1c3o

CRYSTAL STRUCTURE OF THE CARBAMOYL PHOSPHATE SYNTHETASE: SMALL SUBUNIT MUTANT C269S WITH BOUND GLUTAMINE

Method: X-RAY DIFFRACTION

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1. 蛋白身份与相关结构 Protein Identity & Related Structures

CARBAMOYL PHOSPHATE SYNTHETASE: LARGE SUBUNIT

Escherichia coli

当前结构中的状态

Assembly	物理组成	蛋白状态	分子拷贝数	共同组分	数据核对
1	蛋白异源复合物	异源复合物	蛋白 8	CARBAMOYL PHOSPHATE SYNTHETASE: SMALL SUBUNIT × 4 （P00907） MANGANESE (II) ION × 12 POTASSIUM ION × 32 CHLORIDE ION × 16 PHOSPHATE ION × 5 ADENOSINE-5'-DIPHOSPHATE × 8 L-ornithine × 4 GLUTAMINE × 8 TETRAETHYLAMMONIUM ION × 4 water × 8	与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据

UniProt名称	CARB_ECOLI
Isoform	—
PDB实体	1
链与序列区间	作者链 A； PDB构建体 1–1073； UniProt 1–1073 作者链 C； PDB构建体 1–1073； UniProt 1–1073 作者链 E； PDB构建体 1–1073； UniProt 1–1073 作者链 G； PDB构建体 1–1073； UniProt 1–1073

CARBAMOYL PHOSPHATE SYNTHETASE: SMALL SUBUNIT

Escherichia coli

UniProt P00907

当前结构中的状态

Assembly	物理组成	蛋白状态	分子拷贝数	共同组分	数据核对
1	蛋白异源复合物	异源复合物	蛋白 8	CARBAMOYL PHOSPHATE SYNTHETASE: LARGE SUBUNIT × 4 （P00968） MANGANESE (II) ION × 12 POTASSIUM ION × 32 CHLORIDE ION × 16 PHOSPHATE ION × 5 ADENOSINE-5'-DIPHOSPHATE × 8 L-ornithine × 4 GLUTAMINE × 8 TETRAETHYLAMMONIUM ION × 4 water × 8	与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据

UniProt名称	CARA_ECOLI
Isoform	—
PDB实体	2
链与序列区间	作者链 B； PDB构建体 1–382； UniProt 1–382 作者链 D； PDB构建体 1–382； UniProt 1–382 作者链 F； PDB构建体 1–382； UniProt 1–382 作者链 H； PDB构建体 1–382； UniProt 1–382

页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。链映射与序列区间收在“数据证据”中；数据库内部编号、导入时间和 assembly 操作表达式仅用于维护，因此不在读者页面展示。

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2. 结构基本信息 2. Structure Basics

条目编号 entry_id	1c3o
沉积日期 deposition_date	1999-07-28
结构标题 title	CRYSTAL STRUCTURE OF THE CARBAMOYL PHOSPHATE SYNTHETASE: SMALL SUBUNIT MUTANT C269S WITH BOUND GLUTAMINE
关键词 keywords	AMIDOTRANSFERASE, MICHAELIS COMPLEX, ATP-GRASP, LIGASE; LIGASE
实验方法 method	X-RAY DIFFRACTION

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3. Official assembly/model 理论 SAXS Official SAXS Profiles

页面只读取最新 assembly 计算结果。每一条曲线都对应明确的 PDB、official biological assembly 和 coordinate model。

1c3o__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

下载该曲线 .dat

1c3o__assembly_1__model_1 | I(q)

100 个绘图点；横轴和纵轴均采用对数尺度。

1c3o__assembly_1__model_1 | P(r) · Pending

P(r) 将按相同 assembly/model 分别计算和展示。

Rg（Guinier）	72.27 Å
Rg（电子密度）	72.33 Å
总 Rg	72.25 Å
原子数	44673
残基数	5748
排除体积	796150 Å³
最大 q	0.500 Å⁻¹

Assembly	Model	结构单元	聚集说明	状态	CRYSOL	操作
1	1	`1c3o__assembly_1__model_1`	octameric （8）	成功	4.1.3-1-20251215 (887e7ef)	查看下载

