Current Protein Identity：Q86U86
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Difference tags compare only the current result set; every original PDB and assembly record remains separate.
Related-Structure Differences
Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.
| PDB Entry | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Experimental Method | Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 2KTB Solution Structure of the Second Bromodomain of Human Polybromo in complex with an acetylated peptide from Histone 3 Deposited 2010-01-26 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
174–293（120 aa）
Fragment：Polybromo Bromdomain 2
|
Not recorded | No recorded non-water small molecule | SOLUTION NMR |
NMR measurement conditions
pH 6.5；298 K；Ionic strength (raw mmCIF value) 0.1；Pressure ambient
NMR sample composition
0.5 mM [U-100% 15N] Polybromo Bromdomain2, 2.5 mM H3 Peptide, 90% H2O/10% D2O | 90% H2O/10% D2O
NMR sample composition
0.5 mM [U-100% 13C; U-100% 15N] Polybromo Bromdomain2, 2.5 mM H3 Peptide, 90% H2O/10% D2O | 90% H2O/10% D2O
NMR sample composition
0.8 mM [U-100% 13C; U-100% 15N] Polybromo Bromdomain2, 8 mM H3 Peptide, 100% D2O | 100% D2O
|
Resolution not provided |
| 3G0J Crystal Structure of the fifth Bromodomain of Human Poly-bromodomain containing protein 1 (PB1) Deposited 2009-01-28 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
645–766（122 aa）
Fragment：UNP residues 645-766
|
Not recorded | EDO 1,2-ETHANEDIOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；277 K；0.2M Na_nitrate, 25% w/v PEG 3350, 5% v/v ethylene glycol, pH 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 277K
|
Resolution 1.78 Å R-free 0.237 |
| 3G0J Crystal Structure of the fifth Bromodomain of Human Poly-bromodomain containing protein 1 (PB1) Deposited 2009-01-28 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
645–766（122 aa）
Fragment：UNP residues 645-766
|
Not recorded | EDO 1,2-ETHANEDIOL × 3 NO3 NITRATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；277 K；0.2M Na_nitrate, 25% w/v PEG 3350, 5% v/v ethylene glycol, pH 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 277K
|
Resolution 1.78 Å R-free 0.237 |
| 3HMF Crystal Structure of the second Bromodomain of Human Poly-bromodomain containing protein 1 (PB1) Deposited 2009-05-29 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
178–291（114 aa）
Fragment：bromodomain, UNP residues 178-291
|
Not recorded | ZN ZINC ION × 2 EDO 1,2-ETHANEDIOL × 1 CL CHLORIDE ION × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5.5；277 K；0.01M Zn_Cl, 15w/v PEG_6000, 10v/v ethylene_glycol, 5.5pH MES, VAPOR DIFFUSION, SITTING DROP, temperature 277K
|
Resolution 1.63 Å R-free 0.199 |
| 3HMF Crystal Structure of the second Bromodomain of Human Poly-bromodomain containing protein 1 (PB1) Deposited 2009-05-29 | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
178–291（114 aa）
Fragment：bromodomain, UNP residues 178-291
|
Not recorded | ZN ZINC ION × 4 EDO 1,2-ETHANEDIOL × 2 CL CHLORIDE ION × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5.5；277 K；0.01M Zn_Cl, 15w/v PEG_6000, 10v/v ethylene_glycol, 5.5pH MES, VAPOR DIFFUSION, SITTING DROP, temperature 277K
|
Resolution 1.63 Å R-free 0.199 |
| 3IU5 Crystal structure of the first bromodomain of human poly-bromodomain containing protein 1 (PB1) Deposited 2009-08-30 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
43–154（112 aa）
Fragment：Bromo 1 domain: UNP residues 43-154
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；277 K；2.1M Na malate, pH 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 277K
|
Resolution 1.63 Å R-free 0.204 |
| 3IU6 Crystal structure of the sixth bromodomain of human poly-bromodomain containing protein 1 (PB1) Deposited 2009-08-30 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
773–914（142 aa）
Fragment：Bromo 6 domain: UNP residues 773-914
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | EDO 1,2-ETHANEDIOL × 3 ZN ZINC ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8；277 K；0.01M ZnCl2, 0.1M Tris-HCl pH 8.0, 20% PEG 6000, 10% Ethylene glycol, VAPOR DIFFUSION, SITTING DROP, temperature 277K
