当前蛋白身份：Q9H9B1
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差异标签只比较当前检索结果；所有PDB和assembly原始记录仍分别保留。
相关结构差异明细
一行代表一个 PDB 条目中的一个 biological assembly；同一蛋白的多个单体会分别列出。
| PDB 条目 | Assembly / 聚集状态 | 构建体 | 突变与修饰 | 配体、离子与非聚合物 | 实验方法 | 实验环境 | 结构质量 |
|---|---|---|---|---|---|---|---|
| 2IGQ Human euchromatic histone methyltransferase 1 提交 2006-09-23 | Assembly 1 蛋白同源多聚体 同源多聚体；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 A
951–1235（285 aa）
片段：C-terminal domain, residues 951-1235
链 B
951–1235（285 aa）
片段：C-terminal domain, residues 951-1235
|
未记录 | ZN ZINC ION × 8 SAH S-ADENOSYL-L-HOMOCYSTEINE × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7；300 K；20% PEG 4K, 10% Isoproponol, 0.1M Hepes 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 300K
|
分辨率 2.00 Å R-free 0.237 |
| 2RFI Crystal structure of catalytic domain of human euchromatic histone methyltransferase 1 in complex with SAH and dimethylated H3K9 peptide 提交 2007-09-30 | Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 A
951–1235（285 aa）
片段：Catalytic domain: Residues 951-1235
|
未记录 | ZN ZINC ION × 4 SAH S-ADENOSYL-L-HOMOCYSTEINE × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 9；300 K；16% PEG 4000, 10% Isopropanol, 0.1M Bicine pH 9.0, VAPOR DIFFUSION, HANGING DROP, temperature 300K
|
分辨率 1.59 Å R-free 0.220 |
| 2RFI Crystal structure of catalytic domain of human euchromatic histone methyltransferase 1 in complex with SAH and dimethylated H3K9 peptide 提交 2007-09-30 | Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 B
951–1235（285 aa）
片段：Catalytic domain: Residues 951-1235
|
未记录 | ZN ZINC ION × 4 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 9；300 K；16% PEG 4000, 10% Isopropanol, 0.1M Bicine pH 9.0, VAPOR DIFFUSION, HANGING DROP, temperature 300K
|
分辨率 1.59 Å R-free 0.220 |
| 2RFI Crystal structure of catalytic domain of human euchromatic histone methyltransferase 1 in complex with SAH and dimethylated H3K9 peptide 提交 2007-09-30 | Assembly 3 蛋白异源复合物 异源复合物；蛋白 × 4 PDB 声明：tetrameric（4） 与蛋白数一致 |
链 A
951–1235（285 aa）
片段：Catalytic domain: Residues 951-1235
链 B
951–1235（285 aa）
片段：Catalytic domain: Residues 951-1235
|
未记录 | ZN ZINC ION × 8 SAH S-ADENOSYL-L-HOMOCYSTEINE × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 9；300 K；16% PEG 4000, 10% Isopropanol, 0.1M Bicine pH 9.0, VAPOR DIFFUSION, HANGING DROP, temperature 300K
|
分辨率 1.59 Å R-free 0.220 |
| 3B7B EuHMT1 (Glp) Ankyrin Repeat Domain (Structure 1) 提交 2007-10-30 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
734–968（235 aa）
片段：Ankyrin repeat domains 2-7
|
未记录 | SO4 SULFATE ION × 4 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；pH 8.5；289 K；1.5-2.0 M Lithium Sulfate, 1-4% Peg 400 or 550, 0.1 M Tris buffer pH 8.5, VAPOR DIFFUSION, SITTING DROP, temperature 289K
|
分辨率 2.99 Å R-free 0.261 |
| 3B7B EuHMT1 (Glp) Ankyrin Repeat Domain (Structure 1) 提交 2007-10-30 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
734–968（235 aa）
片段：Ankyrin repeat domains 2-7
|
未记录 | SO4 SULFATE ION × 4 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；pH 8.5；289 K；1.5-2.0 M Lithium Sulfate, 1-4% Peg 400 or 550, 0.1 M Tris buffer pH 8.5, VAPOR DIFFUSION, SITTING DROP, temperature 289K
|
分辨率 2.99 Å R-free 0.261 |
