Current Protein Identity：Q9UBH6
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Difference tags compare only the current result set; every original PDB and assembly record remains separate.
Related-Structure Differences
Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.
| PDB Entry | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Experimental Method | Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 5IJH Structure of the SPX domain of the human phosphate transporter XPR1 in complex with a sulfate ion Deposited 2016-03-02 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1–207（207 aa）
Fragment：SPX domain, UNP Residues 1-207
|
Not recorded | SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；298 K；1.4M AmSO4, 0.1M Tris, 16% glycerol
|
Resolution 2.43 Å R-free 0.244 |
| 5IJH Structure of the SPX domain of the human phosphate transporter XPR1 in complex with a sulfate ion Deposited 2016-03-02 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
1–207（207 aa）
Fragment：SPX domain, UNP Residues 1-207
|
Not recorded | SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；298 K；1.4M AmSO4, 0.1M Tris, 16% glycerol
|
Resolution 2.43 Å R-free 0.244 |
| 8TYU High-resolution crystal structure of the SPX domain of XPR1 at 1.4 angstroms Deposited 2023-08-25 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
1–94（94 aa）
Fragment：SPX domain
Chain B
130–207（78 aa）
Fragment：SPX domain
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；298 K；6% PEG 3350, 30% Ethylene Glycol, 0.1 M Sodium Citrate, 0.1 M MgCl2, pH 6.0.
|
Resolution 1.40 Å R-free 0.191 |
| 8TYU High-resolution crystal structure of the SPX domain of XPR1 at 1.4 angstroms Deposited 2023-08-25 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1–94（94 aa）
Fragment：SPX domain
Chain A
130–207（78 aa）
Fragment：SPX domain
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；298 K；6% PEG 3350, 30% Ethylene Glycol, 0.1 M Sodium Citrate, 0.1 M MgCl2, pH 6.0.
|
Resolution 1.40 Å R-free 0.191 |
| 8TYV Crystal structure of the SPX domain of XPR1 in complex with IP8 Deposited 2023-08-25 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
1–94（94 aa）
Fragment：SPX domain
Chain B
130–207（78 aa）
Fragment：SPX domain
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；298 K；2mM IP8 soaked into crystals grown under 6% PEG 3350, 30% Ethylene Glycol, 0.1 M Sodium Citrate, 0.1 M MgCl2, pH 6.0 for 3 Days
|
Resolution 1.85 Å R-free 0.271 |
| 8TYV Crystal structure of the SPX domain of XPR1 in complex with IP8 Deposited 2023-08-25 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1–94（94 aa）
Fragment：SPX domain
Chain A
130–207（78 aa）
Fragment：SPX domain
|
Not recorded | I8P (1R,3S,4R,5S,6R)-2,4,5,6-tetrakis(phosphonooxy)cyclohexane-1,3-diyl bis[trihydrogen (diphosphate)] × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；298 K；2mM IP8 soaked into crystals grown under 6% PEG 3350, 30% Ethylene Glycol, 0.1 M Sodium Citrate, 0.1 M MgCl2, pH 6.0 for 3 Days
|
Resolution 1.85 Å R-free 0.271 |
| 8X5B Cryo-EM structures of human XPR1 in closed states Deposited 2023-11-16 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
229–696（468 aa）
Chain F
229–696（468 aa）
|
Not recorded | PO4 PHOSPHATE ION × 8 POV (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate × 18 CLR CHOLESTEROL × 2 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.84 Å |
| 8X5E Cryo-EM structure of human XPR1 in open state Deposited 2023-11-17 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
229–696（468 aa）
|
Not recorded | PO4 PHOSPHATE ION × 2 6OU [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate × 6 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen OTHER
|
Resolution 3.61 Å |
| 8X5F human XPR1 in complex with InsP6 Deposited 2023-11-17 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–696（696 aa）
Chain B
1–696（696 aa）
|
