Current Protein Identity:Q92633
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Difference tags compare only the current result set; every original PDB and assembly record remains separate.
Related-Structure Differences
Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.
| PDB Entry | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Experimental Method | Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 4Z34 Crystal Structure of Human Lysophosphatidic Acid Receptor 1 in complex with ONO9780307 Deposited 2015-03-30 | Assembly 1 Insufficient information Monomer;Protein × 1 PDB declaration: monomeric(1) Consistent with protein count |
Chain A
2–232(231 aa)
Fragment:unp residues 2-232; unp residues 23-64; unp residues 73-127; unp residues 248-326
Chain A
248–326(79 aa)
Fragment:unp residues 2-232; unp residues 23-64; unp residues 73-127; unp residues 248-326
|
Mutation:M1007W, H1102I, R1106L Mutation:M1007W, H1102I, R1106L | ON7 {1-[(2S,3S)-2-(2,3-dihydro-1H-inden-2-ylmethyl)-3-(3,5-dimethoxy-4-methylphenyl)-3-hydroxypropyl]-4-(methoxycarbonyl)-1 H-pyrrol-3-yl}acetic acid × 1 1WV (2S)-2,3-dihydroxypropyl (7Z)-tetradec-7-enoate × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
LIPIDIC CUBIC PHASE;pH 5.5;293 K;0.1 M sodium citrate (pH 5.5),
34 - 38% (v/v) PEG400 and
200 mM ammonium acetate
|
Resolution 3.00 Å R-free 0.281 |
| 4Z35 Crystal Structure of Human Lysophosphatidic Acid Receptor 1 in complex with ONO-9910539 Deposited 2015-03-30 | Assembly 1 Insufficient information Monomer;Protein × 1 PDB declaration: monomeric(1) Consistent with protein count |
Chain A
2–232(231 aa)
Chain A
248–326(79 aa)
|
Mutation:M1007W, H1102I, R1106L Mutation:M1007W, H1102I, R1106L | ON9 3-{1-[(2S,3S)-3-(4-acetyl-3,5-dimethoxyphenyl)-2-(2,3-dihydro-1H-inden-2-ylmethyl)-3-hydroxypropyl]-4-(methoxycarbonyl)-1H-pyrrol-3-yl}propanoic acid × 1 1WV (2S)-2,3-dihydroxypropyl (7Z)-tetradec-7-enoate × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
LIPIDIC CUBIC PHASE;pH 5.5;293 K;0.1 M sodium citrate
(pH 5.5), 34 - 38% (v/v) PEG400 and 200 mM ammonium acetate
|
Resolution 2.90 Å R-free 0.279 |
| 4Z36 Crystal Structure of Human Lysophosphatidic Acid Receptor 1 in complex with ONO-3080573 Deposited 2015-03-30 | Assembly 1 Insufficient information Monomer;Protein × 1 PDB declaration: monomeric(1) Consistent with protein count |
Chain A
2–232(231 aa)
Fragment:unp residues 2-232; unp residues 23-64; unp residues 78-127; unp residues 249-327
Chain A
249–327(79 aa)
Fragment:unp residues 2-232; unp residues 23-64; unp residues 78-127; unp residues 249-327
|
Mutation:M1007W, H1102I, R1106L Mutation:M1007W, H1102I, R1106L | ON3 1-(4-{[(2S,3R)-2-(2,3-dihydro-1H-inden-2-yloxy)-3-(3,5-dimethoxy-4-methylphenyl)-3-hydroxypropyl]oxy}phenyl)cyclopropan ecarboxylic acid × 1 1WV (2S)-2,3-dihydroxypropyl (7Z)-tetradec-7-enoate × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
LIPIDIC CUBIC PHASE;pH 5.5;293 K;0.1 M sodium citrate
(pH 5.5), 34 - 38% (v/v) PEG400 and 200 mM ammonium acetate
|
Resolution 2.90 Å R-free 0.292 |
| 7TD0 Lysophosphatidic acid receptor 1-Gi complex bound to LPA Deposited 2021-12-30 | Assembly 1 Protein heterocomplex Heteromer;Protein × 4 PDB declaration: tetrameric(4) Consistent with protein count |
Chain R
2–340(339 aa)
|
Not recorded | NKP (2R)-2-hydroxy-3-(phosphonooxy)propyl (9E)-octadec-9-enoate × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.83 Å |
| 7TD1 Lysophosphatidic acid receptor 1-Gi complex bound to LPA, state a Deposited 2021-12-30 | Assembly 1 Protein heterocomplex Heteromer;Protein × 4 PDB declaration: tetrameric(4) Consistent with protein count |
Chain R
2–340(339 aa)
|
Not recorded | NKP (2R)-2-hydroxy-3-(phosphonooxy)propyl (9E)-octadec-9-enoate × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.08 Å |
| 7TD2 Lysophosphatidic acid receptor 1-Gi complex bound to LPA, state a Deposited 2021-12-30 | Assembly 1 Protein heterocomplex Heteromer;Protein × 4 PDB declaration: tetrameric(4) Consistent with protein count |
Chain R
2–340(339 aa)
|
