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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：Q14565 New Search
10PDB entries
14Biological assembly
40chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
1V5W Crystal structure of the human Dmc1 protein Deposited 2003-11-26 Assembly 1 Protein homooligomer Homooligomer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain A 1–340（340 aa）
Chain B 1–340（340 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.8；293 K；PEG2000MME, Magnesium chloride, Sodium citrate, pH 5.8, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 3.20 Å R-free 0.346
1V5W Crystal structure of the human Dmc1 protein Deposited 2003-11-26 Assembly 2 Protein homooligomer Homooligomer；Protein × 16 PDB declaration: hexadecameric（16） Consistent with protein count
Chain A 1–340（340 aa）
Chain B 1–340（340 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.8；293 K；PEG2000MME, Magnesium chloride, Sodium citrate, pH 5.8, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 3.20 Å R-free 0.346
2ZJB Crystal structure of the human Dmc1-M200V polymorphic variant Deposited 2008-03-02 Assembly 1 Protein homooligomer Homooligomer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain A 1–340（340 aa）
Chain B 1–340（340 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.8；293 K；0.1M sodium citrate, 50mM MgCl2, 8% PEG 2000 MME, pH 5.8, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 3.50 Å R-free 0.351
4HYY Filament of octameric rings of DMC1 recombinase from Homo sapiens Deposited 2012-11-14 Assembly 1 Protein homooligomer Homooligomer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain A 84–340（257 aa） Fragment：ATPase domain
Chain B 84–340（257 aa） Fragment：ATPase domain
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.4；294 K；6% PEG 3350, 0.5 M NaCl, 0.05 M MgCl2, 0.05 M HEPES-NACl, pH 7.4, VAPOR DIFFUSION, HANGING DROP, temperature 294.0K
Resolution 2.60 Å R-free 0.246
4HYY Filament of octameric rings of DMC1 recombinase from Homo sapiens Deposited 2012-11-14 Assembly 2 Protein homooligomer Homooligomer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain C 84–340（257 aa） Fragment：ATPase domain
Chain D 84–340（257 aa） Fragment：ATPase domain
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.4；294 K；6% PEG 3350, 0.5 M NaCl, 0.05 M MgCl2, 0.05 M HEPES-NACl, pH 7.4, VAPOR DIFFUSION, HANGING DROP, temperature 294.0K
Resolution 2.60 Å R-free 0.246
4HYY Filament of octameric rings of DMC1 recombinase from Homo sapiens Deposited 2012-11-14 Assembly 3 Protein homooligomer Homooligomer；Protein × 16 PDB declaration: hexadecameric（16） Consistent with protein count
Chain A 84–340（257 aa） Fragment：ATPase domain
Chain B 84–340（257 aa） Fragment：ATPase domain
Chain C 84–340（257 aa） Fragment：ATPase domain
Chain D 84–340（257 aa） Fragment：ATPase domain
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.4；294 K；6% PEG 3350, 0.5 M NaCl, 0.05 M MgCl2, 0.05 M HEPES-NACl, pH 7.4, VAPOR DIFFUSION, HANGING DROP, temperature 294.0K
Resolution 2.60 Å R-free 0.246
6R3P Crystal structure of human DMC1 ATPase domain Deposited 2019-03-20 Assembly 1 Protein homooligomer Homooligomer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain A 83–340（258 aa）
Chain B 83–340（258 aa）
Not recorded EDO 1,2-ETHANEDIOL × 8 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.2；293 K；50 mM HEPES-NaOH pH 7.2, 50 mM MgCl2, 500 mM NaCl, 7.5 % PEG3350
Resolution 2.05 Å R-free 0.219
6R3P Crystal structure of human DMC1 ATPase domain Deposited 2019-03-20 Assembly 2 Protein homooligomer Homooligomer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain C 83–340（258 aa）
Chain D 83–340（258 aa）
Not recorded PEG DI(HYDROXYETHYL)ETHER × 8 PG4 TETRAETHYLENE GLYCOL × 4 P6G HEXAETHYLENE GLYCOL × 8 1PE PENTAETHYLENE GLYCOL × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.2；293 K；50 mM HEPES-NaOH pH 7.2, 50 mM MgCl2, 500 mM NaCl, 7.5 % PEG3350
Resolution 2.05 Å R-free 0.219
7C98 Human DMC1 post-synaptic complexes Deposited 2020-06-05 Assembly 1 Protein–DNA Homooligomer；Protein × 3 PDB declaration: pentameric（5） Consistent with all polymers
Chain A 1–340（340 aa）
Chain B 1–340（340 aa）
Chain C 1–340（340 aa）
Not recorded CA CALCIUM ION × 3 ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 3 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5；25 mM Tris-HCl, pH 7.5, 50 mM KCl and 1 mM dithiothreitol) containing 2 mM AMP-PNP and 5 mM CaCl2
cryo-EM vitrification conditions Cryogen ETHANE；The grids were blotted for 1 sec at 22 degree C with 100% relative humidity and plunge-frozen in liquid ethane cooled by liquid nitrogen using a Vitrobot Mark IV (Thermo Fisher).
