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{
"code": "SASDBZ6",
"status": "Published",
"type_of_curve": "Merged",
"angular_unit": "1/nm",
"project": {
"title": "Structural Basis for Draxin-Modulated Axon Guidance and Fasciculation by Netrin-1 through DCC.",
"publication": {
"title": "Structural Basis for Draxin-Modulated Axon Guidance and Fasciculation by Netrin-1 through DCC.",
"author_list": "Liu Y, Bhowmick T, Liu Y, Gao X, Mertens HDT, Svergun DI, Xiao J, Zhang Y, Wang JH, Meijers R",
"journal": "Neuron",
"doi": "10.1016/j.neuron.2018.02.010",
"pmid": "29503192",
"published_date": "2018 Mar 21"
},
"status": "released",
"submitted_date": "2016-10-10",
"released_date": "2017-11-06"
},
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},
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"city": "DESY; Hamburg",
"country": "Germany",
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},
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{
"long_name": "Draxin",
"short_name": "Draxin",
"sequence": "MAGPAIHTAPMLFLVLLLPLELSLAGALAPGTPARNLPENHIDLPGPALWTPQASHHRRRGPGKKEWGPGLPSQAQDGAVVTATRQASRLPEAEGLLPEQSPAGLLQDKDLLLGLALPYPEKENRPPGWERTRKRSREHKRRRDRLRLHQGRALVRGPSSLMKKAELSEAQVLDAAMEESSTSLAPTMFFLTTFEAAPATEESLILPVTSLRPQQAQPRSDGEVMPTLDMALFDWTDYEDLKPDGWPSAKKKEKHRGKLSSDGNETSPAEGEPCDHHQDCLPGTCCDLREHLCTPHNRGLNNKCFDDCMCVEGLRCYAKFHRNRRVTRRKGRCVEPETANGDQGSFINVGAPLEGSENLYFQGSAWSHPQFEKGGGSGGGSGGSAWSHPQFEKGAHHHHHHHHH",
"organism": "Homo sapiens",
"uniprot_code": "Q8NBI3",
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"oligomerization": "monomer",
"molecular_type": "protein",
"uniprot_sequence": "MAGPAIHTAPMLFLVLLLPLELSLAGALAPGTPARNLPENHIDLPGPALWTPQASHHRRR\nGPGKKEWGPGLPSQAQDGAVVTATRQASRLPEAEGLLPEQSPAGLLQDKDLLLGLALPYP\nEKENRPPGWERTRKRSREHKRRRDRLRLHQGRALVRGPSSLMKKAELSEAQVLDAAMEES\nSTSLAPTMFFLTTFEAAPATEESLILPVTSLRPQQAQPRSDGEVMPTLDMALFDWTDYED\nLKPDGWPSAKKKEKHRGKLSSDGNETSPAEGEPCDHHQDCLPGTCCDLREHLCTPHNRGL\nNNKCFDDCMCVEGLRCYAKFHRNRRVTRRKGRCVEPETANGDQGSFINV",
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"deuteration": null,
"molecule_source": "biological",
"molecule_description": null
}
],
"buffer": {
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"comment": null,
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"concentration": null,
"pka": null,
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},
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"name": "Draxin",
"ext_coefficient": null,
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},
"contributor": [
{
"affiliation": [
{
"short_name": "EMBL-Hamburg",
"address": "Notkestraße 85, Geb. 25A, 22607 Hamburg, Deutschland, Germany",
"full_name": "European Molecular Biology Laboratory (EMBL) - Hamburg outstation",
"webpage": "http://www.embl-hamburg.de/index.php"
}
],
"contributor_name": "Haydyn",
"contributor_surname": "Mertens",
"orcid": null
}
],
"concentration_method": null,
"concentration_unit": null,
"date": "2015-08-19",
"storage_temperature": 20.0,
"cell_temperature": 20.0,
"exposure_time": 0.05,
"number_of_frames": 20,
"wavelength": 1.24,
"sample_detector_distance": 3.1,
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"s_min": 0.022,
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},
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"description": "Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway",
"experiment_description": null,
"tags": [
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"last_modified": "2023-06-21T07:56:39.492710+02:00",
"bragg_peak": []
}
