Current Protein Identity：Q92731
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Difference tags compare only the current result set; every original PDB and assembly record remains separate.
Related-Structure Differences
Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.
| PDB Entry | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Experimental Method | Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 1L2J Human Estrogen Receptor beta Ligand-binding Domain in Complex with (R,R)-5,11-cis-diethyl-5,6,11,12-tetrahydrochrysene-2,8-diol Deposited 2002-02-21 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
256–505（250 aa）
Fragment：ligand-binding domain (residues 256-505)
|
Not recorded | ETC (R,R)-5,11-CIS-DIETHYL-5,6,11,12-TETRAHYDROCHRYSENE-2,8-DIOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.5；295 K；1.5-1.75 M Ammonium sulfate, 100 mM Sodium Acetate pH 4.8-5.2 294-296 K, pH 4.5, VAPOR DIFFUSION, HANGING DROP, temperature 295K
|
Resolution 2.95 Å R-free 0.299 |
| 1L2J Human Estrogen Receptor beta Ligand-binding Domain in Complex with (R,R)-5,11-cis-diethyl-5,6,11,12-tetrahydrochrysene-2,8-diol Deposited 2002-02-21 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
256–505（250 aa）
Fragment：ligand-binding domain (residues 256-505)
|
Not recorded | ETC (R,R)-5,11-CIS-DIETHYL-5,6,11,12-TETRAHYDROCHRYSENE-2,8-DIOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.5；295 K；1.5-1.75 M Ammonium sulfate, 100 mM Sodium Acetate pH 4.8-5.2 294-296 K, pH 4.5, VAPOR DIFFUSION, HANGING DROP, temperature 295K
|
Resolution 2.95 Å R-free 0.299 |
| 1L2J Human Estrogen Receptor beta Ligand-binding Domain in Complex with (R,R)-5,11-cis-diethyl-5,6,11,12-tetrahydrochrysene-2,8-diol Deposited 2002-02-21 | Assembly 3 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain B
256–505（250 aa）
Fragment：ligand-binding domain (residues 256-505)
|
Not recorded | ETC (R,R)-5,11-CIS-DIETHYL-5,6,11,12-TETRAHYDROCHRYSENE-2,8-DIOL × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.5；295 K；1.5-1.75 M Ammonium sulfate, 100 mM Sodium Acetate pH 4.8-5.2 294-296 K, pH 4.5, VAPOR DIFFUSION, HANGING DROP, temperature 295K
|
Resolution 2.95 Å R-free 0.299 |
| 1NDE Estrogen Receptor beta with Selective Triazine Modulator Deposited 2002-12-09 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
256–501（246 aa）
Fragment：residues 256-501
|
Not recorded | MON 4-(2-{[4-{[3-(4-CHLOROPHENYL)PROPYL]SULFANYL}-6-(1-PIPERAZINYL)-1,3,5-TRIAZIN-2-YL]AMINO}ETHYL)PHENOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；295 K；50mM PIPES pH6.5, 200 mM lithium sulfate, 8-12% PEG35000, 5% sucrose, VAPOR DIFFUSION, HANGING DROP, temperature 22K, temperature 295K
|
Resolution 3.00 Å R-free 0.273 |
| 1NDE Estrogen Receptor beta with Selective Triazine Modulator Deposited 2002-12-09 | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
256–501（246 aa）
Fragment：residues 256-501
|
Not recorded | MON 4-(2-{[4-{[3-(4-CHLOROPHENYL)PROPYL]SULFANYL}-6-(1-PIPERAZINYL)-1,3,5-TRIAZIN-2-YL]AMINO}ETHYL)PHENOL × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；295 K；50mM PIPES pH6.5, 200 mM lithium sulfate, 8-12% PEG35000, 5% sucrose, VAPOR DIFFUSION, HANGING DROP, temperature 22K, temperature 295K
|
Resolution 3.00 Å R-free 0.273 |
| 1NDE Estrogen Receptor beta with Selective Triazine Modulator Deposited 2002-12-09 | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
256–501（246 aa）
Fragment：residues 256-501
|
Not recorded | MON 4-(2-{[4-{[3-(4-CHLOROPHENYL)PROPYL]SULFANYL}-6-(1-PIPERAZINYL)-1,3,5-TRIAZIN-2-YL]AMINO}ETHYL)PHENOL × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；295 K；50mM PIPES pH6.5, 200 mM lithium sulfate, 8-12% PEG35000, 5% sucrose, VAPOR DIFFUSION, HANGING DROP, temperature 22K, temperature 295K
|
Resolution 3.00 Å R-free 0.273 |
| 1QKM HUMAN OESTROGEN RECEPTOR BETA LIGAND-BINDING DOMAIN IN COMPLEX WITH PARTIAL AGONIST GENISTEIN Deposited 1999-07-27 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