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4. 晶体学与实验 4. Crystallography & Experiment

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5. 实体与聚合物信息 Entities & Polymers (11)

实体 1 Entity 1 polymer

描述 description	CARBAMOYL PHOSPHATE SYNTHETASE: LARGE SUBUNIT
分子量 formula_weight	117981.8 kDa
EC 编号 ec_number	6.3.5.5
来源方法 src_method	man
拷贝数 entity_count	4

聚合物 Polymer

聚合物类型 type	polypeptide(L)
链编号 strand_id	A,C,E,G
原子数 atom_count	48477

MPKRTDIKSILILGAGPIVIGQACEFDYSGAQACKALREEGYRVILVNSNPATIMTDPEMADATYIEPIHWEVVRKIIEKERPDAVLPTMGGQTALNCALELERQGVLEEFGVTMIGATADAIDKAEDRRRFDVAMKKIGLETARSGIAHTMEEALAVAADVGFPCIIRPSFTMGGSGGGIAYNREEFEEICARGLDLSPTKELLIDESLIGWKEYEMEVVRDKNDNCIIVCSIENFDAMGIHTGDSITVAPAQTLTDKEYQIMRNASMAVLREIGVETGGSNVQFAVNPKNGRLIVIEMNPRVSRSSALASKATGFPIAKVAAKLAVGYTLDELMNDITGGRTPASFEPSIDYVVTKIPRFNFEKFAGANDRLTTQMKSVGEVMAIGRTQQESLQKALRGLEVGATGFDPKVSLDDPEALTKIRRELKDAGADRIWYIADAFRAGLSVDGVFNLTNIDRWFLVQIEELVRLEEKVAEVGITGLNADFLRQLKRKGFADARLAKLAGVREAEIRKLRDQYDLHPVYKRVDTCAAEFATDTAYMYSTYEEECEANPSTDREKIMVLGGGPNRIGQGIEFDYCCVHASLALREDGYETIMVNCNPETVSTDYDTSDRLYFEPVTLEDVLEIVRIEKPKGVIVQYGGQTPLKLARALEAAGVPVIGTSPDAIDRAEDRERFQHAVERLKLKQPANATVTAIEMAVEKAKEIGYPLVVRPSYVLGGRAMEIVYDEADLRRYFQTAVSVSNDAPVLLDHFLDDAVEVDVDAICDGEMVLIGGIMEHIEQAGVHSGDSACSLPAYTLSQEIQDVMRQQVQKLAFELQVRGLMNVQFAVKNNEVYLIEVNPRAARTVPFVSKATGVPLAKVAARVMAGKSLAEQGVTKEVIPPYYSVKEVVLPFNKFPGVDPLLGPEMRSTGEVMGVGRTFAEAFAKAQLGSNSTMKKHGRALLSVREGDKERVVDLAAKLLKQGFELDATHGTAIVLGEAGINPRLVNKVHEGRPHIQDRIKNGEYTYIINTTSGRRAIEDSRVIRRSALQYKVHYDTTLNGGFATAMALNADATEKVISVQEMHAQIK

来源 Source

来源生物 organism	Escherichia coli
NCBI 分类编号 ncbi_taxonomy_id	562
宿主生物 host_organism	Bacteria

实体 2 Entity 2 polymer

描述 description	CARBAMOYL PHOSPHATE SYNTHETASE: SMALL SUBUNIT
分子量 formula_weight	41465.8 kDa
EC 编号 ec_number	6.3.5.5
突变 mutation	C269S
来源方法 src_method	man
拷贝数 entity_count	4

聚合物 Polymer

聚合物类型 type	polypeptide(L)
链编号 strand_id	B,D,F,H

MIKSALLVLEDGTQFHGRAIGATGSAVGEVVFNTSMTGYQEILTDPSYSRQIVTLTYPHIGNVGTNDADEESSQVHAQGLVIRDLPLIASNFRNTEDLSSYLKRHNIVAIADIDTRKLTRLLREKGAQNGCIIAGDNPDAALALEKARAFPGLNGMDLAKEVTTAEAYSWTQGSWTLTGGLPEAKKEDELPFHVVAYDFGAKRNILRMLVDRGCRLTIVPAQTSAEDVLKMNPDGIFLSNGPGDPAPCDYAITAIQKFLETDIPVFGISLGHQLLALASGAKTVKMKFGHHGGNHPVKDVEKNVVMITAQNHGFAVDEATLPANLRVTHKSLFDGTLQGIHRTDKPAFSFQGHPEASPGPHDAAPLFDHFIELIEQYRKTAK

