1aqf

PYRUVATE KINASE FROM RABBIT MUSCLE WITH MG, K, AND L-PHOSPHOLACTATE

Method: X-RAY DIFFRACTION

▼

1. 蛋白身份与相关结构 Protein Identity & Related Structures

PYRUVATE KINASE

物种未注明

UniProt P11974

当前结构中的状态

Assembly	物理组成	蛋白状态	分子拷贝数	共同组分	数据核对
1	蛋白同源多聚体	同源多聚体	蛋白 4	POTASSIUM ION × 4 MAGNESIUM ION × 4 L-PHOSPHOLACTATE × 4 water × 4	与蛋白数一致
2	蛋白同源多聚体	同源多聚体	蛋白 4	POTASSIUM ION × 4 MAGNESIUM ION × 4 L-PHOSPHOLACTATE × 4 water × 4	与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据

UniProt名称	KPYM_RABIT
Isoform	—
PDB实体	1
链与序列区间	作者链 A； PDB构建体 1–530； UniProt 1–530 作者链 B； PDB构建体 1–530； UniProt 1–530 作者链 C； PDB构建体 1–530； UniProt 1–530 作者链 D； PDB构建体 1–530； UniProt 1–530 作者链 E； PDB构建体 1–530； UniProt 1–530 作者链 F； PDB构建体 1–530； UniProt 1–530 作者链 G； PDB构建体 1–530； UniProt 1–530 作者链 H； PDB构建体 1–530； UniProt 1–530

页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。链映射与序列区间收在“数据证据”中；数据库内部编号、导入时间和 assembly 操作表达式仅用于维护，因此不在读者页面展示。

▼

2. 结构基本信息 2. Structure Basics

条目编号 entry_id	1aqf
沉积日期 deposition_date	1997-07-29
结构标题 title	PYRUVATE KINASE FROM RABBIT MUSCLE WITH MG, K, AND L-PHOSPHOLACTATE
关键词 keywords	TRANSFERASE, PYRUVATE KINASE, RABBIT MUSCLE, DOMAIN MOVEMENT, POTASSIUM BINDING; TRANSFERASE
实验方法 method	X-RAY DIFFRACTION

▼

3. Official assembly/model 理论 SAXS Official SAXS Profiles

页面只读取最新 assembly 计算结果。每一条曲线都对应明确的 PDB、official biological assembly 和 coordinate model。

1aqf__assembly_2__model_1

Assembly 2 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

下载该曲线 .dat

1aqf__assembly_2__model_1 | I(q)

100 个绘图点；横轴和纵轴均采用对数尺度。

1aqf__assembly_2__model_1 | P(r) · Pending

P(r) 将按相同 assembly/model 分别计算和展示。

Rg（Guinier）	40.25 Å
Rg（电子密度）	40.06 Å
总 Rg	40.37 Å
原子数	15253
残基数	1983
排除体积	272690 Å³
最大 q	0.500 Å⁻¹

Assembly	Model	结构单元	聚集说明	状态	CRYSOL	操作
1	1	`1aqf__assembly_1__model_1`	tetrameric （4）	成功	4.1.3-1-20251215 (887e7ef)	查看下载
2	1	`1aqf__assembly_2__model_1`	tetrameric （4）	成功	4.1.3-1-20251215 (887e7ef)	查看下载

▶

4. 晶体学与实验 4. Crystallography & Experiment

▶

5. 实体与聚合物信息 Entities & Polymers (5)

实体 1 Entity 1 polymer

描述 description	PYRUVATE KINASE
分子量 formula_weight	57998.8 kDa
EC 编号 ec_number	2.7.1.40
来源方法 src_method	nat
拷贝数 entity_count	8

聚合物 Polymer

聚合物类型 type	polypeptide(L)
链编号 strand_id	A,B,C,D,E,F,G,H
原子数 atom_count	31410

SKSHSEAGSAFIQTQQLHAAMADTFLEHMCRLDIDSAPITARNTGIICTIGPASRSVETLKEMIKSGMNVARMNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVDVGSKVYVDDGLISLQVKQKGPDFLVTEVENGGFLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKAADVHEVRKILGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMIIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAMFHRKLFEELARSSSHSTDLMEAMAMGSVEASYKCLAAALIVLTESGRSAHQVARYRPRAPIIAVTRNHQTARQAHLYRGIFPVVCKDPVQEAWAEDVDLRVNLAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP

实体 2 Entity 2 non-polymer

描述 description	POTASSIUM ION
分子量 formula_weight	39.1 kDa
来源方法 src_method	syn
拷贝数 entity_count	8