|
Resolution 1.79 Å R-free 0.202 |
| 3K2J Crystal Structure of the 3rd Bromodomain of Human Poly-bromodomain containing protein 1 (PB1) Deposited 2009-09-30 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
388–494（107 aa）
Fragment：Bromo 3 domain, UNP residues 388-494
|
Not recorded | CL CHLORIDE ION × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5.5；277 K；0.1M NaOAc.3H20 pH 5.5, 1.1M (NH4)2SO4, VAPOR DIFFUSION, SITTING DROP, temperature 277K
|
Resolution 2.20 Å R-free 0.270 |
| 3K2J Crystal Structure of the 3rd Bromodomain of Human Poly-bromodomain containing protein 1 (PB1) Deposited 2009-09-30 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
388–494（107 aa）
Fragment：Bromo 3 domain, UNP residues 388-494
|
Not recorded | SO4 SULFATE ION × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5.5；277 K；0.1M NaOAc.3H20 pH 5.5, 1.1M (NH4)2SO4, VAPOR DIFFUSION, SITTING DROP, temperature 277K
|
Resolution 2.20 Å R-free 0.270 |
| 3K2J Crystal Structure of the 3rd Bromodomain of Human Poly-bromodomain containing protein 1 (PB1) Deposited 2009-09-30 | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
388–494（107 aa）
Fragment：Bromo 3 domain, UNP residues 388-494
Chain B
388–494（107 aa）
Fragment：Bromo 3 domain, UNP residues 388-494
|
Not recorded | CL CHLORIDE ION × 2 SO4 SULFATE ION × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5.5；277 K；0.1M NaOAc.3H20 pH 5.5, 1.1M (NH4)2SO4, VAPOR DIFFUSION, SITTING DROP, temperature 277K
|
Resolution 2.20 Å R-free 0.270 |
| 3LJW Crystal Structure of the Second Bromodomain of Human Polybromo Deposited 2010-01-26 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
174–293（120 aa）
Fragment：Bromodomain 2 (UNP residues 174-293)
|
Not recorded | ACT ACETATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5.5；298 K；35% PEG 4000, 10 mM Sodium Acetate, pH 5.5, VAPOR DIFFUSION, SITTING DROP, temperature 298K
|
Resolution 1.50 Å R-free 0.197 |
| 3LJW Crystal Structure of the Second Bromodomain of Human Polybromo Deposited 2010-01-26 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
174–293（120 aa）
Fragment：Bromodomain 2 (UNP residues 174-293)
|
Not recorded | ACT ACETATE ION × 1 NA SODIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5.5；298 K；35% PEG 4000, 10 mM Sodium Acetate, pH 5.5, VAPOR DIFFUSION, SITTING DROP, temperature 298K
|
Resolution 1.50 Å R-free 0.197 |
| 3MB4 Crystal Structure of the fifth Bromodomain of Human Poly-bromodomain containing protein 1 (PB1) with NMP Deposited 2010-03-25 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
645–766（122 aa）
Fragment：UNP residues 645-766
|
Not recorded | EDO 1,2-ETHANEDIOL × 2 MB3 1-methylpyrrolidin-2-one × 1 CL CHLORIDE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；277 K；0.15M NaNO3
25% PEG 3350
10% Ethylene Glycol, pH 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 277K
|
Resolution 1.66 Å R-free 0.219 |
| 3MB4 Crystal Structure of the fifth Bromodomain of Human Poly-bromodomain containing protein 1 (PB1) with NMP Deposited 2010-03-25 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
645–766（122 aa）
Fragment：UNP residues 645-766
|
Not recorded | EDO 1,2-ETHANEDIOL × 3 MB3 1-methylpyrrolidin-2-one × 1 CL CHLORIDE ION × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；277 K；0.15M NaNO3
25% PEG 3350
10% Ethylene Glycol, pH 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 277K
|
Resolution 1.66 Å R-free 0.219 |
| 3TLP Crystal structure of the fourth bromodomain of human poly-bromodomain containing protein 1 (PB1) Deposited 2011-08-30 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
496–637（142 aa）
Fragment：UNP residues 496-637
|
Not recorded | NI NICKEL (II) ION × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；277 K；25% PEG_MME_2000, 0.015M NiCl, 0.1M Tris pH 8.5, VAPOR DIFFUSION, SITTING DROP, temperature 277K
|
Resolution 2.13 Å R-free 0.249 |
