The following content comes directly from the SASBDB entry. Missing values are shown as “—”; SAXSdb does not infer undeclared units.
Every source field is expanded here, including empty values, list members and fields already shown above.
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{
"code": "SASDVB5",
"status": "Published",
"type_of_curve": "SEC-SAS",
"angular_unit": "1/A",
"project": {
"title": "The oncogenic CCDC6-RET fusion protein is a dual ATP- and ADP-dependent kinase",
"publication": {
"title": "The oncogenic CCDC6-RET fusion protein is a dual ATP- and ADP-dependent kinase",
"author_list": "Martín-Hurtado A, Contreras J, Sánchez-Wandelmer J, Zarzuela E, García F, Le Coq J, Boskovic J, Muñoz I, Gago F, Muñoz J, Isasa M, Plaza-Menacho I",
"journal": "Nature Communications",
"doi": "10.1038/s41467-026-69833-y",
"pmid": null,
"published_date": "2026 Mar 06"
},
"status": "released",
"submitted_date": "2026-03-16",
"released_date": "2026-03-16"
},
"pddf_data": null,
"intensities_data": "https://www.sasbdb.org/media/intensities_files/SASDVB5.dat",
"intensities_log_plot": "https://www.sasbdb.org/media/intensities_files/scattering_plots/SASDVB5_dat_img.png",
"intensities_kratky_plot": "https://www.sasbdb.org/media/intensities_files/scattering_plots/SASDVB5_kratky_img.png",
"pddf_plot": null,
"intensities_guinier_plot": "https://www.sasbdb.org/media/intensities_files/scattering_plots/SASDVB5_guinier_img.png",
"sascif_data": "https://www.sasbdb.org/media/sascif/sascif_files/SASDVB5.sascif",
"experiment": {
"instrument": {
"detector": {
"type": null,
"name": "Eiger 4M",
"resolution": 75.0
},
"name": "Diamond Light Source",
"city": "Didcot",
"country": "UK",
"beamline_name": "B21",
"beam_geometry": null,
"type_of_source": "X-ray synchrotron",
"point_source": null,
"line_collimation": null,
"sample_path_length": null,
"line_collimation_slitlength": null,
"line_collimation_integrationwidth": null,
"xray_energy": null,
"beam_profile_ah": null,
"beam_profile_al": null
},
"sample": {
"molecule": [
{
"long_name": "CCDC6-RET fusion protein variant c (K147M, Δ216-229)",
"short_name": "CCD6C-RET deltaCT",
"sequence": "MADSASESDTDGAGGNSSSSAAMQSSCSSTSGGGGGGGGGGGGGKSGGIV\r\nISPFRLEELTNRLASLQQENKVLKIELETYKLKCKALQEENRDLRKASVT\r\nIEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVMMLK\r\nENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGS\r\nLRGFLRESRKVGPGYPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDL\r\nAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFD\r\nHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDN\r\nCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRR",
"organism": "Homo sapiens",
"uniprot_code": "J7M8C2",
"uniprot_range_first": 1,
"uniprot_range_last": 402,
"oligomerization": "dimer",
"molecular_type": "protein",
"uniprot_sequence": "MADSASESDTDGAGGNSSSSAAMQSSCSSTSGGGGGGGGGGGGGKSGGIVISPFRLEELT\nNRLASLQQENKVLKIELETYKLKCKALQEENRDLRKASVTIEDPKWEFPRKNLVLGKTLG\nEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLY\nGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDL\nISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQG\nRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRME\nRPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDD\nGLSEEETPLVDCNNAPLPRALPSTWIENKLYGRISHAFTRF",
"mw": 43.085,
"total_mw": 86.17,
"number_molecules": 2,
"complex_state": false,
"deuteration": null,
"molecule_source": "biological",
"molecule_description": "CCDC6-RET fusion (J7M8C2) deltaCT (RET aa 713-1012, CCDC6 aa 1-101)"
}
],
"buffer": {
"name": "20 mM Tris, 500 mM NaCl, 1 mM DTT",
"concentration_unit": null,
"comment": null,
"additive": null,
"concentration": null,
"pka": null,
"ph": 7.5,
"deuteration": null
},
"purity_method": null,
"name": "CCDC6-RET fusion protein variant c",