255–509（255 aa）
Fragment：LIGAND-BINDING DOMAIN
|
Not recorded | GEN GENISTEIN × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 8.1；6-9% (W/V) PEG 6000, 1.6-2.1M NACL, 0.1M TRIS-HCL, PH 8.1
|
Resolution 1.80 Å R-free 0.252 |
| 1U3Q Crystal Structure of Estrogen Receptor beta complexed with CL-272 Deposited 2004-07-22 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
261–500（240 aa）
Chain C
261–500（240 aa）
|
Not recorded | 272 4-(6-HYDROXY-BENZO[D]ISOXAZOL-3-YL)BENZENE-1,3-DIOL × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；291 K；PEG2000, MgCl, hexaminecobalt trichloride, MES, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 2.40 Å R-free 0.279 |
| 1U3Q Crystal Structure of Estrogen Receptor beta complexed with CL-272 Deposited 2004-07-22 | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
261–500（240 aa）
Chain D
261–500（240 aa）
|
Not recorded | 272 4-(6-HYDROXY-BENZO[D]ISOXAZOL-3-YL)BENZENE-1,3-DIOL × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；291 K；PEG2000, MgCl, hexaminecobalt trichloride, MES, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 2.40 Å R-free 0.279 |
| 1U3R Crystal Structure of Estrogen Receptor beta complexed with WAY-338 Deposited 2004-07-22 | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
261–501（241 aa）
Chain B
261–501（241 aa）
|
Not recorded | 338 2-(5-HYDROXY-NAPHTHALEN-1-YL)-1,3-BENZOOXAZOL-6-OL × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.9；291 K；PEG3350, Mg formate, pH 5.9, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 2.21 Å R-free 0.267 |
| 1U3S Crystal Structure of Estrogen Receptor beta complexed with WAY-797 Deposited 2004-07-22 | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
261–500（240 aa）
Chain B
261–500（240 aa）
|
Not recorded | 797 3-(6-HYDROXY-NAPHTHALEN-2-YL)-BENZO[D]ISOOXAZOL-6-OL × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.9；291 K；PEG3350, Mg formate , pH 5.9, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 2.50 Å R-free 0.250 |
| 1U9E CRYSTAL STRUCTURE OF ESTROGEN RECEPTOR BETA COMPLEXED WITH WAY-397 Deposited 2004-08-09 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
261–501（241 aa）
|
Not recorded | 397 2-(4-HYDROXY-PHENYL)BENZOFURAN-5-OL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；291 K；PEG3350, Mg formate , pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 2.40 Å R-free 0.279 |
| 1U9E CRYSTAL STRUCTURE OF ESTROGEN RECEPTOR BETA COMPLEXED WITH WAY-397 Deposited 2004-08-09 | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
261–501（241 aa）
|
Not recorded | 397 2-(4-HYDROXY-PHENYL)BENZOFURAN-5-OL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；291 K；PEG3350, Mg formate , pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 2.40 Å R-free 0.279 |
| 1U9E CRYSTAL STRUCTURE OF ESTROGEN RECEPTOR BETA COMPLEXED WITH WAY-397 Deposited 2004-08-09 | Assembly 3 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
261–501（241 aa）
Chain B
261–501（241 aa）
|
Not recorded | 397 2-(4-HYDROXY-PHENYL)BENZOFURAN-5-OL × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；291 K；PEG3350, Mg formate , pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 2.40 Å R-free 0.279 |
| 1X76 CRYSTAL STRUCTURE OF ESTROGEN RECEPTOR BETA COMPLEXED WITH WAY-697 Deposited 2004-08-13 | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
261–500（240 aa）
Chain B
261–500（240 aa）
|
Not recorded | 697 5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-CARBONITRILE × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.9；291 K；PEG3350, Mg Formate, pH 5.90, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 2.20 Å R-free 0.265 |
| 1X78 CRYSTAL STRUCTURE OF ESTROGEN RECEPTOR BETA COMPLEXED WITH WAY-244 Deposited 2004-08-13 | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
261–500（240 aa）
Chain B
261–500（240 aa）
|