| 3TLP Crystal structure of the fourth bromodomain of human poly-bromodomain containing protein 1 (PB1) Deposited 2011-08-30 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
496–637（142 aa）
Fragment：UNP residues 496-637
|
Not recorded | NI NICKEL (II) ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；277 K；25% PEG_MME_2000, 0.015M NiCl, 0.1M Tris pH 8.5, VAPOR DIFFUSION, SITTING DROP, temperature 277K
|
Resolution 2.13 Å R-free 0.249 |
| 4Q0N Crystal Structure of the fifth bromodomain of Human Poly-bromodomain containing protein 1 (PB1) in complex with a hydroxyphenyl-propenone ligand Deposited 2014-04-02 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
645–766（122 aa）
Fragment：UNP residues 645-766
|
Not recorded | EDO 1,2-ETHANEDIOL × 1 2XD (2E)-1-(2-hydroxyphenyl)-3-(2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)prop-2-en-1-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；277 K；0.20M Na(malonate), 0.1M BTProp pH 6.5, 20.0% PEG 3350
10.0% EtGly, VAPOR DIFFUSION, SITTING DROP, temperature 277K
|
Resolution 1.78 Å R-free 0.214 |
| 4Q0N Crystal Structure of the fifth bromodomain of Human Poly-bromodomain containing protein 1 (PB1) in complex with a hydroxyphenyl-propenone ligand Deposited 2014-04-02 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
645–766（122 aa）
Fragment：UNP residues 645-766
|
Not recorded | 2XD (2E)-1-(2-hydroxyphenyl)-3-(2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)prop-2-en-1-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；277 K；0.20M Na(malonate), 0.1M BTProp pH 6.5, 20.0% PEG 3350
10.0% EtGly, VAPOR DIFFUSION, SITTING DROP, temperature 277K
|
Resolution 1.78 Å R-free 0.214 |
| 4Q0N Crystal Structure of the fifth bromodomain of Human Poly-bromodomain containing protein 1 (PB1) in complex with a hydroxyphenyl-propenone ligand Deposited 2014-04-02 | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain C
645–766（122 aa）
Fragment：UNP residues 645-766
|
Not recorded | EDO 1,2-ETHANEDIOL × 1 2XD (2E)-1-(2-hydroxyphenyl)-3-(2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)prop-2-en-1-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；277 K；0.20M Na(malonate), 0.1M BTProp pH 6.5, 20.0% PEG 3350
10.0% EtGly, VAPOR DIFFUSION, SITTING DROP, temperature 277K
|
Resolution 1.78 Å R-free 0.214 |
| 4Q0N Crystal Structure of the fifth bromodomain of Human Poly-bromodomain containing protein 1 (PB1) in complex with a hydroxyphenyl-propenone ligand Deposited 2014-04-02 | Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain D
645–766（122 aa）
Fragment：UNP residues 645-766
|
Not recorded | EDO 1,2-ETHANEDIOL × 1 2XD (2E)-1-(2-hydroxyphenyl)-3-(2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)prop-2-en-1-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；277 K；0.20M Na(malonate), 0.1M BTProp pH 6.5, 20.0% PEG 3350
10.0% EtGly, VAPOR DIFFUSION, SITTING DROP, temperature 277K
|
Resolution 1.78 Å R-free 0.214 |
| 4Q0N Crystal Structure of the fifth bromodomain of Human Poly-bromodomain containing protein 1 (PB1) in complex with a hydroxyphenyl-propenone ligand Deposited 2014-04-02 | Assembly 5 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain E
645–766（122 aa）
Fragment：UNP residues 645-766
|
Not recorded | EDO 1,2-ETHANEDIOL × 2 2XD (2E)-1-(2-hydroxyphenyl)-3-(2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)prop-2-en-1-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；277 K；0.20M Na(malonate), 0.1M BTProp pH 6.5, 20.0% PEG 3350
10.0% EtGly, VAPOR DIFFUSION, SITTING DROP, temperature 277K
|
Resolution 1.78 Å R-free 0.214 |
| 4Q0N Crystal Structure of the fifth bromodomain of Human Poly-bromodomain containing protein 1 (PB1) in complex with a hydroxyphenyl-propenone ligand Deposited 2014-04-02 | Assembly 6 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain F
645–766（122 aa）
Fragment：UNP residues 645-766
|
Not recorded | EDO 1,2-ETHANEDIOL × 1 2XD (2E)-1-(2-hydroxyphenyl)-3-(2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)prop-2-en-1-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；277 K；0.20M Na(malonate), 0.1M BTProp pH 6.5, 20.0% PEG 3350
