查看完整 summary.json 原文
{
"code": "SASDCS2",
"status": "Published",
"type_of_curve": "Single concentration",
"angular_unit": "1/A",
"project": {
"title": "Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.",
"publication": {
"title": "Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.",
"author_list": "Lambert JP, Picaud S, Fujisawa T, Hou H, Savitsky P, Uusküla-Reimand L, Gupta GD, Abdouni H, Lin ZY, Tucholska M, Knight JDR, Gonzalez-Badillo B, St-Denis N, Newman JA, Stucki M, Pelletier L, Bandeira N, Wilson MD, Filippakopoulos P, Gingras AC",
"journal": "Mol Cell",
"doi": "10.1016/j.molcel.2018.11.006",
"pmid": "30554943",
"published_date": "2018 Dec 13"
},
"status": "released",
"submitted_date": "2017-04-12",
"released_date": "2018-09-10"
},
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},
"name": "Diamond Light Source",
"city": "Didcot",
"country": "UK",
"beamline_name": "B21",
"beam_geometry": "1 x 5 mm",
"type_of_source": "X-ray synchrotron",
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},
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{
"long_name": "Bromodomain-containing protein 3",
"short_name": "BRD3",
"sequence": "SMNPPPPEVSNPSKPGRKTNQLQYMQNVVVKTLWKHQFAWPFYQPVDAIKLNLPDYHKIIKNPMDMGTIKKRLENNYYWSASECMQDFNTMFTNCYIYNKPTDDIVLMAQALEKIFLQKVAQMPQEEVELLPPAPKGKGRKPAAGAQSAGTQQVAAVSSVSPATPFQSVPPTVSQTPVIAATPVPTITANVTSVPVPPAAAPPPPATPIVPVVPPTPPVVKKKGVKRKADTTTPTTSAITASRSESPPPLSDPKQAKVVARRESGGRPIKPPKKDLEDGEVPQHAGKKGKLSEHLRYCDSILREMLSKKHAAYAWPFYKPVDAEALELHDYHDIIKHPMDLSTVKRKMDGREYPDAQGFAADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDE",
"organism": "Homo sapiens",
"uniprot_code": "Q15059",
"uniprot_range_first": 20,
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"oligomerization": "monomer",
"molecular_type": "protein",
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"number_molecules": 1,
"complex_state": false,
"deuteration": null,
"molecule_source": "biological",
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}
],
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"concentration": null,
"pka": null,
"ph": 7.5,
"deuteration": null
},
"purity_method": null,
"name": "Bromodomain-containing protein 3 (BRD3) tandem bromodomains",
"ext_coefficient": null,
"contrast": null,
"specific_vol": null,
"dry_vol": null,
"absorbption": null,
"deuteration": null,
"mixture": null
},
"contributor": [
{
"affiliation": [
{
"short_name": null,
"address": "Oxford, UK",
"full_name": "University of Oxford",
"webpage": "http://www.ox.ac.uk/"
}
],
"contributor_name": "Joseph",
"contributor_surname": "Newman",
"orcid": null
}
],
"concentration_method": null,
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"date": "2017-01-13",
"storage_temperature": 10.0,
"cell_temperature": 10.0,
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},
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}
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}
],
"estimated_volume_method": "DAMMIN",
"pddf_software": "ATSAS GNOM",
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"description": null,
"experiment_description": "Synchrotron SAXS data from solutions of BRD3 tandem bromodomains in 20 mM HEPES, 150 mM NaCl, 2% glycerol, 0.5 mM TCEP, pH 7.5 were collected on the B21 beam line at the Diamond Light Source (Oxfordshire, UK) using a Pilatus 2M detector at a sample-detector distance of 3.9 m and at a wavelength of λ = 0.1 nm (I(s) vs s, where s = 4πsinθ/λ and 2θ is the scattering angle). In-line continuous flow HPLC-SAXS was employed at 10°C with a sample injection concentration of 13 mg/ml onto a Shodex 404 column. 12 successive 10 second frames were collected through the HPLC-elution peak. The data were normalized to the intensity of the transmitted beam and radially averaged; the scattering of the solvent-blank was subtracted and the different curves underwent single-value decomposition to produce the average-median scattering data displayed in this entry.",
"tags": [],
"intensity_unit": null,
"experimental_mw": 44.49,
"experimental_mw_error": null,
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"guinier_rg": 6.22,
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"pddf_dmax": 21.5,
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"porod_volume": 210.0,
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"estimated_volume": 81.0,
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"guinier_point_first": 23,
"guinier_point_last": 71,
"pddf_point_first": null,
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"i0_calibration_standard_data": null,
"intensities_log_log_plot": "SASDCS2_datloglog_img.png",
"symmetry": null,
"last_modified": "2019-12-06T13:07:15.624532+01:00",
"bragg_peak": []
}查看完整 manifest.json 原文
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