CD2-associated protein (CD2AP) K301M point mutant

{
  "code": "SASDXK6",
  "status": "Published",
  "type_of_curve": "Single concentration",
  "angular_unit": "1/nm",
  "project": {
    "title": "CD2AP’s Structure and Oligomerization are compromised by the K301M mutation: implications for Nephrotic syndrome",
    "publication": null,
    "status": "released",
    "submitted_date": "2025-07-16",
    "released_date": "2026-05-09"
  },
  "pddf_data": "https://www.sasbdb.org/media/p_of_R_files/SASDXK6.out",
  "intensities_data": "https://www.sasbdb.org/media/intensities_files/SASDXK6.dat",
  "intensities_log_plot": "https://www.sasbdb.org/media/intensities_files/scattering_plots/SASDXK6_dat_img.png",
  "intensities_kratky_plot": "https://www.sasbdb.org/media/intensities_files/scattering_plots/SASDXK6_kratky_img.png",
  "pddf_plot": "https://www.sasbdb.org/media/p_of_R_files/pofr_images/SASDXK6_pofr_img.png",
  "intensities_guinier_plot": "https://www.sasbdb.org/media/intensities_files/scattering_plots/SASDXK6_guinier_img.png",
  "sascif_data": "https://www.sasbdb.org/media/sascif/sascif_files/SASDXK6.sascif",
  "experiment": {
    "instrument": {
      "detector": {
        "type": "Hybrid Photon Counting (HPC)",
        "name": "Mythen2 R 1K",
        "resolution": null
      },
      "name": "CSIR-Central Drug Research Institute",
      "city": "Lucknow",
      "country": "India",
      "beamline_name": "Anton Paar SAXSpace",
      "beam_geometry": null,
      "type_of_source": "X-ray in house",
      "point_source": null,
      "line_collimation": null,
      "sample_path_length": null,
      "line_collimation_slitlength": null,
      "line_collimation_integrationwidth": null,
      "xray_energy": null,
      "beam_profile_ah": null,
      "beam_profile_al": null
    },
    "sample": {
      "molecule": [
        {
          "long_name": "CD2-associated protein",
          "short_name": null,
          "sequence": "MVDYIVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEI\r\nKRETEFKDDSLPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQCK\r\nVLFEYIPQNEDELELKVGDIIDINEEVEEGWWSGTLNNKLGLFPSNFVKELEVTDDG\r\nETHEAQDDSETVLAGPTSPIPSLGNVSETASGSVTQPKKIRGIGFGDIFKEGSVKLR\r\nTRTSSSETEEKKPEKPLILQSLGPKTQSVEITKTDTEGKIRAKEYCRTLFAYEGTNED\r\nELTFKEGEIIHLISMETGEAGWWRGELNGKEGVFPDNFAVQINELDKDFPKPKKPPP\r\nPAKAPAPKPELIAAEKKYFSLKPEEKDEKSTLEQKPSKPAAPQVPPKKPTPPTKASN\r\nLLRSSGTVYPKRPEKPVPPPPPIAKINGEVSSISSKFETEPVSKLKLDSEQLPLRPKS\r\nVDFDSLTVRTSKETDVVNFDDIASSENLLHLTANRPKMPGRRLPGRFNGGHSPTHS\r\nPEKILKLPKEEDSANLKPSELKKDTCYSPKPSVYLSTPSSASKANTTAFLTPLEIKAK\r\nVETDDVKKNSLDELRAQIIELLCIVEALKKDHGKELEKLRKDLEEEKTMRSNLEMEIE\r\nKLKKAVLSS",
          "organism": "Homo sapiens",
          "uniprot_code": "Q9Y5K6",
          "uniprot_range_first": null,
          "uniprot_range_last": null,
          "oligomerization": "trimer",
          "molecular_type": "protein",
          "uniprot_sequence": "MVDYIVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEIKRE\nTEFKDDSLPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQCKVLFEYI\nPQNEDELELKVGDIIDINEEVEEGWWSGTLNNKLGLFPSNFVKELEVTDDGETHEAQDDS\nETVLAGPTSPIPSLGNVSETASGSVTQPKKIRGIGFGDIFKEGSVKLRTRTSSSETEEKK\nPEKPLILQSLGPKTQSVEITKTDTEGKIKAKEYCRTLFAYEGTNEDELTFKEGEIIHLIS\nKETGEAGWWRGELNGKEGVFPDNFAVQINELDKDFPKPKKPPPPAKAPAPKPELIAAEKK\nYFSLKPEEKDEKSTLEQKPSKPAAPQVPPKKPTPPTKASNLLRSSGTVYPKRPEKPVPPP\nPPIAKINGEVSSISSKFETEPVSKLKLDSEQLPLRPKSVDFDSLTVRTSKETDVVNFDDI\nASSENLLHLTANRPKMPGRRLPGRFNGGHSPTHSPEKILKLPKEEDSANLKPSELKKDTC\nYSPKPSVYLSTPSSASKANTTAFLTPLEIKAKVETDDVKKNSLDELRAQIIELLCIVEAL\nKKDHGKELEKLRKDLEEEKTMRSNLEMEIEKLKKAVLSS",
