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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：P53667 New Search
10PDB entries
19Biological assembly
19chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
3S95 Crystal structure of the human LIMK1 kinase domain in complex with staurosporine Deposited 2011-05-31 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 330–637（308 aa） Fragment：kinase domain (residue 330-637)
Not recorded STU STAUROSPORINE × 1 NA SODIUM ION × 1 GOL GLYCEROL × 9 CL CHLORIDE ION × 1 TRS 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.2；293.15 K；24% MPD, 0.1M Tris pH 7.2, 10mM Phenol, VAPOR DIFFUSION, SITTING DROP, temperature 293.15K
Resolution 1.65 Å R-free 0.181
3S95 Crystal structure of the human LIMK1 kinase domain in complex with staurosporine Deposited 2011-05-31 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain B 330–637（308 aa） Fragment：kinase domain (residue 330-637)
Not recorded STU STAUROSPORINE × 1 NA SODIUM ION × 1 GOL GLYCEROL × 2 CL CHLORIDE ION × 1 TRS 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL × 1 MRD (4R)-2-METHYLPENTANE-2,4-DIOL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.2；293.15 K；24% MPD, 0.1M Tris pH 7.2, 10mM Phenol, VAPOR DIFFUSION, SITTING DROP, temperature 293.15K
Resolution 1.65 Å R-free 0.181
5HVJ Crystal structure of LIMK1 D460N mutant in complex with AMP-PNP Deposited 2016-01-28 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 329–638（310 aa）
Mutation：D460N ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298 K；18-24% PEG 3350, 0.2 M potassium citrate
Resolution 2.20 Å R-free 0.252
5HVJ Crystal structure of LIMK1 D460N mutant in complex with AMP-PNP Deposited 2016-01-28 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain B 329–638（310 aa）
Mutation：D460N No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298 K；18-24% PEG 3350, 0.2 M potassium citrate
Resolution 2.20 Å R-free 0.252
5HVK Crystal structure of LIMK1 mutant D460N in complex with full-length cofilin-1 Deposited 2016-01-28 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 329–638（310 aa） Fragment：UNP residues 329-638
Mutation：D460N Non-standard monomer：Yes (specific site not provided by mmCIF) ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；298 K；1.2-1.4 M tri-Sodium citrate, 0.1 M sodium acetate, pH 5.5. 4 crystals used.
Resolution 3.50 Å R-free 0.310
5HVK Crystal structure of LIMK1 mutant D460N in complex with full-length cofilin-1 Deposited 2016-01-28 Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain C 329–638（310 aa） Fragment：UNP residues 329-638
Mutation：D460N Non-standard monomer：Yes (specific site not provided by mmCIF) ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；298 K；1.2-1.4 M tri-Sodium citrate, 0.1 M sodium acetate, pH 5.5. 4 crystals used.
Resolution 3.50 Å R-free 0.310
5L6W Structure Of the LIMK1-ATPgammaS-CFL1 Complex Deposited 2016-05-31 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain L 330–637（308 aa）
Not recorded AGS PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；277 K；35% pentaerythritol propoxylate 5/4, 0.1 M HEPES pH 7.5, 0.2 M potassium chloride
Resolution 2.53 Å R-free 0.284
5NXC LIM Domain Kinase 1 (LIMK1) In Complex With PF-00477736 Deposited 2017-05-10 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain L 330–637（308 aa） Fragment：UNP residues 330-637
Not recorded 9DB (2~{R})-2-azanyl-2-cyclohexyl-~{N}-[2-(1-methylpyrazol-4-yl)-9-oxidanylidene-3,10,11-triazatricyclo[6.4.1.0^{4,13}]trideca-1,4,6,8(13),11-pentaen-6-yl]ethanamide × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7；277 K；0.1 M HEPES pH 7.0 0.2 M MgCl2 10% PEG8K
Resolution 2.25 Å R-free 0.298
6WLY PAK4 kinase domain in complex with LIMK1 Thr508 substrate peptide Deposited 2020-04-20 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 503–512（10 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；295 K；0.1M Tris-HCl, 2M Na acetate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 295K, 2mM peptide
Resolution 1.90 Å R-free 0.205
7ATS The LIMK1 Kinase Domain Bound To LIJTF500127 Deposited 2020-10-30 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 330–637（308 aa）
Not recorded RXQ N-[3-[5-(4-Chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluorophenyl]benzenesulfonamide × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；20% PEG3350 0.1 M bis-tris-propane pH 7.5 0.2 M potassium thiocyanate 10% ethylene glycol
Resolution 2.80 Å R-free 0.312
