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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：Q92974 New Search
60PDB entries
60Biological assembly
60chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
5EFX Crystal structure of Rho GTPase regulator Deposited 2015-10-26 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 439–582（144 aa） Fragment：UNP residues 439-582
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；289.15 K；0.2M Sodium Nitrate, 20% PEG 3350, PH 6.8
Resolution 2.45 Å R-free 0.253
7G80 ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z1041785508 Deposited 2023-06-22 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 206–448（243 aa）
Mutation：None K34 5-(1,3-thiazol-2-yl)-1H-1,2,4-triazole × 1 DMS DIMETHYL SULFOXIDE × 3 FMT FORMIC ACID × 13 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；100 mM Tris, 2.6M sodium formate
Resolution 1.67 Å R-free 0.230
7G81 ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z104474512 Deposited 2023-06-22 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 206–448（243 aa）
Mutation：None H04 1-(2-ethoxyphenyl)piperazine × 2 DMS DIMETHYL SULFOXIDE × 4 FMT FORMIC ACID × 12 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；100 mM Tris, 2.6M sodium formate
Resolution 1.51 Å R-free 0.216
7G82 ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z1079512010 Deposited 2023-06-22 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 206–448（243 aa）
Mutation：None UWS 6-methyl-2-[(3-methyl-1,2-oxazol-5-yl)methyl]pyridazin-3(2H)-one × 3 DMS DIMETHYL SULFOXIDE × 5 FMT FORMIC ACID × 15 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；100 mM Tris, 2.6M sodium formate
Resolution 1.41 Å R-free 0.209
7G83 ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z108545814 Deposited 2023-06-22 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 206–448（243 aa）
Mutation：None YX2 3-propanamido-1-benzofuran-2-carboxamide × 2 DMS DIMETHYL SULFOXIDE × 4 FMT FORMIC ACID × 14 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；100 mM Tris, 2.6M sodium formate
Resolution 1.31 Å R-free 0.205
7G84 ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z1102357527 Deposited 2023-06-22 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 206–448（243 aa）
Mutation：None YX6 N-[(3R)-6-oxopiperidin-3-yl]-1,3-thiazole-4-carboxamide × 1 DMS DIMETHYL SULFOXIDE × 4 FMT FORMIC ACID × 11 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；100 mM Tris, 2.6M sodium formate
Resolution 1.81 Å R-free 0.232
7G85 ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z111529496 Deposited 2023-06-22 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 206–448（243 aa）
Mutation：None LXA ~{N}-(1~{H}-benzimidazol-2-ylmethyl)-2-methoxy-ethanamide × 2 DMS DIMETHYL SULFOXIDE × 6 FMT FORMIC ACID × 13 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；100 mM Tris, 2.6M sodium formate
Resolution 1.74 Å R-free 0.223
7G86 ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z1137725943 Deposited 2023-06-22 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 206–448（243 aa）
Mutation：None YXB N-[(1H-indol-4-yl)methyl]ethanamine × 3 DMS DIMETHYL SULFOXIDE × 6 FMT FORMIC ACID × 10 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；100 mM Tris, 2.6M sodium formate
Resolution 1.70 Å R-free 0.229
7G87 ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z1148165337 Deposited 2023-06-22 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 206–448（243 aa）
Mutation：None YG5 2-(1H-indazol-1-yl)-N,N-dimethylacetamide × 1 DMS DIMETHYL SULFOXIDE × 5 FMT FORMIC ACID × 14 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；100 mM Tris, 2.6M sodium formate
Resolution 2.05 Å R-free 0.241
7G88 ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z1148747945 Deposited 2023-06-22 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 206–448（243 aa）
Mutation：None WKY N-(3-methylpyridin-4-yl)acetamide × 1 DMS DIMETHYL SULFOXIDE × 5 FMT FORMIC ACID × 10 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；100 mM Tris, 2.6M sodium formate