来源 Source

来源生物 organism	Escherichia coli
NCBI 分类编号 ncbi_taxonomy_id	562
宿主生物 host_organism	Bacteria

实体 3 Entity 3 non-polymer

描述 description	MANGANESE (II) ION
分子量 formula_weight	54.9 kDa
来源方法 src_method	syn
拷贝数 entity_count	12

实体 4 Entity 4 non-polymer

描述 description	POTASSIUM ION
分子量 formula_weight	39.1 kDa
来源方法 src_method	syn
拷贝数 entity_count	32

实体 5 Entity 5 non-polymer

描述 description	CHLORIDE ION
分子量 formula_weight	35.5 kDa
来源方法 src_method	syn
拷贝数 entity_count	16

实体 6 Entity 6 non-polymer

描述 description	PHOSPHATE ION
分子量 formula_weight	95.0 kDa
来源方法 src_method	syn
拷贝数 entity_count	5

实体 7 Entity 7 non-polymer

描述 description	ADENOSINE-5'-DIPHOSPHATE
分子量 formula_weight	427.2 kDa
来源方法 src_method	syn
拷贝数 entity_count	8

实体 8 Entity 8 non-polymer

描述 description	L-ornithine
分子量 formula_weight	132.2 kDa
来源方法 src_method	syn
拷贝数 entity_count	4

实体 9 Entity 9 non-polymer

描述 description	GLUTAMINE
分子量 formula_weight	146.1 kDa
来源方法 src_method	syn
拷贝数 entity_count	8

实体 10 Entity 10 non-polymer

描述 description	TETRAETHYLAMMONIUM ION
分子量 formula_weight	130.3 kDa
来源方法 src_method	syn
拷贝数 entity_count	4

实体 11 Entity 11 water

描述 description	water
分子量 formula_weight	18.0 kDa
来源方法 src_method	nat
拷贝数 entity_count	3666

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6. 折叠分类 (SCOP + CATH) 72 domains

SCOP 2.08 (32 domains)

结构域编号 domain_id	d1c3oa1
类 Class class	a — All alpha proteins
折叠类型 Fold fold	a.92 — Carbamoyl phosphate synthetase, large subunit connection domain
超家族 Superfamily superfamily	a.92.1 — Carbamoyl phosphate synthetase, large subunit connection domain
家族 Family family	a.92.1.1 — Carbamoyl phosphate synthetase, large subunit connection domain

结构域编号 domain_id	d1c3oa2
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.24 — Methylglyoxal synthase-like
超家族 Superfamily superfamily	c.24.1 — Methylglyoxal synthase-like
家族 Family family	c.24.1.1 — Carbamoyl phosphate synthetase, large subunit allosteric, C-terminal domain

结构域编号 domain_id	d1c3oa3
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.30 — PreATP-grasp domain
超家族 Superfamily superfamily	c.30.1 — PreATP-grasp domain
家族 Family family	c.30.1.1 — BC N-terminal domain-like

结构域编号 domain_id	d1c3oa4
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.30 — PreATP-grasp domain
超家族 Superfamily superfamily	c.30.1 — PreATP-grasp domain
家族 Family family	c.30.1.1 — BC N-terminal domain-like

结构域编号 domain_id	d1c3oa5
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.142 — ATP-grasp
超家族 Superfamily superfamily	d.142.1 — Glutathione synthetase ATP-binding domain-like
家族 Family family	d.142.1.2 — BC ATP-binding domain-like

结构域编号 domain_id	d1c3oa6
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.142 — ATP-grasp
超家族 Superfamily superfamily	d.142.1 — Glutathione synthetase ATP-binding domain-like
家族 Family family	d.142.1.2 — BC ATP-binding domain-like