| 3FPD G9a-like protein lysine methyltransferase inhibition by BIX-01294 提交 2009-01-05 | Assembly 1 蛋白同源多聚体 同源多聚体；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 A
975–1235（261 aa）
片段：UNP residues 975-1235, SET domain
链 B
975–1235（261 aa）
片段：UNP residues 975-1235, SET domain
|
未记录 | SAH S-ADENOSYL-L-HOMOCYSTEINE × 2 Q4A N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine × 2 ZN ZINC ION × 8 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION；pH 7.5；289 K；0.1 M HEPES pH 7.5, 18-20 % polyethylene glycol 4000 and 7-10 % isopropanol, in the absence or presence of DMSO (6-36%), VAPOR DIFFUSION, temperature 289K
|
分辨率 2.40 Å R-free 0.262 |
| 3HNA Crystal structure of catalytic domain of human euchromatic histone methyltransferase 1 in complex with SAH and mono-Methylated H3K9 Peptide 提交 2009-05-30 | Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 A
951–1235（285 aa）
|
未记录 | SAH S-ADENOSYL-L-HOMOCYSTEINE × 1 ZN ZINC ION × 4 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 6；300 K；20%PEG3350, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 300K
|
分辨率 1.50 Å R-free 0.193 |
| 3HNA Crystal structure of catalytic domain of human euchromatic histone methyltransferase 1 in complex with SAH and mono-Methylated H3K9 Peptide 提交 2009-05-30 | Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 B
951–1235（285 aa）
|
未记录 | SAH S-ADENOSYL-L-HOMOCYSTEINE × 1 ZN ZINC ION × 4 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 6；300 K；20%PEG3350, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 300K
|
分辨率 1.50 Å R-free 0.193 |
| 3HNA Crystal structure of catalytic domain of human euchromatic histone methyltransferase 1 in complex with SAH and mono-Methylated H3K9 Peptide 提交 2009-05-30 | Assembly 3 蛋白异源复合物 异源复合物；蛋白 × 4 PDB 声明：tetrameric（4） 与蛋白数一致 |
链 A
951–1235（285 aa）
链 B
951–1235（285 aa）
|
未记录 | SAH S-ADENOSYL-L-HOMOCYSTEINE × 2 ZN ZINC ION × 8 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 6；300 K；20%PEG3350, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 300K
|
分辨率 1.50 Å R-free 0.193 |
| 3MO0 Human G9a-like (GLP, also known as EHMT1) in complex with inhibitor E11 提交 2010-04-22 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
951–1235（285 aa）
片段：C-terminal SET domain
|
未记录 | SAH S-ADENOSYL-L-HOMOCYSTEINE × 1 E11 N~4~-(1-benzylpiperidin-4-yl)-N~2~-[3-(dimethylamino)propyl]-6,7-dimethoxyquinazoline-2,4-diamine × 2 ZN ZINC ION × 5 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；289 K；0.1 M HEPES, 18 20% (v/v) polyethylene glycol 4000 and 7 10% (v/v) isopropanol, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 289K
|
分辨率 2.78 Å R-free 0.306 |
| 3MO0 Human G9a-like (GLP, also known as EHMT1) in complex with inhibitor E11 提交 2010-04-22 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
951–1235（285 aa）
片段：C-terminal SET domain
|
未记录 | SAH S-ADENOSYL-L-HOMOCYSTEINE × 1 E11 N~4~-(1-benzylpiperidin-4-yl)-N~2~-[3-(dimethylamino)propyl]-6,7-dimethoxyquinazoline-2,4-diamine × 1 ZN ZINC ION × 5 EDO 1,2-ETHANEDIOL × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；289 K；0.1 M HEPES, 18 20% (v/v) polyethylene glycol 4000 and 7 10% (v/v) isopropanol, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 289K
