ST1 The 3alpha2beta stoichiometry of human alpha4beta2 nicotinic acetylcholine receptor in complex with acetylcholine and calcium Deposited 2023-05-09 Assembly 1 Other combination Heteromer；Protein × 9 PDB declaration: nonameric（9） Consistent with protein count
Chain A 27–364（338 aa） Fragment：UNP residues 27-364,582-627
Chain A 582–627（46 aa） Fragment：UNP residues 27-364,582-627
Chain B 27–364（338 aa） Fragment：UNP residues 27-364,582-627
Chain B 582–627（46 aa） Fragment：UNP residues 27-364,582-627
Chain D 27–364（338 aa） Fragment：UNP residues 27-364,582-627
Chain D 582–627（46 aa） Fragment：UNP residues 27-364,582-627
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 6 ACH ACETYLCHOLINE × 3 CA CALCIUM ION × 4 NA SODIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.41 Å
8ST2 The 3alpha2beta stoichiometry of human alpha4beta2 nicotinic acetylcholine receptor in complex with acetylcholine Deposited 2023-05-09 Assembly 1 Other combination Heteromer；Protein × 9 PDB declaration: nonameric（9） Consistent with protein count
Chain A 27–364（338 aa） Fragment：UNP residues 27-364,582-627
Chain A 582–627（46 aa） Fragment：UNP residues 27-364,582-627
Chain B 27–364（338 aa） Fragment：UNP residues 27-364,582-627
Chain B 582–627（46 aa） Fragment：UNP residues 27-364,582-627
Chain D 27–364（338 aa） Fragment：UNP residues 27-364,582-627
Chain D 582–627（46 aa） Fragment：UNP residues 27-364,582-627
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 9 ACH ACETYLCHOLINE × 3 NA SODIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.94 Å
8ST3 The 2alpha3beta stoichiometry of human alpha4beta2 nicotinic acetylcholine receptor in complex with acetylcholine and calcium Deposited 2023-05-09 Assembly 1 Other combination Heteromer；Protein × 11 PDB declaration: undecameric（11） Consistent with protein count
Chain A 27–364（338 aa） Fragment：UNP residues 27-364,582-627
Chain A 582–627（46 aa） Fragment：UNP residues 27-364,582-627
Chain D 27–364（338 aa） Fragment：UNP residues 27-364,582-627
Chain D 582–627（46 aa） Fragment：UNP residues 27-364,582-627
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 6 ACH ACETYLCHOLINE × 2 CA CALCIUM ION × 3 NA SODIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.93 Å
8ST4 The 2alpha3beta stoichiometry of human alpha4beta2 nicotinic acetylcholine receptor in complex with acetylcholine Deposited 2023-05-09 Assembly 1 Other combination Heteromer；Protein × 11 PDB declaration: undecameric（11） Consistent with protein count
Chain A 27–364（338 aa） Fragment：UNP residues 27-364,582-627
Chain A 582–627（46 aa） Fragment：UNP residues 27-364,582-627
Chain D 27–364（338 aa） Fragment：UNP residues 27-364,582-627
Chain D 582–627（46 aa） Fragment：UNP residues 27-364,582-627
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 6 ACH ACETYLCHOLINE × 2 NA SODIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.35 Å

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.