查看完整 summary.json 原文
{
"code": "SASDCU2",
"status": "Published",
"type_of_curve": "Single concentration",
"angular_unit": "1/A",
"project": {
"title": "Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.",
"publication": {
"title": "Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.",
"author_list": "Lambert JP, Picaud S, Fujisawa T, Hou H, Savitsky P, Uusküla-Reimand L, Gupta GD, Abdouni H, Lin ZY, Tucholska M, Knight JDR, Gonzalez-Badillo B, St-Denis N, Newman JA, Stucki M, Pelletier L, Bandeira N, Wilson MD, Filippakopoulos P, Gingras AC",
"journal": "Mol Cell",
"doi": "10.1016/j.molcel.2018.11.006",
"pmid": "30554943",
"published_date": "2018 Dec 13"
},
"status": "released",
"submitted_date": "2017-04-12",
"released_date": "2018-09-10"
},
"pddf_data": "https://www.sasbdb.org/media/p_of_R_files/SASDCU2.out",
"intensities_data": "https://www.sasbdb.org/media/intensities_files/SASDCU2.dat",
"intensities_log_plot": "https://www.sasbdb.org/media/intensities_files/scattering_plots/SASDCU2_dat_img.png",
"intensities_kratky_plot": "https://www.sasbdb.org/media/intensities_files/scattering_plots/SASDCU2_kratky_img.png",
"pddf_plot": "https://www.sasbdb.org/media/p_of_R_files/pofr_images/SASDCU2_pofr_img.png",
"intensities_guinier_plot": "https://www.sasbdb.org/media/intensities_files/scattering_plots/SASDCU2_guinier_img.png",
"sascif_data": "https://www.sasbdb.org/media/sascif/sascif_files/SASDCU2.sascif",
"experiment": {
"instrument": {
"detector": {
"type": null,
"name": "Pilatus 2M",
"resolution": null
},
"name": "Diamond Light Source",
"city": "Didcot",
"country": "UK",
"beamline_name": "B21",
"beam_geometry": "1 x 5 mm",
"type_of_source": "X-ray synchrotron",
"point_source": null,
"line_collimation": null,
"sample_path_length": null,
"line_collimation_slitlength": null,
"line_collimation_integrationwidth": null,
"xray_energy": null,
"beam_profile_ah": null,
"beam_profile_al": null
},
"sample": {
"molecule": [
{
"long_name": "Bromodomain testis-specific protein",
"short_name": "BRDT",
"sequence": "SMAIIVNPPPPEYINTKKNGRLTNQLQYLQKVVLKDLWKHSFSWPFQRPVDAVKLQLPDYYTIIKNPMDLNTIKKRLENKYYAKASECIEDFNTMFSNCYLYNKPGDDIVLMAQALEKLFMQKLSQMPQEEQVVGVKERIKKGTQQNIAVSSAKEKSSPSATEKVFKQQEIPSVFPKTSISPLNVVQGASVNSSSQTAAQVTKGVKRKADTTTPATSAVKASSEFSPTFTEKSVALPPIKENMPKNVLPDSQQQYNVVKTVKVTEQLRHCSEILKEMLAKKHFSYAWPFYNPVDVNALGLHNYYDVVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYKYNPPDHEVVTMARMLQDVFETHFSKIPIE",
"organism": "Homo sapiens",
"uniprot_code": "Q58F21",
"uniprot_range_first": 9,
"uniprot_range_last": 379,
"oligomerization": "monomer",
"molecular_type": "protein",
"uniprot_sequence": "MSLPSRQTAIIVNPPPPEYINTKKNGRLTNQLQYLQKVVLKDLWKHSFSWPFQRPVDAVK\nLQLPDYYTIIKNPMDLNTIKKRLENKYYAKASECIEDFNTMFSNCYLYNKPGDDIVLMAQ\nALEKLFMQKLSQMPQEEQVVGVKERIKKGTQQNIAVSSAKEKSSPSATEKVFKQQEIPSV\nFPKTSISPLNVVQGASVNSSSQTAAQVTKGVKRKADTTTPATSAVKASSEFSPTFTEKSV\nALPPIKENMPKNVLPDSQQQYNVVKTVKVTEQLRHCSEILKEMLAKKHFSYAWPFYNPVD\nVNALGLHNYYDVVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYKYNPPDHEVVT\nMARMLQDVFETHFSKIPIEPVESMPLCYIKTDITETTGRENTNEASSEGNSSDDSEDERV\nKRLAKLQEQLKAVHQQLQVLSQVPFRKLNKKKEKSKKEKKKEKVNNSNENPRKMCEQMRL\nKEKSKRNQPKKRKQQFIGLKSEDEDNAKPMNYDEKRQLSLNINKLPGDKLGRVVHIIQSR\nEPSLSNSNPDEIEIDFETLKASTLRELEKYVSACLRKRPLKPPAKKIMMSKEELHSQKKQ\nELEKRLLDVNNQLNSRKRQTKSDKTQPSKAVENVSRLSESSSSSSSSSESESSSSDLSSS\nDSSDSESEMFPKFTEVKPNDSPSKENVKKMKNECIPPEGRTGVTQIGYCVQDTTSANTTL\nVHQTTPSHVMPPNHHQLAFNYQELEHLQTVKNISPLQILPPSGDSEQLSNGITVMHPSGD\nSDTTMLESECQAPVQKDIKIKNADSWKSLGKPVKPSGVMKSSDELFNQFRKAAIEKEVKA\nRTQELIRKHLEQNTKELKASQENQRDLGNGLTVESFSNKIQNKCSGEEQKEHQQSSEAQD\nKSKLWLLKDRDLARQKEQERRRREAMVGTIDMTLQSDIMTMFENNFD",
"mw": 42.59,
"total_mw": 42.59,
"number_molecules": 1,
"complex_state": false,
"deuteration": null,
"molecule_source": "biological",
"molecule_description": null
}
],
"buffer": {
"name": "20 mM HEPES, 150 mM NaCl, 2% glycerol, 0.5 mM TCEP",
"concentration_unit": null,
"comment": null,
"additive": null,
"concentration": null,
"pka": null,
"ph": 7.5,
"deuteration": null
},
"purity_method": null,
"name": "Bromodomain testis-specific protein (BRDT) tandem bromodomains",
"ext_coefficient": null,
"contrast": null,
"specific_vol": null,
"dry_vol": null,
"absorbption": null,
"deuteration": null,
"mixture": null
},
"contributor": [
{
"affiliation": [
{
"short_name": null,
"address": "Oxford, UK",
"full_name": "University of Oxford",
"webpage": "http://www.ox.ac.uk/"
}
],
"contributor_name": "Joseph",
"contributor_surname": "Newman",
"orcid": null
}
],
"concentration_method": null,
"concentration_unit": null,
"date": "2017-01-13",
"storage_temperature": 10.0,
"cell_temperature": 10.0,
"exposure_time": 10.0,
"number_of_frames": 12,
"wavelength": 0.1,
"sample_detector_distance": 3.92,
"concentration_min": null,
"concentration_max": 13.0,
"sample_volume": null,
"flow_rate": null,
"s_min": 0.04,
"s_max": 4.398,
"total_exposure_time": null,
"seccolumn": null
},
"fits": [
{
"models": [
{
"model_plot": "https://www.sasbdb.org/media/pdb_file/images/SASDCU2_fit1_model1_img.png",
"software": "DAMMIN",
"pdb_link": [],
"model_title": null,
"type_of_model": "dummy",
"software_version": "",
"model_data": "https://www.sasbdb.org/media/pdb_file/SASDCU2_fit1_model1.pdb",
"model_mw": 40.15,
"bead_radius": 3.75,
"log": "https://www.sasbdb.org/media/log_files/200-slow.log",
"symmetry": "",
"comment": "",
"user": 208
}
],
"fit_unit": "1/A",
"fit_plot": "https://www.sasbdb.org/media/fitting_files/scattering_plots/SASDCU2_fit1_fit_img.png",
"software": "DAMMIN",
"chi_square_value": 1.27,
"p_value": 0.00041,
"fit_residual_plot": "SASDCU2_fit1_fitresiduals_img.png",
"fit_data": "https://www.sasbdb.org/media/fitting_files/SASDCU2_fit1.fir",
"fit_log": "https://www.sasbdb.org/media/fitting_files/log_files/200-slow.log",
"software_version": "",
"description": null
}
],
"estimated_volume_method": "DAMMIN",
"pddf_software": "ATSAS GNOM",
"pddf_software_version": null,
"i0_calibration_standard": null,
"description": null,