Resolution 1.87 Å R-free 0.244
7G89 ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z1192341021 Deposited 2023-06-22 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 206–448（243 aa）
Mutation：None ZT7 1-(5-amino-2H-isoindol-2-yl)ethan-1-one × 2 DMS DIMETHYL SULFOXIDE × 4 FMT FORMIC ACID × 9 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；100 mM Tris, 2.6M sodium formate
Resolution 1.90 Å R-free 0.244
7G8A ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z100642432 Deposited 2023-06-22 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 206–448（243 aa）
Mutation：None WJ7 2-bromo-4-fluoro-N,N-dimethylbenzamide × 1 DMS DIMETHYL SULFOXIDE × 5 FMT FORMIC ACID × 15 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；100 mM Tris, 2.6M sodium formate
Resolution 1.50 Å R-free 0.211
7G8B ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z100643660 Deposited 2023-06-22 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 206–448（243 aa）
Mutation：None LFO N,1-dimethyl-1H-indole-3-carboxamide × 4 DMS DIMETHYL SULFOXIDE × 4 FMT FORMIC ACID × 14 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；100 mM Tris, 2.6M sodium formate
Resolution 1.42 Å R-free 0.216
7G8C ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z1037511924 Deposited 2023-06-22 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 206–448（243 aa）
Mutation：None YXO 1-(difluoromethyl)-1H-indol-5-amine × 1 DMS DIMETHYL SULFOXIDE × 5 FMT FORMIC ACID × 10 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；100 mM Tris, 2.6M sodium formate
Resolution 2.18 Å R-free 0.255
7G8D ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z104474228 Deposited 2023-06-22 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 206–448（243 aa）
Mutation：None DMS DIMETHYL SULFOXIDE × 5 FMT FORMIC ACID × 12 60P 3-methylthiophene-2-carboxylic acid × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；100 mM Tris, 2.6M sodium formate
Resolution 1.94 Å R-free 0.236
7G8E ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z104479710 Deposited 2023-06-22 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 206–448（243 aa）
Mutation：None DMS DIMETHYL SULFOXIDE × 5 FMT FORMIC ACID × 12 YXH 1-(1H-benzimidazol-2-yl)methanamine × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；100 mM Tris, 2.6M sodium formate
Resolution 1.79 Å R-free 0.223
7G8F ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z1079168976 Deposited 2023-06-22 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 206–448（243 aa）
Mutation：None YXK [1-(2,2,2-trifluoroethyl)-1H-imidazol-2-yl]acetonitrile × 1 DMS DIMETHYL SULFOXIDE × 4 FMT FORMIC ACID × 10 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；100 mM Tris, 2.6M sodium formate
Resolution 1.42 Å R-free 0.215
7G8G ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z111529496 Deposited 2023-06-22 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 206–448（243 aa）
Mutation：None LXA ~{N}-(1~{H}-benzimidazol-2-ylmethyl)-2-methoxy-ethanamide × 2 DMS DIMETHYL SULFOXIDE × 5 FMT FORMIC ACID × 12 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；100 mM Tris, 2.6M sodium formate
Resolution 1.92 Å R-free 0.251
7G8H ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z1198180782 Deposited 2023-06-22 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 206–448（243 aa）
Mutation：None YXU 5-methoxy-1H-pyrrolo[3,2-b]pyridine × 3 DMS DIMETHYL SULFOXIDE × 8 FMT FORMIC ACID × 12 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；100 mM Tris, 2.6M sodium formate
Resolution 1.67 Å R-free 0.218
7G8I ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z1198316457 Deposited 2023-06-22 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 206–448（243 aa）
Mutation：None YXY 4,4-difluorocyclohexane-1-carboxamide × 1 DMS DIMETHYL SULFOXIDE × 3 FMT FORMIC ACID × 11 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；100 mM Tris, 2.6M sodium formate
Resolution 2.47 Å R-free 0.273
