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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：Q9R194 New Search
10PDB entries
16Biological assembly
17chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
4I6E A vertebrate cryptochrome Deposited 2012-11-29 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–512（512 aa） Fragment：UNP residues 1-512
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；0.1M MES-imadzole, pH6.5, 7.2% PEG8000, 20% Ethylene glycol (v/v), 0.03M NaF,NaBr,NaI, VAPOR DIFFUSION, HANGING DROP, temperature 277K
Resolution 2.70 Å R-free 0.287
4I6G a vertebrate cryptochrome with FAD Deposited 2012-11-29 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–512（512 aa） Fragment：UNP residues 1-512
Not recorded FAD FLAVIN-ADENINE DINUCLEOTIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；0.1M MES-imadzole, pH 6.5, 7.2% PEG8000, 20% ethylene glyco(v/v), 0.03M NaF,NaBr,NaI, VAPOR DIFFUSION, HANGING DROP, temperature 277K
Resolution 2.20 Å R-free 0.238
4I6G a vertebrate cryptochrome with FAD Deposited 2012-11-29 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain B 1–512（512 aa） Fragment：UNP residues 1-512
Not recorded FAD FLAVIN-ADENINE DINUCLEOTIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；0.1M MES-imadzole, pH 6.5, 7.2% PEG8000, 20% ethylene glyco(v/v), 0.03M NaF,NaBr,NaI, VAPOR DIFFUSION, HANGING DROP, temperature 277K
Resolution 2.20 Å R-free 0.238
4I6J A ubiquitin ligase-substrate complex Deposited 2012-11-29 Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain A 1–544（544 aa） Fragment：UNP residues 1-544
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；277 K；0.2M ammonium citrate, 13-14% PEG3350 7% Acetonitrile, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 277K
Resolution 2.70 Å R-free 0.265
4MLP Mammalian cryptochrome in complex with a small molecule competitor of its ubiquitin ligase Deposited 2013-09-06 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain C 1–512（512 aa） Fragment：photolyase homology region UNP residues 1-512
Not recorded 2CX N-[(2S)-3-(9H-carbazol-9-yl)-2-hydroxypropyl]-N-(furan-2-ylmethyl)methanesulfonamide × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；0.1 M MES and 4-5% PEG8K, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
Resolution 1.94 Å R-free 0.217
4MLP Mammalian cryptochrome in complex with a small molecule competitor of its ubiquitin ligase Deposited 2013-09-06 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–512（512 aa） Fragment：photolyase homology region UNP residues 1-512
Not recorded 2CX N-[(2S)-3-(9H-carbazol-9-yl)-2-hydroxypropyl]-N-(furan-2-ylmethyl)methanesulfonamide × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；0.1 M MES and 4-5% PEG8K, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
Resolution 1.94 Å R-free 0.217
4MLP Mammalian cryptochrome in complex with a small molecule competitor of its ubiquitin ligase Deposited 2013-09-06 Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain B 1–512（512 aa） Fragment：photolyase homology region UNP residues 1-512
Not recorded 2CX N-[(2S)-3-(9H-carbazol-9-yl)-2-hydroxypropyl]-N-(furan-2-ylmethyl)methanesulfonamide × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；0.1 M MES and 4-5% PEG8K, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
Resolution 1.94 Å R-free 0.217
4MLP Mammalian cryptochrome in complex with a small molecule competitor of its ubiquitin ligase Deposited 2013-09-06 Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain D 1–512（512 aa） Fragment：photolyase homology region UNP residues 1-512
Not recorded 2CX N-[(2S)-3-(9H-carbazol-9-yl)-2-hydroxypropyl]-N-(furan-2-ylmethyl)methanesulfonamide × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；0.1 M MES and 4-5% PEG8K, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
Resolution 1.94 Å R-free 0.217
4U8H Crystal Structure of Mammalian Period-Cryptochrome Complex Deposited 2014-08-03 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 1–510（510 aa） Fragment：Photolyase/cryptochrome alpha/beta domain, residues 1-510
Not recorded ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；277 K；0.1 M HEPES, 0.2 M NaCl, 15% PEG3350
Resolution 2.80 Å R-free 0.278
4U8H Crystal Structure of Mammalian Period-Cryptochrome Complex Deposited 2014-08-03 Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain C 1–510（510 aa） Fragment：Photolyase/cryptochrome alpha/beta domain, residues 1-510
Not recorded ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；277 K；0.1 M HEPES, 0.2 M NaCl, 15% PEG3350
Resolution 2.80 Å R-free 0.278
6KX8 Crystal structure of mouse Cryptochrome 2 in complex with TH301 compound Deposited 2019-09-10 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–512（512 aa）
Not recorded DYX 1-(4-chlorophenyl)-N-[2-(4-methoxyphenyl)-5,5-bis(oxidanylidene)-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]cyclopentane-1-carboxamide × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；293 K；100 mM HEPES-NaOH pH 7.0, 15% (w/v) PEG3350, 200 mM NaCl
Resolution 2.25 Å R-free 0.219
6KX8 Crystal structure of mouse Cryptochrome 2 in complex with TH301 compound Deposited 2019-09-10 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain B 1–512（512 aa）
Not recorded DYX 1-(4-chlorophenyl)-N-[2-(4-methoxyphenyl)-5,5-bis(oxidanylidene)-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]cyclopentane-1-carboxamide × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；293 K；100 mM HEPES-NaOH pH 7.0, 15% (w/v) PEG3350, 200 mM NaCl
Resolution 2.25 Å R-free 0.219
7D0N Crystal structure of mouse CRY2 apo form Deposited 2020-09-11 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–512（512 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；293 K；0.1 M HEPES pH 7.0, 100 mM NaCl, 10% w/v PEG 3350
Resolution 2.80 Å R-free 0.293
7EJ9 Alternative crystal structure of mouse Cryptochrome 2 in complex with TH301 compound Deposited 2021-04-01 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 1–512（512 aa）
Chain B 1–512（512 aa）
Not recorded DYX 1-(4-chlorophenyl)-N-[2-(4-methoxyphenyl)-5,5-bis(oxidanylidene)-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]cyclopentane-1-carboxamide × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；293 K；0.1 M HEPES-NaOH pH 7.0, 0.35 M NaCl, 18% (w/v) PEG 3350
Resolution 2.60 Å R-free 0.234
7V8Y Crystal structure of mouse CRY2 in complex with SHP1703 compound Deposited 2021-08-23 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–512（512 aa）
Not recorded 5YH 1-[(2R)-3-[3,6-bis(fluoranyl)carbazol-9-yl]-2-oxidanyl-propyl]imidazolidin-2-one × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；293 K；0.1 M HEPES pH 7.0, 0.15 M NaCl, 12% PEG 3350
Resolution 1.90 Å R-free 0.206
7V8Z Crystal structure of mouse CRY2 in complex with SHP656 compound Deposited 2021-08-23 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–512（512 aa）
Not recorded 5YH 1-[(2R)-3-[3,6-bis(fluoranyl)carbazol-9-yl]-2-oxidanyl-propyl]imidazolidin-2-one × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；293 K；0.1 M HEPES pH 7.0, 0.1 M NaCl, 16% PEG 3350
Resolution 1.95 Å R-free 0.202

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.