Resolution 3.47 Å
7C99 Human DMC1 post-synaptic complexes with mismatched dsDNA Deposited 2020-06-05 Assembly 1 Protein–DNA Homooligomer；Protein × 3 PDB declaration: pentameric（5） Consistent with all polymers
Chain A 1–340（340 aa）
Chain B 1–340（340 aa）
Chain C 1–340（340 aa）
Not recorded CA CALCIUM ION × 3 ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 3 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5；25 mM Tris-HCl, pH 7.5, 50 mM KCl and 1 mM dithiothreitol) containing 2 mM AMP-PNP and 5 mM CaCl2
cryo-EM vitrification conditions Cryogen ETHANE；The grids were blotted for 1 sec at 22 degree C with 100% relative humidity and plunge-frozen in liquid ethane cooled by liquid nitrogen using a Vitrobot Mark IV (Thermo Fisher).
Resolution 3.36 Å
7C9C Human DMC1 pre-synaptic complexes Deposited 2020-06-05 Assembly 1 Protein–DNA Homooligomer；Protein × 3 PDB declaration: tetrameric（4） Consistent with all polymers
Chain A 1–340（340 aa）
Chain B 1–340（340 aa）
Chain C 1–340（340 aa）
Not recorded CA CALCIUM ION × 3 ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 3 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5；25 mM Tris-HCl, pH 7.5, 50 mM KCl and 1 mM dithiothreitol) containing 2 mM AMP-PNP and 5 mM CaCl2
cryo-EM vitrification conditions Cryogen ETHANE；The grids were blotted for 1 sec at 22 degree C with 100% relative humidity and plunge-frozen in liquid ethane cooled by liquid nitrogen using a Vitrobot Mark IV (Thermo Fisher).
Resolution 3.33 Å
7CGY Human DMC1 Q244M mutant of the post-synaptic complexes Deposited 2020-07-03 Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain A 1–340（340 aa）
Chain B 1–340（340 aa）
Chain C 1–340（340 aa）
Mutation：Q244M Mutation：Q244M Mutation：Q244M CA CALCIUM ION × 3 ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 3 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5；25 mM Tris-HCl, pH 7.5, 50 mM KCl and 1 mM dithiothreitol) containing 2 mM AMP-PNP and 5 mM CaCl2
cryo-EM vitrification conditions Cryogen ETHANE；The grids were blotted for 1 sec at 22 degree C with 100% relative humidity and plunge-frozen in liquid ethane cooled by liquid nitrogen using a Vitrobot Mark IV (Thermo Fisher).
Resolution 3.20 Å
8QQE Crystal structure of the complex between DMC1 and the PhePP domain of BRCA2 Deposited 2023-10-04 Assembly 1 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric（16） Consistent with protein count
Chain A 2–340（339 aa）
Chain B 2–340（339 aa）
Not recorded MG MAGNESIUM ION × 4 CL CHLORIDE ION × 8 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 6；293 K；0.1M MES at pH 6, 2.4 M sodium formate
Resolution 3.46 Å R-free 0.261
8R2G Crystal structure of a BRCA2-DMC1 complex Deposited 2023-11-05 Assembly 1 Protein heterocomplex Heteromer；Protein × 15 PDB declaration: pentadecameric（15） Consistent with protein count
Chain A 83–340（258 aa）
Chain B 83–340（258 aa）
Chain C 83–340（258 aa）
Chain D 83–340（258 aa）
Chain E 83–340（258 aa）
Chain F 83–340（258 aa）
Chain G 83–340（258 aa）
Chain H 83–340（258 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；50 mM HEPES-NaOH pH 7.4, 50 mM MgCl2, 500 mM NaCl, 8 % PEG 3350, 20 % glycerol
Resolution 3.45 Å R-free 0.306

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.