Not recorded | 244 [5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-YL]ACETONITRILE × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.9；291 K；PEG3350, Mg Formate, pH 5.90, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 2.30 Å R-free 0.270 |
| 1X7B CRYSTAL STRUCTURE OF ESTROGEN RECEPTOR BETA COMPLEXED WITH ERB-041 Deposited 2004-08-13 | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
261–500（240 aa）
Chain B
261–500（240 aa）
|
Not recorded | 041 2-(3-FLUORO-4-HYDROXYPHENYL)-7-VINYL-1,3-BENZOXAZOL-5-OL × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；291 K；PEG3350, Mg Formate, pH 6.00, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 2.30 Å R-free 0.266 |
| 1X7J CRYSTAL STRUCTURE OF ESTROGEN RECEPTOR BETA COMPLEXED WITH GENISTEIN Deposited 2004-08-14 | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
261–500（240 aa）
Chain B
261–500（240 aa）
|
Not recorded | GEN GENISTEIN × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；291 K；PEG2000, MgCL., pH 6.00, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 2.30 Å R-free 0.282 |
| 1ZAF Crystal structure of estrogen receptor beta complexed with 3-Bromo-6-hydroxy-2-(4-hydroxy-phenyl)-inden-1-one Deposited 2005-04-06 | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
263–500（238 aa）
Chain B
263–500（238 aa）
|
Not recorded | 789 3-BROMO-6-HYDROXY-2-(4-HYDROXYPHENYL)-1H-INDEN-1-ONE × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 7.5；291 K；15% PEG3350, 0.2M Mg Acetate, pH 7.5, VAPOR DIFFUSION, temperature 291K
|
Resolution 2.20 Å R-free 0.286 |
| 2FSZ A second binding site for hydroxytamoxifen within the coactivator-binding groove of estrogen receptor beta Deposited 2006-01-23 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
257–502（246 aa）
Fragment：ligand-binding domain
Chain B
257–502（246 aa）
Fragment：ligand-binding domain
|
Mutation：C334S, C369S, C481S Mutation：C334S, C369S, C481S | OHT 4-HYDROXYTAMOXIFEN × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.6；295 K；0.1M sodium citrate, 1.5M sodium chloride, 4% ethylene imine, pH 5.6, VAPOR DIFFUSION, HANGING DROP, temperature 295K
|
Resolution 2.20 Å R-free 0.299 |
| 2FSZ A second binding site for hydroxytamoxifen within the coactivator-binding groove of estrogen receptor beta Deposited 2006-01-23 | Assembly 2 Protein homooligomer Homooligomer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count |
Chain A
257–502（246 aa）
Fragment：ligand-binding domain
Chain B
257–502（246 aa）
Fragment：ligand-binding domain
|
Mutation：C334S, C369S, C481S Mutation：C334S, C369S, C481S | OHT 4-HYDROXYTAMOXIFEN × 16 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.6；295 K；0.1M sodium citrate, 1.5M sodium chloride, 4% ethylene imine, pH 5.6, VAPOR DIFFUSION, HANGING DROP, temperature 295K
|
Resolution 2.20 Å R-free 0.299 |
| 2GIU Human estrogen receptor beta ligand-binding domain in complex with compound 45 Deposited 2006-03-29 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
260–500（241 aa）
Fragment：LIGAND-BINDING DOMAIN (Residues 260-500)
|
Not recorded | FBR (9aS)-4-bromo-9a-butyl-7-hydroxy-1,2,9,9a-tetrahydro-3H-fluoren-3-one × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.2；298 K；Precipitant 1.8 M NaCl, 6% PEG 6000, 3% isopropanol, 50 mM Tris buffer pH 7.2, VAPOR DIFFUSION, HANGING DROP, temperature 298.0K
|
Resolution 2.20 Å R-free 0.323 |
| 2I0G Benzopyrans are Selective Estrogen Receptor beta Agonists (SERBAs) with Novel Activity in Models of Benign Prostatic Hyperplasia Deposited 2006-08-10 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
256–505（250 aa）
Chain B
256–505（250 aa）
|
Not recorded | I0G (3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；289 K；0.1M Tris, pH 8.0, 2M sodium chloride, 4% PEG 6000, VAPOR DIFFUSION, HANGING DROP, temperature 289K
|
Resolution 2.50 Å R-free 0.271 |
| 2JJ3 Estrogen receptor beta ligand binding domain in complex with a Benzopyran agonist Deposited 2007-07-03 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
256–505（250 aa）
Fragment：LIGAND-BINDING DOMAIN, RESIDUES 256-505