实体 3 Entity 3 non-polymer

描述 description	MAGNESIUM ION
分子量 formula_weight	24.3 kDa
来源方法 src_method	syn
拷贝数 entity_count	8

实体 4 Entity 4 non-polymer

描述 description	L-PHOSPHOLACTATE
分子量 formula_weight	170.1 kDa
来源方法 src_method	syn
拷贝数 entity_count	8

实体 5 Entity 5 water

描述 description	water
分子量 formula_weight	18.0 kDa
来源方法 src_method	nat
拷贝数 entity_count	194

▼

6. 折叠分类 (SCOP + CATH) 47 domains

SCOP 2.08 (24 domains)

结构域编号 domain_id	d1aqfa1
类 Class class	b — All beta proteins
折叠类型 Fold fold	b.58 — PK beta-barrel domain-like
超家族 Superfamily superfamily	b.58.1 — PK beta-barrel domain-like
家族 Family family	b.58.1.1 — Pyruvate kinase beta-barrel domain

结构域编号 domain_id	d1aqfa2
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.1 — TIM beta/alpha-barrel
超家族 Superfamily superfamily	c.1.12 — Phosphoenolpyruvate/pyruvate domain
家族 Family family	c.1.12.1 — Pyruvate kinase

结构域编号 domain_id	d1aqfa3
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.49 — Pyruvate kinase C-terminal domain-like
超家族 Superfamily superfamily	c.49.1 — PK C-terminal domain-like
家族 Family family	c.49.1.1 — Pyruvate kinase, C-terminal domain

结构域编号 domain_id	d1aqfb1
类 Class class	b — All beta proteins
折叠类型 Fold fold	b.58 — PK beta-barrel domain-like
超家族 Superfamily superfamily	b.58.1 — PK beta-barrel domain-like
家族 Family family	b.58.1.1 — Pyruvate kinase beta-barrel domain

结构域编号 domain_id	d1aqfb2
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.1 — TIM beta/alpha-barrel
超家族 Superfamily superfamily	c.1.12 — Phosphoenolpyruvate/pyruvate domain
家族 Family family	c.1.12.1 — Pyruvate kinase

结构域编号 domain_id	d1aqfb3
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.49 — Pyruvate kinase C-terminal domain-like
超家族 Superfamily superfamily	c.49.1 — PK C-terminal domain-like
家族 Family family	c.49.1.1 — Pyruvate kinase, C-terminal domain

结构域编号 domain_id	d1aqfc1
类 Class class	b — All beta proteins
折叠类型 Fold fold	b.58 — PK beta-barrel domain-like
超家族 Superfamily superfamily	b.58.1 — PK beta-barrel domain-like
家族 Family family	b.58.1.1 — Pyruvate kinase beta-barrel domain

结构域编号 domain_id	d1aqfc2
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.1 — TIM beta/alpha-barrel
超家族 Superfamily superfamily	c.1.12 — Phosphoenolpyruvate/pyruvate domain
家族 Family family	c.1.12.1 — Pyruvate kinase

结构域编号 domain_id	d1aqfc3
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.49 — Pyruvate kinase C-terminal domain-like
超家族 Superfamily superfamily	c.49.1 — PK C-terminal domain-like
家族 Family family	c.49.1.1 — Pyruvate kinase, C-terminal domain

结构域编号 domain_id	d1aqfd1
类 Class class	b — All beta proteins
折叠类型 Fold fold	b.58 — PK beta-barrel domain-like
超家族 Superfamily superfamily	b.58.1 — PK beta-barrel domain-like
家族 Family family	b.58.1.1 — Pyruvate kinase beta-barrel domain

结构域编号 domain_id	d1aqfd2
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.1 — TIM beta/alpha-barrel
超家族 Superfamily superfamily	c.1.12 — Phosphoenolpyruvate/pyruvate domain
家族 Family family	c.1.12.1 — Pyruvate kinase

结构域编号 domain_id	d1aqfd3
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.49 — Pyruvate kinase C-terminal domain-like
超家族 Superfamily superfamily	c.49.1 — PK C-terminal domain-like
家族 Family family	c.49.1.1 — Pyruvate kinase, C-terminal domain

结构域编号 domain_id	d1aqfe1
类 Class class	b — All beta proteins
折叠类型 Fold fold	b.58 — PK beta-barrel domain-like
超家族 Superfamily superfamily	b.58.1 — PK beta-barrel domain-like
家族 Family family	b.58.1.1 — Pyruvate kinase beta-barrel domain