7G8J ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z1216861874 Deposited 2023-06-22 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 206–448（243 aa）
Mutation：None YYI 5-(difluoromethoxy)pyridin-2(3H)-one × 1 DMS DIMETHYL SULFOXIDE × 4 FMT FORMIC ACID × 8 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；100 mM Tris, 2.6M sodium formate
Resolution 1.99 Å R-free 0.281
7G8K ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z1217131798 Deposited 2023-06-22 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 206–448（243 aa）
Mutation：None YZK (3M)-3-(2-methyl-1H-imidazol-1-yl)pyridine × 3 DMS DIMETHYL SULFOXIDE × 6 FMT FORMIC ACID × 14 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；100 mM Tris, 2.6M sodium formate
Resolution 1.49 Å R-free 0.216
7G8L ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z1251207602 Deposited 2023-06-22 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 206–448（243 aa）
Mutation：None RWS 1-(5-methyl-1,3,4-thiadiazol-2-yl)piperidine × 4 DMS DIMETHYL SULFOXIDE × 6 FMT FORMIC ACID × 13 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；100 mM Tris, 2.6M sodium formate
Resolution 1.60 Å R-free 0.229
7G8M ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z1255459547 Deposited 2023-06-22 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 206–448（243 aa）
Mutation：None Z0I N-(1H-indol-7-yl)acetamide × 1 DMS DIMETHYL SULFOXIDE × 3 FMT FORMIC ACID × 12 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；100 mM Tris, 2.6M sodium formate
Resolution 2.03 Å R-free 0.260
7G8N ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z1262549981 Deposited 2023-06-22 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 206–448（243 aa）
Mutation：None Z1L 1-anilinocyclopropane-1-carboxylic acid × 1 DMS DIMETHYL SULFOXIDE × 3 FMT FORMIC ACID × 11 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；100 mM Tris, 2.6M sodium formate
Resolution 2.32 Å R-free 0.283
7G8O ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z1267800292 Deposited 2023-06-22 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 206–448（243 aa）
Mutation：None O2A N-methyl-1H-indole-7-carboxamide × 3 DMS DIMETHYL SULFOXIDE × 4 FMT FORMIC ACID × 12 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；100 mM Tris, 2.6M sodium formate
Resolution 1.58 Å R-free 0.230
7G8P ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z1269184613 Deposited 2023-06-22 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 206–448（243 aa）
Mutation：None Z2F 1,3-benzothiazole-6-sulfonamide × 1 DMS DIMETHYL SULFOXIDE × 3 FMT FORMIC ACID × 7 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；100 mM Tris, 2.6M sodium formate
Resolution 2.21 Å R-free 0.324
7G8Q ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z1269220427 Deposited 2023-06-22 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 206–448（243 aa）
Mutation：None Z2Z 8-(methanesulfonyl)quinoline × 2 DMS DIMETHYL SULFOXIDE × 5 FMT FORMIC ACID × 13 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；100 mM Tris, 2.6M sodium formate
Resolution 1.56 Å R-free 0.207
7G8R ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z1270087714 Deposited 2023-06-22 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 206–448（243 aa）
Mutation：None Z5Z (2R,6S)-2,6-dimethyl-4-(3-methyl-1,2,4-thiadiazol-5-yl)morpholine × 1 DMS DIMETHYL SULFOXIDE × 5 FMT FORMIC ACID × 13 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；100 mM Tris, 2.6M sodium formate
Resolution 1.44 Å R-free 0.207
7G8S ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z1270393711 Deposited 2023-06-22 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 206–448（243 aa）
Mutation：None Z5C 5-(methoxymethyl)-1,2-oxazole-3-carboxamide × 3 DMS DIMETHYL SULFOXIDE × 5 FMT FORMIC ACID × 13 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；100 mM Tris, 2.6M sodium formate
Resolution 1.60 Å R-free 0.222
7G8T ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z1273312142 Deposited 2023-06-22 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 206–448（243 aa）
