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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：P57764 New Search
9PDB entries
14Biological assembly
48chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
5NH1 Structure of the C-terminal domain of human Gasdermin D Deposited 2017-03-21 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 278–484（207 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；303 K；1.229 M NaCitrate, HEPES, pH 7.25
Resolution 2.04 Å R-free 0.264
5WQT Structure of a protein involved in pyroptosis Deposited 2016-11-28 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 276–484（209 aa） Fragment：C-terminal (UNP RESIDUES 276-484)
Chain B 276–484（209 aa） Fragment：C-terminal (UNP RESIDUES 276-484)
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) GOL GLYCEROL × 3 CIT CITRIC ACID × 2 X-RAY DIFFRACTION
X-ray crystallization conditions EVAPORATION；pH 7；291 K；20mM Sodium bromide, 0.1M Hepes sodium pH7.0, 1.5M Sodium citrate tribasic dihydrate
Resolution 2.64 Å R-free 0.286
6AO4 Crystal structure of the human gasdermin D C-terminal domain Deposited 2017-08-15 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 277–484（208 aa） Fragment：unp residues 277-484
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7；295 K；2.1 M DL-malic acid, pH 7.0
Resolution 2.90 Å R-free 0.290
6KMZ caspase-4 P22/P10 C258A in complex with human GSDMD-C domain Deposited 2019-08-01 Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count
Chain E 287–480（194 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；100 mM Tris-HCl pH 7.5, 200 mM sodium tartrate, 20% (w/v) polyethylene glycol 3350, 5% glycerol and 4% 1,1,1,3,3,3-hexafluoro-2-propanol
Resolution 3.61 Å R-free 0.319
6KMZ caspase-4 P22/P10 C258A in complex with human GSDMD-C domain Deposited 2019-08-01 Assembly 2 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count
Chain H 286–480（195 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；100 mM Tris-HCl pH 7.5, 200 mM sodium tartrate, 20% (w/v) polyethylene glycol 3350, 5% glycerol and 4% 1,1,1,3,3,3-hexafluoro-2-propanol
Resolution 3.61 Å R-free 0.319
6KN0 caspase-1 P20/P10 C285A in complex with human GSDMD-C domain Deposited 2019-08-02 Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain E 283–480（198 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；150 mM KBr, 30% (w/v) polyethylene glycol mono-methyester 2000
Resolution 2.79 Å R-free 0.300
6KN0 caspase-1 P20/P10 C285A in complex with human GSDMD-C domain Deposited 2019-08-02 Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain F 283–480（198 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；150 mM KBr, 30% (w/v) polyethylene glycol mono-methyester 2000
Resolution 2.79 Å R-free 0.300
6N9O Crystal structure of human GSDMD Deposited 2018-12-03 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–484（484 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；277 K；25% PEG3350, 0.1M Bis-Tris pH 5.5, 200 mM NaCl, and 10 mM DTT
Resolution 3.50 Å R-free 0.345
6N9O Crystal structure of human GSDMD Deposited 2018-12-03 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain B 1–484（484 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；277 K；25% PEG3350, 0.1M Bis-Tris pH 5.5, 200 mM NaCl, and 10 mM DTT
Resolution 3.50 Å R-free 0.345
6N9O Crystal structure of human GSDMD Deposited 2018-12-03 Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain C 1–484（484 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；277 K；25% PEG3350, 0.1M Bis-Tris pH 5.5, 200 mM NaCl, and 10 mM DTT
Resolution 3.50 Å R-free 0.345
6N9O Crystal structure of human GSDMD Deposited 2018-12-03 Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain D 1–484（484 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；277 K；25% PEG3350, 0.1M Bis-Tris pH 5.5, 200 mM NaCl, and 10 mM DTT
Resolution 3.50 Å R-free 0.345
6VFE Gasdermin D pore Deposited 2020-01-03 Assembly 1 Protein homooligomer Homooligomer；Protein × 33 PDB declaration: 33-meric（33） Consistent with protein count
Chain A 1–241（241 aa）
Chain B 1–241（241 aa）
Chain C 1–241（241 aa）
Chain D 1–241（241 aa）
Chain E 1–241（241 aa）
Chain F 1–241（241 aa）
Chain G 1–241（241 aa）
Chain H 1–241（241 aa）
Chain I 1–241（241 aa）
Chain J 1–241（241 aa）
Chain K 1–241（241 aa）
Chain L 1–241（241 aa）
Chain M 1–241（241 aa）
Chain N 1–241（241 aa）
Chain O 1–241（241 aa）
Chain P 1–241（241 aa）
Chain Q 1–241（241 aa）
Chain R 1–241（241 aa）
Chain S 1–241（241 aa）
Chain T 1–241（241 aa）
Chain U 1–241（241 aa）
Chain V 1–241（241 aa）
Chain W 1–241（241 aa）
Chain X 1–241（241 aa）
Chain Y 1–241（241 aa）
Chain Z 1–241（241 aa）
Chain a 1–241（241 aa）
Chain b 1–241（241 aa）
Chain c 1–241（241 aa）
Chain d 1–241（241 aa）
Chain e 1–241（241 aa）
Chain f 1–241（241 aa）
Chain g 1–241（241 aa）
Mutation：L192E Mutation：L192E Mutation：L192E Mutation：L192E Mutation：L192E Mutation：L192E Mutation：L192E Mutation：L192E Mutation：L192E Mutation：L192E Mutation：L192E Mutation：L192E Mutation：L192E Mutation：L192E Mutation：L192E Mutation：L192E Mutation：L192E Mutation：L192E Mutation：L192E Mutation：L192E Mutation：L192E Mutation：L192E Mutation：L192E Mutation：L192E Mutation：L192E Mutation：L192E Mutation：L192E Mutation：L192E Mutation：L192E Mutation：L192E Mutation：L192E Mutation：L192E Mutation：L192E No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.90 Å
7Z1X Crystal structure of human Gasdermin D complexed with nanobodies VHH-2 and VHH-6 Deposited 2022-02-25 Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain A 1–484（484 aa）
Chain D 1–484（484 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 4.4；293 K；20 mg/ml protein complex; 0.04 M NaCl, 25.8% (v/v) PEG400, 0.05 M Na3Cit pH 4.4
Resolution 1.86 Å R-free 0.249
9E0V GSDMD bound to a peptide Deposited 2024-10-19 Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 276–484（209 aa） Fragment：MBP + GSD (UNP residues 276-484)
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.5；289.15 K；0.1 M HEPES, pH 7.5, 1.25 M sodium citrate dihydrate, 20 mM TCEP
Resolution 1.64 Å R-free 0.212

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.