7ATU The LIMK1 Kinase Domain Bound To LIJTF500025 Deposited 2020-10-30 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomer（1） Consistent with protein count
Chain A 330–637（308 aa）
Not recorded RXN (S)-2-benzyl-6-(8-chloro-5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-yl)-7-oxo-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-c]pyridine-3-carboxamide × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；277 K；0.1 M citrate pH 5.9 0.2 M NaCl 8% jeffamine M-600 0.005 M iron chloride
Resolution 2.80 Å R-free 0.316
7ATU The LIMK1 Kinase Domain Bound To LIJTF500025 Deposited 2020-10-30 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomer（1） Consistent with protein count
Chain B 330–637（308 aa）
Not recorded RXN (S)-2-benzyl-6-(8-chloro-5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-yl)-7-oxo-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-c]pyridine-3-carboxamide × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；277 K；0.1 M citrate pH 5.9 0.2 M NaCl 8% jeffamine M-600 0.005 M iron chloride
Resolution 2.80 Å R-free 0.316
7ATU The LIMK1 Kinase Domain Bound To LIJTF500025 Deposited 2020-10-30 Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomer（1） Consistent with protein count
Chain C 330–637（308 aa）
Not recorded RXN (S)-2-benzyl-6-(8-chloro-5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-yl)-7-oxo-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-c]pyridine-3-carboxamide × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；277 K；0.1 M citrate pH 5.9 0.2 M NaCl 8% jeffamine M-600 0.005 M iron chloride
Resolution 2.80 Å R-free 0.316
7ATU The LIMK1 Kinase Domain Bound To LIJTF500025 Deposited 2020-10-30 Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomer（1） Consistent with protein count
Chain D 330–637（308 aa）
Not recorded RXN (S)-2-benzyl-6-(8-chloro-5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-yl)-7-oxo-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-c]pyridine-3-carboxamide × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；277 K；0.1 M citrate pH 5.9 0.2 M NaCl 8% jeffamine M-600 0.005 M iron chloride
Resolution 2.80 Å R-free 0.316
7B8W Structure of LIMK1 Kinase domain with allosteric inhibitor TH-470 Deposited 2020-12-13 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 330–637（308 aa）
Not recorded T3B 2-(2-methylpropanoylamino)-~{N}-[2-[(phenylmethyl)-[4-(phenylsulfamoyl)phenyl]carbonyl-amino]ethyl]-1,3-thiazole-5-carboxamide × 1 EDO 1,2-ETHANEDIOL × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；277.15 K；0.2M Ammonium Citrate dibasic, 20% w/v PEG 3350
Resolution 2.80 Å R-free 0.286
7B8W Structure of LIMK1 Kinase domain with allosteric inhibitor TH-470 Deposited 2020-12-13 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain B 330–637（308 aa）
Not recorded T3B 2-(2-methylpropanoylamino)-~{N}-[2-[(phenylmethyl)-[4-(phenylsulfamoyl)phenyl]carbonyl-amino]ethyl]-1,3-thiazole-5-carboxamide × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；277.15 K；0.2M Ammonium Citrate dibasic, 20% w/v PEG 3350
Resolution 2.80 Å R-free 0.286
7B8W Structure of LIMK1 Kinase domain with allosteric inhibitor TH-470 Deposited 2020-12-13 Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain C 330–637（308 aa）
Not recorded T3B 2-(2-methylpropanoylamino)-~{N}-[2-[(phenylmethyl)-[4-(phenylsulfamoyl)phenyl]carbonyl-amino]ethyl]-1,3-thiazole-5-carboxamide × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；277.15 K；0.2M Ammonium Citrate dibasic, 20% w/v PEG 3350
Resolution 2.80 Å R-free 0.286
7B8W Structure of LIMK1 Kinase domain with allosteric inhibitor TH-470 Deposited 2020-12-13 Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain D 330–637（308 aa）
Not recorded T3B 2-(2-methylpropanoylamino)-~{N}-[2-[(phenylmethyl)-[4-(phenylsulfamoyl)phenyl]carbonyl-amino]ethyl]-1,3-thiazole-5-carboxamide × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；277.15 K；0.2M Ammonium Citrate dibasic, 20% w/v PEG 3350
Resolution 2.80 Å R-free 0.286
8AAU LIM Domain Kinase 1 (LIMK1) bound to LIMKi3 Deposited 2022-07-03 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain L 330–637（308 aa）
Not recorded EDO 1,2-ETHANEDIOL × 1 LH0 ~{N}-[5-[2-[2,6-bis(chloranyl)phenyl]-5-[bis(fluoranyl)methyl]pyrazol-3-yl]-1,3-thiazol-2-yl]-2-methyl-propanamide × 1 SO4 SULFATE ION × 3 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 4.5；277 K；0.1 M acetate pH 4.5, 0.2 M lithium sulfate, 12% PEG8K
Resolution 1.74 Å R-free 0.240

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.