结构域编号 domain_id	d1c3ob1
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.8 — The 'swivelling' beta/beta/alpha domain
超家族 Superfamily superfamily	c.8.3 — Carbamoyl phosphate synthetase, small subunit N-terminal domain
家族 Family family	c.8.3.1 — Carbamoyl phosphate synthetase, small subunit N-terminal domain

结构域编号 domain_id	d1c3ob2
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.23 — Flavodoxin-like
超家族 Superfamily superfamily	c.23.16 — Class I glutamine amidotransferase-like
家族 Family family	c.23.16.1 — Class I glutamine amidotransferases (GAT)

结构域编号 domain_id	d1c3oc1
类 Class class	a — All alpha proteins
折叠类型 Fold fold	a.92 — Carbamoyl phosphate synthetase, large subunit connection domain
超家族 Superfamily superfamily	a.92.1 — Carbamoyl phosphate synthetase, large subunit connection domain
家族 Family family	a.92.1.1 — Carbamoyl phosphate synthetase, large subunit connection domain

结构域编号 domain_id	d1c3oc2
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.24 — Methylglyoxal synthase-like
超家族 Superfamily superfamily	c.24.1 — Methylglyoxal synthase-like
家族 Family family	c.24.1.1 — Carbamoyl phosphate synthetase, large subunit allosteric, C-terminal domain

结构域编号 domain_id	d1c3oc3
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.30 — PreATP-grasp domain
超家族 Superfamily superfamily	c.30.1 — PreATP-grasp domain
家族 Family family	c.30.1.1 — BC N-terminal domain-like

结构域编号 domain_id	d1c3oc4
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.30 — PreATP-grasp domain
超家族 Superfamily superfamily	c.30.1 — PreATP-grasp domain
家族 Family family	c.30.1.1 — BC N-terminal domain-like

结构域编号 domain_id	d1c3oc5
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.142 — ATP-grasp
超家族 Superfamily superfamily	d.142.1 — Glutathione synthetase ATP-binding domain-like
家族 Family family	d.142.1.2 — BC ATP-binding domain-like

结构域编号 domain_id	d1c3oc6
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.142 — ATP-grasp
超家族 Superfamily superfamily	d.142.1 — Glutathione synthetase ATP-binding domain-like
家族 Family family	d.142.1.2 — BC ATP-binding domain-like

结构域编号 domain_id	d1c3od1
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.8 — The 'swivelling' beta/beta/alpha domain
超家族 Superfamily superfamily	c.8.3 — Carbamoyl phosphate synthetase, small subunit N-terminal domain
家族 Family family	c.8.3.1 — Carbamoyl phosphate synthetase, small subunit N-terminal domain

结构域编号 domain_id	d1c3od2
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.23 — Flavodoxin-like
超家族 Superfamily superfamily	c.23.16 — Class I glutamine amidotransferase-like
家族 Family family	c.23.16.1 — Class I glutamine amidotransferases (GAT)

结构域编号 domain_id	d1c3oe1
类 Class class	a — All alpha proteins
折叠类型 Fold fold	a.92 — Carbamoyl phosphate synthetase, large subunit connection domain
超家族 Superfamily superfamily	a.92.1 — Carbamoyl phosphate synthetase, large subunit connection domain
家族 Family family	a.92.1.1 — Carbamoyl phosphate synthetase, large subunit connection domain

结构域编号 domain_id	d1c3oe2
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.24 — Methylglyoxal synthase-like
超家族 Superfamily superfamily	c.24.1 — Methylglyoxal synthase-like
家族 Family family	c.24.1.1 — Carbamoyl phosphate synthetase, large subunit allosteric, C-terminal domain

结构域编号 domain_id	d1c3oe3
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.30 — PreATP-grasp domain
超家族 Superfamily superfamily	c.30.1 — PreATP-grasp domain
家族 Family family	c.30.1.1 — BC N-terminal domain-like

结构域编号 domain_id	d1c3oe4
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.30 — PreATP-grasp domain
超家族 Superfamily superfamily	c.30.1 — PreATP-grasp domain
家族 Family family	c.30.1.1 — BC N-terminal domain-like

结构域编号 domain_id	d1c3oe5
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.142 — ATP-grasp
超家族 Superfamily superfamily	d.142.1 — Glutathione synthetase ATP-binding domain-like
家族 Family family	d.142.1.2 — BC ATP-binding domain-like

