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{
"code": "SASDVL2",
"status": "Published",
"type_of_curve": "SEC-SAS",
"angular_unit": "1/A",
"project": {
"title": "S. aureus Eap is a polyvalent inhibitor of neutrophil serine proteases.",
"publication": {
"title": "S. aureus Eap is a polyvalent inhibitor of neutrophil serine proteases.",
"author_list": "Mishra N, Gido CD, Herdendorf TJ, Hammel M, Hura GL, Fu ZQ, Geisbrecht BV",
"journal": "J Biol Chem",
"doi": "10.1016/j.jbc.2024.107627",
"pmid": "39098536",
"published_date": "2024 Aug 3"
},
"status": "released",
"submitted_date": "2024-06-17",
"released_date": "2024-07-22"
},
"pddf_data": "https://www.sasbdb.org/media/p_of_R_files/SASDVL2.out",
"intensities_data": "https://www.sasbdb.org/media/intensities_files/SASDVL2.dat",
"intensities_log_plot": "https://www.sasbdb.org/media/intensities_files/scattering_plots/SASDVL2_dat_img.png",
"intensities_kratky_plot": "https://www.sasbdb.org/media/intensities_files/scattering_plots/SASDVL2_kratky_img.png",
"pddf_plot": "https://www.sasbdb.org/media/p_of_R_files/pofr_images/SASDVL2_pofr_img.png",
"intensities_guinier_plot": "https://www.sasbdb.org/media/intensities_files/scattering_plots/SASDVL2_guinier_img.png",
"sascif_data": "https://www.sasbdb.org/media/sascif/sascif_files/SASDVL2.sascif",
"experiment": {
"instrument": {
"detector": {
"type": null,
"name": "Pilatus3 X 2M",
"resolution": 172.0
},
"name": "Advanced Light Source (ALS)",
"city": "Berkeley, CA",
"country": "USA",
"beamline_name": "12.3.1 (SIBYLS)",
"beam_geometry": "",
"type_of_source": "X-ray synchrotron",
"point_source": null,
"line_collimation": null,
"sample_path_length": null,
"line_collimation_slitlength": null,
"line_collimation_integrationwidth": null,
"xray_energy": null,
"beam_profile_ah": null,
"beam_profile_al": null
},
"sample": {
"molecule": [
{
"long_name": "Cathepsin G",
"short_name": "CG",
"sequence": "IIGGRESRPHSRPYMAYLQIQSPAGQSRCGGFLVREDFVLTAAHCWGSNINVTLGAHNIQRRENTQQHITARRAIRHPQYNQRTIQNDIMLLQLSRRVRRNRNVNPVALPRAQEGLRPGTLCTVAGWGRVSMRRGTDTLREVQLRVQRDRQCLRIFGSYDPRRQICVGDRRERKAAFKGDSGGPLLCNNVAHGIVSYGKSSGVPPEVFTRVSSFLPWIRTTMR",
"organism": "Homo sapiens",
"uniprot_code": "P08311",
"uniprot_range_first": 22,
"uniprot_range_last": 245,
"oligomerization": "monomer",
"molecular_type": "protein",
"uniprot_sequence": "MQPLLLLLAFLLPTGAEAGEIIGGRESRPHSRPYMAYLQIQSPAGQSRCGGFLVREDFVL\nTAAHCWGSNINVTLGAHNIQRRENTQQHITARRAIRHPQYNQRTIQNDIMLLQLSRRVRR\nNRNVNPVALPRAQEGLRPGTLCTVAGWGRVSMRRGTDTLREVQLRVQRDRQCLRIFGSYD\nPRRQICVGDRRERKAAFKGDSGGPLLCNNVAHGIVSYGKSSGVPPEVFTRVSSFLPWIRT\nTMRSFKLLDQMETPL",
"mw": 25.354,
"total_mw": 25.354,
"number_molecules": 1,
"complex_state": false,
"deuteration": null,
"molecule_source": "biological",
"molecule_description": ""
},
{
"long_name": "MAP domain-containing protein",
"short_name": "EapH2",
"sequence": "GSTAEKDKLPATQKAKEMQNVPYTIAVDGIMAFNQSYLNLPKDSQLSYLDLGNKVKALLYDERGVTPEKIRNAKSAVYTITWKDGSKKEVDLKKDSYTANLFDSNSIKQIDINVKTK",
"organism": "Staphylococcus aureus (strain Mu50 / ATCC 700699)",
"uniprot_code": "A0A0H3JUK5",
"uniprot_range_first": 32,
"uniprot_range_last": 146,
"oligomerization": "monomer",
"molecular_type": "protein",
"uniprot_sequence": "MKLKSFITVTLALGMIATTGATVTSNEVSAAEKDKLPATQKAKEMQNVPYTIAVDGIMAF\nNQSYLNLPKDSQLSYLDLGNKVKALLYDERGVTPEKIRNAKSAVYTITWKDGSKKEVDLK\nKDSYTANLFDSNSIKQIDINVKTK",
"mw": 13.105,
"total_mw": 13.105,
"number_molecules": 1,
"complex_state": false,
"deuteration": null,
"molecule_source": "biological",
"molecule_description": ""
},
{
"long_name": "Neutrophil elastase",
"short_name": "NE",
"sequence": "IVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQ",