Chain B
256–505（250 aa）
Fragment：LIGAND-BINDING DOMAIN, RESIDUES 256-505
|
Not recorded | JJ3 (3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-6-(METHOXYMETHYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 8；2M NACL, 9% PEG 6,000, 100MM TRIS PH 8.0
|
Resolution 2.28 Å R-free 0.255 |
| 2NV7 Crystal Structure of Estrogen Receptor Beta Complexed with WAY-555 Deposited 2006-11-10 | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
263–500（238 aa）
Chain B
263–500（238 aa）
|
Not recorded | 555 4-(4-HYDROXYPHENYL)-1-NAPHTHALDEHYDE OXIME × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；291 K；precipitant: PEG3350, Mg formate, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 2.10 Å R-free 0.265 |
| 2QTU Estrogen receptor beta ligand-binding domain complexed to a benzopyran ligand Deposited 2007-08-02 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
256–505（250 aa）
Fragment：ligand binding domain
Chain B
256–505（250 aa）
Fragment：ligand binding domain
|
Not recorded | 3AS (3aS,4R,9bR)-2,2-difluoro-4-(4-hydroxyphenyl)-6-(methoxymethyl)-1,2,3,3a,4,9b-hexahydrocyclopenta[c]chromen-8-ol × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 8；289 K；0.1 M Tris-HCl, 2 M NaCl, 4% PEG 6000, pH 8.0, VAPOR DIFFUSION, temperature 289K
|
Resolution 2.53 Å R-free 0.279 |
| 2YJD Stapled peptide bound to Estrogen Receptor Beta Deposited 2011-05-19 | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
261–500（240 aa）
Fragment：LIGAND-BINDING DOMAIN, RESIDUES 261-500
Chain B
261–500（240 aa）
Fragment：LIGAND-BINDING DOMAIN, RESIDUES 261-500
|
Not recorded | YJD 4-(2-PROPAN-2-YLOXYBENZIMIDAZOL-1-YL)PHENOL × 2 | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 1.93 Å R-free 0.260 |
| 2YLY Sulfonamides as selective Estrogen Receptor beta Agonists. Deposited 2011-06-06 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
260–500（241 aa）
Fragment：LIGAND BINDING DOMAIN, RESIDUES 260-500
Chain B
260–500（241 aa）
Fragment：LIGAND BINDING DOMAIN, RESIDUES 260-500
|
Not recorded | SU4 N-cyclopropyl-4-oxidanyl-N-[(2R)-2-oxidanyl-2-phenyl-propyl]benzenesulfonamide × 2 SO4 SULFATE ION × 2 | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 3.20 Å R-free 0.275 |
| 2Z4B Estrogen receptor beta ligand-binding domain complexed to a benzopyran ligand Deposited 2007-06-14 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
256–505（250 aa）
Fragment：ligand-binding domain (Residues 251-505)
Chain B
256–505（250 aa）
Fragment：ligand-binding domain (Residues 251-505)
|
Not recorded | DC8 (3AS,4R,9BR)-2,2-DIFLUORO-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 8；289 K；0.1M Tris, pH 8.0, 2M sodium chloride, 4% PEG 6000, VAPOR DIFFUSION, temperature 289.0K
|
Resolution 2.34 Å R-free 0.253 |
| 3OLL Crystal structure of phosphorylated estrogen receptor beta ligand binding domain Deposited 2010-08-26 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
261–500（240 aa）
Fragment：Ligand Binding Domain (UNP residues 261-500)
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | EST ESTRADIOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；277.15 K；0.2 M Ammonium Acetate, 0.1 M BIS-TRIS pH 5.5, 17% PEG10000 (v/v), VAPOR DIFFUSION, HANGING DROP, temperature 277.15K
|
Resolution 1.50 Å R-free 0.208 |
| 3OLL Crystal structure of phosphorylated estrogen receptor beta ligand binding domain Deposited 2010-08-26 | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
261–500（240 aa）
Fragment：Ligand Binding Domain (UNP residues 261-500)
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | EST ESTRADIOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；277.15 K；0.2 M Ammonium Acetate, 0.1 M BIS-TRIS pH 5.5, 17% PEG10000 (v/v), VAPOR DIFFUSION, HANGING DROP, temperature 277.15K
|
Resolution 1.50 Å R-free 0.208 |
| 3OLL Crystal structure of phosphorylated estrogen receptor beta ligand binding domain Deposited 2010-08-26 | Assembly 3 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