10.0% EtGly, VAPOR DIFFUSION, SITTING DROP, temperature 277K
|
Resolution 1.78 Å R-free 0.214 |
| 4Q0N Crystal Structure of the fifth bromodomain of Human Poly-bromodomain containing protein 1 (PB1) in complex with a hydroxyphenyl-propenone ligand Deposited 2014-04-02 | Assembly 7 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain G
645–766（122 aa）
Fragment：UNP residues 645-766
|
Not recorded | EDO 1,2-ETHANEDIOL × 2 2XD (2E)-1-(2-hydroxyphenyl)-3-(2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)prop-2-en-1-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；277 K；0.20M Na(malonate), 0.1M BTProp pH 6.5, 20.0% PEG 3350
10.0% EtGly, VAPOR DIFFUSION, SITTING DROP, temperature 277K
|
Resolution 1.78 Å R-free 0.214 |
| 4Q0N Crystal Structure of the fifth bromodomain of Human Poly-bromodomain containing protein 1 (PB1) in complex with a hydroxyphenyl-propenone ligand Deposited 2014-04-02 | Assembly 8 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain H
645–766（122 aa）
Fragment：UNP residues 645-766
|
Not recorded | EDO 1,2-ETHANEDIOL × 1 2XD (2E)-1-(2-hydroxyphenyl)-3-(2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)prop-2-en-1-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；277 K；0.20M Na(malonate), 0.1M BTProp pH 6.5, 20.0% PEG 3350
10.0% EtGly, VAPOR DIFFUSION, SITTING DROP, temperature 277K
|
Resolution 1.78 Å R-free 0.214 |
| 4Q0O Crystal Structure of the fifth bromodomain of Human Poly-bromodomain containing protein 1 (PB1) in complex with a hydroxyphenyl-propenone ligand Deposited 2014-04-02 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
645–766（122 aa）
Fragment：UNP residues 645-766
|
Not recorded | K POTASSIUM ION × 1 2XC (2E)-1-(2-hydroxyphenyl)-3-[(3R)-3-phenylpiperidin-1-yl]prop-2-en-1-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；277 K；0.20M K3(cit), 0.1M BTProp pH 6.5, 20.0% PEG 3350, 10.0% EtGly, VAPOR DIFFUSION, SITTING DROP, temperature 277K
|
Resolution 1.83 Å R-free 0.224 |
| 4Y03 Crystal Structure of the fifth bromodomain of human PB1 in complex with salicylic acid Deposited 2015-02-05 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
645–766（122 aa）
Fragment：UNP residues 645-766
|
Not recorded | SAL 2-HYDROXYBENZOIC ACID × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；277 K；K3(citrate), 20% PEG3350, 10% EtGly
|
Resolution 1.94 Å R-free 0.281 |
| 4Y03 Crystal Structure of the fifth bromodomain of human PB1 in complex with salicylic acid Deposited 2015-02-05 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
645–766（122 aa）
Fragment：UNP residues 645-766
|
Not recorded | SAL 2-HYDROXYBENZOIC ACID × 1 CIT CITRIC ACID × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；277 K；K3(citrate), 20% PEG3350, 10% EtGly
|
Resolution 1.94 Å R-free 0.281 |
| 5E7D Crystal Structure of the fifth bromodomain of human PB1 in complex with a hydroxyphenyl ligand Deposited 2015-10-12 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
645–766（122 aa）
Fragment：UNP residues 645-766
|
Not recorded | 5KL (2E)-3-(dimethylamino)-1-(2-hydroxyphenyl)prop-2-en-1-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；277 K；0.2M Na2SO4
20w/v PEG_3350
10v/v ethylene_glycol
|
Resolution 1.87 Å R-free 0.248 |
| 5E7D Crystal Structure of the fifth bromodomain of human PB1 in complex with a hydroxyphenyl ligand Deposited 2015-10-12 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
645–766（122 aa）
Fragment：UNP residues 645-766
|
Not recorded | 5KL (2E)-3-(dimethylamino)-1-(2-hydroxyphenyl)prop-2-en-1-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；277 K；0.2M Na2SO4
20w/v PEG_3350
10v/v ethylene_glycol
|
Resolution 1.87 Å R-free 0.248 |
| 5E7D Crystal Structure of the fifth bromodomain of human PB1 in complex with a hydroxyphenyl ligand Deposited 2015-10-12 | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain C
645–766（122 aa）
Fragment：UNP residues 645-766
|
Not recorded | 5KL (2E)-3-(dimethylamino)-1-(2-hydroxyphenyl)prop-2-en-1-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；277 K；0.2M Na2SO4
20w/v PEG_3350
10v/v ethylene_glycol
|