Not recorded | PO4 PHOSPHATE ION × 8 IHP INOSITOL HEXAKISPHOSPHATE × 2 POV (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate × 30 CLR CHOLESTEROL × 2 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
|
Resolution 2.96 Å |
| 8YET Cryo EM structure of human phosphate channel XPR1 in complex with IP6 Deposited 2024-02-23 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–620（620 aa）
Chain B
1–620（620 aa）
|
Not recorded | IHP INOSITOL HEXAKISPHOSPHATE × 2 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 4.16 Å |
| 8YEX Cryo EM structure of human phosphate channel XPR1 at apo state Deposited 2024-02-23 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
228–619（392 aa）
Chain B
228–619（392 aa）
|
Not recorded | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.68 Å |
| 8YF4 Cryo EM structure of human phosphate channel XPR1 at open and inward-facing state Deposited 2024-02-24 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
227–619（393 aa）
Chain B
227–619（393 aa）
|
Not recorded | Y01 CHOLESTEROL HEMISUCCINATE × 2 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.41 Å |
| 8YFD Cryo EM structure of human phosphate channel XPR1 at open state Deposited 2024-02-24 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
227–622（396 aa）
Chain B
227–622（396 aa）
|
Not recorded | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.57 Å |
| 8YFU Cryo EM structure of human phosphate channel XPR1 at intermediate state Deposited 2024-02-25 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
21–620（600 aa）
Chain B
21–620（600 aa）
|
Not recorded | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 4.59 Å |
| 8YFW Cryo EM structure of human phosphate channel XPR1 at intermediate state Deposited 2024-02-25 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
21–620（600 aa）
Chain B
21–620（600 aa）
|
Not recorded | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.65 Å |
| 8YFX Cryo EM structure of human phosphate channel XPR1 at inward-facing state Deposited 2024-02-25 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
227–622（396 aa）
Chain B
227–622（396 aa）
|
Not recorded | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.56 Å |
| 8ZTO Cryo-EM structure of the human XPR1 Deposited 2024-06-07 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–696（696 aa）
Chain B
1–696（696 aa）
|
Not recorded | K9G [(2~{R})-1-hexadecanoyloxy-3-[oxidanyl-[2-(trimethyl-$l^{4}-azanyl)ethoxy]phosphoryl]oxy-propan-2-yl] octadec-9-enoate × 2 PO4 PHOSPHATE ION × 2 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.55 Å |
| 9CKZ Cryo-EM structure of human XPR1 in apo state Deposited 2024-07-10 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–696（696 aa）
Chain B
1–696（696 aa）
|
Not recorded | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.45 Å |
| 9CL0 Cryo-EM structure of human XPR1 in presence of inorganic phosphate and phytic acid Deposited 2024-07-10 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–696（696 aa）
Chain B
1–696（696 aa）
|
Not recorded | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.30 Å |
| 9DVJ "Structure of the phosphate exporter XPR1/SLC53A1 Deposited 2024-10-08 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–696（696 aa）
Chain B
1–696（696 aa）
|
Not recorded | PO4 PHOSPHATE ION × 2 CLR CHOLESTEROL × 2 CPL 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.52 Å |
| 9DVK Structure of the phosphate exporter XPR1/SLC53A1, rotated dimer Deposited 2024-10-08 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–696（696 aa）
Chain B
1–696（696 aa）
|
Not recorded | PO4 PHOSPHATE ION × 2 CLR CHOLESTEROL × 1 CPL 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 3 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.06 Å |
| 9DVL Structure of the phosphate exporter XPR1/SLC53A1, InsP6-supplemented Deposited 2024-10-08 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–696（696 aa）
Chain B
1–696（696 aa）
|
Not recorded | PO4 PHOSPHATE ION × 6 CLR CHOLESTEROL × 2 CPL 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.97 Å |
