Current Protein Identity：Q8NB78
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Difference tags compare only the current result set; every original PDB and assembly record remains separate.
Related-Structure Differences
Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.
| PDB Entry | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Experimental Method | Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 4FWE Native structure of LSD2 /AOF1/KDM1b in spacegroup of C2221 at 2.13A Deposited 2012-07-01 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
30–822（793 aa）
Fragment：UNP residues 30-822
|
Not recorded | ZN ZINC ION × 3 FAD FLAVIN-ADENINE DINUCLEOTIDE × 1 FLC CITRATE ANION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
EVAPORATION；pH 7；289 K；21% PEG3350, 200mM diammonium citrate, pH 7, EVAPORATION, temperature 289K
|
Resolution 2.13 Å R-free 0.246 |
| 4FWE Native structure of LSD2 /AOF1/KDM1b in spacegroup of C2221 at 2.13A Deposited 2012-07-01 | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
30–822（793 aa）
Fragment：UNP residues 30-822
|
Not recorded | ZN ZINC ION × 6 FAD FLAVIN-ADENINE DINUCLEOTIDE × 2 FLC CITRATE ANION × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
EVAPORATION；pH 7；289 K；21% PEG3350, 200mM diammonium citrate, pH 7, EVAPORATION, temperature 289K
|
Resolution 2.13 Å R-free 0.246 |
| 4FWF Complex structure of LSD2/AOF1/KDM1b with H3K4 mimic Deposited 2012-07-01 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
30–822（793 aa）
Fragment：UNP residues 30-822
|
Not recorded | ZN ZINC ION × 3 FAD FLAVIN-ADENINE DINUCLEOTIDE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 7；298 K；21% PEG3350, 200mM diammonium citrate, pH 7, VAPOR DIFFUSION, temperature 298K
|
Resolution 2.70 Å R-free 0.237 |
| 4FWJ Native structure of LSD2/AOF1/KDM1b in spacegroup of I222 at 2.9A Deposited 2012-07-01 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
30–822（793 aa）
Fragment：UNP residues 30-822
|
Not recorded | ZN ZINC ION × 3 FAD FLAVIN-ADENINE DINUCLEOTIDE × 1 K POTASSIUM ION × 1 | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 2.90 Å R-free 0.222 |
| 4FWJ Native structure of LSD2/AOF1/KDM1b in spacegroup of I222 at 2.9A Deposited 2012-07-01 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
30–822（793 aa）
Fragment：UNP residues 30-822
|
Not recorded | ZN ZINC ION × 3 FAD FLAVIN-ADENINE DINUCLEOTIDE × 1 PO4 PHOSPHATE ION × 1 | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 2.90 Å R-free 0.222 |
| 4FWJ Native structure of LSD2/AOF1/KDM1b in spacegroup of I222 at 2.9A Deposited 2012-07-01 | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
30–822（793 aa）
Fragment：UNP residues 30-822
Chain B
30–822（793 aa）
Fragment：UNP residues 30-822
|
Not recorded | ZN ZINC ION × 6 FAD FLAVIN-ADENINE DINUCLEOTIDE × 2 K POTASSIUM ION × 1 PO4 PHOSPHATE ION × 1 | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 2.90 Å R-free 0.222 |
| 4GU0 Crystal structure of LSD2 with H3 Deposited 2012-08-29 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
51–822（772 aa）
Fragment：UNP residues 51-822
Chain C
51–822（772 aa）
Fragment：UNP residues 51-822
|
Not recorded | FAD FLAVIN-ADENINE DINUCLEOTIDE × 2 ZN ZINC ION × 6 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；291 K；0.2M (NH4)2 Tartrate, 0.1M HEPES, 10% PEG20000, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 3.10 Å R-free 0.221 |
| 4GU0 Crystal structure of LSD2 with H3 Deposited 2012-08-29 | Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain B
51–822（772 aa）
Fragment：UNP residues 51-822
Chain D
51–822（772 aa）
Fragment：UNP residues 51-822
|