|
分辨率 2.78 Å R-free 0.306 |
| 3MO0 Human G9a-like (GLP, also known as EHMT1) in complex with inhibitor E11 提交 2010-04-22 | Assembly 3 蛋白同源多聚体 同源多聚体；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 A
951–1235（285 aa）
片段：C-terminal SET domain
链 B
951–1235（285 aa）
片段：C-terminal SET domain
|
未记录 | SAH S-ADENOSYL-L-HOMOCYSTEINE × 2 E11 N~4~-(1-benzylpiperidin-4-yl)-N~2~-[3-(dimethylamino)propyl]-6,7-dimethoxyquinazoline-2,4-diamine × 3 ZN ZINC ION × 10 EDO 1,2-ETHANEDIOL × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；289 K；0.1 M HEPES, 18 20% (v/v) polyethylene glycol 4000 and 7 10% (v/v) isopropanol, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 289K
|
分辨率 2.78 Å R-free 0.306 |
| 3MO2 human G9a-like (GLP, also known as EHMT1) in complex with inhibitor E67 提交 2010-04-22 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
951–1235（285 aa）
片段：C-terminal SET domain
|
未记录 | ZN ZINC ION × 4 E67 7-[(5-aminopentyl)oxy]-N~4~-(1-benzylpiperidin-4-yl)-N~2~-[3-(dimethylamino)propyl]-6-methoxyquinazoline-2,4-diamine × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；289 K；0.1 M Hepes pH 7.5, 14% polyethylene glycol 4000, 9% isopropanol, and 12% dimethyl sulfoxide, VAPOR DIFFUSION, HANGING DROP, temperature 289K
|
分辨率 2.49 Å R-free 0.248 |
| 3MO2 human G9a-like (GLP, also known as EHMT1) in complex with inhibitor E67 提交 2010-04-22 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
951–1235（285 aa）
片段：C-terminal SET domain
|
未记录 | ZN ZINC ION × 4 E67 7-[(5-aminopentyl)oxy]-N~4~-(1-benzylpiperidin-4-yl)-N~2~-[3-(dimethylamino)propyl]-6-methoxyquinazoline-2,4-diamine × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；289 K；0.1 M Hepes pH 7.5, 14% polyethylene glycol 4000, 9% isopropanol, and 12% dimethyl sulfoxide, VAPOR DIFFUSION, HANGING DROP, temperature 289K
|
分辨率 2.49 Å R-free 0.248 |
| 3MO2 human G9a-like (GLP, also known as EHMT1) in complex with inhibitor E67 提交 2010-04-22 | Assembly 3 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 C
951–1235（285 aa）
片段：C-terminal SET domain
|
未记录 | ZN ZINC ION × 4 E67 7-[(5-aminopentyl)oxy]-N~4~-(1-benzylpiperidin-4-yl)-N~2~-[3-(dimethylamino)propyl]-6-methoxyquinazoline-2,4-diamine × 1 SAH S-ADENOSYL-L-HOMOCYSTEINE × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；289 K；0.1 M Hepes pH 7.5, 14% polyethylene glycol 4000, 9% isopropanol, and 12% dimethyl sulfoxide, VAPOR DIFFUSION, HANGING DROP, temperature 289K
|
分辨率 2.49 Å R-free 0.248 |
| 3MO2 human G9a-like (GLP, also known as EHMT1) in complex with inhibitor E67 提交 2010-04-22 | Assembly 4 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 D
951–1235（285 aa）
片段：C-terminal SET domain
|
未记录 | ZN ZINC ION × 4 E67 7-[(5-aminopentyl)oxy]-N~4~-(1-benzylpiperidin-4-yl)-N~2~-[3-(dimethylamino)propyl]-6-methoxyquinazoline-2,4-diamine × 1 SAH S-ADENOSYL-L-HOMOCYSTEINE × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；289 K；0.1 M Hepes pH 7.5, 14% polyethylene glycol 4000, 9% isopropanol, and 12% dimethyl sulfoxide, VAPOR DIFFUSION, HANGING DROP, temperature 289K
|
分辨率 2.49 Å R-free 0.248 |
| 3MO2 human G9a-like (GLP, also known as EHMT1) in complex with inhibitor E67 提交 2010-04-22 | Assembly 5 蛋白同源多聚体 同源多聚体；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 A
