Current Protein Identity：Q16881
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Difference tags compare only the current result set; every original PDB and assembly record remains separate.
Related-Structure Differences
Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.
| PDB Entry | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Experimental Method | Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 2CFY Crystal structure of human thioredoxin reductase 1 Deposited 2006-02-26 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–499（499 aa）
Chain B
1–499（499 aa）
|
Not recorded | FAD FLAVIN-ADENINE DINUCLEOTIDE × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；150 UL SITTING DROPS, 20% PEG3350, 0.1 M TRIS PH 7, ADDITIVE: NSDB-221
|
Resolution 2.70 Å R-free 0.248 |
| 2CFY Crystal structure of human thioredoxin reductase 1 Deposited 2006-02-26 | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain C
1–499（499 aa）
Chain D
1–499（499 aa）
|
Not recorded | FAD FLAVIN-ADENINE DINUCLEOTIDE × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；150 UL SITTING DROPS, 20% PEG3350, 0.1 M TRIS PH 7, ADDITIVE: NSDB-221
|
Resolution 2.70 Å R-free 0.248 |
| 2CFY Crystal structure of human thioredoxin reductase 1 Deposited 2006-02-26 | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain E
1–499（499 aa）
Chain F
1–499（499 aa）
|
Not recorded | FAD FLAVIN-ADENINE DINUCLEOTIDE × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；150 UL SITTING DROPS, 20% PEG3350, 0.1 M TRIS PH 7, ADDITIVE: NSDB-221
|
Resolution 2.70 Å R-free 0.248 |
| 2J3N X-ray structure of human thioredoxin reductase 1 Deposited 2006-08-22 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–499（499 aa）
Chain B
1–499（499 aa）
|
Not recorded | FAD FLAVIN-ADENINE DINUCLEOTIDE × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 MPD (4S)-2-METHYL-2,4-PENTANEDIOL × 3 | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 2.80 Å R-free 0.287 |
| 2J3N X-ray structure of human thioredoxin reductase 1 Deposited 2006-08-22 | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain C
1–499（499 aa）
Chain D
1–499（499 aa）
|
Not recorded | FAD FLAVIN-ADENINE DINUCLEOTIDE × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 MPD (4S)-2-METHYL-2,4-PENTANEDIOL × 1 | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 2.80 Å R-free 0.287 |
| 2J3N X-ray structure of human thioredoxin reductase 1 Deposited 2006-08-22 | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain E
1–499（499 aa）
Chain F
1–499（499 aa）
|
Not recorded | FAD FLAVIN-ADENINE DINUCLEOTIDE × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 MPD (4S)-2-METHYL-2,4-PENTANEDIOL × 1 | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 2.80 Å R-free 0.287 |
| 2ZZ0 Crystal structure of human thioredoxin reductase I (SeCys 498 Cys) Deposited 2009-02-02 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
150–649（500 aa）
Fragment：residues (-13)-499
Chain B
150–649（500 aa）
Fragment：residues (-13)-499
|
Mutation：SeCys498Cys Mutation：SeCys498Cys | FAD FLAVIN-ADENINE DINUCLEOTIDE × 2 SO4 SULFATE ION × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6；298 K；5% PEG 3350, 0.005M magnesium Sulfate, 0.05M MES, pH 6.0, 20% 1,6 Hexanediol (0.001mL), VAPOR DIFFUSION, SITTING DROP, temperature 298K
|
Resolution 2.80 Å R-free 0.277 |
| 2ZZ0 Crystal structure of human thioredoxin reductase I (SeCys 498 Cys) Deposited 2009-02-02 | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain C
150–649（500 aa）
Fragment：residues (-13)-499
Chain D
150–649（500 aa）
Fragment：residues (-13)-499
|
Mutation：SeCys498Cys Mutation：SeCys498Cys | FAD FLAVIN-ADENINE DINUCLEOTIDE × 2 SO4 SULFATE ION × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6；298 K；5% PEG 3350, 0.005M magnesium Sulfate, 0.05M MES, pH 6.0, 20% 1,6 Hexanediol (0.001mL), VAPOR DIFFUSION, SITTING DROP, temperature 298K
|
Resolution 2.80 Å R-free 0.277 |
| 2ZZB Crystal structure of human thioredoxin reductase I and terpyridine platinum(II) Deposited 2009-02-09 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
