Current Protein Identity：Q12923
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Difference tags compare only the current result set; every original PDB and assembly record remains separate.
Related-Structure Differences
Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.
| PDB Entry | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Experimental Method | Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 1D5G SOLUTION STRUCTURE OF THE PDZ2 DOMAIN FROM HUMAN PHOSPHATASE HPTP1E COMPLEXED WITH A PEPTIDE Deposited 1999-10-07 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1361–1456（96 aa）
Fragment：PDZ2 DOMAIN
|
Not recorded | No recorded non-water small molecule | SOLUTION NMR |
NMR measurement conditions
pH 6.8；293 K；Ionic strength (raw mmCIF value) 0.15 M NACL；Pressure AMBIENT
NMR measurement conditions
pH 6.8；293 K；Ionic strength (raw mmCIF value) 0.15 M NACL；Pressure AMBIENT
NMR measurement conditions
pH 6.8；293 K；Ionic strength (raw mmCIF value) 0.15 M NACL；Pressure AMBIENT
NMR measurement conditions
pH 6.8；293 K；Ionic strength (raw mmCIF value) 0.15 M NACL；Pressure AMBIENT
NMR sample composition
1.0-5.0 MM OF N15-LABELED PDZ2 DOMAIN WITH 20% MOLAR EXCESS OF UNLABELED PEPTIDE
NMR sample composition
1.0-5.0 MM OF UNLABELED PDZ2 DOMAIN WITH 20% MOLAR EXCESS OF UNLABELED PEPTIDE
NMR sample composition
1.0-5.0 MM OF UNLABELED PDZ2 DOMAIN WITH 20% MOLAR EXCESS OF UNLABELED PEPTIDE
NMR sample composition
1.0-5.0 MM OF DOUBLE-LABELED PDZ2 DOMAIN WITH 20% MOLAR EXCESS OF UNLABELED
PEPTIDE
|
Resolution not provided |
| 1Q7X Solution structure of the alternatively spliced PDZ2 domain (PDZ2b) of PTP-Bas (hPTP1E) Deposited 2003-08-20 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1357–1464（108 aa）
|
Not recorded | No recorded non-water small molecule | SOLUTION NMR |
NMR measurement conditions
pH 6.8；293 K；Ionic strength (raw mmCIF value) 50mM sodium phosphate, 150mM sodium chloride；Pressure ambient
NMR sample composition
2mM PDZ2b U-15N, 13C; 50mM phosphate buffer with 150mM sodium chloride | 92% H20, 8% D2O
NMR sample composition
2mM PDZ2b U-15N; 50mM phosphate buffer with 150mM sodium chloride | 92% H20, 8% D2O
NMR sample composition
2mM PDZ2b unlabeled; 50mM phosphate buffer with 150mM sodium chloride | 92% H20, 8% D2O
|
Resolution not provided |
| 1WCH Crystal structure of PTPL1 human tyrosine phosphatase mutated in colorectal cancer - evidence for a second phosphotyrosine substrate recognition pocket Deposited 2004-11-16 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
2163–2477（315 aa）
Fragment：RESIDUES 2163-2477
|
Not recorded | PO4 PHOSPHATE ION × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION
|
Resolution 1.85 Å R-free 0.204 |
| 2M0Z cis form of a photoswitchable PDZ domain crosslinked with an azobenzene derivative Deposited 2012-11-09 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1361–1456（96 aa）
Fragment：PDZ 2 domain residues 1361-1456
|
Mutation：S1381C, E1436C | 33B 3,3'-(E)-diazene-1,2-diylbis{6-[(chloroacetyl)amino]benzenesulfonic acid} × 1 | SOLUTION NMR |
NMR measurement conditions
pH 6.8；298 K；Ionic strength (raw mmCIF value) 0.2；Pressure ambient
NMR sample composition
0.75 mM [U-100% 15N] protein, 50 mM sodium phosphate, 150 mM sodium chloride, 0.1 mM sodium azide, 4.3 % C12E5, 1.8 % n-hexanol, 90% H2O/10% D2O | 90% H2O/10% D2O
NMR sample composition
0.75 mM [U-100% 15N] protein, 50 mM sodium phosphate, 150 mM sodium chloride, 0.1 mM sodium azide, 8.5 mg/mL Pf1 phage, 90% H2O/10% D2O | 90% H2O/10% D2O
NMR sample composition
0.75 mM [U-99% 13C; U-99% 15N] protein, 50 mM sodium phosphate, 150 mM sodium chloride, 0.1 mM sodium azide, 90% H2O/10% D2O | 90% H2O/10% D2O
|
Resolution not provided |
| 2M10 trans form of a photoswitchable PDZ domain crosslinked with an azobenzene derivative Deposited 2012-11-09 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1361–1456（96 aa）
Fragment：PDZ 2 domain residues 1361-1456
|
Mutation：S1381C, E1436C | 33B 3,3'-(E)-diazene-1,2-diylbis{6-[(chloroacetyl)amino]benzenesulfonic acid} × 1 | SOLUTION NMR |
NMR measurement conditions
pH 6.8；298 K；Ionic strength (raw mmCIF value) 0.2；Pressure ambient
NMR sample composition
0.75 mM [U-100% 15N] protein, 50 mM sodium phosphate, 150 mM sodium chloride, 0.1 mM sodium azide, 4.3 % C12E5, 1.8 % n-hexanol, 90% H2O/10% D2O | 90% H2O/10% D2O
