Current Protein Identity：Q9ULW0
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Difference tags compare only the current result set; every original PDB and assembly record remains separate.
Related-Structure Differences
Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.
| PDB Entry | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Experimental Method | Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 1OL5 Structure of Aurora-A 122-403, phosphorylated on Thr287, Thr288 and bound to TPX2 1-43 Deposited 2003-08-06 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
1–43（43 aa）
Fragment：N-TERMINAL, RESIDUES 1-43
|
Not recorded | ADP ADENOSINE-5'-DIPHOSPHATE × 1 MG MAGNESIUM ION × 3 SO4 SULFATE ION × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 6.5；18% (W/V) PEG8000, 100 MM MES PH 6.5, 200 MM MGSO4
|
Resolution 2.50 Å R-free 0.252 |
| 3E5A Crystal structure of Aurora A in complex with VX-680 and TPX2 Deposited 2008-08-13 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
1–43（43 aa）
Fragment：Residues 1-43
|
Not recorded | VX6 CYCLOPROPANECARBOXYLIC ACID {4-[4-(4-METHYL-PIPERAZIN-1-YL)-6-(5-METHYL-2H-PYRAZOL-3-YLAMINO)-PYRIMIDIN-2-YLSULFANYL]-PHENYL}-AMIDE × 1 SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.9；293 K；16% PEG 3350 and 0.2 M Lithium sulfate buffered with 100 mM Bis-Tris, pH 6.9, VAPOR DIFFUSION, SITTING DROP, temperature 293.0K
|
Resolution 2.30 Å R-free 0.256 |
| 3HA6 Crystal structure of aurora A in complex with TPX2 and compound 10 Deposited 2009-05-01 | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain B
1–43（43 aa）
Fragment：UNP residues 1-43
|
Not recorded | 2JZ N~2~-(3,4-dimethoxyphenyl)-N~4~-[2-(2-fluorophenyl)ethyl]-N~6~-quinolin-6-yl-1,3,5-triazine-2,4,6-triamine × 2 | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 2.36 Å R-free 0.252 |
| 3HA6 Crystal structure of aurora A in complex with TPX2 and compound 10 Deposited 2009-05-01 | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
1–43（43 aa）
Fragment：UNP residues 1-43
|
Not recorded | 2JZ N~2~-(3,4-dimethoxyphenyl)-N~4~-[2-(2-fluorophenyl)ethyl]-N~6~-quinolin-6-yl-1,3,5-triazine-2,4,6-triamine × 1 | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 2.36 Å R-free 0.252 |
| 4C3P Structure of dephosphorylated Aurora A (122-403) bound to TPX2 and AMPPCP Deposited 2013-08-26 | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain B
1–43（43 aa）
Fragment：AURORA A KINASE BINDING DOMAIN, RESIDUES 1-43
Chain E
1–43（43 aa）
Fragment：AURORA A KINASE BINDING DOMAIN, RESIDUES 1-43
|
Not recorded | ACP PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER × 2 SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；291 K；CRYSTALS OF DEPHOSPHORYLATED A(122-403) IN COMPLEX WITH AMPPCP AND TPX2(1-43) WERE GROWN AT 18C BY VAPOR DIFFUSION AND THE HANGING DROP OBTAINED BY COMBINING 300UM DEP A(122-403) WITH 1.5MM AMPPCP AND 300UM TPX2(1-43) WITH 0.2M LITHIUM SULFATE MONOHYDRATE, 0.1M BISTRIS PH5.5, 25% PEG3350.
|
Resolution 2.69 Å R-free 0.289 |
| 5LXM Crystal structure of Aurora-A bound to a hydrocarbon-stapled proteomimetic of TPX2 Deposited 2016-09-22 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain D
6–43（38 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | ADP ADENOSINE-5'-DIPHOSPHATE × 1 PG4 TETRAETHYLENE GLYCOL × 1 SO4 SULFATE ION × 1 PEG DI(HYDROXYETHYL)ETHER × 2 MES 2-(N-MORPHOLINO)-ETHANESULFONIC ACID × 1 P4G 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE × 1 CL CHLORIDE ION × 1 MG MAGNESIUM ION × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；295 K；MORPHEUS Crystallization Screen condition C1
|
Resolution 2.08 Å R-free 0.243 |
| 6BJC TPX2_mini decorated GMPCPP-microtubule Deposited 2017-11-05 | Assembly 1 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: tetradecameric（14） Consistent with protein count |
Chain P
1–747（747 aa）
Chain T
1–747（747 aa）
|
Not recorded | GTP GUANOSINE-5'-TRIPHOSPHATE × 6 MG MAGNESIUM ION × 12 G2P PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER × 6 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 6.8；BRB80
cryo-EM vitrification conditions
Cryogen ETHANE；blot for 4 seconds before plunging
|
Resolution 3.30 Å |
| 6VPG TPX2 residues 7-20 fused to Aurora A residues 116-389 in complex with AMP-PNP Deposited 2020-02-03 | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
7–20（14 aa）
Fragment：kinase domain,kinase domain
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 1 GOL GLYCEROL × 1 CL CHLORIDE ION × 2 MG MAGNESIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
