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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：P52564 New Search
9PDB entries
17Biological assembly
19chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
2Y8O Crystal structure of human p38alpha complexed with a MAPK docking peptide Deposited 2011-02-08 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 4–17（14 aa） Fragment：N-TERMINAL DOCKING PEPTIDE OF MKK6, RESIDUES 4-17
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions pH 7.5；22% PEG3350 100MM HEPES 7.5
Resolution 1.95 Å R-free 0.209
3ENM The structure of the MAP2K MEK6 reveals an autoinhibitory dimer Deposited 2008-09-25 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 45–332（288 aa） Fragment：residues 45-334
Chain C 45–332（288 aa） Fragment：residues 45-334
Mutation：S207D T211D Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：S207D T211D Non-standard monomer：Yes (specific site not provided by mmCIF) SO4 SULFATE ION × 2 GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；289 K；1.6M Li2SO4 0.1M Tris-HCl, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 289K
Resolution 2.35 Å R-free 0.269
3ENM The structure of the MAP2K MEK6 reveals an autoinhibitory dimer Deposited 2008-09-25 Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 45–332（288 aa） Fragment：residues 45-334
Chain D 45–332（288 aa） Fragment：residues 45-334
Mutation：S207D T211D Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：S207D T211D Non-standard monomer：Yes (specific site not provided by mmCIF) SO4 SULFATE ION × 2 EDO 1,2-ETHANEDIOL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；289 K；1.6M Li2SO4 0.1M Tris-HCl, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 289K
Resolution 2.35 Å R-free 0.269
3FME Crystal Structure of Human Mitogen-Activated Protein Kinase Kinase 6 (MEK6) Activated Mutant (S207D, T211D) Deposited 2008-12-21 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 47–334（288 aa） Fragment：UNP residues 47-334, Protein kinase domain
Mutation：S207D, T211D STU STAUROSPORINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5.9；277 K；0.05M Mg(COO)2 10w/v PEG_3350, pH 5.9, VAPOR DIFFUSION, SITTING DROP, temperature 277K
Resolution 2.26 Å R-free 0.236
3VN9 Rifined Crystal structure of non-phosphorylated MAP2K6 in a putative auto-inhibition state Deposited 2012-01-05 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–334（334 aa）
Not recorded ANK 9-{5-O-[(R)-hydroxy{[(S)-hydroxy(phosphonoamino)phosphoryl]oxy}phosphoryl]-beta-L-ribofuranosyl}-9H-purin-6-amine × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；277 K；20% PEG4000, 10% 2-propanol, 0.1mol/L Na-HEPES-HCl, pH 6.0, VAPOR DIFFUSION, SITTING DROP, temperature 277K
Resolution 2.60 Å R-free 0.280
5ETF Structure of dead kinase MAPK14 with bound the KIM domain of MKK6 Deposited 2015-11-17 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 4–18（15 aa） Fragment：UNP residues 4-18
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；25% (w/v) PEG 3350 and 0.1 mM Bis-Tris pH6.5
Resolution 2.40 Å R-free 0.231
8A8M Structure of the MAPK p38alpha in complex with its activating MAP2K MKK6 Deposited 2022-06-23 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 15–334（320 aa）
Mutation：S207D, T211D AP2 PHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER × 2 MG MAGNESIUM ION × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；blot for 3.5 seconds
Resolution 4.00 Å
8P7J Crystal structure of MAP2K6 with a covalent compound GCL96 Deposited 2023-05-30 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 47–334（288 aa）
Not recorded X3K N-[3-(1H-pyrrolo[2,3-b]pyridin-4-yl)phenyl]prop-2-enamide × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293.15 K；0.05M magnesium chloride -- 30% PEG500MME -- 0.1M HEPES pH 7.5