          "mw": 71.481,
          "total_mw": 214.443,
          "number_molecules": 3,
          "complex_state": false,
          "deuteration": null,
          "molecule_source": "biological",
          "molecule_description": "It is the mutant form is Human CD2AP"
        }
      ],
      "buffer": {
        "name": "10 mM potassium phosphate",
        "concentration_unit": null,
        "comment": null,
        "additive": null,
        "concentration": null,
        "pka": null,
        "ph": 7.6,
        "deuteration": null
      },
      "purity_method": null,
      "name": "CD2-associated protein (CD2AP) K301M point mutant",
      "ext_coefficient": null,
      "contrast": null,
      "specific_vol": null,
      "dry_vol": null,
      "absorbption": null,
      "deuteration": null,
      "mixture": null
    },
    "contributor": [
      {
        "affiliation": [
          {
            "short_name": null,
            "address": null,
            "full_name": "university of Hyderabad India ",
            "webpage": null
          }
        ],
        "contributor_name": "Anil Kumar",
        "contributor_surname": "Pasupulati et .al",
        "orcid": "https://orcid.org/0000-0001-9467-7650"
      }
    ],
    "concentration_method": null,
    "concentration_unit": null,
    "date": "2025-05-18",
    "storage_temperature": 10.0,
    "cell_temperature": 10.0,
    "exposure_time": 900.0,
    "number_of_frames": 4,
    "wavelength": 0.514,
    "sample_detector_distance": 0.317,
    "concentration_min": null,
    "concentration_max": 7.0,
    "sample_volume": null,
    "flow_rate": null,
    "s_min": 0.084,
    "s_max": 7.782,
    "total_exposure_time": null,
    "seccolumn": null
  },
  "fits": [],
  "estimated_volume_method": null,
  "pddf_software": "ATSAS GNOM",
  "pddf_software_version": "5.0",
  "i0_calibration_standard": null,
  "description": "mutant of CD2AP, First eleven points removed for display purposes. Porod volume estimation for the molecule is inconclusive.",
  "experiment_description": null,
  "tags": [],
  "intensity_unit": "arbitrary",
  "experimental_mw": 318.0,
  "experimental_mw_error": null,
  "guinier_i0_mw": 5.01,
  "guinier_i0_mw_error": 3.0,
  "porod_mw": null,
  "porod_mw_error": null,
  "pddf_i0": 6.423,
  "pddf_i0_error": null,
  "guinier_i0": 5.85344,
  "guinier_i0_error": null,
  "pddf_rg": 10.71,
  "pddf_rg_error": null,
  "guinier_rg": 9.586,
  "guinier_rg_error": 1.926,
  "pddf_dmax": 33.87,
  "pddf_dmax_error": null,
  "porod_volume": null,
  "porod_volume_error": null,
  "estimated_volume": null,
  "estimated_volume_error": null,
  "guinier_point_first": 1,
  "guinier_point_last": 19,
  "pddf_point_first": null,
  "pddf_point_last": null,
  "i0_calibration_standard_data": null,
  "intensities_log_log_plot": "SASDXK6_datloglog_img.png",
  "symmetry": null,
  "last_modified": "2026-05-19T09:31:36.092850+02:00",
  "bragg_peak": []
}

{
  "code": "SASDXK6",
  "status": "success",
  "started_at": "2026-08-11T16:31:51.510849+00:00",
  "finished_at": "2026-08-11T16:31:58.599418+00:00",
  "source_last_modified": "2026-05-19T09:31:36.092850+02:00",
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