"experiment_description": "Synchrotron SAXS data from solutions of BRDT tandem bromodomains in 20 mM HEPES, 150 mM NaCl, 2% glycerol, 0.5 mM TCEP, pH 7.5 were collected on the B21 beam line at the Diamond Light Source (Oxfordshire, UK) using a Pilatus 2M detector at a sample-detector distance of 3.9 m and at a wavelength of λ = 0.1 nm (I(s) vs s, where s = 4πsinθ/λ and 2θ is the scattering angle). In-line continuous flow HPLC-SAXS was employed at 10°C with a sample injection concentration of 13 mg/ml onto a Shodex 404 column. 12 successive 10 second frames were collected through the HPLC-elution peak. The data were normalized to the intensity of the transmitted beam and radially averaged; the scattering of the solvent-blank was subtracted and the different curves underwent single-value decomposition to produce the average-median scattering data displayed in this entry.",
"tags": [],
"intensity_unit": null,
"experimental_mw": 42.0,
"experimental_mw_error": null,
"guinier_i0_mw": null,
"guinier_i0_mw_error": null,
"porod_mw": 39.0,
"porod_mw_error": null,
"pddf_i0": 0.0853,
"pddf_i0_error": null,
"guinier_i0": 0.083,
"guinier_i0_error": 0.0008,
"pddf_rg": 5.55,
"pddf_rg_error": 0.06,
"guinier_rg": 5.13,
"guinier_rg_error": 0.09,
"pddf_dmax": 20.0,
"pddf_dmax_error": null,
"porod_volume": 200.0,
"porod_volume_error": null,
"estimated_volume": 80.0,
"estimated_volume_error": null,
"guinier_point_first": 26,
"guinier_point_last": 80,
"pddf_point_first": null,
"pddf_point_last": null,
"i0_calibration_standard_data": null,
"intensities_log_log_plot": "SASDCU2_datloglog_img.png",
"symmetry": null,
"last_modified": "2019-12-06T13:07:15.624532+01:00",
"bragg_peak": []
}查看完整 manifest.json 原文
{
"code": "SASDCU2",
"status": "success",
"started_at": "2026-08-11T16:39:33.162877+00:00",
"finished_at": "2026-08-11T16:39:41.809279+00:00",
"source_last_modified": "2019-12-06T13:07:15.624532+01:00",
"files": [
{
"status": "downloaded",
"url": "https://www.sasbdb.org/rest-api/entry/summary/SASDCU2/",
"path": "/data/saxsdb/sasbdb/entries/u2/sasdcu2/source/summary.json",
"size": 8679,
"sha256": "9e878f97531476d6eb96c31e213d3b70e4603f6710172840be0ac55a39221cbe"
},
{
"status": "downloaded",
"url": "https://www.sasbdb.org/media/intensities_files/SASDCU2.dat",
"path": "/data/saxsdb/sasbdb/entries/u2/sasdcu2/source/SASDCU2.dat",
"size": 73603,
"sha256": "588edcde19be95733795912eb51b078640cb678a81057c653ff5caa83f102645",
"role": "curve"
},
{
"status": "downloaded",
"url": "https://www.sasbdb.org/media/p_of_R_files/SASDCU2.out",
"path": "/data/saxsdb/sasbdb/entries/u2/sasdcu2/source/SASDCU2.out",
"size": 38914,
"sha256": "4ab2cfb1a3f382d8461ebd26d6563ae58b2f8b57b3637b613f5101a346c82a9d",
"role": "pddf"
},
{
"status": "downloaded",
"url": "https://www.sasbdb.org/media/sascif/sascif_files/SASDCU2.sascif",
"path": "/data/saxsdb/sasbdb/entries/u2/sasdcu2/source/SASDCU2.sascif",
"size": 182860,
"sha256": "d37325b182ed08b803f4e7f6b85060f7c2a064b736497b81dea514e0d5b71a63",
"role": "sascif"
},
{
"status": "downloaded",
"url": "https://www.sasbdb.org/media/zip_directories/SASDCU2.zip",
"path": "/data/saxsdb/sasbdb/entries/u2/sasdcu2/source/SASDCU2.zip",
"size": 43839,
"sha256": "e321dbf833d4ffe6db2eebbc8efa9819b08a7eade9cebd1dbcc616312177bef7",
"role": "full_entry_zip",
"zip_member_count": 4,
"zip_validation": "central_directory_readable"
}
]
}