"organism": "Homo sapiens",
"uniprot_code": "P08246",
"uniprot_range_first": 31,
"uniprot_range_last": 249,
"oligomerization": "monomer",
"molecular_type": "protein",
"uniprot_sequence": "MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI\nAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI\nLQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL\nCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN\nWIDSIIQRSEDNPCPHPRDPDPASRTH",
"mw": 23.295,
"total_mw": 23.295,
"number_molecules": 1,
"complex_state": false,
"deuteration": null,
"molecule_source": "biological",
"molecule_description": ""
}
],
"buffer": {
"name": "20 mM HEPES, 140 mM NaCl",
"concentration_unit": null,
"comment": null,
"additive": null,
"concentration": null,
"pka": null,
"ph": 7.4,
"deuteration": null
},
"purity_method": null,
"name": "Ternary complex consisted of Human Chatepsin G, Neutrophil elastase and S.aureus MAP domain-containing protein",
"ext_coefficient": null,
"contrast": null,
"specific_vol": null,
"dry_vol": null,
"absorbption": null,
"deuteration": null,
"mixture": null
},
"contributor": [
{
"affiliation": [
{
"short_name": null,
"address": null,
"full_name": "Kansas State University",
"webpage": null
}
],
"contributor_name": "Nitin",
"contributor_surname": "Mishra",
"orcid": "https://orcid.org/0000-0001-8931-7351"
}
],
"concentration_method": null,
"concentration_unit": null,
"date": "2023-06-03",
"storage_temperature": 4.0,
"cell_temperature": 4.0,
"exposure_time": 2.0,
"number_of_frames": 912,
"wavelength": 0.1127,
"sample_detector_distance": 2.1,
"concentration_min": null,
"concentration_max": 5.0,
"sample_volume": 60.0,
"flow_rate": 0.65,
"s_min": 0.114,
"s_max": 4.729,
"total_exposure_time": null,
"seccolumn": 18
},
"fits": [
{
"models": [
{
"model_plot": "https://www.sasbdb.org/media/pdb_file/images/SASDVL2_fit1_model1_img.png",
"software": "PDB (Protein Data Bank)",
"pdb_link": [
{
"pdb_code": "8g24",
"ext_code": "8G24",
"ext_type": "pdb",
"difference_with_model": "identical"
}
],
"model_title": null,
"type_of_model": "atomic",
"software_version": null,
"model_data": "https://www.sasbdb.org/media/pdb_file/SASDVL2_fit1_model1.pdb",
"model_mw": 61.79,
"bead_radius": null,
"log": null,
"symmetry": null,
"comment": null,
"user": 1074
}
],
"fit_unit": "1/A",
"fit_plot": "https://www.sasbdb.org/media/fitting_files/scattering_plots/SASDVL2_fit1_fixed_fit_img.png",
"software": "FoXS",
"chi_square_value": 0.862488,
"p_value": 0.5898,
"fit_residual_plot": "SASDVL2_fit1_fitresiduals_img.png",
"fit_data": "https://www.sasbdb.org/media/fitting_files/SASDVL2_fit1.fit",
"fit_log": null,
"software_version": null,
"description": ""
}
],
"estimated_volume_method": null,
"pddf_software": "ATSAS GNOM",
"pddf_software_version": "5.0",
"i0_calibration_standard": null,
"description": null,
"experiment_description": null,
"tags": [],
"intensity_unit": "arbitrary",
"experimental_mw": 49.0,
"experimental_mw_error": null,
"guinier_i0_mw": null,
"guinier_i0_mw_error": null,
"porod_mw": 47.0,
"porod_mw_error": null,
"pddf_i0": 57.08,
"pddf_i0_error": null,
"guinier_i0": 55.9915,
"guinier_i0_error": null,
"pddf_rg": 2.94,
"pddf_rg_error": null,
"guinier_rg": 2.831,
"guinier_rg_error": 0.284,
"pddf_dmax": 9.4,
"pddf_dmax_error": null,
"porod_volume": 77.0,
"porod_volume_error": null,
"estimated_volume": null,
"estimated_volume_error": null,
"guinier_point_first": 3,
"guinier_point_last": 52,
"pddf_point_first": null,
"pddf_point_last": null,
"i0_calibration_standard_data": null,
"intensities_log_log_plot": "SASDVL2_datloglog_img.png",
"symmetry": null,
"last_modified": "2024-10-07T14:58:22.403940+02:00",
"bragg_peak": []
}
