Polyglutamine-binding protein 1 p.Arg153Serfs*41 (PQBP-1 XLID mutant R153Sfs*41)

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    "title": "Frameshift PQBP-1 mutants K192S<sup>fs*7</sup> and R153S<sup>fs*41</sup> implicated in X-linked intellectual disability form stable dimers.",
    "publication": {
      "title": "Frameshift PQBP-1 mutants K192S<sup>fs*7</sup> and R153S<sup>fs*41</sup> implicated in X-linked intellectual disability form stable dimers.",
      "author_list": "Rahman SK, Okazawa H, Chen YW",
      "journal": "J Struct Biol",
      "doi": "10.1016/j.jsb.2019.04.003",
      "pmid": "30951824",
      "published_date": "2019 Apr 2"
    },
    "status": "released",
    "submitted_date": "2018-10-23",
    "released_date": "2019-04-08"
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    "instrument": {
      "detector": {
        "type": null,
        "name": "Pilatus 2M",
        "resolution": null
      },
      "name": "DORIS III, DESY",
      "city": "Hamburg",
      "country": "Germany",
      "beamline_name": "EMBL X33",
      "beam_geometry": null,
      "type_of_source": "X-ray synchrotron",
      "point_source": null,
      "line_collimation": null,
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    "sample": {
      "molecule": [
        {
          "long_name": "Polyglutamine-binding protein 1 p.Arg153Serfs*41",
          "short_name": "R153Sfs*41",
          "sequence": ">sp|O60828|PQBP1_HUMAN Polyglutamine-binding protein 1 OS=Homo sapiens\r\nGPMPLPVALQTRLAKRGILKHLEPEPEEEIIAEDYDDDPVDYEATRLEGLPP \r\nSWYKVFDPSCGLPYYWNADTDLVSWLSPHDPNSVVTKSAKKLRSSNADAE \r\nEKLDRSHDKSDRGHDKSDRSHEKLDRGHDKSDRGHDKSDRDRERGYDKVD \r\nRESETGNGIGTAGMTRQTGKRAKNGATIAGRSWLPIPRARRQ",
          "organism": "Homo sapiens",
          "uniprot_code": "O60828",
          "uniprot_range_first": 1,
          "uniprot_range_last": 154,
          "oligomerization": "dimer",
          "molecular_type": "protein",
          "uniprot_sequence": "MPLPVALQTRLAKRGILKHLEPEPEEEIIAEDYDDDPVDYEATRLEGLPPSWYKVFDPSC\nGLPYYWNADTDLVSWLSPHDPNSVVTKSAKKLRSSNADAEEKLDRSHDKSDRGHDKSDRS\nHEKLDRGHDKSDRGHDKSDRDRERGYDKVDRERERDRERDRDRGYDKADREEGKERRHHR\nREELAPYPKSKKAVSRKDEELDPMDPSSYSDAPRGTWSTGLPKRNEAKTGADTTAAGPLF\nQQRPYPSPGAVLRANAEASRTKQQD",
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          "number_molecules": 2,
          "complex_state": false,
          "deuteration": null,
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        "name": "Phosphate-buffered saline",
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        "concentration": null,
        "pka": null,
        "ph": 7.4,
        "deuteration": null
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      "purity_method": null,
      "name": "Polyglutamine-binding protein 1 p.Arg153Serfs*41 (PQBP-1 XLID mutant R153Sfs*41)",
      "ext_coefficient": null,
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      "specific_vol": null,
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      "absorbption": null,
      "deuteration": null,
      "mixture": null
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    "contributor": [
      {
        "affiliation": [
          {
            "short_name": null,
            "address": "London, UK",
            "full_name": "King's College London",
            "webpage": "https://www.kcl.ac.uk"
          }
        ],
        "contributor_name": "Yu Wai",
        "contributor_surname": "Chen",
        "orcid": "http://orcid.org/0000-0001-7833-7533"
      }
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    "concentration_method": null,
    "concentration_unit": null,
    "date": "2013-02-15",
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    "cell_temperature": 10.0,
    "exposure_time": 0.045,
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    "wavelength": 0.124,
    "sample_detector_distance": 3.0,
    "concentration_min": 1.0,
    "concentration_max": 7.3,
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    "flow_rate": null,
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    "s_max": 4.182,
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  "experiment_description": "Synchrotron SAXS data from solutions of polyglutamine-binding protein 1 p.Arg153Serfs*41 in phosphate-buffered saline, pH 7.4 were collected on the EMBL X33 beam line at the DORIS III storage ring (DESY, Hamburg, Germany) using a Pilatus 2M detector at a sample-detector distance of 3 m and at a wavelength of λ = 0.124 nm (l(s) vs s, where s = 4πsinθ/λ, and 2θ is the scattering angle). Solute concentrations ranging between 1 and 7.3 mg/ml were measured at 10°C using an X-ray exposure time of 45 ms. The data were normalized to the intensity of the transmitted beam and radially averaged; the scattering of the solvent-blank was subtracted. The low angle data collected at lower concentration were merged with the highest concentration high angle data to yield the final composite scattering curve.",
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  "last_modified": "2023-05-25T11:22:08.798758+02:00",
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