Not recorded | FAD FLAVIN-ADENINE DINUCLEOTIDE × 2 ZN ZINC ION × 6 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；291 K；0.2M (NH4)2 Tartrate, 0.1M HEPES, 10% PEG20000, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 3.10 Å R-free 0.221 |
| 4GU1 Crystal structure of LSD2 Deposited 2012-08-29 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
51–822（772 aa）
Fragment：UNP residues 51-822
|
Not recorded | FAD FLAVIN-ADENINE DINUCLEOTIDE × 1 CL CHLORIDE ION × 2 NA SODIUM ION × 1 ZN ZINC ION × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；291 K；0.2M Sodium chloride, 0.1M Na/K phosphate, 7% PEG 8000, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 2.94 Å R-free 0.228 |
| 4GU1 Crystal structure of LSD2 Deposited 2012-08-29 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
51–822（772 aa）
Fragment：UNP residues 51-822
|
Not recorded | FAD FLAVIN-ADENINE DINUCLEOTIDE × 1 CL CHLORIDE ION × 2 NA SODIUM ION × 1 ZN ZINC ION × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；291 K；0.2M Sodium chloride, 0.1M Na/K phosphate, 7% PEG 8000, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 2.94 Å R-free 0.228 |
| 4GU1 Crystal structure of LSD2 Deposited 2012-08-29 | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
51–822（772 aa）
Fragment：UNP residues 51-822
Chain B
51–822（772 aa）
Fragment：UNP residues 51-822
|
Not recorded | FAD FLAVIN-ADENINE DINUCLEOTIDE × 2 CL CHLORIDE ION × 4 NA SODIUM ION × 2 ZN ZINC ION × 6 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；291 K；0.2M Sodium chloride, 0.1M Na/K phosphate, 7% PEG 8000, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 2.94 Å R-free 0.228 |
| 4GUR Crystal structure of LSD2-NPAC with H3 in space group P21 Deposited 2012-08-29 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
51–822（772 aa）
Fragment：UNP residues 51-822
|
Not recorded | FAD FLAVIN-ADENINE DINUCLEOTIDE × 1 GOL GLYCEROL × 1 ZN ZINC ION × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；277 K；0.02M Citric acid, 0.03M Bis_tris propane, 10% PEG3350, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.51 Å R-free 0.204 |
| 4GUS Crystal structure of LSD2-NPAC with H3 in space group P3221 Deposited 2012-08-29 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
51–822（772 aa）
Fragment：UNP residues 51-822
|
Not recorded | FAD FLAVIN-ADENINE DINUCLEOTIDE × 1 IOD IODIDE ION × 6 GOL GLYCEROL × 2 ZN ZINC ION × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.2；277 K；0.1M Ammonium Iodide, 0.1M MES, 10% PEG3350, pH 6.2, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.23 Å R-free 0.237 |
| 4GUT Crystal structure of LSD2-NPAC Deposited 2012-08-29 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
51–822（772 aa）
Fragment：UNP residues 51-822
|
Not recorded | FAD FLAVIN-ADENINE DINUCLEOTIDE × 1 GOL GLYCEROL × 2 ZN ZINC ION × 3 PGE TRIETHYLENE GLYCOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；277 K；0.02M Citric acid, 0.03M Bis_tris propane, 10% PEG3350, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.00 Å R-free 0.207 |
| 4GUU Crystal structure of LSD2-NPAC with tranylcypromine Deposited 2012-08-29 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
51–822（772 aa）
Fragment：UNP residues 51-822
|
Not recorded | FA9 [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (2R,3S,4S)-5-[(3R,3aS,7aR)-10,11-dimethyl-1,4,6-trioxo-3-phenyl-2,3,5,6,7,7a-hexahydro-1H-benzo[g]pyrrolo[2,1-e]pteridin-8(4H)-yl]-2,3,4-trihydroxypentyl dihydrogen diphosphate × 1 ZN ZINC ION × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；277 K；0.02M Citric acid, 0.03M Bis_tris propane, 10% PEG3350, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.30 Å R-free 0.231 |
| 4HSU Crystal structure of LSD2-NPAC with H3(1-26)in space group P21 Deposited 2012-10-30 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
