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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：Q8NEZ4 New Search
9PDB entries
12Biological assembly
16chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
2YSM Solution structure of the second and third PHD domain from Histone-lysine N-methyltransferase 2C (KMT2C/MLL3) Deposited 2007-04-03 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 342–439（98 aa） Fragment：PHD domain
Not recorded ZN ZINC ION × 4 SOLUTION NMR
NMR measurement conditions pH 7；293 K；Ionic strength (raw mmCIF value) 120mM；Pressure ambient
NMR sample composition 0.94mM 13C, 15N-labeled protein; 20mM d-Tris-HCl(pH7.0); 100mM NaCl; 1mM d-DTT; 0.02% NaN3; 0.05mM ZnCl2+1mM IDA; 90% H2O, 10% D2O | 90% H2O/10% D2O
Resolution not provided
2YUK Solution structure of the HMG box of human Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog Deposited 2007-04-06 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1631–1713（83 aa） Fragment：HMG (high mobility group) box, UNP residues 1631-1713
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 7；298 K；Ionic strength (raw mmCIF value) 120mM；Pressure ambient
NMR sample composition 1.11mM Protein; 20mM d-Tris-HCl; 100mM NaCl; 1mM d-DTT; 0.02% NaN3; 90% H2O, 10% D2O | 90% H2O/10% D2O
Resolution not provided
3UVL Crystal structure of WDR5 in complex with the WDR5-interacting motif of MLL3 Deposited 2011-11-30 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 4707–4717（11 aa） Fragment：WDR5-interacting motif (UNP residues 4707-4717)
Mutation：C4708S,S4711A No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；323 K；0.1 M ammonium acetate, 25% PEG3350, 0.1 M Bis-Tris, pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 323K
Resolution 2.20 Å R-free 0.220
4ERY X-ray structure of WDR5-MLL3 Win motif peptide binary complex Deposited 2012-04-21 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain D 4703–4716（14 aa） Fragment：UNP residues 4703-4716
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions hanging drop；pH 7.5；294 K；PEG3350, Ammonium Sulfate, HEPES, pH 7.5, hanging drop, temperature 294K
Resolution 1.30 Å R-free 0.209
5F59 The crystal structure of MLL3 SET domain Deposited 2015-12-04 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 4757–4910（154 aa） Fragment：MLL3 SET domain (UNP RESIDUES 4757-4910)
Not recorded ZN ZINC ION × 1 SAH S-ADENOSYL-L-HOMOCYSTEINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；277 K；100 mM Tris-HCl, pH8.5, 3M NaCl
Resolution 2.80 Å R-free 0.229
5F6K Crystal structure of the MLL3-Ash2L-RbBP5 complex Deposited 2015-12-06 Assembly 1 Protein heterocomplex Heteromer；Protein × 7 PDB declaration: heptameric（7） Consistent with protein count
Chain C 4757–4911（155 aa） Fragment：UNP RESIDUES 4757-4911
Chain E 4757–4911（155 aa） Fragment：UNP RESIDUES 4757-4911
Not recorded ZN ZINC ION × 2 SAH S-ADENOSYL-L-HOMOCYSTEINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；100 mM Na-Cacodylate, pH 6.5, 10% PEG 3350, 0.1 M MgCl2
Resolution 2.41 Å R-free 0.228
5F6K Crystal structure of the MLL3-Ash2L-RbBP5 complex Deposited 2015-12-06 Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain E 4757–4911（155 aa） Fragment：UNP RESIDUES 4757-4911
Not recorded ZN ZINC ION × 1 SAH S-ADENOSYL-L-HOMOCYSTEINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；100 mM Na-Cacodylate, pH 6.5, 10% PEG 3350, 0.1 M MgCl2
Resolution 2.41 Å R-free 0.228
5F6K Crystal structure of the MLL3-Ash2L-RbBP5 complex Deposited 2015-12-06 Assembly 3 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain C 4757–4911（155 aa） Fragment：UNP RESIDUES 4757-4911
Not recorded ZN ZINC ION × 1 SAH S-ADENOSYL-L-HOMOCYSTEINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；100 mM Na-Cacodylate, pH 6.5, 10% PEG 3350, 0.1 M MgCl2
Resolution 2.41 Å R-free 0.228
6KIW Cryo-EM structure of human MLL3-ubNCP complex (4.0 angstrom) Deposited 2019-07-20 Assembly 1 Protein–DNA Heteromer；Protein × 13 PDB declaration: pentadecameric（15） Consistent with all polymers
Chain K 4707–4911（205 aa）
Mutation：C4708S ZN ZINC ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.00 Å
6MLC PHD6 domain of MLL3 in complex with histone H4 Deposited 2018-09-27 Assembly 1 Protein heterocomplex Heteromer；Protein × 18 PDB declaration: octadecameric（18） Consistent with protein count
Chain A 1055–1144（90 aa） Fragment：PHD-type 7 zinc finger, residues 1055-1144
Chain B 1055–1144（90 aa） Fragment：PHD-type 7 zinc finger, residues 1055-1144
Not recorded ZN ZINC ION × 42 GOL GLYCEROL × 6 UNX UNKNOWN LIGAND × 30 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；291 K；2 M Na-Form, 0.1 M Tris, pH 8.5
Resolution 1.80 Å R-free 0.216
6MLC PHD6 domain of MLL3 in complex with histone H4 Deposited 2018-09-27 Assembly 2 Protein heterocomplex Heteromer；Protein × 18 PDB declaration: octadecameric（18） Consistent with protein count
Chain C 1055–1144（90 aa） Fragment：PHD-type 7 zinc finger, residues 1055-1144
Chain D 1055–1144（90 aa） Fragment：PHD-type 7 zinc finger, residues 1055-1144
Not recorded ZN ZINC ION × 42 GOL GLYCEROL × 24 UNX UNKNOWN LIGAND × 12 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；291 K；2 M Na-Form, 0.1 M Tris, pH 8.5
Resolution 1.80 Å R-free 0.216
7W6L The crystal structure of MLL3-RBBP5-ASH2L in complex with H3K4me0 peptide Deposited 2021-12-01 Assembly 1 Protein heterocomplex Heteromer；Protein × 7 PDB declaration: heptameric（7） Consistent with protein count
Chain C 4757–4911（155 aa）
Chain E 4757–4911（155 aa）
Not recorded ZN ZINC ION × 2 SAH S-ADENOSYL-L-HOMOCYSTEINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.5；277 K；100 mM sodium cacodylate, pH 6.5, 10% polyethylene glycol 3350, 0.1 M MgCl2
Resolution 2.26 Å R-free 0.223

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.