| 9DVM Structure of the phosphate exporter XPR1/SLC53A1, InsP8-bound, intracellular gate open/intracellular gate closed state Deposited 2024-10-08 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–696（696 aa）
Chain B
1–696（696 aa）
|
Not recorded | PO4 PHOSPHATE ION × 6 I8P (1R,3S,4R,5S,6R)-2,4,5,6-tetrakis(phosphonooxy)cyclohexane-1,3-diyl bis[trihydrogen (diphosphate)] × 4 CLR CHOLESTEROL × 2 CPL 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.92 Å |
| 9DVN Structure of the phosphate exporter XPR1/SLC53A1, InsP8-bound, intracellular gate closed state Deposited 2024-10-08 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–696（696 aa）
Chain B
1–696（696 aa）
|
Not recorded | PO4 PHOSPHATE ION × 6 I8P (1R,3S,4R,5S,6R)-2,4,5,6-tetrakis(phosphonooxy)cyclohexane-1,3-diyl bis[trihydrogen (diphosphate)] × 4 CLR CHOLESTEROL × 2 CPL 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.75 Å |
| 9DVO Structure of the phosphate exporter XPR1/SLC53A1, Pi and InsP8-bound, intracellular gate open/intracellular gate closed state Deposited 2024-10-08 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–696（696 aa）
Chain B
1–696（696 aa）
|
Not recorded | PO4 PHOSPHATE ION × 4 I8P (1R,3S,4R,5S,6R)-2,4,5,6-tetrakis(phosphonooxy)cyclohexane-1,3-diyl bis[trihydrogen (diphosphate)] × 4 CLR CHOLESTEROL × 2 CPL 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.10 Å |
| 9DVP Structure of the phosphate exporter XPR1/SLC53A1, Pi and InsP8-bound, intracellular gate closed state Deposited 2024-10-08 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–696（696 aa）
Chain B
1–696（696 aa）
|
Not recorded | PO4 PHOSPHATE ION × 5 I8P (1R,3S,4R,5S,6R)-2,4,5,6-tetrakis(phosphonooxy)cyclohexane-1,3-diyl bis[trihydrogen (diphosphate)] × 4 CLR CHOLESTEROL × 2 CPL 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.81 Å |
| 9IJY Homo sapiens Xenotropic and Polytropic Retrovirus Receptor 1 (XPR1) with Y22A/E23A/K26A mutations Deposited 2024-06-25 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–696（696 aa）
Chain B
1–696（696 aa）
|
Mutation：Y22A,E23A,K26A Mutation：Y22A,E23A,K26A | PO4 PHOSPHATE ION × 2 6PL (4S,7R)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSAN-1-AMINIUM 4-OXIDE × 2 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.64 Å |
| 9IJZ Wild type Homo sapiens Xenotropic and Polytropic Retrovirus Receptor 1 (XPR1) Deposited 2024-06-25 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–696（696 aa）
Chain B
1–696（696 aa）
|
Not recorded | PO4 PHOSPHATE ION × 2 6PL (4S,7R)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSAN-1-AMINIUM 4-OXIDE × 2 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.91 Å |
| 9INE Cryo-EM structure of human XPR1 in closed state in the presence of KIDINS220-1-432 Deposited 2024-07-06 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–696（696 aa）
Chain B
1–696（696 aa）
|
Not recorded | CLR CHOLESTEROL × 14 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 6 LPE 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 PLM PALMITIC ACID × 2 ACD ARACHIDONIC ACID × 2 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.32 Å |
| 9INF Cryo-EM structure of human XPR1 in closed state in the presence of KIDINS220-1-432 and 10 mM KH2PO4 Deposited 2024-07-06 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–696（696 aa）
Chain B
1–696（696 aa）
|
Not recorded | CLR CHOLESTEROL × 8 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 6 PLM PALMITIC ACID × 2 ACD ARACHIDONIC ACID × 2 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.36 Å |
| 9INH Cryo-EM structure of human XPR1 in complex with InsP6 in outward-facing state (SPX visible)-in the presence of KIDINS220-1-432 and 10 mM KH2PO4 Deposited 2024-07-06 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–696（696 aa）
Chain D
1–696（696 aa）
|
Not recorded | IHP INOSITOL HEXAKISPHOSPHATE × 2 CLR CHOLESTEROL × 12 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 6 PLM PALMITIC ACID × 2 ACD ARACHIDONIC ACID × 2 PO4 PHOSPHATE ION × 10 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.68 Å |