51–822（772 aa）
Fragment：UNP residues 51-822
|
Not recorded | FAD FLAVIN-ADENINE DINUCLEOTIDE × 1 ZN ZINC ION × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；277 K；0.02M Citric acid, 0.03M Bis_tris propane, 10% PEG3350, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.99 Å R-free 0.232 |
| 6R1U Structure of LSD2/NPAC-linker/nucleosome core particle complex: Class 2 Deposited 2019-03-15 | Assembly 1 Protein–DNA Heteromer；Protein × 11 PDB declaration: tridecameric（13） Consistent with all polymers |
Chain K
51–822（772 aa）
|
Not recorded | FAD FLAVIN-ADENINE DINUCLEOTIDE × 1 ZN ZINC ION × 3 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 4.36 Å |
| 6R25 Structure of LSD2/NPAC-linker/nucleosome core particle complex: Class 3 Deposited 2019-03-15 | Assembly 1 Protein–DNA Heteromer；Protein × 11 PDB declaration: tridecameric（13） Consistent with all polymers |
Chain K
51–822（772 aa）
|
Not recorded | FAD FLAVIN-ADENINE DINUCLEOTIDE × 1 ZN ZINC ION × 3 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 4.61 Å |
| 7XE1 Crystal structure of LSD2 in complex with cis-4-Br-PCPA Deposited 2022-03-29 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
30–822（793 aa）
|
Not recorded | ZN ZINC ION × 3 FAD FLAVIN-ADENINE DINUCLEOTIDE × 1 DIJ 3-(4-bromophenyl)propanal × 1 FLC CITRATE ANION × 1 PGE TRIETHYLENE GLYCOL × 1 GOL GLYCEROL × 9 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；320mM Ammonium citrate, 22% PEG 3350
|
Resolution 2.07 Å R-free 0.192 |
| 7XE1 Crystal structure of LSD2 in complex with cis-4-Br-PCPA Deposited 2022-03-29 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
30–822（793 aa）
|
Not recorded | ZN ZINC ION × 3 FAD FLAVIN-ADENINE DINUCLEOTIDE × 1 DIJ 3-(4-bromophenyl)propanal × 1 GOL GLYCEROL × 4 PEG DI(HYDROXYETHYL)ETHER × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；320mM Ammonium citrate, 22% PEG 3350
|
Resolution 2.07 Å R-free 0.192 |
| 7XE2 Crystal structure of LSD2 in complex with trans-4-Br-PCPA Deposited 2022-03-29 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
30–822（793 aa）
|
Not recorded | ZN ZINC ION × 3 FAD FLAVIN-ADENINE DINUCLEOTIDE × 2 DIJ 3-(4-bromophenyl)propanal × 2 FLC CITRATE ANION × 1 PGE TRIETHYLENE GLYCOL × 1 GOL GLYCEROL × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；288 K；300mM Ammonium citrate, 24% PEG 3350
|
Resolution 2.05 Å R-free 0.194 |
| 7XE2 Crystal structure of LSD2 in complex with trans-4-Br-PCPA Deposited 2022-03-29 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
30–822（793 aa）
|
Not recorded | ZN ZINC ION × 3 FAD FLAVIN-ADENINE DINUCLEOTIDE × 2 DIJ 3-(4-bromophenyl)propanal × 2 GOL GLYCEROL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；288 K；300mM Ammonium citrate, 24% PEG 3350
|
Resolution 2.05 Å R-free 0.194 |
| 7XE3 Crystal structure of LSD2 in complex with cis-4-Br-2,5-F2-PCPA (S1024) Deposited 2022-03-29 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
30–822（793 aa）
|
Not recorded | ZN ZINC ION × 3 FAD FLAVIN-ADENINE DINUCLEOTIDE × 1 8A2 3-[4-bromanyl-2,5-bis(fluoranyl)phenyl]propanal × 1 FLC CITRATE ANION × 1 PG4 TETRAETHYLENE GLYCOL × 1 EDO 1,2-ETHANEDIOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；330mM Ammonium citrate, 26% PEG 3350
|
Resolution 2.82 Å R-free 0.222 |
| 7XE3 Crystal structure of LSD2 in complex with cis-4-Br-2,5-F2-PCPA (S1024) Deposited 2022-03-29 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
30–822（793 aa）
|
Not recorded | ZN ZINC ION × 3 FAD FLAVIN-ADENINE DINUCLEOTIDE × 1 8A2 3-[4-bromanyl-2,5-bis(fluoranyl)phenyl]propanal × 1 EDO 1,2-ETHANEDIOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；330mM Ammonium citrate, 26% PEG 3350
|
Resolution 2.82 Å R-free 0.222 |