Resolution 2.40 Å R-free 0.257
8P7J Crystal structure of MAP2K6 with a covalent compound GCL96 Deposited 2023-05-30 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain B 47–334（288 aa）
Not recorded X3K N-[3-(1H-pyrrolo[2,3-b]pyridin-4-yl)phenyl]prop-2-enamide × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293.15 K；0.05M magnesium chloride -- 30% PEG500MME -- 0.1M HEPES pH 7.5
Resolution 2.40 Å R-free 0.257
8PM3 Crystal structure of MAP2K6 with a covalent compound GCL94 Deposited 2023-06-28 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 47–334（288 aa）
Not recorded ZLE ~{N}-[3-(2-azanylpyridin-4-yl)phenyl]propanamide × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；293.15 K；0.05M magnesium chloride -- 30% PEG500MME -- 0.1M HEPES pH 7.5
Resolution 2.00 Å R-free 0.236
8PM3 Crystal structure of MAP2K6 with a covalent compound GCL94 Deposited 2023-06-28 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain B 47–334（288 aa）
Not recorded ZLE ~{N}-[3-(2-azanylpyridin-4-yl)phenyl]propanamide × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；293.15 K；0.05M magnesium chloride -- 30% PEG500MME -- 0.1M HEPES pH 7.5
Resolution 2.00 Å R-free 0.236
8PM3 Crystal structure of MAP2K6 with a covalent compound GCL94 Deposited 2023-06-28 Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain C 47–334（288 aa）
Not recorded ZLE ~{N}-[3-(2-azanylpyridin-4-yl)phenyl]propanamide × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；293.15 K；0.05M magnesium chloride -- 30% PEG500MME -- 0.1M HEPES pH 7.5
Resolution 2.00 Å R-free 0.236
8PM3 Crystal structure of MAP2K6 with a covalent compound GCL94 Deposited 2023-06-28 Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain D 47–334（288 aa）
Not recorded ZLE ~{N}-[3-(2-azanylpyridin-4-yl)phenyl]propanamide × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；293.15 K；0.05M magnesium chloride -- 30% PEG500MME -- 0.1M HEPES pH 7.5
Resolution 2.00 Å R-free 0.236
9M1Z Crystal Structure of MAP2K6 complexed with 5Z-7-oxozeaenol Deposited 2025-02-26 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain D 1–334（334 aa）
Not recorded 1FM (3S,5Z,8S,9S,11E)-8,9,16-trihydroxy-14-methoxy-3-methyl-3,4,9,10-tetrahydro-1H-2-benzoxacyclotetradecine-1,7(8H)-dione × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；277 K；0.1 M Citrate pH5.0, 20% PEG4000, 0.2 M L-proline
Resolution 3.00 Å R-free 0.332
9M1Z Crystal Structure of MAP2K6 complexed with 5Z-7-oxozeaenol Deposited 2025-02-26 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–334（334 aa）
Not recorded 1FM (3S,5Z,8S,9S,11E)-8,9,16-trihydroxy-14-methoxy-3-methyl-3,4,9,10-tetrahydro-1H-2-benzoxacyclotetradecine-1,7(8H)-dione × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；277 K；0.1 M Citrate pH5.0, 20% PEG4000, 0.2 M L-proline
Resolution 3.00 Å R-free 0.332
9M1Z Crystal Structure of MAP2K6 complexed with 5Z-7-oxozeaenol Deposited 2025-02-26 Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain B 1–334（334 aa）
Not recorded 1FM (3S,5Z,8S,9S,11E)-8,9,16-trihydroxy-14-methoxy-3-methyl-3,4,9,10-tetrahydro-1H-2-benzoxacyclotetradecine-1,7(8H)-dione × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；277 K；0.1 M Citrate pH5.0, 20% PEG4000, 0.2 M L-proline
Resolution 3.00 Å R-free 0.332
9M1Z Crystal Structure of MAP2K6 complexed with 5Z-7-oxozeaenol Deposited 2025-02-26 Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain C 1–334（334 aa）
Not recorded 1FM (3S,5Z,8S,9S,11E)-8,9,16-trihydroxy-14-methoxy-3-methyl-3,4,9,10-tetrahydro-1H-2-benzoxacyclotetradecine-1,7(8H)-dione × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；277 K；0.1 M Citrate pH5.0, 20% PEG4000, 0.2 M L-proline
Resolution 3.00 Å R-free 0.332

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.