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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：Q03526 New Search
12PDB entries
13Biological assembly
15chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
1AWJ INTRAMOLECULAR ITK-PROLINE COMPLEX, NMR, MINIMIZED AVERAGE STRUCTURE Deposited 1997-10-02 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 160–236（77 aa） Fragment：SH3-PROLINE DOMAINS
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 6；298 K
Resolution not provided
1LUI NMR Structures of Itk SH2 domain, Pro287cis isoform, ensemble of 20 low energy structures Deposited 2002-05-22 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 238–344（107 aa） Fragment：src homology 2 (SH2) domain (residues 238-344)
Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 7.4；298 K；Ionic strength (raw mmCIF value) 125mM；Pressure ambient
NMR sample composition 1 mM Itk SH2 domain U-15N, U-13C, 125 mM Phosphate buffer, pH 7.4, 2 mM DTT | 90% H20, 10% D20
NMR sample composition 1 mM Itk SH2 domain U-15N, 125 mM Phosphate buffer, pH 7.4, 2 mM DTT | 90% H20, 10% D20
NMR sample composition 1 mM Itk SH2 domain, 125 mM Phosphate buffer, pH 7.4, 2 mM DTT | 90% H20, 10% D20
Resolution not provided
1LUK NMR Structure of the Itk SH2 domain, Pro287cis, Energy minimized average structure Deposited 2002-05-22 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 238–344（107 aa） Fragment：src homology 2 (SH2) domain (residues 238-344)
Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 7.4；298 K；Ionic strength (raw mmCIF value) 125mM；Pressure ambient
NMR sample composition 1 mM Itk SH2, U-15N,13C, 125mM phosphate buffer, pH 7.4 | 90% H2O/10% D2O
NMR sample composition 1 mM Itk SH2, U-15N, 125mM phosphate buffer, pH 7.4 | 90% H2O/10% D2O
NMR sample composition 1 mM Itk SH2, 125mM phosphate buffer, pH 7.4 | 90% H2O/10% D2O
Resolution not provided
1LUM NMR Structure of the Itk SH2 domain, Pro287trans, 20 low energy structures Deposited 2002-05-22 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 238–344（107 aa） Fragment：src homology 2 (SH2) domain (residues 238-344)
Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 7.4；298 K；Ionic strength (raw mmCIF value) 125mM；Pressure ambient
NMR sample composition 1 mM Itk SH2, U-15N,13C, 125mM phosphate buffer, pH 7.4 | 90% H2O/10% D2O
NMR sample composition 1 mM Itk SH2, U-15N, 125mM phosphate buffer, pH 7.4 | 90% H2O/10% D2O
NMR sample composition 1 mM Itk SH2, 125mM phosphate buffer, pH 7.4 | 90% H2O/10% D2O
Resolution not provided
1LUN NMR Structure of the Itk SH2 domain, Pro287trans, energy minimized average structure Deposited 2002-05-22 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 238–344（107 aa） Fragment：src homology 2 (SH2) domain (residues 238-344)
Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 7.4；298 K；Ionic strength (raw mmCIF value) 125mM；Pressure ambient
NMR sample composition 1 mM Itk SH2, U-15N,13C, 125mM phosphate buffer, pH 7.4 | 90% H2O/10% D2O
NMR sample composition 1 mM Itk SH2, U-15N, 125mM phosphate buffer, pH 7.4 | 90% H2O/10% D2O
NMR sample composition 1 mM Itk SH2, 125mM phosphate buffer, pH 7.4 | 90% H2O/10% D2O
Resolution not provided
2ETZ The NMR minimized average structure of the Itk SH2 domain bound to a phosphopeptide Deposited 2005-10-27 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 238–344（107 aa） Fragment：SH2 domain
Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 7.4；298 K；Ionic strength (raw mmCIF value) 125mM；Pressure ambient
NMR sample composition 1mM Itk SH2 domain, 20mM phosphopeptide, 50mM KH2PO4, 75mM NaCl, 2mM DTT, 0.02% NaN3, pH 7.4 | 90% H2O/10% D2O
NMR sample composition U-15N labeled, 1mM Itk SH2 domain, 20mM phosphopeptide, 50mM KH2PO4, 75mM NaCl, 2mM DTT, 0.02% NaN3, pH 7.4 | 90% H2O/10% D2O
NMR sample composition U-15N, 13-C labeled, 1mM Itk SH2 domain, 20mM phosphopeptide, 50mM KH2PO4, 75mM NaCl, 2mM DTT, 0.02% NaN3, pH 7.4 | 90%H20, 10%D2O
NMR sample composition 5mM phosphopeptide, 50mM KH2PO4, 75mM NaCl, 2mM DTT, 0.02% NaN3, pH 7.4 | 90%H20, 10%D2O
NMR sample composition 1mM Itk SH2 domain, 20mM phosphopeptide, 50mM KH2PO4, 75mM NaCl, 2mM DTT, 0.02% NaN3, pH 7.4 | 100% D2O
Resolution not provided
2EU0 The NMR ensemble structure of the Itk SH2 domain bound to a phosphopeptide Deposited 2005-10-27 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 238–344（107 aa） Fragment：SH2 domain
Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 7.4；298 K；Ionic strength (raw mmCIF value) 125mM；Pressure ambient
NMR sample composition 1mM Itk SH2 domain, 20mM phosphopeptide, 50mM KH2PO4, 75mM NaCl, 2mM DTT, 0.02% NaN3, pH 7.4 | 90% H2O/10% D2O
NMR sample composition U-15N labeled, 1mM Itk SH2 domain, 20mM phosphopeptide, 50mM KH2PO4, 75mM NaCl, 2mM DTT, 0.02% NaN3, pH 7.4 | 90% H2O/10% D2O
NMR sample composition U-15N, 13-C labeled, 1mM Itk SH2 domain, 20mM phosphopeptide, 50mM KH2PO4, 75mM NaCl, 2mM DTT, 0.02% NaN3, pH 7.4 | 90% H2O/10% D2O
NMR sample composition 5mM phosphopeptide, 50mM KH2PO4, 75mM NaCl, 2mM DTT, 0.02% NaN3, pH 7.4 | 90%H20, 10%D2O
NMR sample composition 1mM Itk SH2 domain, 20mM phosphopeptide, 50mM KH2PO4, 75mM NaCl, 2mM DTT, 0.02% NaN3, pH 7.4 | 100% D2O
Resolution not provided
2K79 Solution Structure of the binary complex between the SH3 and SH2 domain of interleukin-2 tyrosine kinase Deposited 2008-08-08 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 177–237（61 aa）
Chain B 238–344（107 aa）
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 7.4；298 K；Ionic strength (raw mmCIF value) 75；Pressure ambient
NMR sample composition 3.4 mM [U-100% 13C; U-100% 15N] Itk SH3 domain, 1.5 mM Itk SH2 domain, 95% H2O/5% D2O | 95% H2O/5% D2O
NMR sample composition 3.4 mM [U-100% 13C; U-100% 15N] Itk SH2 domain, 1.5 mM Itk SH3 domain, 95% H2O/5% D2O | 95% H2O/5% D2O
NMR sample composition 1.5 mM [U-100% 13C; U-100% 15N] Itk SH2 domain, 3.4 mM Itk SH3 domain, 95% H2O/5% D2O | 95% H2O/5% D2O
NMR sample composition 1.5 mM [U-100% 13C; U-100% 15N] Itk SH3 domain, 3.4 mM Itk SH2 domain, 95% H2O/5% D2O | 95% H2O/5% D2O
Resolution not provided
2K7A Ensemble Structures of the binary complex between the SH3 and SH2 domain of interleukin-2 tyrosine kinase. Deposited 2008-08-08 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 177–237（61 aa）
Chain B 238–344（107 aa）
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 7.4；298 K；Ionic strength (raw mmCIF value) 75；Pressure ambient
NMR sample composition 3.4 mM [U-100% 13C; U-100% 15N] Itk SH3 domain, 1.5 mM Itk SH2 domain, 95% H2O/5% D2O | 95% H2O/5% D2O
NMR sample composition 3.4 mM [U-100% 13C; U-100% 15N] Itk SH2 domain, 1.5 mM Itk SH3 domain, 95% H2O/5% D2O | 95% H2O/5% D2O
NMR sample composition 1.5 mM [U-100% 13C; U-100% 15N] Itk SH2 domain, 3.4 mM Itk SH3 domain, 95% H2O/5% D2O | 95% H2O/5% D2O
NMR sample composition 1.5 mM [U-100% 13C; U-100% 15N] Itk SH3 domain, 3.4 mM Itk SH2 domain, 95% H2O/5% D2O | 95% H2O/5% D2O
Resolution not provided
2RN8 NMR structure note: murine Itk SH3 domain Deposited 2007-12-08 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 177–238（62 aa） Fragment：SH3 domain
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 7.4；298 K；Ionic strength (raw mmCIF value) 75 mM NaCl；Pressure ambient
NMR sample composition 3.4mM [U-100% 13C; U-100% 15N] Itk Sh3, 95% H2O/5% D2O | 95% H2O/5% D2O
Resolution not provided
2RNA Itk SH3 average minimized Deposited 2007-12-08 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 177–238（62 aa） Fragment：SH3 domain
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 7.4；298 K；Ionic strength (raw mmCIF value) 75mM NaCl；Pressure ambient
NMR sample composition 3.4mM [U-100% 13C; U-100% 15N] Itk Sh3, 95% H2O/5% D2O | 95% H2O/5% D2O
Resolution not provided
3S9K Crystal structure of the Itk SH2 domain. Deposited 2011-06-01 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 236–344（109 aa） Fragment：SH2 domain (UNP Residues 236-344)
Not recorded CIT CITRIC ACID × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.3；298 K；0.1 M Sodium citrate, 10 % iso-propanol, 20 % w/v PEG 4000, 2 mM DTT with 12.5 mM Glycyl-glycyl-glycine as an additive, pH 5.3, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 2.35 Å R-free 0.283
3S9K Crystal structure of the Itk SH2 domain. Deposited 2011-06-01 Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 236–344（109 aa） Fragment：SH2 domain (UNP Residues 236-344)
Not recorded CIT CITRIC ACID × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.3；298 K；0.1 M Sodium citrate, 10 % iso-propanol, 20 % w/v PEG 4000, 2 mM DTT with 12.5 mM Glycyl-glycyl-glycine as an additive, pH 5.3, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 2.35 Å R-free 0.283

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.