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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：P56696 New Search
13PDB entries
25Biological assembly
60chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
2OVC Crystal structure of a coiled-coil tetramerization domain from Kv7.4 channels Deposited 2007-02-13 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 610–640（31 aa） Fragment：coiled-coil assembly domain, residues 611-640
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；289 K；45% MPD, 0.2M ammonium acetate, 0.1M Bis-Tris, pH 5.5, vapor diffusion, hanging drop, temperature 289K
Resolution 2.07 Å R-free 0.224
4GOW Crystal Structure of Ca2+/CaM:Kv7.4 (KCNQ4) B helix complex Deposited 2012-08-20 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 522–593（72 aa） Fragment：UNP residues 522-593
Not recorded CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；298 K；1.6M ammonium sulfate, 0.2M sodium citrate (pH 6.0), 0.1M sodium tartrate, 4% isopropanol, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 2.60 Å R-free 0.268
6B8L Crystal Structure of the Apo/CaM:Kv7.4 (KCNQ4) AB Domain Complex Deposited 2017-10-09 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 325–367（43 aa）
Chain A 524–557（34 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；2M ammonium sulfate, 0.1M BisTris pH 6.5
Resolution 2.30 Å R-free 0.246
6B8L Crystal Structure of the Apo/CaM:Kv7.4 (KCNQ4) AB Domain Complex Deposited 2017-10-09 Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain C 325–367（43 aa）
Chain C 524–557（34 aa）
Not recorded SO4 SULFATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；2M ammonium sulfate, 0.1M BisTris pH 6.5
Resolution 2.30 Å R-free 0.246
6B8L Crystal Structure of the Apo/CaM:Kv7.4 (KCNQ4) AB Domain Complex Deposited 2017-10-09 Assembly 3 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain E 325–367（43 aa）
Chain E 524–557（34 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；2M ammonium sulfate, 0.1M BisTris pH 6.5
Resolution 2.30 Å R-free 0.246
6B8L Crystal Structure of the Apo/CaM:Kv7.4 (KCNQ4) AB Domain Complex Deposited 2017-10-09 Assembly 4 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain G 325–367（43 aa）
Chain G 524–557（34 aa）
Not recorded SO4 SULFATE ION × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；2M ammonium sulfate, 0.1M BisTris pH 6.5
Resolution 2.30 Å R-free 0.246
6B8M Crystal Structure of the Ca2+/CaM:Kv7.4 (KCNQ4) AB Domain Complex, 1 mM CaCl2 soak Deposited 2017-10-09 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 325–367（43 aa）
Chain A 524–557（34 aa）
Not recorded CA CALCIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；2M ammonium sulfate, 0.1M BisTris pH 6.5, 1mM CaCl2
Resolution 2.30 Å R-free 0.262
6B8M Crystal Structure of the Ca2+/CaM:Kv7.4 (KCNQ4) AB Domain Complex, 1 mM CaCl2 soak Deposited 2017-10-09 Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain C 325–367（43 aa）
Chain C 524–557（34 aa）
Not recorded CA CALCIUM ION × 1 SO4 SULFATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；2M ammonium sulfate, 0.1M BisTris pH 6.5, 1mM CaCl2
Resolution 2.30 Å R-free 0.262
6B8M Crystal Structure of the Ca2+/CaM:Kv7.4 (KCNQ4) AB Domain Complex, 1 mM CaCl2 soak Deposited 2017-10-09 Assembly 3 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain E 325–367（43 aa）
Chain E 524–557（34 aa）
Not recorded CA CALCIUM ION × 2 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；2M ammonium sulfate, 0.1M BisTris pH 6.5, 1mM CaCl2
Resolution 2.30 Å R-free 0.262
