Fc-region of Immunoglobulin G1, M135Y/S137T/T139E mutant (IgG1 Fc-YTE)

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  "status": "Published",
  "type_of_curve": "Merged",
  "angular_unit": "1/A",
  "project": {
    "title": "Conformational Plasticity of the Immunoglobulin Fc Domain in Solution.",
    "publication": {
      "title": "Conformational Plasticity of the Immunoglobulin Fc Domain in Solution.",
      "author_list": "Remesh SG, Armstrong AA, Mahan AD, Luo J, Hammel M",
      "journal": "Structure",
      "doi": "10.1016/j.str.2018.03.017",
      "pmid": "29731233",
      "published_date": "2018 Jul 3"
    },
    "status": "released",
    "submitted_date": "2018-03-06",
    "released_date": "2018-04-10"
  },
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  "intensities_kratky_plot": "https://www.sasbdb.org/media/intensities_files/scattering_plots/SASDDV4_kratky_img.png",
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  "experiment": {
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      "detector": {
        "type": null,
        "name": "Pilatus3 X 2M",
        "resolution": 172.0
      },
      "name": "Advanced Light Source (ALS)",
      "city": "Berkeley, CA",
      "country": "USA",
      "beamline_name": "12.3.1 (SIBYLS)",
      "beam_geometry": "",
      "type_of_source": "X-ray synchrotron",
      "point_source": null,
      "line_collimation": null,
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      "line_collimation_integrationwidth": null,
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    },
    "sample": {
      "molecule": [
        {
          "long_name": "Immunoglobulin heavy constant gamma 1 M255Y/S257T/T259E",
          "short_name": "IgG1 Fc-YTE",
          "sequence": "TCPPCPAPELLGGPSVFLFPPKPKDTLYITREPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPR\r\nEEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTK\r\nNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVM\r\nHEALHNHYTQKSLSLSPGK",
          "organism": "Homo sapiens",
          "uniprot_code": "P01857",
          "uniprot_range_first": null,
          "uniprot_range_last": null,
          "oligomerization": "dimer",
          "molecular_type": "protein",
          "uniprot_sequence": "ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSS\nGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGG\nPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYN\nSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDE\nLTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRW\nQQGNVFSCSVMHEALHNHYTQKSLSLSPGK",
          "mw": 26.6,
          "total_mw": 53.2,
          "number_molecules": 2,
          "complex_state": false,
          "deuteration": null,
          "molecule_source": "biological",
          "molecule_description": null
        }
      ],
      "buffer": {
        "name": "20 mM HEPES, 50mM NaCl",
        "concentration_unit": null,
        "comment": null,
        "additive": null,
        "concentration": null,
        "pka": null,
        "ph": 7.5,
        "deuteration": null
      },
      "purity_method": null,
      "name": "Fc-region of Immunoglobulin G1, M135Y/S137T/T139E mutant (IgG1 Fc-YTE)",
      "ext_coefficient": null,
      "contrast": null,
      "specific_vol": null,
      "dry_vol": null,
      "absorbption": null,
      "deuteration": null,
      "mixture": null
    },
    "contributor": [
      {
        "affiliation": [
          {
            "short_name": "UCSF",
            "address": "San Francisco, CA, USA",
            "full_name": "University of California, San Francisco (UCSF)",
            "webpage": "https://www.ucsf.edu/"
          }
        ],
        "contributor_name": "Soumya",
        "contributor_surname": "G Remesh",
        "orcid": ""
      }
    ],
    "concentration_method": null,
    "concentration_unit": null,
    "date": "2016-02-17",
    "storage_temperature": 4.0,
    "cell_temperature": 20.0,
    "exposure_time": 0.3,
    "number_of_frames": 33,
    "wavelength": 0.103,
    "sample_detector_distance": 1.5,
    "concentration_min": 1.0,
    "concentration_max": 14.0,
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    "flow_rate": null,
    "s_min": 0.109,
    "s_max": 5.319,
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      "software": "MultiFoXS",
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      "p_value": 0.0,
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  "pddf_software": "ATSAS GNOM",
  "pddf_software_version": "5.0",
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  "description": null,
  "experiment_description": "Synchrotron SAXS data from solutions of the Fc-region of Immunoglobulin G1, M135Y/S137T/T139E mutant (IgG1 Fc-YTE) in 20 mM HEPES, 50mM NaCl, pH 7.5, were collected on the 12.3.1 (SIBYLS) beam line at the Advanced Light Source (ALS; Berkeley, CA, USA) using a Pilatus3 X 2M detector at a sample-detector distance of 1.5 m and at a wavelength of λ = 0.103 nm (l(s) vs s, where s = 4πsinθ/λ, and 2θ is the scattering angle). Solute concentrations ranging between 1 and 14 mg/ml were measured at 20°C. 33 successive 0.300 second frames were collected. The data were normalized to the intensity of the transmitted beam and radially averaged; the scattering of the solvent-blank was subtracted. The low angle data collected at lower concentration were merged with the highest concentration high angle data to yield the final composite scattering curve.",
  "tags": [],
  "intensity_unit": "arbitrary",
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  "experimental_mw_error": null,
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  "guinier_i0_mw_error": null,
  "porod_mw": null,
  "porod_mw_error": null,
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  "pddf_i0_error": 1.0,
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  "guinier_i0_error": 1.4,
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  "pddf_rg_error": 0.006,
  "guinier_rg": 2.73,
  "guinier_rg_error": 0.01,
  "pddf_dmax": 10.0,
  "pddf_dmax_error": 0.01,
  "porod_volume": 74.0,
  "porod_volume_error": null,
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  "estimated_volume_error": null,
  "guinier_point_first": 5,
  "guinier_point_last": 67,
  "pddf_point_first": null,
  "pddf_point_last": null,
  "i0_calibration_standard_data": null,
  "intensities_log_log_plot": "SASDDV4_datloglog_img.png",
  "symmetry": null,
  "last_modified": "2019-12-06T13:07:15.624532+01:00",
  "bragg_peak": []
}

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