951–1235（285 aa）
片段：C-terminal SET domain
链 B
951–1235（285 aa）
片段：C-terminal SET domain
|
未记录 | ZN ZINC ION × 8 E67 7-[(5-aminopentyl)oxy]-N~4~-(1-benzylpiperidin-4-yl)-N~2~-[3-(dimethylamino)propyl]-6-methoxyquinazoline-2,4-diamine × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；289 K；0.1 M Hepes pH 7.5, 14% polyethylene glycol 4000, 9% isopropanol, and 12% dimethyl sulfoxide, VAPOR DIFFUSION, HANGING DROP, temperature 289K
|
分辨率 2.49 Å R-free 0.248 |
| 3MO2 human G9a-like (GLP, also known as EHMT1) in complex with inhibitor E67 提交 2010-04-22 | Assembly 6 蛋白同源多聚体 同源多聚体；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 C
951–1235（285 aa）
片段：C-terminal SET domain
链 D
951–1235（285 aa）
片段：C-terminal SET domain
|
未记录 | ZN ZINC ION × 8 E67 7-[(5-aminopentyl)oxy]-N~4~-(1-benzylpiperidin-4-yl)-N~2~-[3-(dimethylamino)propyl]-6-methoxyquinazoline-2,4-diamine × 2 SAH S-ADENOSYL-L-HOMOCYSTEINE × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；289 K；0.1 M Hepes pH 7.5, 14% polyethylene glycol 4000, 9% isopropanol, and 12% dimethyl sulfoxide, VAPOR DIFFUSION, HANGING DROP, temperature 289K
|
分辨率 2.49 Å R-free 0.248 |
| 3MO5 Human G9a-like (GLP, also known as EHMT1) in complex with inhibitor E72 提交 2010-04-22 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
951–1235（285 aa）
片段：C-terminal SET domain
|
未记录 | ZN ZINC ION × 4 E72 7-[(5-aminopentyl)oxy]-N~4~-[1-(5-aminopentyl)piperidin-4-yl]-N~2~-[3-(dimethylamino)propyl]-6-methoxyquinazoline-2,4-diamine × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；289 K；0.1 M Hepes pH 7.5, 14% polyethylene glycol 4000, 9% isopropanol, and 12% dimethyl sulfoxide, VAPOR DIFFUSION, HANGING DROP, temperature 289K
|
分辨率 2.14 Å R-free 0.233 |
| 3MO5 Human G9a-like (GLP, also known as EHMT1) in complex with inhibitor E72 提交 2010-04-22 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
951–1235（285 aa）
片段：C-terminal SET domain
|
未记录 | ZN ZINC ION × 4 E72 7-[(5-aminopentyl)oxy]-N~4~-[1-(5-aminopentyl)piperidin-4-yl]-N~2~-[3-(dimethylamino)propyl]-6-methoxyquinazoline-2,4-diamine × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；289 K；0.1 M Hepes pH 7.5, 14% polyethylene glycol 4000, 9% isopropanol, and 12% dimethyl sulfoxide, VAPOR DIFFUSION, HANGING DROP, temperature 289K
|
分辨率 2.14 Å R-free 0.233 |
| 3MO5 Human G9a-like (GLP, also known as EHMT1) in complex with inhibitor E72 提交 2010-04-22 | Assembly 3 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 C
951–1235（285 aa）
片段：C-terminal SET domain
|
未记录 | ZN ZINC ION × 4 E72 7-[(5-aminopentyl)oxy]-N~4~-[1-(5-aminopentyl)piperidin-4-yl]-N~2~-[3-(dimethylamino)propyl]-6-methoxyquinazoline-2,4-diamine × 1 SAH S-ADENOSYL-L-HOMOCYSTEINE × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；289 K；0.1 M Hepes pH 7.5, 14% polyethylene glycol 4000, 9% isopropanol, and 12% dimethyl sulfoxide, VAPOR DIFFUSION, HANGING DROP, temperature 289K
|
分辨率 2.14 Å R-free 0.233 |
| 3MO5 Human G9a-like (GLP, also known as EHMT1) in complex with inhibitor E72 提交 2010-04-22 | Assembly 4 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 D
951–1235（285 aa）
片段：C-terminal SET domain
|