Mutation：None DMS DIMETHYL SULFOXIDE × 5 FMT FORMIC ACID × 14 Z4X 2-ethoxy-3-fluoro-N,N-dimethylbenzamide × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；100 mM Tris, 2.6M sodium formate
Resolution 1.39 Å R-free 0.198
7G8U ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z131833926 Deposited 2023-06-22 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 206–448（243 aa）
Mutation：None DMS DIMETHYL SULFOXIDE × 3 FMT FORMIC ACID × 6 Z3O (3S)-3-{[(4R)-4-methyl-3,4-dihydropyridin-1(2H)-yl]methyl}-3H-indole × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；100 mM Tris, 2.6M sodium formate
Resolution 2.44 Å R-free 0.294
7G8V ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z133716556 Deposited 2023-06-22 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 206–448（243 aa）
Mutation：None Z3H N-[(4R)-3,4-dihydro-2H-1-benzopyran-4-yl]methanesulfonamide × 1 DMS DIMETHYL SULFOXIDE × 5 FMT FORMIC ACID × 14 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；100 mM Tris, 2.6M sodium formate
Resolution 1.45 Å R-free 0.219
7G8W ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z1416193393 Deposited 2023-06-22 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 206–448（243 aa）
Mutation：None Z6I 4-(5-methyl-1H-pyrazol-4-yl)piperidine × 1 DMS DIMETHYL SULFOXIDE × 5 FMT FORMIC ACID × 13 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；100 mM Tris, 2.6M sodium formate
Resolution 1.94 Å R-free 0.250
7G8X ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z1416571195 Deposited 2023-06-22 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 206–448（243 aa）
Mutation：None Z7T 2-(cyclopentylamino)pyridine-4-carboxamide × 1 DMS DIMETHYL SULFOXIDE × 5 FMT FORMIC ACID × 12 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；100 mM Tris, 2.6M sodium formate
Resolution 1.71 Å R-free 0.227
7G8Y ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z1449748885 Deposited 2023-06-22 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 206–448（243 aa）
Mutation：None WZY N-(4-methoxyphenyl)glycinamide × 1 DMS DIMETHYL SULFOXIDE × 5 FMT FORMIC ACID × 14 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；100 mM Tris, 2.6M sodium formate
Resolution 1.75 Å R-free 0.222
7G8Z ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z1493056027 Deposited 2023-06-22 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 206–448（243 aa）
Mutation：None DMS DIMETHYL SULFOXIDE × 7 FMT FORMIC ACID × 14 Z9I 1-[(2R)-1-(methanesulfonyl)pyrrolidin-2-yl]methanamine × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；100 mM Tris, 2.6M sodium formate
Resolution 1.51 Å R-free 0.221
7G90 ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z1509195674 Deposited 2023-06-22 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 206–448（243 aa）
Mutation：None ZA9 4-[(3S)-piperidin-3-yl]-1H-indole × 1 DMS DIMETHYL SULFOXIDE × 5 FMT FORMIC ACID × 11 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；100 mM Tris, 2.6M sodium formate
Resolution 1.91 Å R-free 0.249
7G91 ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z1509257513 Deposited 2023-06-22 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 206–448（243 aa）
Mutation：None ZBH (4S)-N,2-dimethyl-4,5,6,7-tetrahydro-1,3-benzothiazole-4-carboxamide × 1 DMS DIMETHYL SULFOXIDE × 3 FMT FORMIC ACID × 11 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；100 mM Tris, 2.6M sodium formate
Resolution 2.29 Å R-free 0.253
7G92 ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z1545313172 Deposited 2023-06-22 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 206–448（243 aa）
Mutation：None LWA (2~{S})-~{N}-(4-aminocarbonylphenyl)oxolane-2-carboxamide × 1 DMS DIMETHYL SULFOXIDE × 5 FMT FORMIC ACID × 14 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；100 mM Tris, 2.6M sodium formate
Resolution 1.87 Å R-free 0.237