结构域编号 domain_id	d1aqfe2
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.1 — TIM beta/alpha-barrel
超家族 Superfamily superfamily	c.1.12 — Phosphoenolpyruvate/pyruvate domain
家族 Family family	c.1.12.1 — Pyruvate kinase

结构域编号 domain_id	d1aqfe3
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.49 — Pyruvate kinase C-terminal domain-like
超家族 Superfamily superfamily	c.49.1 — PK C-terminal domain-like
家族 Family family	c.49.1.1 — Pyruvate kinase, C-terminal domain

结构域编号 domain_id	d1aqff1
类 Class class	b — All beta proteins
折叠类型 Fold fold	b.58 — PK beta-barrel domain-like
超家族 Superfamily superfamily	b.58.1 — PK beta-barrel domain-like
家族 Family family	b.58.1.1 — Pyruvate kinase beta-barrel domain

结构域编号 domain_id	d1aqff2
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.1 — TIM beta/alpha-barrel
超家族 Superfamily superfamily	c.1.12 — Phosphoenolpyruvate/pyruvate domain
家族 Family family	c.1.12.1 — Pyruvate kinase

结构域编号 domain_id	d1aqff3
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.49 — Pyruvate kinase C-terminal domain-like
超家族 Superfamily superfamily	c.49.1 — PK C-terminal domain-like
家族 Family family	c.49.1.1 — Pyruvate kinase, C-terminal domain

结构域编号 domain_id	d1aqfg1
类 Class class	b — All beta proteins
折叠类型 Fold fold	b.58 — PK beta-barrel domain-like
超家族 Superfamily superfamily	b.58.1 — PK beta-barrel domain-like
家族 Family family	b.58.1.1 — Pyruvate kinase beta-barrel domain

结构域编号 domain_id	d1aqfg2
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.1 — TIM beta/alpha-barrel
超家族 Superfamily superfamily	c.1.12 — Phosphoenolpyruvate/pyruvate domain
家族 Family family	c.1.12.1 — Pyruvate kinase

结构域编号 domain_id	d1aqfg3
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.49 — Pyruvate kinase C-terminal domain-like
超家族 Superfamily superfamily	c.49.1 — PK C-terminal domain-like
家族 Family family	c.49.1.1 — Pyruvate kinase, C-terminal domain

结构域编号 domain_id	d1aqfh1
类 Class class	b — All beta proteins
折叠类型 Fold fold	b.58 — PK beta-barrel domain-like
超家族 Superfamily superfamily	b.58.1 — PK beta-barrel domain-like
家族 Family family	b.58.1.1 — Pyruvate kinase beta-barrel domain

结构域编号 domain_id	d1aqfh2
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.1 — TIM beta/alpha-barrel
超家族 Superfamily superfamily	c.1.12 — Phosphoenolpyruvate/pyruvate domain
家族 Family family	c.1.12.1 — Pyruvate kinase

结构域编号 domain_id	d1aqfh3
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.49 — Pyruvate kinase C-terminal domain-like
超家族 Superfamily superfamily	c.49.1 — PK C-terminal domain-like
家族 Family family	c.49.1.1 — Pyruvate kinase, C-terminal domain

CATH v4.4 (23 domains)

结构域编号 domain_id	1aqfA01
类 Class class	3 — Alpha Beta
架构 Architecture architecture	40 — 3-Layer(aba) Sandwich
拓扑 Topology topology	1380 — Pyruvate Kinase; Chain: A, domain 1
同源超家族 H-superfamily homologous superfamily	20 — Pyruvate kinase, C-terminal domain

结构域编号 domain_id	1aqfA02
类 Class class	3 — Alpha Beta
架构 Architecture architecture	20 — Alpha-Beta Barrel
拓扑 Topology topology	20 — TIM Barrel
同源超家族 H-superfamily homologous superfamily	60 — Phosphoenolpyruvate-binding domains

结构域编号 domain_id	1aqfA03
类 Class class	2 — Mainly Beta
架构 Architecture architecture	40 — Beta Barrel
拓扑 Topology topology	33 — M1 Pyruvate Kinase; Domain 3
同源超家族 H-superfamily homologous superfamily	10 — PK beta-barrel domain-like

结构域编号 domain_id	1aqfB01
类 Class class	3 — Alpha Beta
架构 Architecture architecture	40 — 3-Layer(aba) Sandwich
拓扑 Topology topology	1380 — Pyruvate Kinase; Chain: A, domain 1
同源超家族 H-superfamily homologous superfamily	20 — Pyruvate kinase, C-terminal domain

结构域编号 domain_id	1aqfB02
类 Class class	3 — Alpha Beta
架构 Architecture architecture	20 — Alpha-Beta Barrel
拓扑 Topology topology	20 — TIM Barrel
同源超家族 H-superfamily homologous superfamily	60 — Phosphoenolpyruvate-binding domains