结构域编号 domain_id	d1c3oe6
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.142 — ATP-grasp
超家族 Superfamily superfamily	d.142.1 — Glutathione synthetase ATP-binding domain-like
家族 Family family	d.142.1.2 — BC ATP-binding domain-like

结构域编号 domain_id	d1c3of1
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.8 — The 'swivelling' beta/beta/alpha domain
超家族 Superfamily superfamily	c.8.3 — Carbamoyl phosphate synthetase, small subunit N-terminal domain
家族 Family family	c.8.3.1 — Carbamoyl phosphate synthetase, small subunit N-terminal domain

结构域编号 domain_id	d1c3of2
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.23 — Flavodoxin-like
超家族 Superfamily superfamily	c.23.16 — Class I glutamine amidotransferase-like
家族 Family family	c.23.16.1 — Class I glutamine amidotransferases (GAT)

结构域编号 domain_id	d1c3og1
类 Class class	a — All alpha proteins
折叠类型 Fold fold	a.92 — Carbamoyl phosphate synthetase, large subunit connection domain
超家族 Superfamily superfamily	a.92.1 — Carbamoyl phosphate synthetase, large subunit connection domain
家族 Family family	a.92.1.1 — Carbamoyl phosphate synthetase, large subunit connection domain

结构域编号 domain_id	d1c3og2
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.24 — Methylglyoxal synthase-like
超家族 Superfamily superfamily	c.24.1 — Methylglyoxal synthase-like
家族 Family family	c.24.1.1 — Carbamoyl phosphate synthetase, large subunit allosteric, C-terminal domain

结构域编号 domain_id	d1c3og3
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.30 — PreATP-grasp domain
超家族 Superfamily superfamily	c.30.1 — PreATP-grasp domain
家族 Family family	c.30.1.1 — BC N-terminal domain-like

结构域编号 domain_id	d1c3og4
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.30 — PreATP-grasp domain
超家族 Superfamily superfamily	c.30.1 — PreATP-grasp domain
家族 Family family	c.30.1.1 — BC N-terminal domain-like

结构域编号 domain_id	d1c3og5
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.142 — ATP-grasp
超家族 Superfamily superfamily	d.142.1 — Glutathione synthetase ATP-binding domain-like
家族 Family family	d.142.1.2 — BC ATP-binding domain-like

结构域编号 domain_id	d1c3og6
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.142 — ATP-grasp
超家族 Superfamily superfamily	d.142.1 — Glutathione synthetase ATP-binding domain-like
家族 Family family	d.142.1.2 — BC ATP-binding domain-like

结构域编号 domain_id	d1c3oh1
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.8 — The 'swivelling' beta/beta/alpha domain
超家族 Superfamily superfamily	c.8.3 — Carbamoyl phosphate synthetase, small subunit N-terminal domain
家族 Family family	c.8.3.1 — Carbamoyl phosphate synthetase, small subunit N-terminal domain

结构域编号 domain_id	d1c3oh2
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.23 — Flavodoxin-like
超家族 Superfamily superfamily	c.23.16 — Class I glutamine amidotransferase-like
家族 Family family	c.23.16.1 — Class I glutamine amidotransferases (GAT)

CATH v4.4 (40 domains)

结构域编号 domain_id	1c3oA01
类 Class class	3 — Alpha Beta
架构 Architecture architecture	40 — 3-Layer(aba) Sandwich
拓扑 Topology topology	50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily	20 —

结构域编号 domain_id	1c3oA02
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	470 — D-amino Acid Aminotransferase; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily	20 — ATP-grasp fold, B domain

结构域编号 domain_id	1c3oA03
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	1490 — Dna Ligase; domain 1
同源超家族 H-superfamily homologous superfamily	20 — ATP-grasp fold, A domain

结构域编号 domain_id	1c3oA04
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	1030 — Carbamoyl Phosphate Synthetase; Chain A, domain 4
同源超家族 H-superfamily homologous superfamily	10 — Carbamoyl-phosphate synthetase, large subunit oligomerisation domain

