查看完整 summary.json 原文
{
"code": "SASDVN6",
"status": "Published",
"type_of_curve": "SEC-SAS",
"angular_unit": "1/A",
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"title": "Design of a Cereblon construct for crystallographic and biophysical studies of protein degraders",
"publication": {
"title": "Design of a Cereblon construct for crystallographic and biophysical studies of protein degraders",
"author_list": "Kroupova A, Spiteri V, Rutter Z, Furihata H, Darren D, Ramachandran S, Chakraborti S, Haubrich K, Pethe J, Gonzales D, Wijaya A, Rodriguez-Rios M, Sturbaut M, Lynch D, Farnaby W, Nakasone M, Zollman D, Ciulli A",
"journal": "Nature Communications",
"doi": "10.1038/s41467-024-52871-9",
"pmid": null,
"published_date": "2024 Oct 15"
},
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},
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"name": "Diamond Light Source",
"city": "Didcot",
"country": "UK",
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{
"long_name": "Cereblon-midi",
"short_name": "CRBNmidi",
"sequence": "SAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSIQVIPVLPQVMMILVPGQTLPLQLFHPQEVSMVRNLIQNDRTFAVLAYSNVQEREAEFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPEGSGDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYWVAANLPIDDSLRIQLLKIDSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSREGPMAAYVNPHGYVHEILTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALIPTI",
"organism": "synthetic construct",
"uniprot_code": null,
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"oligomerization": "monomer",
"molecular_type": "protein",
"uniprot_sequence": "",
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"complex_state": false,
"deuteration": null,
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"molecule_description": "CRBN-midi, an engineered Cereblon construct for crystallographic and biophysical studies of protein degraders (derived from human Cereblon, Uniprot Q96SW2)"
}
],
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"pka": null,
"ph": 7.5,
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},
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"name": "Cereblon-midi (CRBNmidi), an engineered Cereblon construct for crystallographic and biophysical studies, bound to Boc-VcN",
"ext_coefficient": null,
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"deuteration": null,
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},
"contributor": [
{
"affiliation": [
{
"short_name": null,
"address": null,
"full_name": "Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee",
"webpage": null
}
],
"contributor_name": "Zoe",
"contributor_surname": "Rutter",
"orcid": null
}
],
"concentration_method": null,
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"date": "2024-06-29",
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"wavelength": 0.09464,
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},
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"description": "CRBN-midi, an engineered Cereblon construct for crystallographic and biophysical studies of protein degraders (derived from human Cereblon, Uniprot Q96SW2).",
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"symmetry": null,
"last_modified": "2025-12-18T16:28:43.495264+01:00",
"bragg_peak": []
}查看完整 manifest.json 原文
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