7G93 ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z1565771450 Deposited 2023-06-22 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 206–448（243 aa）
Mutation：None VW7 N-(8-methyl-1,2,3,4-tetrahydroquinolin-5-yl)acetamide × 2 DMS DIMETHYL SULFOXIDE × 5 FMT FORMIC ACID × 10 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；100 mM Tris, 2.6M sodium formate
Resolution 1.69 Å R-free 0.225
7G94 ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z1575337975 Deposited 2023-06-22 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 206–448（243 aa）
Mutation：None ZC9 (2P)-5-fluoro-2-(1H-pyrazol-5-yl)pyridine × 3 DMS DIMETHYL SULFOXIDE × 4 FMT FORMIC ACID × 13 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；100 mM Tris, 2.6M sodium formate
Resolution 1.47 Å R-free 0.224
7G95 ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z165170770 Deposited 2023-06-22 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 206–448（243 aa）
Mutation：None W0Y N-methyl-4-sulfamoylbenzamide × 4 DMS DIMETHYL SULFOXIDE × 5 FMT FORMIC ACID × 11 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；100 mM Tris, 2.6M sodium formate
Resolution 1.55 Å R-free 0.218
7G96 ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z1203730981 Deposited 2023-06-22 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 206–448（243 aa）
Mutation：None ZCI 2-bromo-1H-imidazole × 2 DMS DIMETHYL SULFOXIDE × 3 FMT FORMIC ACID × 9 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；100 mM Tris, 2.6M sodium formate
Resolution 2.30 Å R-free 0.266
7G97 ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z57899718 Deposited 2023-06-22 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 206–448（243 aa）
Mutation：None APY 2-AMINOMETHYL-PYRIDINE × 1 DMS DIMETHYL SULFOXIDE × 3 FMT FORMIC ACID × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；100 mM Tris, 2.6M sodium formate
Resolution 2.30 Å R-free 0.249
7G98 ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z4605084898 Deposited 2023-06-22 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 206–448（243 aa）
Mutation：None DMS DIMETHYL SULFOXIDE × 2 FMT FORMIC ACID × 4 ZDL 1,3-dimethylimidazolidine × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；100 mM Tris, 2.6M sodium formate
Resolution 2.88 Å R-free 0.295
7G99 ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with PCM-0102102-001 Deposited 2023-06-22 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 206–448（243 aa）
Mutation：None ZE9 1-[(3R,5R)-5-(furan-2-yl)-3-(5-methylfuran-2-yl)pyrazolidin-1-yl]ethan-1-one × 2 DMS DIMETHYL SULFOXIDE × 6 FMT FORMIC ACID × 13 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；100 mM Tris, 2.6M sodium formate
Resolution 1.78 Å R-free 0.237
7G9A ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with PCM-0102113-001 Deposited 2023-06-22 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 206–448（243 aa）
Mutation：None DMS DIMETHYL SULFOXIDE × 2 FMT FORMIC ACID × 11 ZEK 3-acetamido-N-methylbenzamide × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；100 mM Tris, 2.6M sodium formate
Resolution 2.58 Å R-free 0.295
7G9B ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with PCM-0102116-001 Deposited 2023-06-22 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 206–448（243 aa）
Mutation：None DMS DIMETHYL SULFOXIDE × 2 FMT FORMIC ACID × 7 ZG0 N-(3-methylphenyl)acetamide × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；100 mM Tris, 2.6M sodium formate
Resolution 2.55 Å R-free 0.298
7G9C ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with PCM-0102141-001 Deposited 2023-06-22 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 206–448（243 aa）
Mutation：None DMS DIMETHYL SULFOXIDE × 4 FMT FORMIC ACID × 8 ZFI N-[2-(methanesulfonyl)phenyl]acetamide × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；100 mM Tris, 2.6M sodium formate
Resolution 2.69 Å R-free 0.274
7G9D ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with PCM-0102179-001 Deposited 2023-06-22 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 206–448（243 aa）