结构域编号 domain_id	1aqfB03
类 Class class	2 — Mainly Beta
架构 Architecture architecture	40 — Beta Barrel
拓扑 Topology topology	33 — M1 Pyruvate Kinase; Domain 3
同源超家族 H-superfamily homologous superfamily	10 — PK beta-barrel domain-like

结构域编号 domain_id	1aqfC01
类 Class class	3 — Alpha Beta
架构 Architecture architecture	40 — 3-Layer(aba) Sandwich
拓扑 Topology topology	1380 — Pyruvate Kinase; Chain: A, domain 1
同源超家族 H-superfamily homologous superfamily	20 — Pyruvate kinase, C-terminal domain

结构域编号 domain_id	1aqfC02
类 Class class	3 — Alpha Beta
架构 Architecture architecture	20 — Alpha-Beta Barrel
拓扑 Topology topology	20 — TIM Barrel
同源超家族 H-superfamily homologous superfamily	60 — Phosphoenolpyruvate-binding domains

结构域编号 domain_id	1aqfC03
类 Class class	2 — Mainly Beta
架构 Architecture architecture	40 — Beta Barrel
拓扑 Topology topology	33 — M1 Pyruvate Kinase; Domain 3
同源超家族 H-superfamily homologous superfamily	10 — PK beta-barrel domain-like

结构域编号 domain_id	1aqfD01
类 Class class	3 — Alpha Beta
架构 Architecture architecture	40 — 3-Layer(aba) Sandwich
拓扑 Topology topology	1380 — Pyruvate Kinase; Chain: A, domain 1
同源超家族 H-superfamily homologous superfamily	20 — Pyruvate kinase, C-terminal domain

结构域编号 domain_id	1aqfD02
类 Class class	3 — Alpha Beta
架构 Architecture architecture	20 — Alpha-Beta Barrel
拓扑 Topology topology	20 — TIM Barrel
同源超家族 H-superfamily homologous superfamily	60 — Phosphoenolpyruvate-binding domains

结构域编号 domain_id	1aqfD03
类 Class class	2 — Mainly Beta
架构 Architecture architecture	40 — Beta Barrel
拓扑 Topology topology	33 — M1 Pyruvate Kinase; Domain 3
同源超家族 H-superfamily homologous superfamily	10 — PK beta-barrel domain-like

结构域编号 domain_id	1aqfE01
类 Class class	3 — Alpha Beta
架构 Architecture architecture	40 — 3-Layer(aba) Sandwich
拓扑 Topology topology	1380 — Pyruvate Kinase; Chain: A, domain 1
同源超家族 H-superfamily homologous superfamily	20 — Pyruvate kinase, C-terminal domain

结构域编号 domain_id	1aqfE02
类 Class class	3 — Alpha Beta
架构 Architecture architecture	20 — Alpha-Beta Barrel
拓扑 Topology topology	20 — TIM Barrel
同源超家族 H-superfamily homologous superfamily	60 — Phosphoenolpyruvate-binding domains

结构域编号 domain_id	1aqfF01
类 Class class	3 — Alpha Beta
架构 Architecture architecture	40 — 3-Layer(aba) Sandwich
拓扑 Topology topology	1380 — Pyruvate Kinase; Chain: A, domain 1
同源超家族 H-superfamily homologous superfamily	20 — Pyruvate kinase, C-terminal domain

结构域编号 domain_id	1aqfF02
类 Class class	3 — Alpha Beta
架构 Architecture architecture	20 — Alpha-Beta Barrel
拓扑 Topology topology	20 — TIM Barrel
同源超家族 H-superfamily homologous superfamily	60 — Phosphoenolpyruvate-binding domains

结构域编号 domain_id	1aqfF03
类 Class class	2 — Mainly Beta
架构 Architecture architecture	40 — Beta Barrel
拓扑 Topology topology	33 — M1 Pyruvate Kinase; Domain 3
同源超家族 H-superfamily homologous superfamily	10 — PK beta-barrel domain-like

结构域编号 domain_id	1aqfG01
类 Class class	3 — Alpha Beta
架构 Architecture architecture	40 — 3-Layer(aba) Sandwich
拓扑 Topology topology	1380 — Pyruvate Kinase; Chain: A, domain 1
同源超家族 H-superfamily homologous superfamily	20 — Pyruvate kinase, C-terminal domain