261–500（240 aa）
Fragment：Ligand Binding Domain (UNP residues 261-500)
Chain B
261–500（240 aa）
Fragment：Ligand Binding Domain (UNP residues 261-500)
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | EST ESTRADIOL × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；277.15 K；0.2 M Ammonium Acetate, 0.1 M BIS-TRIS pH 5.5, 17% PEG10000 (v/v), VAPOR DIFFUSION, HANGING DROP, temperature 277.15K
|
Resolution 1.50 Å R-free 0.208 |
| 3OLS Crystal structure of estrogen receptor beta ligand binding domain Deposited 2010-08-26 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
261–500（240 aa）
Fragment：Ligand Binding Domain (UNP residues 261-500)
|
Not recorded | EST ESTRADIOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；277.15 K；0.2 M Ammonium Acetate, 0.1 M BIS-TRIS pH 5.5, 17% PEG10000 (v/v), VAPOR DIFFUSION, HANGING DROP, temperature 277.15K
|
Resolution 2.20 Å R-free 0.266 |
| 3OLS Crystal structure of estrogen receptor beta ligand binding domain Deposited 2010-08-26 | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
261–500（240 aa）
Fragment：Ligand Binding Domain (UNP residues 261-500)
|
Not recorded | EST ESTRADIOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；277.15 K；0.2 M Ammonium Acetate, 0.1 M BIS-TRIS pH 5.5, 17% PEG10000 (v/v), VAPOR DIFFUSION, HANGING DROP, temperature 277.15K
|
Resolution 2.20 Å R-free 0.266 |
| 3OLS Crystal structure of estrogen receptor beta ligand binding domain Deposited 2010-08-26 | Assembly 3 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
261–500（240 aa）
Fragment：Ligand Binding Domain (UNP residues 261-500)
Chain B
261–500（240 aa）
Fragment：Ligand Binding Domain (UNP residues 261-500)
|
Not recorded | EST ESTRADIOL × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；277.15 K；0.2 M Ammonium Acetate, 0.1 M BIS-TRIS pH 5.5, 17% PEG10000 (v/v), VAPOR DIFFUSION, HANGING DROP, temperature 277.15K
|
Resolution 2.20 Å R-free 0.266 |
| 3OMO Fragment-Based Design of novel Estrogen Receptor Ligands Deposited 2010-08-27 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
261–500（240 aa）
Fragment：Ligand Binding Domain (UNP residues 261-500)
|
Not recorded | WV7 2-(trifluoroacetyl)-1,2,3,4-tetrahydroisoquinolin-6-ol × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；277.15 K；0.2 M Ammonium Acetate, 0.1 M BIS-TRIS pH 5.5, 17% PEG10000 (v/v), VAPOR DIFFUSION, HANGING DROP, temperature 277.15K
|
Resolution 2.21 Å R-free 0.264 |
| 3OMO Fragment-Based Design of novel Estrogen Receptor Ligands Deposited 2010-08-27 | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
261–500（240 aa）
Fragment：Ligand Binding Domain (UNP residues 261-500)
|
Not recorded | WV7 2-(trifluoroacetyl)-1,2,3,4-tetrahydroisoquinolin-6-ol × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；277.15 K；0.2 M Ammonium Acetate, 0.1 M BIS-TRIS pH 5.5, 17% PEG10000 (v/v), VAPOR DIFFUSION, HANGING DROP, temperature 277.15K
|
Resolution 2.21 Å R-free 0.264 |
| 3OMO Fragment-Based Design of novel Estrogen Receptor Ligands Deposited 2010-08-27 | Assembly 3 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
261–500（240 aa）
Fragment：Ligand Binding Domain (UNP residues 261-500)
Chain B
261–500（240 aa）
Fragment：Ligand Binding Domain (UNP residues 261-500)
|
Not recorded | WV7 2-(trifluoroacetyl)-1,2,3,4-tetrahydroisoquinolin-6-ol × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；277.15 K；0.2 M Ammonium Acetate, 0.1 M BIS-TRIS pH 5.5, 17% PEG10000 (v/v), VAPOR DIFFUSION, HANGING DROP, temperature 277.15K
|
Resolution 2.21 Å R-free 0.264 |
| 3OMP Fragment-Based Design of novel Estrogen Receptor Ligands Deposited 2010-08-27 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
261–500（240 aa）
Fragment：Ligand Binding Domain (UNP residues 261-500)
|
Not recorded | W14 2-(trifluoroacetyl)-1,2,3,4-tetrahydroisoquinolin-7-ol × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；277.15 K；0.2 M Ammonium Acetate, 0.1 M BIS-TRIS pH 5.5, 17% PEG10000 (v/v), VAPOR DIFFUSION, HANGING DROP, temperature 277.15K