Resolution 1.87 Å R-free 0.248 |
| 5E7D Crystal Structure of the fifth bromodomain of human PB1 in complex with a hydroxyphenyl ligand Deposited 2015-10-12 | Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain D
645–766（122 aa）
Fragment：UNP residues 645-766
|
Not recorded | 5KL (2E)-3-(dimethylamino)-1-(2-hydroxyphenyl)prop-2-en-1-one × 1 EDO 1,2-ETHANEDIOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；277 K；0.2M Na2SO4
20w/v PEG_3350
10v/v ethylene_glycol
|
Resolution 1.87 Å R-free 0.248 |
| 5FH6 Crystal structure of the fifth bromodomain of human PB1 in complex with compound 10 Deposited 2015-12-21 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
645–766（122 aa）
|
Not recorded | 5XM (3~{R})-3-(piperidin-1-ylmethyl)-2,3-dihydro-1~{H}-pyrrolo[1,2-a]quinazolin-5-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；277.15 K；0.2 M LiSO4, 0.1 M bis-tris pH 6.5, 25% PEG 3350
|
Resolution 2.30 Å R-free 0.310 |
| 5FH6 Crystal structure of the fifth bromodomain of human PB1 in complex with compound 10 Deposited 2015-12-21 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
645–766（122 aa）
|
Not recorded | 5XM (3~{R})-3-(piperidin-1-ylmethyl)-2,3-dihydro-1~{H}-pyrrolo[1,2-a]quinazolin-5-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；277.15 K；0.2 M LiSO4, 0.1 M bis-tris pH 6.5, 25% PEG 3350
|
Resolution 2.30 Å R-free 0.310 |
| 5FH6 Crystal structure of the fifth bromodomain of human PB1 in complex with compound 10 Deposited 2015-12-21 | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain C
645–766（122 aa）
|
Not recorded | 5XM (3~{R})-3-(piperidin-1-ylmethyl)-2,3-dihydro-1~{H}-pyrrolo[1,2-a]quinazolin-5-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；277.15 K；0.2 M LiSO4, 0.1 M bis-tris pH 6.5, 25% PEG 3350
|
Resolution 2.30 Å R-free 0.310 |
| 5FH6 Crystal structure of the fifth bromodomain of human PB1 in complex with compound 10 Deposited 2015-12-21 | Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain D
645–766（122 aa）
|
Not recorded | 5XM (3~{R})-3-(piperidin-1-ylmethyl)-2,3-dihydro-1~{H}-pyrrolo[1,2-a]quinazolin-5-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；277.15 K；0.2 M LiSO4, 0.1 M bis-tris pH 6.5, 25% PEG 3350
|
Resolution 2.30 Å R-free 0.310 |
| 5FH7 Crystal structure of the fifth bromodomain of human PB1 in complex with compound 18 Deposited 2015-12-21 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
645–766（122 aa）
|
Not recorded | EDO 1,2-ETHANEDIOL × 2 5XL 6-chloranyl-3-[(dimethylamino)methyl]-4~{H}-pyrrolo[1,2-a]quinazolin-5-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；277.15 K；0.1 M magnesium formate, 15% PEG 3350
|
Resolution 1.47 Å R-free 0.208 |
| 5FH7 Crystal structure of the fifth bromodomain of human PB1 in complex with compound 18 Deposited 2015-12-21 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
645–766（122 aa）
|
Not recorded | 5XL 6-chloranyl-3-[(dimethylamino)methyl]-4~{H}-pyrrolo[1,2-a]quinazolin-5-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；277.15 K；0.1 M magnesium formate, 15% PEG 3350
|
Resolution 1.47 Å R-free 0.208 |
| 5FH8 Crystal structure of the fifth bromodomain of human PB1 in complex with compound 28 Deposited 2015-12-21 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
645–766（122 aa）
|
Not recorded | 5XK 6-chloranyl-3-(2-ethylbutyl)-4~{H}-pyrrolo[1,2-a]quinazolin-5-one × 1 DMS DIMETHYL SULFOXIDE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；277.15 K；10% MPD, 0.1 M bicine pH 9
|
Resolution 1.55 Å R-free 0.224 |
| 5FH8 Crystal structure of the fifth bromodomain of human PB1 in complex with compound 28 Deposited 2015-12-21 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
645–766（122 aa）
|
Not recorded | 5XK 6-chloranyl-3-(2-ethylbutyl)-4~{H}-pyrrolo[1,2-a]quinazolin-5-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；277.15 K；10% MPD, 0.1 M bicine pH 9
|
Resolution 1.55 Å R-free 0.224 |
| 5FH8 Crystal structure of the fifth bromodomain of human PB1 in complex with compound 28 Deposited 2015-12-21 | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain C