Not recorded | NKP (2R)-2-hydroxy-3-(phosphonooxy)propyl (9E)-octadec-9-enoate × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.11 Å |
| 7YU3 Human Lysophosphatidic Acid Receptor 1-Gi complex bound to ONO-0740556 Deposited 2022-08-16 | Assembly 1 Protein heterocomplex Heteromer;Protein × 5 PDB declaration: pentameric(5) Consistent with protein count |
Chain R
2–364(363 aa)
|
Not recorded | K6L [(2~{R})-2-[5-(2-hexylphenyl)pentanoylamino]-3-oxidanyl-propyl] dihydrogen phosphate × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.50 Å |
| 7YU4 Human Lysophosphatidic Acid Receptor 1-Gi complex bound to ONO-0740556, focused on receptor Deposited 2022-08-16 | Assembly 1 Protein monomer Monomer;Protein × 1 PDB declaration: monomeric(1) Consistent with protein count |
Chain A
2–364(363 aa)
|
Not recorded | K6L [(2~{R})-2-[5-(2-hexylphenyl)pentanoylamino]-3-oxidanyl-propyl] dihydrogen phosphate × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.70 Å |
| 7YU5 Human Lysophosphatidic Acid Receptor 1-Gi complex bound to ONO-0740556, state1 Deposited 2022-08-16 | Assembly 1 Protein heterocomplex Heteromer;Protein × 5 PDB declaration: pentameric(5) Consistent with protein count |
Chain R
2–364(363 aa)
|
Not recorded | K6L [(2~{R})-2-[5-(2-hexylphenyl)pentanoylamino]-3-oxidanyl-propyl] dihydrogen phosphate × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.70 Å |
| 7YU6 Human Lysophosphatidic Acid Receptor 1-Gi complex bound to ONO-0740556, state2 Deposited 2022-08-16 | Assembly 1 Protein heterocomplex Heteromer;Protein × 5 PDB declaration: pentameric(5) Consistent with protein count |
Chain R
2–364(363 aa)
|
Not recorded | K6L [(2~{R})-2-[5-(2-hexylphenyl)pentanoylamino]-3-oxidanyl-propyl] dihydrogen phosphate × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.90 Å |
| 7YU7 Human Lysophosphatidic Acid Receptor 1-Gi complex bound to ONO-0740556, state3 Deposited 2022-08-16 | Assembly 1 Protein heterocomplex Heteromer;Protein × 5 PDB declaration: pentameric(5) Consistent with protein count |
Chain R
2–364(363 aa)
|
Not recorded | K6L [(2~{R})-2-[5-(2-hexylphenyl)pentanoylamino]-3-oxidanyl-propyl] dihydrogen phosphate × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 4.50 Å |
| 7YU8 Human Lysophosphatidic Acid Receptor 1-Gi complex bound to ONO-0740556, state4 Deposited 2022-08-16 | Assembly 1 Protein heterocomplex Heteromer;Protein × 5 PDB declaration: pentameric(5) Consistent with protein count |
Chain R
2–364(363 aa)
|
Not recorded | K6L [(2~{R})-2-[5-(2-hexylphenyl)pentanoylamino]-3-oxidanyl-propyl] dihydrogen phosphate × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 5.60 Å |
| 9IZF Cryo-EM structure of LPA1-Gi complex with LPA Deposited 2024-08-01 | Assembly 1 Insufficient information Heteromer;Protein × 5 PDB declaration: pentameric(5) Consistent with protein count |
Chain R
2–364(363 aa)
|
Not recorded | NKP (2R)-2-hydroxy-3-(phosphonooxy)propyl (9E)-octadec-9-enoate × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.14 Å |
| 9IZG Cryo-EM structure of LPA1-Gq complex with LPA Deposited 2024-08-01 | Assembly 1 Insufficient information Heteromer;Protein × 5 PDB declaration: pentameric(5) Consistent with protein count |
Chain R
2–364(363 aa)
|
Not recorded | NKP (2R)-2-hydroxy-3-(phosphonooxy)propyl (9E)-octadec-9-enoate × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.04 Å |
| 9IZH Cryo-EM structure of LPA1-G13 complex with LPA Deposited 2024-08-01 | Assembly 1 Insufficient information Heteromer;Protein × 5 PDB declaration: pentameric(5) Consistent with protein count |
Chain R
2–364(363 aa)
|
Not recorded | NKP (2R)-2-hydroxy-3-(phosphonooxy)propyl (9E)-octadec-9-enoate × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.04 Å |
| 9J5V Human Lysophosphatidic Acid Receptor 1-Gi complex bound to CpY Deposited 2024-08-13 | Assembly 1 Protein heterocomplex Heteromer;Protein × 5 PDB declaration: pentameric(5) Consistent with protein count |
Chain R
2–364(363 aa)
|
Not recorded | A1L3Q CpY × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.86 Å |