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11ha

Crystal structure of a GII.4 norovirus capsid P domain in complex with neutralizing antibody 24C10

Method: X-RAY DIFFRACTION D_max: 138.2 Å Quality: GOOD

SAXS Profile

P(r) Distribution

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1. Structure Basics

entry_id	11ha
deposition_date	2026-02-23
last_revision	2026-05-27
title	Crystal structure of a GII.4 norovirus capsid P domain in complex with neutralizing antibody 24C10
keywords	Norovirus GII.4, P domain, Capsid protein, Antibody, VIRAL PROTEIN; VIRAL PROTEIN
method	X-RAY DIFFRACTION

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Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

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2. SAXS Parameters (CRYSOL)

rg_guinier	42.21 Å
rg_electron	42.41 Å
i0	387045000.00
molecular_weight	158630.0 kDa
excluded_volume	197130 Å³
envelope_volume	259840 Å³
shell_volume	53623 Å³
envelope_diameter	140.9 Å
shell_rg	44.58 Å
envelope_rg	42.76 Å
shape_rg	42.36 Å
total_rg	42.66 Å
total_atoms	11177
n_residues	1451
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

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3. P(r) Analysis (GNOM)

dmax	138.2 Å
rg_real	42.36 Å
rg_real_error	1.10 Å
i0_real	3.8700e+08
i0_real_error	6.5600e+06
rg_reciprocal	42.21 Å
i0_reciprocal	387000000.0000
total_estimate	0.8140
solution_quality	GOOD a GOOD solution
n_peaks	1
r_peak_primary	37.4 Å
skewness	0.370
kurtosis	-0.613
angular_range	— – 0.1850 Å⁻¹
current_alpha	0.0000
highest_alpha	50490000.0000
n_real_points	38
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.878; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.946; Smooth: 0.000

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4. Crystallography & Experiment

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5. Entities & Polymer Info (3)

Entity 1 polymer

description	Major capsid protein VP1
formula_weight	34560.5 kDa
src_method	man
entity_count	2

Polymer

type	polypeptide(L)
strand_id	A,B
atom_count	11185

GESRTKPFSVPVLTVEEMTNSRFPIPLEKLFTGPSSAFVVQPQNGRCTTDGVLLGTTQLSPVNICNFRGDVTHITGSRNYTMNLASQNWNNYDPTEEIPAPLGTPDFVGKIQGMLTQTTRTDGSTRGHKATVYTGSADFAPKLGRVQFETDTDHDFEANQNTKFTPVGVIQDGSTTHRNEPQQWVLPSYSGRNTHNVHLAPAVAPTFPGEQLLFFRSTMPGCSGYPNMDLDCLLPQEWVQYFYQEAAPAQSDVALLRFVNPDTGRVLFECKLHKSGYVTVAHTGQHDLVIPPNGYFRFDSWVNQFYTLAPM

Source

organism	Norovirus GII.4 Sydney 2012
ncbi_taxonomy_id	1776356
host_organism	Escherichia coli

Entity 2 polymer

description	24C10 Light Chain
formula_weight	23352.7 kDa
src_method	man
entity_count	2

Polymer

type	polypeptide(L)
strand_id	L,K

QIVLTQSPAIMSASPGEKVTMTCSASSSVSYMHWYQQKSGTSPKRWIYDTSKLASGVPARFSGSGSGTSYSLTISSMEAEDAATYYCQQWSSNPYTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC

Source

organism	Mus musculus
common_name	Mouse
ncbi_taxonomy_id	10090
host_organism	Cricetulus griseus

Entity 3 polymer

description	24C10 Heavy Chain
formula_weight	24661.5 kDa
src_method	man
entity_count	2

Polymer

type	polypeptide(L)
strand_id	H,G

QVQLQQSGAELMKPGASVKISCKATGYTFSSYWIEWVKQRPGHGLEWIGEILPGSGSTNYNEKFKGKATFTADTSSNTAYMQLSSLTSEDSAVYYCARSWGFPYYAIDYWGQGTSVTVSSAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSPRPSETVTCNVAHPASSTKVDKKIVPRDCHHHHHH

Source

organism	Mus musculus
common_name	Mouse
ncbi_taxonomy_id	10090
host_organism	Cricetulus griseus

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6. Citations (1)

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length_a	88.117 Å
length_b	56.428 Å
length_c	182.117 Å
angle_alpha	90.00 °
angle_beta	99.57 °
angle_gamma	90.00 °
z_pdb	4

space_group	P 1 21 1
int_tables_number	4
crystal_system	monoclinic

resolution	2.700 Å
resolution_low	47.780 Å
r_factor	0.2099
r_work	0.2084
r_free	0.2455

fit	/app/data/saxs_computation/1h/11ha/11ha.fit
pddf	/app/data/pr_computation/1h/11ha/11ha.pr.out
profile	/app/data/saxs_computation/1h/11ha/11ha.dat

Crystal structure of a GII.4 norovirus capsid P domain in complex with neutralizing antibody 24C10

SAXS Profile

P(r) Distribution

1. Structure Basics

Download Data

2. SAXS Parameters (CRYSOL)

3. P(r) Analysis (GNOM)

4. Crystallography & Experiment

Unit Cell

Symmetry

Refinement

Diffraction

5. Entities & Polymer Info (3)

Entity 1 polymer

Polymer

Source

Entity 2 polymer

Polymer

Source

Entity 3 polymer

Polymer

Source

6. Citations (1)

7. Files & Curves (10)

Files (7)

Curves (3)