645–766（122 aa）
|
Not recorded | 5XK 6-chloranyl-3-(2-ethylbutyl)-4~{H}-pyrrolo[1,2-a]quinazolin-5-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；277.15 K；10% MPD, 0.1 M bicine pH 9
|
Resolution 1.55 Å R-free 0.224 |
| 5FH8 Crystal structure of the fifth bromodomain of human PB1 in complex with compound 28 Deposited 2015-12-21 | Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain D
645–766（122 aa）
|
Not recorded | 5XK 6-chloranyl-3-(2-ethylbutyl)-4~{H}-pyrrolo[1,2-a]quinazolin-5-one × 1 EDO 1,2-ETHANEDIOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；277.15 K；10% MPD, 0.1 M bicine pH 9
|
Resolution 1.55 Å R-free 0.224 |
| 5HRV Crystal structure of the fifth bromodomain of human PB1 in complex with 1-ethylisochromeno[3,4-c]pyrazol-5(2H)-one) compound Deposited 2016-01-24 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
613–734（122 aa）
Fragment：UNP Residues 613-734
|
Not recorded | 64C 1-ethylisochromeno[3,4-c]pyrazol-5(3H)-one × 1 EDO 1,2-ETHANEDIOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；277 K；0.1 M tris-sodium citrate dihydrate pH 5.6, 20% isopropanol, 20% PEG4K
|
Resolution 1.70 Å R-free 0.208 |
| 5HRW Crystal structure of the fifth bromodomain of human PB1 in complex with 1-propylisochromeno[3,4-c]pyrazol-5(2H)-one) compound Deposited 2016-01-24 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
613–734（122 aa）
Fragment：UNP Residues 613-734
|
Not recorded | 64E 1-propylisochromeno[3,4-c]pyrazol-5(3H)-one × 1 EDO 1,2-ETHANEDIOL × 4 SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；277 K；0.2 M ammonium sulfate, 0.1 M MES pH 6.5, 30% PEGMME5k
|
Resolution 1.80 Å R-free 0.236 |
| 5HRW Crystal structure of the fifth bromodomain of human PB1 in complex with 1-propylisochromeno[3,4-c]pyrazol-5(2H)-one) compound Deposited 2016-01-24 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
613–734（122 aa）
Fragment：UNP Residues 613-734
|
Not recorded | 64E 1-propylisochromeno[3,4-c]pyrazol-5(3H)-one × 1 EDO 1,2-ETHANEDIOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；277 K；0.2 M ammonium sulfate, 0.1 M MES pH 6.5, 30% PEGMME5k
|
Resolution 1.80 Å R-free 0.236 |
| 5HRX Crystal structure of the fifth bromodomain of human PB1 in complex with 1-butylisochromeno[3,4-c]pyrazol-5(2H)-one) compound Deposited 2016-01-24 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
613–734（122 aa）
Fragment：UNP Residues 613-734
|
Not recorded | EDO 1,2-ETHANEDIOL × 2 64F 1-butylisochromeno[3,4-c]pyrazol-5(3H)-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；277 K；0.1M lithium sulfate monohydrate, 0.1 M Tris pH 8.5, 30% PEG4K
|
Resolution 1.73 Å R-free 0.254 |
| 5HRX Crystal structure of the fifth bromodomain of human PB1 in complex with 1-butylisochromeno[3,4-c]pyrazol-5(2H)-one) compound Deposited 2016-01-24 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
613–734（122 aa）
Fragment：UNP Residues 613-734
|
Not recorded | 64F 1-butylisochromeno[3,4-c]pyrazol-5(3H)-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；277 K；0.1M lithium sulfate monohydrate, 0.1 M Tris pH 8.5, 30% PEG4K
|
Resolution 1.73 Å R-free 0.254 |
| 5II1 Crystal Structure of the fifth bromodomain of human polybromo (PB1) in complex with 1-methylisochromeno[3,4-c]pyrazol-5(3H)-one Deposited 2016-03-01 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
645–766（122 aa）
|
Not recorded | 6BL 1-methyl[2]benzopyrano[3,4-c]pyrazol-5(3H)-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.1；277 K；18% PEG_3350
0.15M Na_malonate_pH7.0
10v/v ethylene_glycol
0.1M bis_tris_propane pH 8.1
|
Resolution 2.02 Å R-free 0.255 |
| 5II1 Crystal Structure of the fifth bromodomain of human polybromo (PB1) in complex with 1-methylisochromeno[3,4-c]pyrazol-5(3H)-one Deposited 2016-03-01 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
645–766（122 aa）
|
Not recorded | 6BL 1-methyl[2]benzopyrano[3,4-c]pyrazol-5(3H)-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.1；277 K；18% PEG_3350
0.15M Na_malonate_pH7.0
10v/v ethylene_glycol
0.1M bis_tris_propane pH 8.1
|
Resolution 2.02 Å R-free 0.255 |