未记录 | ZN ZINC ION × 4 E72 7-[(5-aminopentyl)oxy]-N~4~-[1-(5-aminopentyl)piperidin-4-yl]-N~2~-[3-(dimethylamino)propyl]-6-methoxyquinazoline-2,4-diamine × 1 SAH S-ADENOSYL-L-HOMOCYSTEINE × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；289 K；0.1 M Hepes pH 7.5, 14% polyethylene glycol 4000, 9% isopropanol, and 12% dimethyl sulfoxide, VAPOR DIFFUSION, HANGING DROP, temperature 289K
|
分辨率 2.14 Å R-free 0.233 |
| 3MO5 Human G9a-like (GLP, also known as EHMT1) in complex with inhibitor E72 提交 2010-04-22 | Assembly 5 蛋白同源多聚体 同源多聚体；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 A
951–1235（285 aa）
片段：C-terminal SET domain
链 B
951–1235（285 aa）
片段：C-terminal SET domain
|
未记录 | ZN ZINC ION × 8 E72 7-[(5-aminopentyl)oxy]-N~4~-[1-(5-aminopentyl)piperidin-4-yl]-N~2~-[3-(dimethylamino)propyl]-6-methoxyquinazoline-2,4-diamine × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；289 K；0.1 M Hepes pH 7.5, 14% polyethylene glycol 4000, 9% isopropanol, and 12% dimethyl sulfoxide, VAPOR DIFFUSION, HANGING DROP, temperature 289K
|
分辨率 2.14 Å R-free 0.233 |
| 3MO5 Human G9a-like (GLP, also known as EHMT1) in complex with inhibitor E72 提交 2010-04-22 | Assembly 6 蛋白同源多聚体 同源多聚体；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 C
951–1235（285 aa）
片段：C-terminal SET domain
链 D
951–1235（285 aa）
片段：C-terminal SET domain
|
未记录 | ZN ZINC ION × 8 E72 7-[(5-aminopentyl)oxy]-N~4~-[1-(5-aminopentyl)piperidin-4-yl]-N~2~-[3-(dimethylamino)propyl]-6-methoxyquinazoline-2,4-diamine × 2 SAH S-ADENOSYL-L-HOMOCYSTEINE × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；289 K；0.1 M Hepes pH 7.5, 14% polyethylene glycol 4000, 9% isopropanol, and 12% dimethyl sulfoxide, VAPOR DIFFUSION, HANGING DROP, temperature 289K
|
分辨率 2.14 Å R-free 0.233 |
| 3SW9 GLP (G9a-like protein) SET domain in complex with Dnmt3aK44me0 peptide 提交 2011-07-13 | Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 A
982–1266（285 aa）
片段：unp residues 982-1266
|
未记录 | ZN ZINC ION × 4 SFG SINEFUNGIN × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；289 K；0.1 M Hepes, 16% polyethylene glycol 4000 and 8% isopropanol, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 289K
|
分辨率 3.05 Å R-free 0.248 |
| 3SW9 GLP (G9a-like protein) SET domain in complex with Dnmt3aK44me0 peptide 提交 2011-07-13 | Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 B
982–1266（285 aa）
片段：unp residues 982-1266
|
未记录 | ZN ZINC ION × 4 SFG SINEFUNGIN × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；289 K；0.1 M Hepes, 16% polyethylene glycol 4000 and 8% isopropanol, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 289K
|
分辨率 3.05 Å R-free 0.248 |
| 3SW9 GLP (G9a-like protein) SET domain in complex with Dnmt3aK44me0 peptide 提交 2011-07-13 | Assembly 3 蛋白异源复合物 异源复合物；蛋白 × 4 PDB 声明：tetrameric（4） 与蛋白数一致 |
链 A
982–1266（285 aa）
片段：unp residues 982-1266
链 B
982–1266（285 aa）
片段：unp residues 982-1266
|
未记录 | ZN ZINC ION × 8 SFG SINEFUNGIN × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；289 K；0.1 M Hepes, 16% polyethylene glycol 4000 and 8% isopropanol, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 289K
|
分辨率 3.05 Å R-free 0.248 |
| 3SWC GLP (G9a-like protein) SET domain in complex with Dnmt3aK44me2 peptide 提交 2011-07-13 | Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 A