结构域编号 domain_id	1aqfG02
类 Class class	3 — Alpha Beta
架构 Architecture architecture	20 — Alpha-Beta Barrel
拓扑 Topology topology	20 — TIM Barrel
同源超家族 H-superfamily homologous superfamily	60 — Phosphoenolpyruvate-binding domains

结构域编号 domain_id	1aqfG03
类 Class class	2 — Mainly Beta
架构 Architecture architecture	40 — Beta Barrel
拓扑 Topology topology	33 — M1 Pyruvate Kinase; Domain 3
同源超家族 H-superfamily homologous superfamily	10 — PK beta-barrel domain-like

结构域编号 domain_id	1aqfH01
类 Class class	3 — Alpha Beta
架构 Architecture architecture	40 — 3-Layer(aba) Sandwich
拓扑 Topology topology	1380 — Pyruvate Kinase; Chain: A, domain 1
同源超家族 H-superfamily homologous superfamily	20 — Pyruvate kinase, C-terminal domain

结构域编号 domain_id	1aqfH02
类 Class class	3 — Alpha Beta
架构 Architecture architecture	20 — Alpha-Beta Barrel
拓扑 Topology topology	20 — TIM Barrel
同源超家族 H-superfamily homologous superfamily	60 — Phosphoenolpyruvate-binding domains

结构域编号 domain_id	1aqfH03
类 Class class	2 — Mainly Beta
架构 Architecture architecture	40 — Beta Barrel
拓扑 Topology topology	33 — M1 Pyruvate Kinase; Domain 3
同源超家族 H-superfamily homologous superfamily	10 — PK beta-barrel domain-like

▶

晶胞边长 a length_a	144.400 Å
晶胞边长 b length_b	112.600 Å
晶胞边长 c length_c	171.200 Å
晶胞夹角 α angle_alpha	90.00 °
晶胞夹角 β angle_beta	93.70 °
晶胞夹角 γ angle_gamma	90.00 °
晶胞分子数 Z z_pdb	16

空间群 space_group	P 1 21 1
空间群编号 int_tables_number	4
晶系 crystal_system	—

分辨率 resolution	2.700 Å
最低分辨率 resolution_low	30.000 Å
R 因子 r_factor	—
R_work r_work	0.1960
R_free r_free	—

PYRUVATE KINASE FROM RABBIT MUSCLE WITH MG, K, AND L-PHOSPHOLACTATE

1. 蛋白身份与相关结构 Protein Identity & Related Structures

PYRUVATE KINASE

当前结构中的状态

数据库中的同蛋白其他状态

2. 结构基本信息 2. Structure Basics

3. Official assembly/model 理论 SAXS Official SAXS Profiles

1aqf__assembly_2__model_1

1aqf__assembly_2__model_1 | I(q)

1aqf__assembly_2__model_1 | P(r) · Pending

4. 晶体学与实验 4. Crystallography & Experiment

晶胞参数 Unit Cell

对称性 Symmetry

精修参数 Refinement

衍射实验 Diffraction

5. 实体与聚合物信息 Entities & Polymers (5)

实体 1 Entity 1 polymer

聚合物 Polymer

实体 2 Entity 2 non-polymer

实体 3 Entity 3 non-polymer

实体 4 Entity 4 non-polymer

实体 5 Entity 5 water

6. 折叠分类 (SCOP + CATH) 47 domains

SCOP 2.08 (24 domains)

CATH v4.4 (23 domains)

7. 引用文献 (1)

PYRUVATE KINASE FROM RABBIT MUSCLE WITH MG, K, AND L-PHOSPHOLACTATE

1. 蛋白身份与相关结构 Protein Identity & Related Structures

PYRUVATE KINASE

当前结构中的状态

数据库中的同蛋白其他状态

单体

同源二聚体

同源四聚体

其他同源多聚体

异源或核酸复合物

2. 结构基本信息 2. Structure Basics

3. Official assembly/model 理论 SAXS Official SAXS Profiles

1aqf__assembly_2__model_1

1aqf__assembly_2__model_1 | I(q)

1aqf__assembly_2__model_1 | P(r) · Pending

4. 晶体学与实验 4. Crystallography & Experiment

晶胞参数 Unit Cell

对称性 Symmetry

精修参数 Refinement

衍射实验 Diffraction

5. 实体与聚合物信息 Entities & Polymers (5)

实体 1 Entity 1 polymer

聚合物 Polymer

实体 2 Entity 2 non-polymer

实体 3 Entity 3 non-polymer

实体 4 Entity 4 non-polymer

实体 5 Entity 5 water

6. 折叠分类 (SCOP + CATH) 47 domains

SCOP 2.08 (24 domains)

CATH v4.4 (23 domains)

7. 引用文献 (1)