| 5II2 Crystal Structure of the fifth bromodomain of human polybromo (PB1) in complex with 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one Deposited 2016-03-01 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
645–766（122 aa）
|
Not recorded | K POTASSIUM ION × 1 CIT CITRIC ACID × 1 LU2 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；277 K；0.20M K3(cit)
0.1M BTProp pH 7.5
20.0% PEG 3350
10.0% EtGly
|
Resolution 2.10 Å R-free 0.227 |
| 5II2 Crystal Structure of the fifth bromodomain of human polybromo (PB1) in complex with 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one Deposited 2016-03-01 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
645–766（122 aa）
|
Not recorded | K POTASSIUM ION × 1 LU2 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；277 K；0.20M K3(cit)
0.1M BTProp pH 7.5
20.0% PEG 3350
10.0% EtGly
|
Resolution 2.10 Å R-free 0.227 |
| 5IID Crystal Structure of the fifth bromodomain of human polybromo (PB1) in complex with 2-(3,4-dihydroxyphenyl)-5-hydroxy-4H-chromen-4-one Deposited 2016-03-01 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
645–766（122 aa）
|
Not recorded | 6BK 2-(3,4-dihydroxyphenyl)-5-hydroxy-4H-1-benzopyran-4-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；277 K；0.20M Na2SO4
0.1M BTProp pH 8.5
20.0% PEG 3350
10.0% EtGly
|
Resolution 2.40 Å R-free 0.282 |
| 5IID Crystal Structure of the fifth bromodomain of human polybromo (PB1) in complex with 2-(3,4-dihydroxyphenyl)-5-hydroxy-4H-chromen-4-one Deposited 2016-03-01 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
645–766（122 aa）
|
Not recorded | 6BK 2-(3,4-dihydroxyphenyl)-5-hydroxy-4H-1-benzopyran-4-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；277 K；0.20M Na2SO4
0.1M BTProp pH 8.5
20.0% PEG 3350
10.0% EtGly
|
Resolution 2.40 Å R-free 0.282 |
| 6OXB First bromo-adjacent homology (BAH) domain of human Polybromo-1 (PBRM1) Deposited 2019-05-13 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
934–1105（172 aa）
|
Not recorded | SO4 SULFATE ION × 5 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8；292 K；0.1 M Tris HCl pH 8.0
18% sucrose
1.9 M Ammonium sulfate
|
Resolution 1.86 Å R-free 0.217 |
| 6OXB First bromo-adjacent homology (BAH) domain of human Polybromo-1 (PBRM1) Deposited 2019-05-13 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
934–1105（172 aa）
|
Not recorded | SO4 SULFATE ION × 6 CL CHLORIDE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8；292 K；0.1 M Tris HCl pH 8.0
18% sucrose
1.9 M Ammonium sulfate
|
Resolution 1.86 Å R-free 0.217 |
| 6OXB First bromo-adjacent homology (BAH) domain of human Polybromo-1 (PBRM1) Deposited 2019-05-13 | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain C
934–1105（172 aa）
|
Not recorded | SO4 SULFATE ION × 5 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8；292 K；0.1 M Tris HCl pH 8.0
18% sucrose
1.9 M Ammonium sulfate
|
Resolution 1.86 Å R-free 0.217 |
| 6OXB First bromo-adjacent homology (BAH) domain of human Polybromo-1 (PBRM1) Deposited 2019-05-13 | Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain D
934–1105（172 aa）
|
Not recorded | SO4 SULFATE ION × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8；292 K；0.1 M Tris HCl pH 8.0
18% sucrose
1.9 M Ammonium sulfate
|
Resolution 1.86 Å R-free 0.217 |
| 6OXB First bromo-adjacent homology (BAH) domain of human Polybromo-1 (PBRM1) Deposited 2019-05-13 | Assembly 5 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain E
934–1105（172 aa）
|
Not recorded | SO4 SULFATE ION × 5 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8；292 K；0.1 M Tris HCl pH 8.0
18% sucrose
1.9 M Ammonium sulfate
|
Resolution 1.86 Å R-free 0.217 |
| 6OXB First bromo-adjacent homology (BAH) domain of human Polybromo-1 (PBRM1) Deposited 2019-05-13 | Assembly 6 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain F
934–1105（172 aa）
|
Not recorded | SO4 SULFATE ION × 5 CL CHLORIDE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8；292 K；0.1 M Tris HCl pH 8.0
18% sucrose
1.9 M Ammonium sulfate
|
Resolution 1.86 Å R-free 0.217 |