982–1266（285 aa）
片段：unp residues 982-1266
|
未记录 | ZN ZINC ION × 4 SAH S-ADENOSYL-L-HOMOCYSTEINE × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；289 K；0.1 M Hepes, 16% polyethylene glycol 4000 and 8% isopropanol, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 289K
|
分辨率 2.33 Å R-free 0.227 |
| 3SWC GLP (G9a-like protein) SET domain in complex with Dnmt3aK44me2 peptide 提交 2011-07-13 | Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 B
982–1266（285 aa）
片段：unp residues 982-1266
|
未记录 | ZN ZINC ION × 4 SAH S-ADENOSYL-L-HOMOCYSTEINE × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；289 K；0.1 M Hepes, 16% polyethylene glycol 4000 and 8% isopropanol, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 289K
|
分辨率 2.33 Å R-free 0.227 |
| 3SWC GLP (G9a-like protein) SET domain in complex with Dnmt3aK44me2 peptide 提交 2011-07-13 | Assembly 3 蛋白异源复合物 异源复合物；蛋白 × 4 PDB 声明：tetrameric（4） 与蛋白数一致 |
链 A
982–1266（285 aa）
片段：unp residues 982-1266
链 B
982–1266（285 aa）
片段：unp residues 982-1266
|
未记录 | ZN ZINC ION × 8 SAH S-ADENOSYL-L-HOMOCYSTEINE × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7.5；289 K；0.1 M Hepes, 16% polyethylene glycol 4000 and 8% isopropanol, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 289K
|
分辨率 2.33 Å R-free 0.227 |
| 4I51 Methyltransferase domain of HUMAN EUCHROMATIC HISTONE METHYLTRANSFERASE 1, mutant Y1211A 提交 2012-11-28 | Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 5 PDB 声明：pentameric（5） 与蛋白数一致 |
链 A
982–1266（285 aa）
链 B
982–1266（285 aa）
|
突变：Y1211A 突变：Y1211A | SAH S-ADENOSYL-L-HOMOCYSTEINE × 2 ZN ZINC ION × 8 GOL GLYCEROL × 3 UNX UNKNOWN LIGAND × 9 | X-RAY DIFFRACTION |
X-ray结晶条件
pH 7.5；10% ISOPROPANOL, 20% PEG4000; 0.1M HEPES PH7.5, VAPOR DIFFUSION HANGING DROP, TEMPERATURE 297K
|
分辨率 1.90 Å R-free 0.195 |
| 5TTG Crystal structure of catalytic domain of GLP with MS012 提交 2016-11-03 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
982–1266（285 aa）
片段：UNP residues 879-1159
|
未记录 | SAM S-ADENOSYLMETHIONINE × 1 7KZ N4-(1-methylpiperidin-4-yl)-N2-hexyl-6,7-dimethoxyquinazoline-2,4-diamine × 1 ZN ZINC ION × 4 CL CHLORIDE ION × 1 GOL GLYCEROL × 1 UNX UNKNOWN LIGAND × 6 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；pH 5.6；293 K；20% PEG 4000, 20% IProp, 0.1 M NaCitrate pH5.6
|
分辨率 1.66 Å R-free 0.192 |
| 5TTG Crystal structure of catalytic domain of GLP with MS012 提交 2016-11-03 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
982–1266（285 aa）
片段：UNP residues 879-1159
|
未记录 | SAM S-ADENOSYLMETHIONINE × 1 7KZ N4-(1-methylpiperidin-4-yl)-N2-hexyl-6,7-dimethoxyquinazoline-2,4-diamine × 1 ZN ZINC ION × 4 UNX UNKNOWN LIGAND × 9 DMS DIMETHYL SULFOXIDE × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；pH 5.6；293 K；20% PEG 4000, 20% IProp, 0.1 M NaCitrate pH5.6
|
分辨率 1.66 Å R-free 0.192 |
| 5TUZ Structure of human GLP SET-domain (EHMT1) in complex with inhibitor MS0124 提交 2016-11-07 | Assembly 1 蛋白同源多聚体 同源多聚体；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 A
1006–1266（261 aa）
片段：UNP residues 1006-1266
链 B
1006–1266（261 aa）
片段：UNP residues 1006-1266
|