Mutation：None DMS DIMETHYL SULFOXIDE × 2 FMT FORMIC ACID × 9 T7Y N-[3-(2-oxopyrrolidin-1-yl)phenyl]acetamide × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；100 mM Tris, 2.6M sodium formate
Resolution 2.66 Å R-free 0.286
7G9E ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with PCM-0102197-001 Deposited 2023-06-22 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 206–448（243 aa）
Mutation：None DMS DIMETHYL SULFOXIDE × 5 FMT FORMIC ACID × 10 ZG6 N-(3-methyl-1,2-oxazol-5-yl)acetamide × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；100 mM Tris, 2.6M sodium formate
Resolution 2.15 Å R-free 0.292
7G9F ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with PCM-0102209-001 Deposited 2023-06-22 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 206–448（243 aa）
Mutation：None DMS DIMETHYL SULFOXIDE × 4 FMT FORMIC ACID × 10 ZGF N-(6-chloro-2H-1,3-benzodioxol-5-yl)acetamide × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；100 mM Tris, 2.6M sodium formate
Resolution 1.94 Å R-free 0.260
7G9G ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with PCM-0102236-001 Deposited 2023-06-22 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 206–448（243 aa）
Mutation：None DMS DIMETHYL SULFOXIDE × 3 FMT FORMIC ACID × 11 ZGK N-(2-methoxyphenyl)acetamide × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；100 mM Tris, 2.6M sodium formate
Resolution 2.08 Å R-free 0.286
7G9H ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with PCM-0102245-001 Deposited 2023-06-22 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 206–448（243 aa）
Mutation：None DMS DIMETHYL SULFOXIDE × 2 FMT FORMIC ACID × 7 KLU (2S)-4-(chloroacetyl)-3,4-dihydro-2H-1,4-benzoxazine-2-carboxamide × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；100 mM Tris, 2.6M sodium formate
Resolution 2.75 Å R-free 0.274
7G9I ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with PCM-0102253-001 Deposited 2023-06-22 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 206–448（243 aa）
Mutation：None ZGQ N-[(2-methylphenyl)methyl]acetamide × 1 DMS DIMETHYL SULFOXIDE × 4 FMT FORMIC ACID × 10 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；100 mM Tris, 2.6M sodium formate
Resolution 2.20 Å R-free 0.274
7G9J ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with PCM-0102281-001 Deposited 2023-06-22 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 206–448（243 aa）
Mutation：None ZGX 1-(3,4-dihydropyrazin-1(2H)-yl)ethan-1-one × 1 DMS DIMETHYL SULFOXIDE × 5 FMT FORMIC ACID × 11 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；100 mM Tris, 2.6M sodium formate
Resolution 1.97 Å R-free 0.245
8BNT The DH domain of ARHGEF2 bound to RhoA Deposited 2022-11-25 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 206–448（243 aa）
Not recorded DMS DIMETHYL SULFOXIDE × 5 FMT FORMIC ACID × 15 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；2.6 M sodium formate, 100 mM Tris
Resolution 1.40 Å R-free 0.175
9H1O Cryo-EM structure of taxol-microtubules in complex with the C1 domain of GEFH1 Deposited 2024-10-09 Assembly 1 Protein heterocomplex Heteromer；Protein × 7 PDB declaration: heptameric（7） Consistent with protein count
Chain C 28–100（73 aa）
Not recorded ZN ZINC ION × 2 GTP GUANOSINE-5'-TRIPHOSPHATE × 2 MG MAGNESIUM ION × 2 GDP GUANOSINE-5'-DIPHOSPHATE × 4 TA1 TAXOL × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 6.9；BRB80 buffer 80mM PIPES, 1mM MgCl2, 1mM EGTA, pH 6.9
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.40 Å
9H75 NMR solution structure of the GEFH1 C1 domain Deposited 2024-10-26 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 28–100（73 aa）
Not recorded ZN ZINC ION × 2 SOLUTION NMR
NMR measurement conditions pH 7.2；298 K；Ionic strength (raw mmCIF value) 175；Pressure 1
NMR sample composition 1.0 mM [U-13C; U-15N] GEFH1 28-100, 150 mM NaCl, 25 mM NaPi, 10 % v/v [U-2H] D2O, 90 % v/v H2O, 90% H2O/10% D2O | 90% H2O/10% D2O
Resolution not provided

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.