结构域编号 domain_id	1c3oA05
类 Class class	3 — Alpha Beta
架构 Architecture architecture	40 — 3-Layer(aba) Sandwich
拓扑 Topology topology	50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily	20 —

结构域编号 domain_id	1c3oA06
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	470 — D-amino Acid Aminotransferase; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily	20 — ATP-grasp fold, B domain

结构域编号 domain_id	1c3oA07
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	1490 — Dna Ligase; domain 1
同源超家族 H-superfamily homologous superfamily	20 — ATP-grasp fold, A domain

结构域编号 domain_id	1c3oA08
类 Class class	3 — Alpha Beta
架构 Architecture architecture	40 — 3-Layer(aba) Sandwich
拓扑 Topology topology	50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily	1380 — Methylglyoxal synthase-like domain

结构域编号 domain_id	1c3oB01
类 Class class	3 — Alpha Beta
架构 Architecture architecture	50 — 3-Layer(bba) Sandwich
拓扑 Topology topology	30 — Glucose Oxidase; domain 1
同源超家族 H-superfamily homologous superfamily	20 — Carbamoyl-phosphate synthase small subunit, N-terminal domain

结构域编号 domain_id	1c3oB02
类 Class class	3 — Alpha Beta
架构 Architecture architecture	40 — 3-Layer(aba) Sandwich
拓扑 Topology topology	50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily	880 — Class I glutamine amidotransferase (GATase) domain

结构域编号 domain_id	1c3oC01
类 Class class	3 — Alpha Beta
架构 Architecture architecture	40 — 3-Layer(aba) Sandwich
拓扑 Topology topology	50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily	20 —

结构域编号 domain_id	1c3oC02
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	470 — D-amino Acid Aminotransferase; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily	20 — ATP-grasp fold, B domain

结构域编号 domain_id	1c3oC03
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	1490 — Dna Ligase; domain 1
同源超家族 H-superfamily homologous superfamily	20 — ATP-grasp fold, A domain

结构域编号 domain_id	1c3oC04
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	1030 — Carbamoyl Phosphate Synthetase; Chain A, domain 4
同源超家族 H-superfamily homologous superfamily	10 — Carbamoyl-phosphate synthetase, large subunit oligomerisation domain

结构域编号 domain_id	1c3oC05
类 Class class	3 — Alpha Beta
架构 Architecture architecture	40 — 3-Layer(aba) Sandwich
拓扑 Topology topology	50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily	20 —

结构域编号 domain_id	1c3oC06
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	470 — D-amino Acid Aminotransferase; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily	20 — ATP-grasp fold, B domain

结构域编号 domain_id	1c3oC07
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	1490 — Dna Ligase; domain 1
同源超家族 H-superfamily homologous superfamily	20 — ATP-grasp fold, A domain

结构域编号 domain_id	1c3oC08
类 Class class	3 — Alpha Beta
架构 Architecture architecture	40 — 3-Layer(aba) Sandwich
拓扑 Topology topology	50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily	1380 — Methylglyoxal synthase-like domain

结构域编号 domain_id	1c3oD01
类 Class class	3 — Alpha Beta
架构 Architecture architecture	50 — 3-Layer(bba) Sandwich
拓扑 Topology topology	30 — Glucose Oxidase; domain 1
同源超家族 H-superfamily homologous superfamily	20 — Carbamoyl-phosphate synthase small subunit, N-terminal domain

结构域编号 domain_id	1c3oD02
类 Class class	3 — Alpha Beta
架构 Architecture architecture	40 — 3-Layer(aba) Sandwich
拓扑 Topology topology	50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily	880 — Class I glutamine amidotransferase (GATase) domain

结构域编号 domain_id	1c3oE01
类 Class class	3 — Alpha Beta
架构 Architecture architecture	40 — 3-Layer(aba) Sandwich
拓扑 Topology topology	50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily	20 —

结构域编号 domain_id	1c3oE02
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	470 — D-amino Acid Aminotransferase; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily	20 — ATP-grasp fold, B domain

结构域编号 domain_id	1c3oE03
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	1490 — Dna Ligase; domain 1
同源超家族 H-superfamily homologous superfamily	20 — ATP-grasp fold, A domain