未记录 | SAM S-ADENOSYLMETHIONINE × 2 ZN ZINC ION × 8 7L6 6,7-dimethoxy-N-(1-methylpiperidin-4-yl)-2-(morpholin-4-yl)quinazolin-4-amine × 2 EDO 1,2-ETHANEDIOL × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION；pH 9；290 K；20% PEG 20,000, 2% (v/v) 1,4-Dioxane, 0.1 M Bicine (pH 9.0)
|
分辨率 1.95 Å R-free 0.201 |
| 5V9J Crystal structure of catalytic domain of GLP with MS0105 提交 2017-03-23 | Assembly 1 蛋白同源多聚体 同源多聚体；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 A
982–1266（285 aa）
片段：residues 982-1266
链 B
982–1266（285 aa）
片段：residues 982-1266
|
未记录 | SAM S-ADENOSYLMETHIONINE × 2 90P N~2~-cyclohexyl-N~4~-(1-ethylpiperidin-4-yl)-6,7-dimethoxy-N~2~-methylquinazoline-2,4-diamine × 2 ZN ZINC ION × 8 CL CHLORIDE ION × 3 UNX UNKNOWN LIGAND × 13 DMS DIMETHYL SULFOXIDE × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；pH 5.6；293 K；20% PEG 4000, 20% IProp, 0.1 M NaCitrate pH5.6
|
分辨率 1.74 Å R-free 0.197 |
| 5VSD Structure of human GLP SET-domain (EHMT1) in complex with inhibitor 13 提交 2017-05-11 | Assembly 1 蛋白同源多聚体 同源多聚体；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 A
1006–1266（261 aa）
片段：GLP catalytic SET-domain residues 1006-1266
链 B
1006–1266（261 aa）
片段：GLP catalytic SET-domain residues 1006-1266
|
未记录 | SAM S-ADENOSYLMETHIONINE × 2 ZN ZINC ION × 8 9HJ 6,7-dimethoxy-N~2~-methyl-N~4~-(1-methylpiperidin-4-yl)-N~2~-propylquinazoline-2,4-diamine × 2 DIO 1,4-DIETHYLENE DIOXIDE × 1 GOL GLYCEROL × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION；pH 9；290 K；7 % PEG 20K, 1.4% v/v 1,4-Dioxane, 10% glycerol, 0.07 M Bicine, pH 9.0
|
分辨率 1.85 Å R-free 0.235 |
| 5VSF Structure of human GLP SET-domain (EHMT1) in complex with inhibitor 17 提交 2017-05-11 | Assembly 1 蛋白同源多聚体 同源多聚体；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 A
1006–1266（261 aa）
片段：GLP catalytic SET-domain residues 1006-1266
链 B
1006–1266（261 aa）
片段：GLP catalytic SET-domain residues 1006-1266
|
未记录 | SAM S-ADENOSYLMETHIONINE × 2 ZN ZINC ION × 8 9HG N~2~-cyclopentyl-6,7-dimethoxy-N~2~-methyl-N~4~-(1-methylpiperidin-4-yl)quinazoline-2,4-diamine × 2 DIO 1,4-DIETHYLENE DIOXIDE × 1 GOL GLYCEROL × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION；pH 9；290 K；10 % PEG 20K, 1.4% v/v 1,4-Dioxane, 10% glycerol, 0 0.1 M Bicine, pH 9.0
|
分辨率 1.70 Å R-free 0.185 |
| 6BY9 Crystal structure of EHMT1 提交 2017-12-20 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
672–999（328 aa）
|
未记录 | UNX UNKNOWN LIGAND × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；0.1M BIS-TRIS pH6.5,3.0M NaCl
|
分辨率 2.30 Å R-free 0.238 |
| 6MBO GLP Methyltransferase with Inhibitor EML741-P212121 Crystal Form 提交 2018-08-30 | Assembly 1 蛋白同源多聚体 同源多聚体；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 A
1006–1266（261 aa）
链 B
1006–1266（261 aa）
|
未记录 | JDG 2-cyclohexyl-7-methoxy-N-[1-(propan-2-yl)piperidin-4-yl]-8-[3-(pyrrolidin-1-yl)propoxy]-3H-1,4-benzodiazepin-5-amine × 4 ZN ZINC ION × 8 SAH S-ADENOSYL-L-HOMOCYSTEINE × 2 EDO 1,2-ETHANEDIOL × 14 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；pH 5.5；292 K；15% PEG 4000, 20% isopropanol and 100mM citrate (pH 5.5)
|
分辨率 1.59 Å R-free 0.194 |
| 6MBP GLP Methyltransferase with Inhibitor EML741- P3121 Crystal Form 提交 2018-08-30 | Assembly 1 蛋白同源多聚体 同源多聚体；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 A
1006–1266（261 aa）