|
Resolution 2.05 Å R-free 0.255 |
| 3OMP Fragment-Based Design of novel Estrogen Receptor Ligands Deposited 2010-08-27 | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
261–500（240 aa）
Fragment：Ligand Binding Domain (UNP residues 261-500)
|
Not recorded | W14 2-(trifluoroacetyl)-1,2,3,4-tetrahydroisoquinolin-7-ol × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；277.15 K；0.2 M Ammonium Acetate, 0.1 M BIS-TRIS pH 5.5, 17% PEG10000 (v/v), VAPOR DIFFUSION, HANGING DROP, temperature 277.15K
|
Resolution 2.05 Å R-free 0.255 |
| 3OMP Fragment-Based Design of novel Estrogen Receptor Ligands Deposited 2010-08-27 | Assembly 3 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
261–500（240 aa）
Fragment：Ligand Binding Domain (UNP residues 261-500)
Chain B
261–500（240 aa）
Fragment：Ligand Binding Domain (UNP residues 261-500)
|
Not recorded | W14 2-(trifluoroacetyl)-1,2,3,4-tetrahydroisoquinolin-7-ol × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；277.15 K；0.2 M Ammonium Acetate, 0.1 M BIS-TRIS pH 5.5, 17% PEG10000 (v/v), VAPOR DIFFUSION, HANGING DROP, temperature 277.15K
|
Resolution 2.05 Å R-free 0.255 |
| 3OMQ Fragment-Based Design of novel Estrogen Receptor Ligands Deposited 2010-08-27 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
261–500（240 aa）
Fragment：Ligand Binding Domain (UNP residues 261-500)
|
Not recorded | W23 2-[(trifluoromethyl)sulfonyl]-1,2,3,4-tetrahydroisoquinolin-6-ol × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；277.15 K；0.2 M Ammonium Acetate, 0.1 M BIS-TRIS pH 5.5, 17% PEG10000 (v/v), VAPOR DIFFUSION, HANGING DROP, temperature 277.15K
|
Resolution 1.97 Å R-free 0.260 |
| 3OMQ Fragment-Based Design of novel Estrogen Receptor Ligands Deposited 2010-08-27 | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
261–500（240 aa）
Fragment：Ligand Binding Domain (UNP residues 261-500)
|
Not recorded | W23 2-[(trifluoromethyl)sulfonyl]-1,2,3,4-tetrahydroisoquinolin-6-ol × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；277.15 K；0.2 M Ammonium Acetate, 0.1 M BIS-TRIS pH 5.5, 17% PEG10000 (v/v), VAPOR DIFFUSION, HANGING DROP, temperature 277.15K
|
Resolution 1.97 Å R-free 0.260 |
| 3OMQ Fragment-Based Design of novel Estrogen Receptor Ligands Deposited 2010-08-27 | Assembly 3 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
261–500（240 aa）
Fragment：Ligand Binding Domain (UNP residues 261-500)
Chain B
261–500（240 aa）
Fragment：Ligand Binding Domain (UNP residues 261-500)
|
Not recorded | W23 2-[(trifluoromethyl)sulfonyl]-1,2,3,4-tetrahydroisoquinolin-6-ol × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；277.15 K；0.2 M Ammonium Acetate, 0.1 M BIS-TRIS pH 5.5, 17% PEG10000 (v/v), VAPOR DIFFUSION, HANGING DROP, temperature 277.15K
|
Resolution 1.97 Å R-free 0.260 |
| 4J24 Estrogen Receptor in complex with proline-flanked LXXLL peptides Deposited 2013-02-04 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
261–500（240 aa）
Fragment：;Ligand Binding Domain, UNP residue 261-500'
;
|
Not recorded | EST ESTRADIOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 4.5；277 K；0.2M Magnesium acetate, 20%(w/v) PEG3350, pH 4.5, VAPOR DIFFUSION, temperature 277K
|
Resolution 2.10 Å R-free 0.224 |
| 4J24 Estrogen Receptor in complex with proline-flanked LXXLL peptides Deposited 2013-02-04 | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
261–500（240 aa）
Fragment：;Ligand Binding Domain, UNP residue 261-500'
;
|
Not recorded | EST ESTRADIOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 4.5；277 K；0.2M Magnesium acetate, 20%(w/v) PEG3350, pH 4.5, VAPOR DIFFUSION, temperature 277K
|
Resolution 2.10 Å R-free 0.224 |
| 4J24 Estrogen Receptor in complex with proline-flanked LXXLL peptides Deposited 2013-02-04 | Assembly 3 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain C
261–500（240 aa）
Fragment：;Ligand Binding Domain, UNP residue 261-500'