NMR sample composition
0.75 mM [U-100% 15N] protein, 50 mM sodium phosphate, 150 mM sodium chloride, 0.1 mM sodium azide, 8.5 mg/mL Pf1 phage, 90% H2O/10% D2O | 90% H2O/10% D2O
NMR sample composition
0.75 mM [U-99% 13C; U-99% 15N] protein, 50 mM sodium phosphate, 150 mM sodium chloride, 0.1 mM sodium azide, 90% H2O/10% D2O | 90% H2O/10% D2O
|
Resolution not provided |
| 3LNX Second PDZ domain from human PTP1E Deposited 2010-02-03 | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain A
1361–1456（96 aa）
Fragment：PDZ2 domain
Chain B
1361–1456（96 aa）
Fragment：PDZ2 domain
Chain C
1361–1456（96 aa）
Fragment：PDZ2 domain
Chain D
1361–1456（96 aa）
Fragment：PDZ2 domain
Chain E
1361–1456（96 aa）
Fragment：PDZ2 domain
Chain F
1361–1456（96 aa）
Fragment：PDZ2 domain
|
Not recorded | IOD IODIDE ION × 25 SCN THIOCYANATE ION × 14 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.5；298 K；28% PEG 3350, 0.2 M KI, 0.2 M NaSCN, 0.1 M NaAc, pH 4.5, hanging drop, temperature 298K, VAPOR DIFFUSION, HANGING DROP
|
Resolution 1.64 Å R-free 0.237 |
| 3LNY Second PDZ domain from human PTP1E in complex with RA-GEF2 peptide Deposited 2010-02-03 | Assembly 1 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric（12） Consistent with protein count |
Chain A
1361–1456（96 aa）
Fragment：PDZ2 domain
|
Not recorded | SCN THIOCYANATE ION × 6 SO4 SULFATE ION × 12 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；277 K；20% PEG 3350, 0.8 M (NH4)2SO4, 0.2 M NaSCN, 0.1 M Na citrate, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.30 Å R-free 0.189 |
| 3PDZ SOLUTION STRUCTURE OF THE PDZ2 DOMAIN FROM HUMAN PHOSPHATASE HPTP1E Deposited 1999-05-10 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1361–1456（96 aa）
Fragment：PDZ2 DOMAIN
|
Not recorded | No recorded non-water small molecule | SOLUTION NMR |
NMR measurement conditions
pH 6.8；293 K；Pressure 1
NMR sample composition
10% D2O/90% WATER
|
Resolution not provided |
| 5GLJ Crystal Structure of PDZ1 Domain of Human Protein Tyrosine Phosphatase PTP-Bas Deposited 2016-07-11 | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
1086–1178（93 aa）
Fragment：PDZ1 Domain (UNP RESIDUES 1086-1178)
Chain B
1086–1178（93 aa）
Fragment：PDZ1 Domain (UNP RESIDUES 1086-1178)
Chain C
1086–1178（93 aa）
Fragment：PDZ1 Domain (UNP RESIDUES 1086-1178)
Chain D
1086–1178（93 aa）
Fragment：PDZ1 Domain (UNP RESIDUES 1086-1178)
|
Not recorded | CL CHLORIDE ION × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5.5；293 K；0.2 M Magnesium chloride hexahydrate , 0.1 M BIS-TRIS pH5.5, 25 % w/v Polyethylene glycol 3350
|
Resolution 1.60 Å R-free 0.206 |
| 7QCX Two-state liquid NMR Structure of a PDZ2 Domain from hPTP1E, apo form Deposited 2021-11-25 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1361–1456（96 aa）
|
Not recorded | No recorded non-water small molecule | SOLUTION NMR |
NMR measurement conditions
pH 6.8；298 K；Ionic strength (raw mmCIF value) 150；Pressure 1
NMR sample composition
2.0 mM [U-100% 13C; U-100% 15N] PDZ2 domain from hPTP1E, 95% H2O/5% D2O | 95% H2O/5% D2O
|
Resolution not provided |
| 7QCY Two-state liquid NMR Structure of a PDZ2 Domain from hPTP1E, complexed with RA-GEF2 peptide Deposited 2021-11-25 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1361–1456（96 aa）
|
Not recorded | No recorded non-water small molecule | SOLUTION NMR |
NMR measurement conditions
pH 6.8；298 K；Ionic strength (raw mmCIF value) 150；Pressure 1
NMR sample composition
2 mM [U-100% 13C; U-100% 15N] PDZ2 domain, 2 mM RA-GEF2 peptide, 95% H2O/5% D2O | 95% H2O/5% D2O
|
Resolution not provided |
| 7XTY Crystal Structure of the second PDZ domain from human PTPN13 in complex with APC peptide Deposited 2022-05-18 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1362–1456（95 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 6.8；289 K；0.1M citric acid (pH 3.5), 3M NaCl
|
Resolution 2.10 Å R-free 0.240 |
| 7XTY Crystal Structure of the second PDZ domain from human PTPN13 in complex with APC peptide Deposited 2022-05-18 | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
1362–1456（95 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 6.8；289 K；0.1M citric acid (pH 3.5), 3M NaCl
|
Resolution 2.10 Å R-free 0.240 |