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10af

Crystal Structure of cyclophilin B, from Brugia malayi (K5H/S166A mutant)

Method: X-RAY DIFFRACTION D_max: 47.7 Å Quality: REASONABLE

SAXS Profile

P(r) Distribution

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1. Structure Basics

entry_id	10af
deposition_date	2026-01-08
last_revision	2026-01-21
title	Crystal Structure of cyclophilin B, from Brugia malayi (K5H/S166A mutant)
keywords	SSGCID, STRUCTURAL GENOMICS, SEATTLE STRUCTURAL GENOMICS CENTER FOR INFECTIOUS DISEASE, cyclophilin B, TRANSFERASE; TRANSFERASE
method	X-RAY DIFFRACTION

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Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

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2. SAXS Parameters (CRYSOL)

rg_guinier	16.03 Å
rg_electron	14.58 Å
i0	7484530.00
molecular_weight	18745.0 kDa
excluded_volume	22924 Å³
envelope_volume	25350 Å³
shell_volume	14361 Å³
envelope_diameter	46.6 Å
shell_rg	20.86 Å
envelope_rg	14.86 Å
shape_rg	14.51 Å
total_rg	15.85 Å
total_atoms	1306
n_residues	170
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

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3. P(r) Analysis (GNOM)

dmax	47.7 Å
rg_real	15.88 Å
rg_real_error	0.18 Å
i0_real	7.4850e+06
i0_real_error	8.2570e+04
rg_reciprocal	15.89 Å
i0_reciprocal	7485000.0000
total_estimate	0.7417
solution_quality	REASONABLE a REASONABLE solution
n_peaks	2
r_peak_primary	21.1 Å
skewness	0.027
kurtosis	-0.482
angular_range	— – 0.4950 Å⁻¹
current_alpha	0.0000
highest_alpha	1530000.0000
n_real_points	80
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.928; Stabil: 1.000; Sysdev: 0.302; Positv: 1.000; Valcen: 0.974; Smooth: 0.972

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4. Crystallography & Experiment

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5. Entities & Polymer Info (4)

Entity 1 polymer

description	Peptidyl-prolyl cis-trans isomerase
formula_weight	19535.2 kDa
ec_number	5.2.1.8
mutation	K5H, S166A
src_method	man
entity_count	1

Polymer

type	polypeptide(L)
strand_id	A
atom_count	1606

MAHHHHHHMSRPHVFFDITIGGSNAGRIVMELFADIVPKTAENFRCLCTGERGMGRSGKKLHYKGSKFHRVIPNFMLQGGDFTRGNGTGGESIYGEKFPDENFQEKHTGPGVLSMANAGPNTNGSQFFICTAKTEWLDGKHVVFGRVVEGMNVVKAVESKGSQSGRTSADIVIADCGQL

Source

organism	Brugia malayi
ncbi_taxonomy_id	6279
host_organism	Escherichia coli BL21(DE3)

Entity 2 non-polymer

description	SULFATE ION
formula_weight	96.1 kDa
src_method	syn
entity_count	3

Entity 3 non-polymer

description	CHLORIDE ION
formula_weight	35.5 kDa
src_method	syn
entity_count	3

Entity 4 water

description	water
formula_weight	18.0 kDa
src_method	nat
entity_count	245

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6. Citations (1)

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length_a	57.614 Å
length_b	57.614 Å
length_c	97.260 Å
angle_alpha	90.00 °
angle_beta	90.00 °
angle_gamma	120.00 °
z_pdb	6

space_group	P 31 2 1
int_tables_number	152
crystal_system	—

resolution	1.250 Å
resolution_low	44.390 Å
r_factor	0.1158
r_work	0.1148
r_free	0.1348

fit	/app/data/saxs_computation/0a/10af/10af.fit
pddf	/app/data/pr_computation/0a/10af/10af.pr.out
profile	/app/data/saxs_computation/0a/10af/10af.dat

Crystal Structure of cyclophilin B, from Brugia malayi (K5H/S166A mutant)

SAXS Profile

P(r) Distribution

1. Structure Basics

Download Data

2. SAXS Parameters (CRYSOL)

3. P(r) Analysis (GNOM)

4. Crystallography & Experiment

Unit Cell

Symmetry

Refinement

Diffraction