Current Protein Identity：Q00688
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Difference tags compare only the current result set; every original PDB and assembly record remains separate.
Related-Structure Differences
Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.
| PDB Entry | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Experimental Method | Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 1PBK HOMOLOGOUS DOMAIN OF HUMAN FKBP25 Deposited 1995-09-01 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
109–224（116 aa）
Fragment：FKBP12 HOMOLOGOUS DOMAIN, RESIDUES PRO 109 - ASP 2
|
Not recorded | RAP RAPAMYCIN IMMUNOSUPPRESSANT DRUG × 1 | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 2.50 Å R-free 0.243 |
| 2KFV Structure of the amino-terminal domain of human FK506-binding protein 3 / Northeast Structural Genomics Consortium Target HT99A Deposited 2009-02-27 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1–73（73 aa）
Fragment：FKBP3-N Nterminal domain, residues 20-92
|
Not recorded | No recorded non-water small molecule | SOLUTION NMR |
NMR measurement conditions
pH 7；298 K；Ionic strength (raw mmCIF value) 0.5；Pressure ambient
NMR sample composition
12.5 mg/ml [U-100% 13C; U-100% 15N] FKBP3-N, 10 mM TRIS, 500 mM NaCl, 90% H2O/10% D2O | 90% H2O/10% D2O
|
Resolution not provided |
| 2MPH Solution Structure of human FK506 binding Protein 25 Deposited 2014-05-18 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1–224（224 aa）
|
Not recorded | No recorded non-water small molecule | SOLUTION NMR |
NMR measurement conditions
pH 7；298 K；Ionic strength (raw mmCIF value) 70；Pressure ambient
NMR sample composition
0.5 mM [U-13C; U-15N] human FK506 binding protein 25 (hFKBP25)-1, 10 % [U-100% 2H] D2O-2, 90 % H2O-3, 50 mM sodium chloride-4, 20 mM sodium phosphate-5, 0.001 % sodium azide-6, 90% H2O/10% D2O | 90% H2O/10% D2O
NMR sample composition
0.5 mM [U-15N] human FK506 binding protein 25 (hFKBP25)-7, 10 % [U-100% 2H] D2O-8, 90 % H2O-9, 50 mM sodium chloride-10, 20 mM sodium phosphate-11, 0.001 % sodium azide-12, 90% H2O/10% D2O | 90% H2O/10% D2O
NMR sample composition
0.5 mM [U-13C] human FK506 binding protein 25 (hFKBP25)-13, 100 % [U-100% 2H] D2O-14, 50 mM sodium chloride-15, 20 mM sodium phosphate-16, 0.001 % sodium phosphate-17, 100% D2O | 100% D2O
|
Resolution not provided |
| 5D75 Crystal structure of Human FKBD25 in complex with FK506 Deposited 2015-08-13 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
109–224（116 aa）
Fragment：UNP RESIDUES 109-224
|
Not recorded | FK5 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN × 1 JEF O-(O-(2-AMINOPROPYL)-O'-(2-METHOXYETHYL)POLYPROPYLENE GLYCOL 500) × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；291 K；30% v/v Jeffamine ED-2001, 0.1M HEPES pH 7.0
|
Resolution 1.83 Å R-free 0.233 |
| 5GPG Co-crystal structure of the FK506 binding domain of human FKBP25, Rapamycin and the FRB domain of human mTOR Deposited 2016-08-02 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
109–224（116 aa）
Fragment：UNP residues 109-224
|
Not recorded | RAP RAPAMYCIN IMMUNOSUPPRESSANT DRUG × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；30% polyethyleneglycol 8000, 100mM sodium cacodylate, 200mM sodium acetate, 10mM manganese chloride
|
Resolution 1.67 Å R-free 0.212 |