| 6ZN6 Protein polybromo-1 (PB1 BD2) Bound To MW278 Deposited 2020-07-06 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
178–291（114 aa）
|
Not recorded | QMT 2-[6-azanyl-5-[(3~{R})-3-phenoxypiperidin-1-yl]pyridazin-3-yl]phenol × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5.5；277 K；0.2 M NaCl
25% (w/v) PEG3350
0.1 M bis-tris pH 5.5
|
Resolution 2.02 Å R-free 0.278 |
| 6ZN6 Protein polybromo-1 (PB1 BD2) Bound To MW278 Deposited 2020-07-06 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
178–291（114 aa）
|
Not recorded | QMT 2-[6-azanyl-5-[(3~{R})-3-phenoxypiperidin-1-yl]pyridazin-3-yl]phenol × 1 EDO 1,2-ETHANEDIOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5.5；277 K；0.2 M NaCl
25% (w/v) PEG3350
0.1 M bis-tris pH 5.5
|
Resolution 2.02 Å R-free 0.278 |
| 6ZNV Protein polybromo-1 (PB1 BD2) Bound To DP28 Deposited 2020-07-06 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
178–291（114 aa）
|
Not recorded | QMW 1-[3-azanyl-6-(2-hydroxyphenyl)pyridazin-4-yl]piperidin-4-ol × 1 ZN ZINC ION × 2 EDO 1,2-ETHANEDIOL × 1 CL CHLORIDE ION × 1 ACT ACETATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.4；277 K；0.005 M zinc acetate
20% (w/v) PEG 3350
|
Resolution 1.14 Å R-free 0.205 |
| 6ZS3 Crystal structure of the fifth bromodomain of human protein polybromo-1 in complex with 2-(6-amino-5-(piperazin-1-yl)pyridazin-3-yl)phenol Deposited 2020-07-15 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
645–766（122 aa）
|
Not recorded | FX5 2-(6-azanyl-5-piperazin-4-ium-1-yl-pyridazin-3-yl)phenol × 1 EDO 1,2-ETHANEDIOL × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；22% (w/v) PEG 3350, 0.2 M sodium malonate, 10% (v/v) ethylene glycol, 0.1 M bis-tris propane pH 7.1
|
Resolution 1.67 Å R-free 0.243 |
| 6ZS3 Crystal structure of the fifth bromodomain of human protein polybromo-1 in complex with 2-(6-amino-5-(piperazin-1-yl)pyridazin-3-yl)phenol Deposited 2020-07-15 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
645–766（122 aa）
|
Not recorded | FX5 2-(6-azanyl-5-piperazin-4-ium-1-yl-pyridazin-3-yl)phenol × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；22% (w/v) PEG 3350, 0.2 M sodium malonate, 10% (v/v) ethylene glycol, 0.1 M bis-tris propane pH 7.1
|
Resolution 1.67 Å R-free 0.243 |
| 6ZS4 Crystal structure of the fifth bromodomain of human protein polybromo-1 in complex with tert-butyl 4-[3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl]piperazine-1-carboxylate Deposited 2020-07-15 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
645–766（122 aa）
|
Not recorded | QP8 tert-butyl 4-[3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl]piperazine-1-carboxylate × 1 EDO 1,2-ETHANEDIOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277 K；30% PEG 5000 MME, 0.2 M (NH4)2SO4, 0.1 M MES pH 5.8
|
Resolution 2.00 Å R-free 0.230 |
| 7VDV The overall structure of human chromatin remodeling PBAF-nucleosome complex Deposited 2021-09-07 | Assembly 1 Protein–DNA Heteromer；Protein × 22 PDB declaration: 24-meric（24） Consistent with all polymers |
Chain a
631–1689（1059 aa）
|
Not recorded | BEF BERYLLIUM TRIFLUORIDE ION × 1 MG MAGNESIUM ION × 1 ADP ADENOSINE-5'-DIPHOSPHATE × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.40 Å |
| 7Y8R The nucleosome-bound human PBAF complex Deposited 2022-06-24 | Assembly 1 Protein–DNA Heteromer；Protein × 25 PDB declaration: 27-meric（27） Consistent with all polymers |
Chain U
1–1597（1597 aa）
|
Not recorded | ADP ADENOSINE-5'-DIPHOSPHATE × 1 MG MAGNESIUM ION × 1 BEF BERYLLIUM TRIFLUORIDE ION × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 4.40 Å |
| 8FTA Crystal Structure of the second bromodomain of human Polybromo-1 (PB1) in complex with compound 16 Deposited 2023-01-11 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
178–291（114 aa）
|
Not recorded | Y8X (2S)-5-chloro-2-(3-methylphenyl)-2,3-dihydroquinazolin-4(1H)-one × 1 ZN ZINC ION × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5.5；277 K；0.1 M MES pH 5.5, 14.4% PEG 8000, 10% Ethylene Glycol, 0.01M ZnCl2
|
Resolution 1.78 Å R-free 0.207 |