Homo sapiens
| Assembly | 物理组成 | 蛋白状态 | 分子拷贝数 | 共同组分 | 数据核对 |
|---|---|---|---|---|---|
| 1 | 蛋白同源多聚体 | 同源多聚体 | 蛋白 2 | ;(2S)-2-[(2-amino-1,3-thiazol-4-yl)methyl]-N~1~-{(1S,2S)-1-(cyclohexylmethyl)-2-hydroxy-2-[(3R)-1,5,5-trimethyl-2-oxopyrrolidin-3-yl]ethyl}-N~4~-[2-(dimethylamino)-2-oxoethyl]-N~4~-[(1S)-1-phenylethyl]butanediamide ; × 2 | 与蛋白数一致 |
| UniProt名称 | RENI_HUMAN |
| Isoform | — |
| PDB实体 | 1 |
| 链与序列区间 | 作者链 A； PDB构建体 1–337； UniProt 70–406 作者链 B； PDB构建体 1–337； UniProt 70–406 |
页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。 链映射与序列区间收在“数据证据”中；数据库内部编号、导入时间和 assembly 操作表达式仅用于维护，因此不在读者页面展示。
| 条目编号 entry_id | 1bim |
| 沉积日期 deposition_date | 1995-09-27 |
| 结构标题 title | CRYSTALLOGRAPHIC STUDIES ON THE BINDING MODES OF P2-P3 BUTANEDIAMIDE RENIN INHIBITORS |
| 关键词 keywords | ;ASPARTIC PROTEINASE, Aspartyl protease, Cleavage on pair of basic residues, Disease mutation, Disulfide bond, Glycoprotein, Hydrolase, Membrane, Protease, Secreted, Zymogen, HYDROLASE-HYDROLASE INHIBITOR complex ;; HYDROLASE/HYDROLASE INHIBITOR |
| 实验方法 method | X-RAY DIFFRACTION |
页面只读取最新 assembly 计算结果。每一条曲线都对应明确的 PDB、official biological assembly 和 coordinate model。
Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)
| Rg（Guinier） | 28.16 Å |
| Rg（电子密度） | 27.34 Å |
| 总 Rg | 28.24 Å |
| 原子数 | 5221 |
| 残基数 | 667 |
| 排除体积 | 92712 ų |
| 最大 q | 0.500 Å⁻¹ |
| 结构域编号 domain_id | d1bima_ |
| 类 Class class | b — All beta proteins |
| 折叠类型 Fold fold | b.50 — Acid proteases |
| 超家族 Superfamily superfamily | b.50.1 — Acid proteases |
| 家族 Family family | b.50.1.2 — Pepsin-like |
| 结构域编号 domain_id | d1bimb_ |
| 类 Class class | b — All beta proteins |
| 折叠类型 Fold fold | b.50 — Acid proteases |
| 超家族 Superfamily superfamily | b.50.1 — Acid proteases |
| 家族 Family family | b.50.1.2 — Pepsin-like |
| 结构域编号 domain_id | 1bimA01 |
| 类 Class class | 2 — Mainly Beta |
| 架构 Architecture architecture | 40 — Beta Barrel |
| 拓扑 Topology topology | 70 — Cathepsin D, subunit A; domain 1 |
| 同源超家族 H-superfamily homologous superfamily | 10 — Acid Proteases |
| 结构域编号 domain_id | 1bimA02 |
| 类 Class class | 2 — Mainly Beta |
| 架构 Architecture architecture | 40 — Beta Barrel |
| 拓扑 Topology topology | 70 — Cathepsin D, subunit A; domain 1 |
| 同源超家族 H-superfamily homologous superfamily | 10 — Acid Proteases |
| 结构域编号 domain_id | 1bimB01 |
| 类 Class class | 2 — Mainly Beta |
| 架构 Architecture architecture | 40 — Beta Barrel |
| 拓扑 Topology topology | 70 — Cathepsin D, subunit A; domain 1 |
| 同源超家族 H-superfamily homologous superfamily | 10 — Acid Proteases |
| 结构域编号 domain_id | 1bimB02 |
| 类 Class class | 2 — Mainly Beta |
| 架构 Architecture architecture | 40 — Beta Barrel |
| 拓扑 Topology topology | 70 — Cathepsin D, subunit A; domain 1 |
| 同源超家族 H-superfamily homologous superfamily | 10 — Acid Proteases |