片段：residues 1006-1266
链 B
1006–1266（261 aa）
片段：residues 1006-1266
|
未记录 | JDG 2-cyclohexyl-7-methoxy-N-[1-(propan-2-yl)piperidin-4-yl]-8-[3-(pyrrolidin-1-yl)propoxy]-3H-1,4-benzodiazepin-5-amine × 2 ZN ZINC ION × 8 SAH S-ADENOSYL-L-HOMOCYSTEINE × 2 EDO 1,2-ETHANEDIOL × 12 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；pH 5.5；292 K；15% PEG 4000, 20% isopropanol and 100mM citrate (pH 5.5)
|
分辨率 1.95 Å R-free 0.182 |
| 7T7M Structure of human GLP SET-domain (EHMT1) in complex with covalent inhibitor (Compound 1) 提交 2021-12-15 | Assembly 1 蛋白同源多聚体 同源多聚体；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 A
982–1266（285 aa）
片段：residues 982-1266
链 D
982–1266（285 aa）
片段：residues 982-1266
|
未记录 | ZN ZINC ION × 8 G4R N-(6-methoxy-4-{[1-(propan-2-yl)piperidin-4-yl]amino}-7-[3-(pyrrolidin-1-yl)propoxy]quinazolin-2-yl)prop-2-enamide × 1 G5U N-(6-methoxy-4-{[1-(propan-2-yl)piperidin-4-yl]amino}-7-[3-(pyrrolidin-1-yl)propoxy]quinazolin-2-yl)propanamide × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；290.15 K；0.2 Magnesium Formate, 15% w/v Polyethylene glycol 3350
|
分辨率 2.85 Å R-free 0.244 |
| 7T7M Structure of human GLP SET-domain (EHMT1) in complex with covalent inhibitor (Compound 1) 提交 2021-12-15 | Assembly 2 蛋白同源多聚体 同源多聚体；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 B
982–1266（285 aa）
片段：residues 982-1266
链 C
982–1266（285 aa）
片段：residues 982-1266
|
未记录 | ZN ZINC ION × 8 G4R N-(6-methoxy-4-{[1-(propan-2-yl)piperidin-4-yl]amino}-7-[3-(pyrrolidin-1-yl)propoxy]quinazolin-2-yl)prop-2-enamide × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；290.15 K；0.2 Magnesium Formate, 15% w/v Polyethylene glycol 3350
|
分辨率 2.85 Å R-free 0.244 |
| 8XPT The Crystal Structure of EHMT1 from Biortus. 提交 2024-01-04 | Assembly 1 蛋白同源多聚体 同源多聚体；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 A
982–1266（285 aa）
链 C
982–1266（285 aa）
|
未记录 | SAH S-ADENOSYL-L-HOMOCYSTEINE × 2 ZN ZINC ION × 8 SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；293 K；0.2M Li2SO4, 0.1M Tris-HCl pH8.5, 25% PEG MME 5000
|
分辨率 3.35 Å R-free 0.262 |
| 8XPT The Crystal Structure of EHMT1 from Biortus. 提交 2024-01-04 | Assembly 2 蛋白同源多聚体 同源多聚体；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 B
982–1266（285 aa）
链 D
982–1266（285 aa）
|
未记录 | SAH S-ADENOSYL-L-HOMOCYSTEINE × 2 ZN ZINC ION × 8 SO4 SULFATE ION × 3 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；293 K；0.2M Li2SO4, 0.1M Tris-HCl pH8.5, 25% PEG MME 5000
|
分辨率 3.35 Å R-free 0.262 |
| 9YKR Crystal structure of the GLP (EHMT1) SET domain in complex with SAM and TNG917 提交 2025-10-07 | Assembly 1 蛋白同源多聚体 同源多聚体；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 A
1006–1266（261 aa）
片段：catalytic SET domain (UNP residues 1006-1266)
链 B
1006–1266（261 aa）
片段：catalytic SET domain (UNP residues 1006-1266)
|
未记录 | ZN ZINC ION × 8 SAM S-ADENOSYLMETHIONINE × 2 A1CXM N~2~-[(7M)-6-fluoro-7-(2,5,6,7-tetrahydro-1H-azepin-4-yl)-2,3-dihydro-1-benzofuran-5-yl]-N~4~,6-dimethylpyrimidine-2,4-diamine × 2 PEG DI(HYDROXYETHYL)ETHER × 4 SO4 SULFATE ION × 16 EDO 1,2-ETHANEDIOL × 21 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION；pH 5.5；298 K；30% PEG3350, 200 mM lithium sulfate, 100 mM Bis-Tris, pH 5.5
|
分辨率 1.38 Å R-free 0.154 |