| 9ITG Cryo-EM structure of human XPR1-E622A/F623A mutant in complex with InsP6 in inward-facing state in the presence of 10 mM KH2PO4 Deposited 2024-07-20 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–696（696 aa）
Chain B
1–696（696 aa）
|
Mutation：E622A, F623A Mutation：E622A, F623A | PO4 PHOSPHATE ION × 2 IHP INOSITOL HEXAKISPHOSPHATE × 2 CLR CHOLESTEROL × 2 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 Y01 CHOLESTEROL HEMISUCCINATE × 2 PLM PALMITIC ACID × 2 1T9 (2S,3R,4E)-3-hydroxy-2-(octanoylamino)octadec-4-en-1-yl dihydrogen phosphate × 2 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.03 Å |
| 9IUC Cryo-EM structure of human XPR1 in complex with InsP6 in closed state - in the presence of KIDINS220-1-432 without substrate KH2PO4 Deposited 2024-07-20 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–696（696 aa）
Chain B
1–696（696 aa）
|
Not recorded | CLR CHOLESTEROL × 12 IHP INOSITOL HEXAKISPHOSPHATE × 2 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 6 PLM PALMITIC ACID × 4 ACD ARACHIDONIC ACID × 2 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.80 Å |
| 9IWS Cryo EM structure of human phosphate channel XPR1 in complex with IP7 Deposited 2024-07-25 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–631（631 aa）
Chain B
1–631（631 aa）
|
Not recorded | I7P (1r,2R,3S,4s,5R,6S)-2,3,4,5,6-pentakis(phosphonooxy)cyclohexyl trihydrogen diphosphate × 4 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.86 Å |
| 9J4X CryoEM structure of human XPR1 in apo state Deposited 2024-08-10 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–696（696 aa）
Chain B
1–696（696 aa）
|
Not recorded | PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.90 Å |
| 9J51 CryoEM structure of human XPR1 in complex with phosphate in state A Deposited 2024-08-11 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–696（696 aa）
Chain B
1–696（696 aa）
|
Not recorded | PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 PO4 PHOSPHATE ION × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.10 Å |
| 9J52 CryoEM structure of human XPR1 in complex with phosphate in state B Deposited 2024-08-11 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–696（696 aa）
Chain B
1–696（696 aa）
|
Not recorded | PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 PO4 PHOSPHATE ION × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.10 Å |
| 9J53 CryoEM structure of human XPR1 in complex with phosphate in state C Deposited 2024-08-11 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–696（696 aa）
Chain B
1–696（696 aa）
|
Not recorded | PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 PO4 PHOSPHATE ION × 2 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.30 Å |
| 9J97 Closed structure of human XPR1 Deposited 2024-08-22 | Assembly 1 Insufficient information Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–696（696 aa）
Chain B
1–696（696 aa）
|
Not recorded | 8PE (2R)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(tetradecanoyloxy)propyl octadecanoate × 2 CLR CHOLESTEROL × 2 PO4 PHOSPHATE ION × 2 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.30 Å |
| 9J98 Open structure of human XPR1 Deposited 2024-08-22 | Assembly 1 Insufficient information Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–696（696 aa）
Chain B
1–696（696 aa）
|
Not recorded | 8PE (2R)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(tetradecanoyloxy)propyl octadecanoate × 2 CLR CHOLESTEROL × 2 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.33 Å |
| 9JXD Cryo-EM structure of human XPR1 in apo state Deposited 2024-10-11 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
230–625（396 aa）
Chain B
230–625（396 aa）
|
Not recorded | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.29 Å |