EVAPORATION；pH 7；298 K；0.1 M HEPES pH 7, 0.9 M KCl, 1.08 M ammonium sulfate, 12% glycerol
|
Resolution 2.64 Å R-free 0.245 |
| 6VPH TPX2 residues 7-20 fused to Aurora A residues 116-389 modified with cacodylate and in complex with AMP-PNP Deposited 2020-02-03 | Assembly 1 Insufficient information Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
7–20（14 aa）
Fragment：kinase domain
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | CL CHLORIDE ION × 4 DTD DITHIANE DIOL × 2 ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 2 GOL GLYCEROL × 8 | X-RAY DIFFRACTION |
X-ray crystallization conditions
EVAPORATION；pH 6；298 K；0.1 M sodium cacodylate pH 6, 2 M NaCl, 9% PEG 3350
|
Resolution 2.14 Å R-free 0.216 |
| 6VPI TPX2 residues 7-20 fused to Aurora A residues 116-389 C247V + D256N + C319V triple mutant disulfide homodimer in complex with AMP-PNP Deposited 2020-02-03 | Assembly 1 Insufficient information Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
7–20（14 aa）
Fragment：kinase domain
|
Not recorded | ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 2 MG MAGNESIUM ION × 4 MLA MALONIC ACID × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
EVAPORATION；pH 7；298 K；0.336 M sodium malonate pH 7.5, 0.348 M sodium malonate pH 6.5
|
Resolution 2.00 Å R-free 0.215 |
| 6VPJ TPX2 residues 7-20 fused to Aurora A residues 116-389 C247V + C319V double mutant dephosphorylated, and in complex with AMP-PNP Deposited 2020-02-03 | Assembly 1 Insufficient information Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
7–20（14 aa）
Fragment：kinase domain
|
Not recorded | ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
EVAPORATION；298 K；0.2 M sodium citrate pH 4, 0.8 M sodium citrate pH 5.5, 6% PEG 3350, 8% trehalose
|
Resolution 2.10 Å R-free 0.215 |
| 6VPL TPX2 residues 7-20 fused to Aurora A residues 116-389 with C290 disulfide bonded to compound 7-80, and in complex with AMP-PNP Deposited 2020-02-03 | Assembly 1 Insufficient information Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
7–20（14 aa）
Fragment：kinase domain
Chain B
7–20（14 aa）
Fragment：kinase domain
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | MG MAGNESIUM ION × 4 ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 2 MLA MALONIC ACID × 2 R7D N~2~-{(2R)-2-hydroxy-2-[4-(trifluoromethyl)phenyl]acetyl}-N-[(pyridin-2-yl)methyl]-L-cysteinamide × 2 GOL GLYCEROL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
EVAPORATION；pH 5.5；298 K；0.1 M sodium malonate pH 5.5, 12% PEG 3350, 17% glycerol
|
Resolution 1.86 Å R-free 0.201 |
| 6VPM TPX2 residues 7-20 fused to Aurora A residues 116-389 with C290 disulfide bonded to compound 8-34, and in complex with AMP-PNP Deposited 2020-02-03 | Assembly 1 Insufficient information Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
7–20（14 aa）
Fragment：kinase domain
Chain B
7–20（14 aa）
Fragment：kinase domain
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | MG MAGNESIUM ION × 2 AMP ADENOSINE MONOPHOSPHATE × 2 R74 N~2~-[(2H-1,3-benzodioxol-5-yl)acetyl]-N-[(pyridin-4-yl)methyl]-L-cysteinamide × 2 MLA MALONIC ACID × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
EVAPORATION；pH 5.5；298 K；0.1 M sodium malonate pH 5.5, 7.5% PEG 3350, 11% glycerol
|
Resolution 1.58 Å R-free 0.203 |
| 6XKA TPX2 residues 7-20 fused to Aurora A residues 116-389 dephosphorylated, and CoAlated on C290 Deposited 2020-06-26 | Assembly 1 Insufficient information Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
7–20（14 aa）
Fragment：kinase domain
|
Not recorded | COA COENZYME A × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
EVAPORATION；298 K；0.2 M sodium citrate pH 4, 0.1 M sodium citrate pH 5.5, 18 mM sodium malonate pH 6, 4 mM MgCl2
|
Resolution 2.65 Å R-free 0.279 |
| 9SUY TPX2 7-20 fused to Aurora-A residues 116-389, covalently modified on Cys290 by F104 (7-((perfluorophenyl)sulfonyl)-3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine) Deposited 2025-09-30 | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
7–20（14 aa）
|
Mutation：D274N | MG MAGNESIUM ION × 2 ADP ADENOSINE-5'-DIPHOSPHATE × 1 A1JQV 7-[2,3,5,6-tetrakis(fluoranyl)phenyl]sulfonyl-3-(trifluoromethyl)-6,8-dihydro-5~{H}-[1,2,4]triazolo[4,3-a]pyrazine × 1 GOL GLYCEROL × 1 PGE TRIETHYLENE GLYCOL × 1 MES 2-(N-MORPHOLINO)-ETHANESULFONIC ACID × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；291 K；Morpheus fusion condition E4 (0.1M Carboxylic acids, 1.2% Cholic acid derivative, 0.1M Buffer system 1, 30% precipitant mix 3).
|
Resolution 2.27 Å R-free 0.251 |