结构域编号 domain_id	1c3oE04
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	1030 — Carbamoyl Phosphate Synthetase; Chain A, domain 4
同源超家族 H-superfamily homologous superfamily	10 — Carbamoyl-phosphate synthetase, large subunit oligomerisation domain

结构域编号 domain_id	1c3oE05
类 Class class	3 — Alpha Beta
架构 Architecture architecture	40 — 3-Layer(aba) Sandwich
拓扑 Topology topology	50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily	20 —

结构域编号 domain_id	1c3oE06
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	470 — D-amino Acid Aminotransferase; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily	20 — ATP-grasp fold, B domain

结构域编号 domain_id	1c3oE07
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	1490 — Dna Ligase; domain 1
同源超家族 H-superfamily homologous superfamily	20 — ATP-grasp fold, A domain

结构域编号 domain_id	1c3oE08
类 Class class	3 — Alpha Beta
架构 Architecture architecture	40 — 3-Layer(aba) Sandwich
拓扑 Topology topology	50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily	1380 — Methylglyoxal synthase-like domain

结构域编号 domain_id	1c3oF01
类 Class class	3 — Alpha Beta
架构 Architecture architecture	50 — 3-Layer(bba) Sandwich
拓扑 Topology topology	30 — Glucose Oxidase; domain 1
同源超家族 H-superfamily homologous superfamily	20 — Carbamoyl-phosphate synthase small subunit, N-terminal domain

结构域编号 domain_id	1c3oF02
类 Class class	3 — Alpha Beta
架构 Architecture architecture	40 — 3-Layer(aba) Sandwich
拓扑 Topology topology	50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily	880 — Class I glutamine amidotransferase (GATase) domain

结构域编号 domain_id	1c3oG01
类 Class class	3 — Alpha Beta
架构 Architecture architecture	40 — 3-Layer(aba) Sandwich
拓扑 Topology topology	50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily	20 —

结构域编号 domain_id	1c3oG02
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	470 — D-amino Acid Aminotransferase; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily	20 — ATP-grasp fold, B domain

结构域编号 domain_id	1c3oG03
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	1490 — Dna Ligase; domain 1
同源超家族 H-superfamily homologous superfamily	20 — ATP-grasp fold, A domain

结构域编号 domain_id	1c3oG04
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	1030 — Carbamoyl Phosphate Synthetase; Chain A, domain 4
同源超家族 H-superfamily homologous superfamily	10 — Carbamoyl-phosphate synthetase, large subunit oligomerisation domain

结构域编号 domain_id	1c3oG05
类 Class class	3 — Alpha Beta
架构 Architecture architecture	40 — 3-Layer(aba) Sandwich
拓扑 Topology topology	50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily	20 —

结构域编号 domain_id	1c3oG06
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	470 — D-amino Acid Aminotransferase; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily	20 — ATP-grasp fold, B domain

结构域编号 domain_id	1c3oG07
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	1490 — Dna Ligase; domain 1
同源超家族 H-superfamily homologous superfamily	20 — ATP-grasp fold, A domain

结构域编号 domain_id	1c3oG08
类 Class class	3 — Alpha Beta
架构 Architecture architecture	40 — 3-Layer(aba) Sandwich
拓扑 Topology topology	50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily	1380 — Methylglyoxal synthase-like domain

结构域编号 domain_id	1c3oH01
类 Class class	3 — Alpha Beta
架构 Architecture architecture	50 — 3-Layer(bba) Sandwich
拓扑 Topology topology	30 — Glucose Oxidase; domain 1
同源超家族 H-superfamily homologous superfamily	20 — Carbamoyl-phosphate synthase small subunit, N-terminal domain

结构域编号 domain_id	1c3oH02
类 Class class	3 — Alpha Beta
架构 Architecture architecture	40 — 3-Layer(aba) Sandwich
拓扑 Topology topology	50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily	880 — Class I glutamine amidotransferase (GATase) domain

▶

晶胞边长 a length_a	152.500 Å
晶胞边长 b length_b	164.400 Å
晶胞边长 c length_c	332.600 Å
晶胞夹角 α angle_alpha	90.00 °
晶胞夹角 β angle_beta	90.00 °
晶胞夹角 γ angle_gamma	90.00 °
晶胞分子数 Z z_pdb	16