150–649（500 aa）
Fragment：residues (-13)-499
Chain B
150–649（500 aa）
Fragment：residues (-13)-499
|
Mutation：SeCys498Cys Mutation：SeCys498Cys | FAD FLAVIN-ADENINE DINUCLEOTIDE × 2 SO4 SULFATE ION × 2 TPT 2,2':6',2''-TERPYRIDINE PLATINUM(II) Chloride × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6；298 K；5% PEG 3350, 0.005M magnesium Sulfate, 0.05M MES, pH 6.0, additive: 20% 1,6 Hexanediol (0.001mL), VAPOR DIFFUSION, SITTING DROP, temperature 298K
|
Resolution 3.20 Å R-free 0.305 |
| 2ZZB Crystal structure of human thioredoxin reductase I and terpyridine platinum(II) Deposited 2009-02-09 | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain C
150–649（500 aa）
Fragment：residues (-13)-499
Chain D
150–649（500 aa）
Fragment：residues (-13)-499
|
Mutation：SeCys498Cys Mutation：SeCys498Cys | FAD FLAVIN-ADENINE DINUCLEOTIDE × 2 SO4 SULFATE ION × 2 TPT 2,2':6',2''-TERPYRIDINE PLATINUM(II) Chloride × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6；298 K；5% PEG 3350, 0.005M magnesium Sulfate, 0.05M MES, pH 6.0, additive: 20% 1,6 Hexanediol (0.001mL), VAPOR DIFFUSION, SITTING DROP, temperature 298K
|
Resolution 3.20 Å R-free 0.305 |
| 2ZZC Crystal structure of NADP(H):human thioredoxin reductase I Deposited 2009-02-09 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
150–649（500 aa）
Fragment：residues (-13)-499
Chain B
150–649（500 aa）
Fragment：residues (-13)-499
|
Mutation：SeCys498Cys Mutation：SeCys498Cys | FAD FLAVIN-ADENINE DINUCLEOTIDE × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6；298 K；5% PEG 3350, 0.005M Magnesium Sulfate, 0.05M MES, pH 6.0, additive: 20% 1,6 Hexanediol (0.001mL), VAPOR DIFFUSION, SITTING DROP, temperature 298K
|
Resolution 2.60 Å R-free 0.260 |
| 2ZZC Crystal structure of NADP(H):human thioredoxin reductase I Deposited 2009-02-09 | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain C
150–649（500 aa）
Fragment：residues (-13)-499
Chain D
150–649（500 aa）
Fragment：residues (-13)-499
|
Mutation：SeCys498Cys Mutation：SeCys498Cys | FAD FLAVIN-ADENINE DINUCLEOTIDE × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6；298 K；5% PEG 3350, 0.005M Magnesium Sulfate, 0.05M MES, pH 6.0, additive: 20% 1,6 Hexanediol (0.001mL), VAPOR DIFFUSION, SITTING DROP, temperature 298K
|
Resolution 2.60 Å R-free 0.260 |
| 3QFA Crystal structure of the human thioredoxin reductase-thioredoxin complex Deposited 2011-01-21 | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
1–499（499 aa）
Chain B
1–499（499 aa）
|
Mutation：C497S, U498C Mutation：C497S, U498C | FAD FLAVIN-ADENINE DINUCLEOTIDE × 2 GOL GLYCEROL × 6 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；297.15 K；15% PEG 6000, 0.1M MES, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 297.15 K
|
Resolution 2.20 Å R-free 0.283 |
| 3QFB Crystal structure of the human thioredoxin reductase-thioredoxin complex Deposited 2011-01-21 | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
1–499（499 aa）
Chain B
1–499（499 aa）
|
Mutation：C497S, U498C Mutation：C497S, U498C | FAD FLAVIN-ADENINE DINUCLEOTIDE × 2 GOL GLYCEROL × 6 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.6；297.15 K；15% PEG 4000, pH 7.6, VAPOR DIFFUSION, HANGING DROP, temperature 297.15K
|
Resolution 2.60 Å R-free 0.297 |
| 7X1R Cryo-EM structure of human thioredoxin reductase bound by Au Deposited 2022-02-24 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
152–649（498 aa）
Chain B
152–649（498 aa）
|
Not recorded | FAD FLAVIN-ADENINE DINUCLEOTIDE × 2 AU GOLD ION × 2 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.90 Å |
| 9UIN Human thioredoxin reductase 1 (SeCys 498 Cys) with Cu(I) Deposited 2025-04-15 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
151–649（499 aa）
Chain B
151–649（499 aa）
|
Mutation：SEC498C Mutation：SEC498C | TXP 1,4,5,6-TETRAHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE × 2 FAD FLAVIN-ADENINE DINUCLEOTIDE × 2 CU COPPER (II) ION × 6 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.03 Å |