查看完整 summary.json 原文
{
"code": "SASDW84",
"status": "Published",
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"angular_unit": "1/nm",
"project": {
"title": "The CRISPR-Cas9 knockout DDC SH-SY5Y in vitro model for AADC deficiency provides insight into the pathogenicity of R347Q and L353P variants: a cross-sectional structural and functional analysis.",
"publication": {
"title": "The CRISPR-Cas9 knockout DDC SH-SY5Y in vitro model for AADC deficiency provides insight into the pathogenicity of R347Q and L353P variants: a cross-sectional structural and functional analysis.",
"author_list": "Carmona-Carmona CA, Bisello G, Franchini R, Lunardi G, Galavotti R, Perduca M, Ribeiro RP, Belviso BD, Giorgetti A, Caliandro R, Lievens PM, Bertoldi M",
"journal": "FEBS J",
"doi": "10.1111/febs.70120",
"pmid": "40318155",
"published_date": "2025 May 3"
},
"status": "released",
"submitted_date": "2024-12-20",
"released_date": "2025-04-02"
},
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"name": "Pilatus3 2M",
"resolution": 0.172
},
"name": "ESRF",
"city": "Grenoble",
"country": "France",
"beamline_name": "BM29",
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"long_name": "Aromatic-L-amino-acid decarboxylase (R347Q)",
"short_name": "AADC",
"sequence": "MNASEFRRRGKEMVDYMANYMEGIEGRQVYPDVEPGYLRPLIPAAAPQEPDTFEDIINDV\r\nEKIIMPGVTHWHSPYFFAYFPTASSYPAMLADMLCGAIGCIGFSWAASPACTELETVMMD\r\nWLGKMLELPKAFLNEKAGEGGGVIQGSASEATLVALLAARTKVIHRLQAASPELTQAAIM\r\nEKLVAYSSDQAHSSVERAGLIGGVKLKAIPSDGNFAMRASALQEALERDKAAGLIPFFMV\r\nATLGTTTCCSFDNLLEVGPICNKEDIWLHVDAAYAGSAFICPEFRHLLNGVEFADSFNFN\r\nPHKWLLVNFDCSAMWVKKRTDLTGAFRLDPTYLKHSHQDSGLITDYQHWQIPLGRRFRSL\r\nKMWFVFRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVN\r\nEALLQRINSAKKIHLVPCHLRDKFVLRFAICSRTVESAHVQRAWEHIKELAADVLRAERE",
"organism": "Homo sapiens",
"uniprot_code": "P20711",
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"oligomerization": "dimer",
"molecular_type": "protein",
"uniprot_sequence": "MNASEFRRRGKEMVDYMANYMEGIEGRQVYPDVEPGYLRPLIPAAAPQEPDTFEDIINDV\nEKIIMPGVTHWHSPYFFAYFPTASSYPAMLADMLCGAIGCIGFSWAASPACTELETVMMD\nWLGKMLELPKAFLNEKAGEGGGVIQGSASEATLVALLAARTKVIHRLQAASPELTQAAIM\nEKLVAYSSDQAHSSVERAGLIGGVKLKAIPSDGNFAMRASALQEALERDKAAGLIPFFMV\nATLGTTTCCSFDNLLEVGPICNKEDIWLHVDAAYAGSAFICPEFRHLLNGVEFADSFNFN\nPHKWLLVNFDCSAMWVKKRTDLTGAFRLDPTYLKHSHQDSGLITDYRHWQIPLGRRFRSL\nKMWFVFRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVN\nEALLQRINSAKKIHLVPCHLRDKFVLRFAICSRTVESAHVQRAWEHIKELAADVLRAERE",
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"complex_state": false,
"deuteration": null,
"molecule_source": "biological",
"molecule_description": ""
}
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"pka": null,
"ph": 7.4,
"deuteration": null
},
"purity_method": null,
"name": "Aromatic-L-amino-acid decarboxylase R347Q bound to pyridoxal 5'-phosphate (PLP)",
"ext_coefficient": null,
"contrast": null,
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"absorbption": null,
"deuteration": null,
"mixture": null
},
"contributor": [
{
"affiliation": [
{
"short_name": null,
"address": null,
"full_name": "National Research Council",
"webpage": null
}
],
"contributor_name": "Benny Danilo",
"contributor_surname": "Belviso",
"orcid": "https://orcid.org/0000-0003-2880-1064"
}
],
"concentration_method": null,
"concentration_unit": null,
"date": "2021-07-07",
"storage_temperature": 4.0,
"cell_temperature": 4.0,
"exposure_time": 5.0,
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"description": "Pyridoxal 5'-phosphate: https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:18405. CAUTION: Potentially aggregated.",
"experiment_description": "Synchrotron SAXS data from solutions of aromatic-L-amino-acid decarboxylase (R347Q) bound to pyridoxal 5'-phosphate in 50 mM HEPES, 100 µM pyridoxal 5'-phosphate, pH 7.4 were collected on the BM29 beam line at the ESRF (Grenoble, France) using a Pilatus3 2M detector at a sample-detector distance of 2.9 m and at a wavelength of λ = 0.1 nm (I(s) vs s, where s = 4πsinθ/λ, and 2θ is the scattering angle). Solute concentrations ranging between 5.4 and 5.4 mg/ml were measured at 4°C. Four successive 5 second frames were collected. The data were normalized to the intensity of the transmitted beam and radially averaged; the scattering of the solvent-blank was subtracted.",
"tags": [],
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"i0_calibration_standard_data": null,
"intensities_log_log_plot": "SASDW84_datloglog_img.png",
"symmetry": null,
"last_modified": "2025-05-08T08:55:24.409452+02:00",
"bragg_peak": []
}查看完整 manifest.json 原文
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