| 9JXE Cryo-EM structure of apo human XPR1, class 1, with one visible SPX domain Deposited 2024-10-11 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–625（625 aa）
Chain B
1–625（625 aa）
|
Not recorded | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.85 Å |
| 9JXF Cryo-EM structure of apo human XPR1, class 2, with asymmetrically dimerized SPX domains Deposited 2024-10-11 | Assembly 1 Protein homooligomer Homooligomer；Protein × 10 PDB declaration: 12-meric（12） Review required |
Chain A
1–696（696 aa）
Chain B
1–696（696 aa）
|
Not recorded | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 4.31 Å |
| 9JXG Cryo-EM structure of apo human XPR1, class 3, with symmetrically dimerized SPX domains Deposited 2024-10-11 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–696（696 aa）
Chain B
1–696（696 aa）
|
Not recorded | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.75 Å |
| 9JXH Cryo-EM structure of human XPR1 in complex with InsP8 Deposited 2024-10-11 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
2–632（631 aa）
Chain B
2–632（631 aa）
|
Not recorded | I8P (1R,3S,4R,5S,6R)-2,4,5,6-tetrakis(phosphonooxy)cyclohexane-1,3-diyl bis[trihydrogen (diphosphate)] × 4 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.15 Å |
| 9JXI Cryo-EM structure of human XPR1 with InsP8 in an 'arch-like' intermediate state of the SPX domain Deposited 2024-10-11 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
2–624（623 aa）
Chain B
2–624（623 aa）
|
Not recorded | I8P (1R,3S,4R,5S,6R)-2,4,5,6-tetrakis(phosphonooxy)cyclohexane-1,3-diyl bis[trihydrogen (diphosphate)] × 4 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.31 Å |
| 9JXJ Cryo-EM structure of human XPR1 in a closed state at both the extracellular and intracellular gates, obtained through local refinement Deposited 2024-10-11 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
1–624（624 aa）
|
Not recorded | PO4 PHOSPHATE ION × 3 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.22 Å |
| 9JXK Cryo-EM structure of human XPR1 in a closed state at the intracellular gate and an open state at the extracellular gate, obtained through local refinement Deposited 2024-10-11 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
1–625（625 aa）
|
Not recorded | PO4 PHOSPHATE ION × 2 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.38 Å |
| 9JXL Cryo-EM structure of human XPR1 in an open state at the intracellular gate and a closed state at the extracellular gate, obtained through local refinement Deposited 2024-10-11 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
1–632（632 aa）
|
Not recorded | PO4 PHOSPHATE ION × 3 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.23 Å |
| 9JXM Cryo-EM structure of one subunit of the human XPR1 homodimer with both the intracellular and extracellular gates in an open state, obtained through local refinement Deposited 2024-10-11 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
1–632（632 aa）
|
Not recorded | PO4 PHOSPHATE ION × 2 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.48 Å |
| 9JXN Cryo-EM structure of human XPR1-R459C Deposited 2024-10-11 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
2–634（633 aa）
Chain B
2–634（633 aa）
|
Mutation：R459C Mutation：R459C | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.12 Å |
| 9JXO Cryo-EM structure of human XPR1-G621A Deposited 2024-10-11 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
2–632（631 aa）
Chain B
2–632（631 aa）
|
Mutation：G621A Mutation：G621A | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.48 Å |
| 9JXP Cryo-EM structure of human XPR1-R570L Deposited 2024-10-11 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
230–625（396 aa）
Chain B
230–625（396 aa）
|
Mutation：R570L Mutation：R570L | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.53 Å |
| 9JXQ Complex of XPR1-KIDINS220 Deposited 2024-10-11 | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
1–655（655 aa）
Chain B
1–655（655 aa）
|
Not recorded | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.44 Å |