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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：Q9Y572 New Search
8PDB entries
12Biological assembly
23chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
12KL SSNMR Structure of Anti-necroptosis Viral:Human Functional Hetero-amyloid M45:RIPK3 Deposited 2026-04-09 Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain A 388–518（131 aa）
Chain C 388–518（131 aa）
Chain E 388–518（131 aa）
Chain G 388–518（131 aa）
Not recorded No recorded non-water small molecule SOLID-STATE NMR
NMR measurement conditions pH 7.4；285 K；Ionic strength (raw mmCIF value) 50；Pressure 1
NMR sample composition 5 mM U-13C,15N M45, 5 mM RIPK3, water | water
NMR sample composition 5 mM 2-13C-glycerol,15N M45, 5 mM 1,3-13C-glycerol,15N RIPK3, water | water
NMR sample composition 5 mM U-13C,15N RIPK3, 5 mM M45, water | water
NMR sample composition 5 mM U-13C,15N RIPK3, water | water
NMR sample composition 5 mM U-13C,15N M45, water | water
NMR sample composition 5 mM 1,3-13C-glycerol, 15N M45, 5 mM RIPK3, water | water
NMR sample composition 5 mM 2-13C-glycerol,15N M45, 5 mM RIPK3, water | water
NMR sample composition 5 mM 1,3-13C-glycerol,15N RIPK3, 5 mM M45, water | water
NMR sample composition 5 mM 2-13C-glycerol,15N RIPK3, 5 mM M45, water | water
NMR sample composition 5 mM 2-13C-glycerol,15N RIPK3, 5 mM 1,3-13C-glycerol,15N M45, water | water
Resolution not provided
5ZCK Structure of the RIP3 core region Deposited 2018-02-18 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 458–461（4 aa）
Not recorded NA SODIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；0.2 M magnesium chloride, 0.1 M sodium cacodylate, 20% (v/v) PEG 200
Resolution 1.27 Å R-free 0.152
7DA4 Cryo-EM structure of amyloid fibril formed by human RIPK3 Deposited 2020-10-14 Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain A 388–518（131 aa） Fragment：C-terminal domain
Chain B 388–518（131 aa） Fragment：C-terminal domain
Chain C 388–518（131 aa） Fragment：C-terminal domain
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.24 Å
7DAC Human RIPK3 amyloid fibril revealed by solid-state NMR Deposited 2020-10-16 Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count
Chain A 418–518（101 aa）
Chain B 418–518（101 aa）
Chain C 418–518（101 aa）
Chain D 418–518（101 aa）
Chain E 418–518（101 aa）
Not recorded No recorded non-water small molecule SOLID-STATE NMR
NMR measurement conditions pH 7.5；298 K；Ionic strength (raw mmCIF value) 0；Pressure 1
NMR sample composition 5 mg/mL [U-100% 13C; U-100% 15N] human RIPK3 fibrils, 95% H2O/5% D2O | 95% H2O/5% D2O
NMR sample composition 5 mg/mL [U-100% 2-13C Glycerol; U-100% 15N] human RIPK3 fibrils, 95% H2O/5% D2O | 95% H2O/5% D2O
NMR sample composition 5 mg/mL [U-100% 1, 3-13C Glycerol; U-100% 15N] human RIPK3 fibrils, 95% H2O/5% D2O | 95% H2O/5% D2O
NMR sample composition 5 mg/mL [U-50% 13C; natural abundance N][natural abandance 13C; U-50% 15N] human RIPK3 fibrils, 95% H2O/5% D2O | 95% H2O/5% D2O
Resolution not provided
7MON Structure of human RIPK3-MLKL complex Deposited 2021-05-03 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 1–316（316 aa）
Mutation：C3S, C110A Non-standard monomer：Yes (specific site not provided by mmCIF) ZL1 N-[4-({2-[(cyclopropanecarbonyl)amino]pyridin-4-yl}oxy)-3-fluorophenyl]-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；281.15 K；0.2 M ammonium acetate 30%w/v PEG 4000 0.1 M trisodium citrate-citric acid pH 5.5
Resolution 2.23 Å R-free 0.260
7MX3 Crystal structure of human RIPK3 complexed with GSK'843 Deposited 2021-05-18 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 2–315（314 aa）
Mutation：C3S, C110A ZOV 3-(1,3-benzothiazol-5-yl)-7-(1,3-dimethyl-1H-pyrazol-5-yl)thieno[3,2-c]pyridin-4-amine × 1 EDO 1,2-ETHANEDIOL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；281.15 K；0.2 M magnesium chloride, 25% (w/v) polyethylene glycol 3350, 0.1 M Tris pH 8.5
Resolution 3.23 Å R-free 0.285
7MX3 Crystal structure of human RIPK3 complexed with GSK'843 Deposited 2021-05-18 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain B 2–315（314 aa）
Mutation：C3S, C110A ZOV 3-(1,3-benzothiazol-5-yl)-7-(1,3-dimethyl-1H-pyrazol-5-yl)thieno[3,2-c]pyridin-4-amine × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；281.15 K；0.2 M magnesium chloride, 25% (w/v) polyethylene glycol 3350, 0.1 M Tris pH 8.5
Resolution 3.23 Å R-free 0.285
7MX3 Crystal structure of human RIPK3 complexed with GSK'843 Deposited 2021-05-18 Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain C 2–315（314 aa）
Mutation：C3S, C110A ZOV 3-(1,3-benzothiazol-5-yl)-7-(1,3-dimethyl-1H-pyrazol-5-yl)thieno[3,2-c]pyridin-4-amine × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；281.15 K；0.2 M magnesium chloride, 25% (w/v) polyethylene glycol 3350, 0.1 M Tris pH 8.5
Resolution 3.23 Å R-free 0.285
7MX3 Crystal structure of human RIPK3 complexed with GSK'843 Deposited 2021-05-18 Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain D 2–315（314 aa）
Mutation：C3S, C110A ZOV 3-(1,3-benzothiazol-5-yl)-7-(1,3-dimethyl-1H-pyrazol-5-yl)thieno[3,2-c]pyridin-4-amine × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；281.15 K；0.2 M magnesium chloride, 25% (w/v) polyethylene glycol 3350, 0.1 M Tris pH 8.5
Resolution 3.23 Å R-free 0.285
8Z94 Cryo-EM structure of RIPK1 RHIM PFFs cross seeded RIPK3 RHIM amyloid fibril Deposited 2024-04-22 Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain A 388–518（131 aa）
Chain B 388–518（131 aa）
Chain C 388–518（131 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.56 Å
9LFU Crystal structure of human RIP3 kinase domain complexed with LK01003 Deposited 2025-01-09 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 2–315（314 aa）
Mutation：C3S, C110A A1D97 2-cyclopentyl-~{N}-(6-propan-2-ylsulfonylquinolin-4-yl)-1,3-benzothiazol-5-amine × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；293 K；0.2 M magnesium chloride, 22.5% (w/v) polyethylene glycol 3350, 0.1 M Tris, pH 7.5
Resolution 2.93 Å R-free 0.319
9LFU Crystal structure of human RIP3 kinase domain complexed with LK01003 Deposited 2025-01-09 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain B 2–315（314 aa）
Mutation：C3S, C110A A1D97 2-cyclopentyl-~{N}-(6-propan-2-ylsulfonylquinolin-4-yl)-1,3-benzothiazol-5-amine × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；293 K；0.2 M magnesium chloride, 22.5% (w/v) polyethylene glycol 3350, 0.1 M Tris, pH 7.5
Resolution 2.93 Å R-free 0.319

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.