"ext_coefficient": null,
"contrast": null,
"specific_vol": null,
"dry_vol": null,
"absorbption": null,
"deuteration": null,
"mixture": null
},
"contributor": [
{
"affiliation": [
{
"short_name": null,
"address": null,
"full_name": "Spanish National Cancer Research Centre (CNIO)",
"webpage": null
}
],
"contributor_name": "INÉS",
"contributor_surname": "MUÑOZ",
"orcid": "https://orcid.org/0000-0001-6732-4059"
}
],
"concentration_method": null,
"concentration_unit": null,
"date": "2023-09-18",
"storage_temperature": 4.0,
"cell_temperature": 18.0,
"exposure_time": 3.0,
"number_of_frames": 600,
"wavelength": 0.1,
"sample_detector_distance": 3.7,
"concentration_min": null,
"concentration_max": 5.0,
"sample_volume": 40.0,
"flow_rate": 0.16,
"s_min": 0.045,
"s_max": 3.397,
"total_exposure_time": null,
"seccolumn": 48
},
"fits": [
{
"models": [
{
"model_plot": "https://www.sasbdb.org/media/pdb_file/images/SASDVB5_fit1_model1_img.png",
"software": "DAMMIN",
"pdb_link": [],
"model_title": null,
"type_of_model": "dummy",
"software_version": null,
"model_data": "https://www.sasbdb.org/media/pdb_file/SASDVB5_fit1_model1.pdb",
"model_mw": 155.31,
"bead_radius": 5.0,
"log": null,
"symmetry": "P1",
"comment": null,
"user": 973
}
],
"fit_unit": "1/A",
"fit_plot": "https://www.sasbdb.org/media/fitting_files/scattering_plots/SASDVB5_fit1_fixed_fit_img.png",
"software": "FoXS",
"chi_square_value": 2.222609,
"p_value": 0.0,
"fit_residual_plot": "SASDVB5_fit1_fitresiduals_img.png",
"fit_data": "https://www.sasbdb.org/media/fitting_files/SASDVB5_fit1.fit",
"fit_log": null,
"software_version": null,
"description": ""
}
],
"estimated_volume_method": null,
"pddf_software": "ATSAS GNOM",
"pddf_software_version": "5.0",
"i0_calibration_standard": null,
"description": null,
"experiment_description": "SAXS experiments were conducted at the beamline B21 of the Diamond Light Source (Didcot, UK). CCDC6-RET∆CT (40 µL, 5 mg/mL) was injected at room temperature into a Superdex 200 Increase 3.2 column connected to an in-line Agilent 1200 HPLC system. The buffer used for the SEC column was the same protein buffer (20 mM Tris pH 7.5, 500 mM NaCl, 1 mM DTT). The eluted samples were exposed for 3s and 600 frames taken using an X-ray wavelength of 1 nm, and a sample to detector (Eiger 4M) distance of 3.7 m. The data covered a momentum transfer range of 0.032 < s < 3.4 nm-1. The frames recorded immediately before elution of the sample were subtracted from the protein scattering profiles. The Scåtter software package was used to analyze data, buffer-subtraction, scaling, merging and checking possible radiation damage of the samples.\r\nThe Rg value was calculated with the Guinier approximation assuming that at very small angles s < 1.3/Rg. The particle distance distribution, Dmax, was calculated from the scattering pattern with GNOM, and shape estimation was carried out with DAMMIF/DAMMIN, all these programs included in the ATSAS package.",
"tags": [],
"intensity_unit": "arbitrary",
"experimental_mw": 171.74,
"experimental_mw_error": null,
"guinier_i0_mw": null,
"guinier_i0_mw_error": null,
"porod_mw": 162.0,
"porod_mw_error": null,
"pddf_i0": 0.07398,
"pddf_i0_error": null,
"guinier_i0": 0.0745331,
"guinier_i0_error": null,
"pddf_rg": 5.54,
"pddf_rg_error": null,
"guinier_rg": 5.507,
"guinier_rg_error": 0.474,
"pddf_dmax": 19.5,
"pddf_dmax_error": null,
"porod_volume": 259.7,
"porod_volume_error": null,
"estimated_volume": null,
"estimated_volume_error": null,
"guinier_point_first": 42,
"guinier_point_last": 101,
"pddf_point_first": null,
"pddf_point_last": null,
"i0_calibration_standard_data": null,
"intensities_log_log_plot": "SASDVB5_datloglog_img.png",
"symmetry": null,
"last_modified": "2026-03-16T10:35:21.105494+01:00",
"bragg_peak": []
}