;
|
Not recorded | EST ESTRADIOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 4.5；277 K；0.2M Magnesium acetate, 20%(w/v) PEG3350, pH 4.5, VAPOR DIFFUSION, temperature 277K
|
Resolution 2.10 Å R-free 0.224 |
| 4J24 Estrogen Receptor in complex with proline-flanked LXXLL peptides Deposited 2013-02-04 | Assembly 4 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain D
261–500（240 aa）
Fragment：;Ligand Binding Domain, UNP residue 261-500'
;
|
Not recorded | EST ESTRADIOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 4.5；277 K；0.2M Magnesium acetate, 20%(w/v) PEG3350, pH 4.5, VAPOR DIFFUSION, temperature 277K
|
Resolution 2.10 Å R-free 0.224 |
| 4J26 Estrogen Receptor in complex with proline-flanked LXXLL peptides Deposited 2013-02-04 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
261–500（240 aa）
Fragment：Ligand Binding Domain, UNP residues 261-500
|
Not recorded | EST ESTRADIOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 5；277 K；10%-20% PEG6000, 0.6M-2M LiCl, 100mM Citric Acid, pH 5.0, VAPOR DIFFUSION, temperature 277K
|
Resolution 2.30 Å R-free 0.242 |
| 4J26 Estrogen Receptor in complex with proline-flanked LXXLL peptides Deposited 2013-02-04 | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
261–500（240 aa）
Fragment：Ligand Binding Domain, UNP residues 261-500
|
Not recorded | EST ESTRADIOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 5；277 K；10%-20% PEG6000, 0.6M-2M LiCl, 100mM Citric Acid, pH 5.0, VAPOR DIFFUSION, temperature 277K
|
Resolution 2.30 Å R-free 0.242 |
| 4ZI1 HUMAN ESTROGEN RECEPTOR BETA LIGAND-BINDING DOMAIN IN COMPLEX WITH KB095285 AND CIA12 COACTIVATOR PEPTIDE Deposited 2015-04-27 | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
262–509（248 aa）
Fragment：LIGAND BINDING DOMAIN, UNP residues 262-509
|
Not recorded | KB0 2-(4-hydroxyphenyl)-7-methyl-3-phenyl-1H-inden-5-ol × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.2；293 K；10.5% (W/V) P6000, 1.75M NACL
0.1 M MES, PH 5.2, 12.5% (V/V) GLYCEROL, 2 TIMES EXCESS OF
CIA12 PEPTIDE
|
Resolution 2.10 Å R-free 0.223 |
| 5TOA Crystal Structure of ER beta bound to Estradiol Deposited 2016-10-17 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
262–509（248 aa）
Fragment：UNP residues 262-509
Chain B
262–509（248 aa）
Fragment：UNP residues 262-509
|
Not recorded | EST ESTRADIOL × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；292 K；0.1 M Na-citrate, 10% [w/v] PEG-4000, 10% [v/v] isopropanol
|
Resolution 2.50 Å R-free 0.244 |
| 7XVY Human Estrogen Receptor beta Ligand-binding Domain in Complex with S-DPN Deposited 2022-05-25 | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
261–500（240 aa）
Fragment：ligand-binding domain
Chain B
261–500（240 aa）
Fragment：ligand-binding domain
|
Mutation：C334S, C369S, C481S Mutation：C334S, C369S, C481S | I0K (2~{S})-2,3-bis(4-hydroxyphenyl)propanenitrile × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；16-20% PEG3350, 100 mM BisTris pH6.5, 200 mM Magnesium Acetate
|
Resolution 1.54 Å R-free 0.237 |
| 7XVZ Human Estrogen Receptor beta Ligand-binding Domain in Complex with (R)-3-(2-chloro-4-hydroxyphenyl)-2-(4-hydroxyphenyl)propanenitrile Deposited 2022-05-25 | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
261–500（240 aa）
Fragment：ligand-binding domain
Chain B
261–500（240 aa）
Fragment：ligand-binding domain
|
Mutation：C334S,C369S,C481S Mutation：C334S,C369S,C481S | I1D (2~{R})-3-(2-chloranyl-4-oxidanyl-phenyl)-2-(4-hydroxyphenyl)propanenitrile × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；16-20% PEG3350, 100 mM BisTris pH6.5, 200 mM Magnesium Acetate
|
Resolution 2.08 Å R-free 0.307 |
| 7XWP Human Estrogen Receptor beta Ligand-binding Domain in Complex with (S)-3-(2-chloro-4-hydroxyphenyl)-2-(4-hydroxyphenyl)propanenitrile Deposited 2022-05-27 | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
261–500（240 aa）
Fragment：ligand-binding domain
Chain B
261–500（240 aa）
Fragment：ligand-binding domain