6B8M Crystal Structure of the Ca2+/CaM:Kv7.4 (KCNQ4) AB Domain Complex, 1 mM CaCl2 soak Deposited 2017-10-09 Assembly 4 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain G 325–367（43 aa）
Chain G 524–557（34 aa）
Not recorded CA CALCIUM ION × 2 SO4 SULFATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；2M ammonium sulfate, 0.1M BisTris pH 6.5, 1mM CaCl2
Resolution 2.30 Å R-free 0.262
6B8N Crystal Structure of the Ca2+/CaM:Kv7.4 (KCNQ4) AB Domain Complex, 10 uM CaCl2 soak Deposited 2017-10-09 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 325–367（43 aa）
Chain A 524–557（34 aa）
Not recorded CA CALCIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；2M ammonium sulfate, 0.1M BisTris pH 6.5, 0.01mM CaCl2
Resolution 2.20 Å R-free 0.264
6B8N Crystal Structure of the Ca2+/CaM:Kv7.4 (KCNQ4) AB Domain Complex, 10 uM CaCl2 soak Deposited 2017-10-09 Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain C 325–367（43 aa）
Chain C 524–557（34 aa）
Not recorded CA CALCIUM ION × 1 SO4 SULFATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；2M ammonium sulfate, 0.1M BisTris pH 6.5, 0.01mM CaCl2
Resolution 2.20 Å R-free 0.264
6B8N Crystal Structure of the Ca2+/CaM:Kv7.4 (KCNQ4) AB Domain Complex, 10 uM CaCl2 soak Deposited 2017-10-09 Assembly 3 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain E 325–367（43 aa）
Chain E 524–557（34 aa）
Not recorded CA CALCIUM ION × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；2M ammonium sulfate, 0.1M BisTris pH 6.5, 0.01mM CaCl2
Resolution 2.20 Å R-free 0.264
6B8N Crystal Structure of the Ca2+/CaM:Kv7.4 (KCNQ4) AB Domain Complex, 10 uM CaCl2 soak Deposited 2017-10-09 Assembly 4 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain G 325–367（43 aa）
Chain G 524–557（34 aa）
Not recorded CA CALCIUM ION × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；2M ammonium sulfate, 0.1M BisTris pH 6.5, 0.01mM CaCl2
Resolution 2.20 Å R-free 0.264
6B8P Crystal Structure of the Mg2+/CaM:Kv7.4 (KCNQ4) AB domain complex Deposited 2017-10-09 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 325–367（43 aa）
Chain A 524–557（34 aa）
Not recorded MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；2M ammonium sulfate, 0.1M BisTris pH 6.5, 1mM MgCl2
Resolution 2.20 Å R-free 0.240
6B8P Crystal Structure of the Mg2+/CaM:Kv7.4 (KCNQ4) AB domain complex Deposited 2017-10-09 Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain C 325–367（43 aa）
Chain C 524–557（34 aa）
Not recorded MG MAGNESIUM ION × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；2M ammonium sulfate, 0.1M BisTris pH 6.5, 1mM MgCl2
Resolution 2.20 Å R-free 0.240
6B8P Crystal Structure of the Mg2+/CaM:Kv7.4 (KCNQ4) AB domain complex Deposited 2017-10-09 Assembly 3 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain E 325–367（43 aa）
Chain E 524–557（34 aa）
Not recorded MG MAGNESIUM ION × 1 SO4 SULFATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；2M ammonium sulfate, 0.1M BisTris pH 6.5, 1mM MgCl2
Resolution 2.20 Å R-free 0.240
6B8P Crystal Structure of the Mg2+/CaM:Kv7.4 (KCNQ4) AB domain complex Deposited 2017-10-09 Assembly 4 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain G 325–367（43 aa）
Chain G 524–557（34 aa）
Not recorded MG MAGNESIUM ION × 1 SO4 SULFATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；2M ammonium sulfate, 0.1M BisTris pH 6.5, 1mM MgCl2
Resolution 2.20 Å R-free 0.240
6N5W Crystal structure of the Ca2+/CaM complex with independent peptides of Kv7.4 (KCNQ4) A & B domains Deposited 2018-11-22 Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain A 336–362（27 aa）