空间群 space_group	P 21 21 21
空间群编号 int_tables_number	19
晶系 crystal_system	—

分辨率 resolution	2.100 Å
最低分辨率 resolution_low	30.000 Å
R 因子 r_factor	0.1890
R_work r_work	0.1880
R_free r_free	0.2580

CRYSTAL STRUCTURE OF THE CARBAMOYL PHOSPHATE SYNTHETASE: SMALL SUBUNIT MUTANT C269S WITH BOUND GLUTAMINE

1. 蛋白身份与相关结构 Protein Identity & Related Structures

CARBAMOYL PHOSPHATE SYNTHETASE: LARGE SUBUNIT

当前结构中的状态

数据库中的同蛋白其他状态

CARBAMOYL PHOSPHATE SYNTHETASE: SMALL SUBUNIT

当前结构中的状态

数据库中的同蛋白其他状态

2. 结构基本信息 2. Structure Basics

3. Official assembly/model 理论 SAXS Official SAXS Profiles

1c3o__assembly_1__model_1

1c3o__assembly_1__model_1 | I(q)

1c3o__assembly_1__model_1 | P(r) · Pending

4. 晶体学与实验 4. Crystallography & Experiment

晶胞参数 Unit Cell

对称性 Symmetry

精修参数 Refinement

衍射实验 Diffraction

5. 实体与聚合物信息 Entities & Polymers (11)

实体 1 Entity 1 polymer

聚合物 Polymer

来源 Source

实体 2 Entity 2 polymer

聚合物 Polymer

来源 Source

实体 3 Entity 3 non-polymer

实体 4 Entity 4 non-polymer

实体 5 Entity 5 non-polymer

实体 6 Entity 6 non-polymer

实体 7 Entity 7 non-polymer

实体 8 Entity 8 non-polymer

实体 9 Entity 9 non-polymer

实体 10 Entity 10 non-polymer

实体 11 Entity 11 water

6. 折叠分类 (SCOP + CATH) 72 domains

SCOP 2.08 (32 domains)

CATH v4.4 (40 domains)

7. 引用文献 (1)

CRYSTAL STRUCTURE OF THE CARBAMOYL PHOSPHATE SYNTHETASE: SMALL SUBUNIT MUTANT C269S WITH BOUND GLUTAMINE

1. 蛋白身份与相关结构 Protein Identity & Related Structures

CARBAMOYL PHOSPHATE SYNTHETASE: LARGE SUBUNIT

当前结构中的状态

数据库中的同蛋白其他状态

单体

同源二聚体

同源四聚体

其他同源多聚体

异源或核酸复合物

CARBAMOYL PHOSPHATE SYNTHETASE: SMALL SUBUNIT

当前结构中的状态

数据库中的同蛋白其他状态

单体

同源二聚体

同源四聚体

其他同源多聚体

异源或核酸复合物

2. 结构基本信息 2. Structure Basics

3. Official assembly/model 理论 SAXS Official SAXS Profiles

1c3o__assembly_1__model_1

1c3o__assembly_1__model_1 | I(q)

1c3o__assembly_1__model_1 | P(r) · Pending

4. 晶体学与实验 4. Crystallography & Experiment

晶胞参数 Unit Cell

对称性 Symmetry

精修参数 Refinement

衍射实验 Diffraction

5. 实体与聚合物信息 Entities & Polymers (11)

实体 1 Entity 1 polymer

聚合物 Polymer

来源 Source

实体 2 Entity 2 polymer

聚合物 Polymer

来源 Source

实体 3 Entity 3 non-polymer

实体 4 Entity 4 non-polymer

实体 5 Entity 5 non-polymer

实体 6 Entity 6 non-polymer

实体 7 Entity 7 non-polymer

实体 8 Entity 8 non-polymer

实体 9 Entity 9 non-polymer

实体 10 Entity 10 non-polymer

实体 11 Entity 11 water

6. 折叠分类 (SCOP + CATH) 72 domains

SCOP 2.08 (32 domains)

CATH v4.4 (40 domains)

7. 引用文献 (1)