|
Mutation：C334S,C369S,C481S Mutation：C334S,C369S,C481S | I1I (2~{S})-3-(2-chloranyl-4-oxidanyl-phenyl)-2-(4-hydroxyphenyl)propanenitrile × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；16-20% PEG3350, 100 mM BisTris pH6.5, 200 mM Magnesium Acetate
|
Resolution 1.92 Å R-free 0.255 |
| 7XWQ Human Estrogen Receptor beta Ligand-binding Domain in Complex with (R)-2-(2-chloro-4-hydroxyphenyl)-3-(4-hydroxyphenyl)propanenitrile Deposited 2022-05-27 | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
261–500（240 aa）
Fragment：ligand-binding domain
Chain B
261–500（240 aa）
Fragment：ligand-binding domain
|
Mutation：C334S,C369S,C481S Mutation：C334S,C369S,C481S | I1M (2~{R})-2-(2-chloranyl-4-oxidanyl-phenyl)-3-(4-hydroxyphenyl)propanenitrile × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；16-20% PEG3350, 100 mM BisTris pH6.5, 200 mM Magnesium Acetate
|
Resolution 1.89 Å R-free 0.239 |
| 7XWR Human Estrogen Receptor beta Ligand-binding Domain in Complex with (S)-2-(2-chloro-4-hydroxyphenyl)-3-(4-hydroxyphenyl)propanenitrile Deposited 2022-05-27 | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
261–500（240 aa）
Fragment：ligand-binding domain
Chain B
261–500（240 aa）
Fragment：ligand-binding domain
|
Mutation：C334S,C369S,C481S Mutation：C334S,C369S,C481S | I2B (2~{S})-2-(2-chloranyl-4-oxidanyl-phenyl)-3-(4-hydroxyphenyl)propanenitrile × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；16-20% PEG3350, 100 mM BisTris pH6.5, 200 mM Magnesium Acetate
|
Resolution 2.16 Å R-free 0.318 |
| 9EBL Crystal structure of the hERbeta LBD complexed with androstenediol and SRC 2-2 peptide (crystal form 1) Deposited 2024-11-12 | Assembly 1 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: octameric（8） Review required |
Chain A
262–500（239 aa）
Chain B
262–500（239 aa）
Chain E
262–500（239 aa）
Chain F
262–500（239 aa）
|
Not recorded | B81 (3alpha,8alpha,17beta)-androst-5-ene-3,17-diol × 8 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；289.15 K；0.1 M sodium HEPES pH 7.5, 22% w/v PEG 5000 MME
|
Resolution 2.20 Å R-free 0.277 |
| 9ECF Crystal structure of the hERbeta LBD complexed with androstenediol and SRC 2-2 peptide (crystal form 2) Deposited 2024-11-14 | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain E
261–500（240 aa）
Chain F
261–500（240 aa）
|
Not recorded | B81 (3alpha,8alpha,17beta)-androst-5-ene-3,17-diol × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；289.15 K；0.2 M ammonium acetate, 0.1 M Bis-Tris pH 5.5, 25% w/v PEG 3350
|
Resolution 2.00 Å R-free 0.278 |
| 9ECF Crystal structure of the hERbeta LBD complexed with androstenediol and SRC 2-2 peptide (crystal form 2) Deposited 2024-11-14 | Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
261–500（240 aa）
Chain B
261–500（240 aa）
|
Not recorded | B81 (3alpha,8alpha,17beta)-androst-5-ene-3,17-diol × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；289.15 K；0.2 M ammonium acetate, 0.1 M Bis-Tris pH 5.5, 25% w/v PEG 3350
|
Resolution 2.00 Å R-free 0.278 |
| 9ECF Crystal structure of the hERbeta LBD complexed with androstenediol and SRC 2-2 peptide (crystal form 2) Deposited 2024-11-14 | Assembly 3 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain I
261–500（240 aa）
Chain J
261–500（240 aa）
|
Not recorded | B81 (3alpha,8alpha,17beta)-androst-5-ene-3,17-diol × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；289.15 K；0.2 M ammonium acetate, 0.1 M Bis-Tris pH 5.5, 25% w/v PEG 3350
|
Resolution 2.00 Å R-free 0.278 |
| 9ECF Crystal structure of the hERbeta LBD complexed with androstenediol and SRC 2-2 peptide (crystal form 2) Deposited 2024-11-14 | Assembly 4 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain M
261–500（240 aa）
Chain N
261–500（240 aa）
|
Not recorded | B81 (3alpha,8alpha,17beta)-androst-5-ene-3,17-diol × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；289.15 K；0.2 M ammonium acetate, 0.1 M Bis-Tris pH 5.5, 25% w/v PEG 3350
|
Resolution 2.00 Å R-free 0.278 |