Chain B 470–495（26 aa）
Not recorded CA CALCIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；295 K；1.3 M sodium citrate, 0.1 M HEPES pH 7.0
Resolution 2.15 Å R-free 0.274
7BYL Cryo-EM structure of human KCNQ4 Deposited 2020-04-23 Assembly 1 Insufficient information Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain A 1–695（695 aa）
Chain C 1–695（695 aa）
Chain E 1–695（695 aa）
Chain G 1–695（695 aa）
Mutation：F64L/S65T/K107T/A206K Mutation：F64L/S65T/K107T/A206K Mutation：F64L/S65T/K107T/A206K Mutation：F64L/S65T/K107T/A206K PT5 [(2R)-1-octadecanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8Z)-icosa-5,8,11,14-tetraenoate × 4 K POTASSIUM ION × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.50 Å
7BYM Cryo-EM structure of human KCNQ4 with retigabine Deposited 2020-04-23 Assembly 1 Insufficient information Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain A 1–695（695 aa）
Chain C 1–695（695 aa）
Chain E 1–695（695 aa）
Chain G 1–695（695 aa）
Mutation：F64L/S65T/K107T/A206K/H231L Mutation：F64L/S65T/K107T/A206K/H231L Mutation：F64L/S65T/K107T/A206K/H231L Mutation：F64L/S65T/K107T/A206K/H231L PT5 [(2R)-1-octadecanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8Z)-icosa-5,8,11,14-tetraenoate × 4 FBX ethyl N-[2-azanyl-4-[(4-fluorophenyl)methylamino]phenyl]carbamate × 4 K POTASSIUM ION × 3 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
7BYN Cryo-EM structure of human KCNQ4 with linopirdine Deposited 2020-04-23 Assembly 1 Insufficient information Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain A 1–695（695 aa）
Chain C 1–695（695 aa）
Chain E 1–695（695 aa）
Chain G 1–695（695 aa）
Mutation：F64L/S65T/K107T/A206K/H231L Mutation：F64L/S65T/K107T/A206K/H231L Mutation：F64L/S65T/K107T/A206K/H231L Mutation：F64L/S65T/K107T/A206K/H231L PT5 [(2R)-1-octadecanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8Z)-icosa-5,8,11,14-tetraenoate × 4 K POTASSIUM ION × 3 FCC 1-phenyl-3,3-bis(pyridin-4-ylmethyl)indol-2-one × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.30 Å
7VNP Structure of human KCNQ4-ML213 complex with PIP2 Deposited 2021-10-11 Assembly 1 Insufficient information Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain A 2–650（649 aa）
Chain C 2–650（649 aa）
Chain E 2–650（649 aa）
Chain G 2–650（649 aa）
Not recorded PT5 [(2R)-1-octadecanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8Z)-icosa-5,8,11,14-tetraenoate × 8 K POTASSIUM ION × 4 7YV (1S,2S,4R)-N-(2,4,6-trimethylphenyl)bicyclo[2.2.1]heptane-2-carboxamid × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.79 Å
7VNQ Structure of human KCNQ4-ML213 complex in nanodisc Deposited 2021-10-11 Assembly 1 Insufficient information Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain A 2–650（649 aa）
Chain C 2–650（649 aa）
Chain E 2–650（649 aa）
Chain G 2–650（649 aa）
Not recorded 7YV (1S,2S,4R)-N-(2,4,6-trimethylphenyl)bicyclo[2.2.1]heptane-2-carboxamid × 4 K POTASSIUM ION × 3 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.96 Å
7VNR Structure of human KCNQ4-ML213 complex in digitonin Deposited 2021-10-11 Assembly 1 Insufficient information Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain A 2–650（649 aa）
Chain C 2–650（649 aa）
Chain E 2–650（649 aa）
Chain G 2–650（649 aa）
Not recorded 7YV (1S,2S,4R)-N-(2,4,6-trimethylphenyl)bicyclo[2.2.1]heptane-2-carboxamid × 4 K POTASSIUM ION × 3 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.80 Å

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.