1ce8

CARBAMOYL PHOSPHATE SYNTHETASE FROM ESCHERICHIS COLI WITH COMPLEXED WITH THE ALLOSTERIC LIGAND IMP

Method: X-RAY DIFFRACTION D_max: 255.6 Å Quality: GOOD

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1. 蛋白身份与相关结构 Protein Identity & Related Structures

PROTEIN (CARBAMOYL-PHOSPHATE SYNTHASE)

Escherichia coli

当前结构中的状态

Assembly	聚集状态	构建体	突变与修饰	配体、离子与共同组分	实验方法与环境	结构质量
1	蛋白异源复合物异源复合物蛋白 × 8 PDB 声明：octameric（8）与蛋白拷贝数一致	链 A； UniProt 1–1073 链 C； UniProt 1–1073 链 E； UniProt 1–1073 链 G； UniProt 1–1073	未记录	PROTEIN (CARBAMOYL-PHOSPHATE SYNTHASE) × 4 （P0A6F1） MN MANGANESE (II) ION × 12 K POTASSIUM ION × 28 CL CHLORIDE ION × 12 PO4 PHOSPHATE ION × 4 ADP ADENOSINE-5'-DIPHOSPHATE × 8 ORN L-ornithine × 8 IMP INOSINIC ACID × 4 NET TETRAETHYLAMMONIUM ION × 4	X-RAY DIFFRACTION X-ray结晶条件：pH 7.4；pH 7.4	分辨率 2.10 Å R-free 0.250
2	蛋白异源复合物异源复合物蛋白 × 2 PDB 声明：dimeric（2）与蛋白拷贝数一致	链 A； UniProt 1–1073	未记录	PROTEIN (CARBAMOYL-PHOSPHATE SYNTHASE) × 1 （P0A6F1） MN MANGANESE (II) ION × 3 K POTASSIUM ION × 7 CL CHLORIDE ION × 3 PO4 PHOSPHATE ION × 1 ADP ADENOSINE-5'-DIPHOSPHATE × 2 ORN L-ornithine × 2 IMP INOSINIC ACID × 1 NET TETRAETHYLAMMONIUM ION × 1	X-RAY DIFFRACTION X-ray结晶条件：pH 7.4；pH 7.4	分辨率 2.10 Å R-free 0.250
3	蛋白异源复合物异源复合物蛋白 × 2 PDB 声明：dimeric（2）与蛋白拷贝数一致	链 G； UniProt 1–1073	未记录	PROTEIN (CARBAMOYL-PHOSPHATE SYNTHASE) × 1 （P0A6F1） MN MANGANESE (II) ION × 3 K POTASSIUM ION × 7 CL CHLORIDE ION × 3 PO4 PHOSPHATE ION × 1 ADP ADENOSINE-5'-DIPHOSPHATE × 2 ORN L-ornithine × 2 IMP INOSINIC ACID × 1 NET TETRAETHYLAMMONIUM ION × 1	X-RAY DIFFRACTION X-ray结晶条件：pH 7.4；pH 7.4	分辨率 2.10 Å R-free 0.250
4	蛋白异源复合物异源复合物蛋白 × 2 PDB 声明：dimeric（2）与蛋白拷贝数一致	链 C； UniProt 1–1073	未记录	PROTEIN (CARBAMOYL-PHOSPHATE SYNTHASE) × 1 （P0A6F1） MN MANGANESE (II) ION × 3 K POTASSIUM ION × 7 CL CHLORIDE ION × 3 PO4 PHOSPHATE ION × 1 ADP ADENOSINE-5'-DIPHOSPHATE × 2 ORN L-ornithine × 2 IMP INOSINIC ACID × 1 NET TETRAETHYLAMMONIUM ION × 1	X-RAY DIFFRACTION X-ray结晶条件：pH 7.4；pH 7.4	分辨率 2.10 Å R-free 0.250
5	蛋白异源复合物异源复合物蛋白 × 2 PDB 声明：dimeric（2）与蛋白拷贝数一致	链 E； UniProt 1–1073	未记录	PROTEIN (CARBAMOYL-PHOSPHATE SYNTHASE) × 1 （P0A6F1） MN MANGANESE (II) ION × 3 K POTASSIUM ION × 7 CL CHLORIDE ION × 3 PO4 PHOSPHATE ION × 1 ADP ADENOSINE-5'-DIPHOSPHATE × 2 ORN L-ornithine × 2 IMP INOSINIC ACID × 1 NET TETRAETHYLAMMONIUM ION × 1	X-RAY DIFFRACTION X-ray结晶条件：pH 7.4；pH 7.4	分辨率 2.10 Å R-free 0.250

数据库中的同蛋白其他状态

以下每一行都是同一 UniProt 蛋白在另一个 PDB 条目中的 biological assembly， “相对当前条目”直接指出证据层面的不同；没有差异标签表示当前已读取字段一致。

其他 PDB	相对当前条目 1CE8	Assembly / 聚集状态	构建体	突变与修饰	配体、离子与非聚合物	实验方法与环境	结构质量
1A9X CARBAMOYL PHOSPHATE SYNTHETASE: CAUGHT IN THE ACT OF GLUTAMINE HYDROLYSIS 提交 1998-04-14	构建体不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 A 1–1072（1072 aa）链 C 1–1072（1072 aa）链 E 1–1072（1072 aa）链 G 1–1072（1072 aa）	未记录	PO4 PHOSPHATE ION × 15 MN MANGANESE (II) ION × 12 K POTASSIUM ION × 32 CL CHLORIDE ION × 28 ADP ADENOSINE-5'-DIPHOSPHATE × 8 ORN L-ornithine × 4 NET TETRAETHYLAMMONIUM ION × 4	X-RAY DIFFRACTION X-ray结晶条件 pH 7.4；0.65M NET4CL 8% PEG 8000 100MM KCL 2.5MM MNCL2 2.5MM ADP 2.5MM ORNITHINE 5MM GLUTAMINE 25MM HEPES PH 7.4 THEN SOAKED INTO: 1.4M NET4CL 8% PEG 8000 250MM KCL 2.5MM MNCL2 2.5MM ADP 2.5MM ORNITHINE 5MM GLUTAMINE 25MM HEPES PH 7.4 7.5% ETHYLENE GLYCOL	分辨率 1.80 Å
1A9X CARBAMOYL PHOSPHATE SYNTHETASE: CAUGHT IN THE ACT OF GLUTAMINE HYDROLYSIS 提交 1998-04-14	构建体不同配体/离子不同实验环境不同结构质量不同	Assembly 2 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 A 1–1072（1072 aa）	未记录	PO4 PHOSPHATE ION × 4 MN MANGANESE (II) ION × 3 K POTASSIUM ION × 8 CL CHLORIDE ION × 7 ADP ADENOSINE-5'-DIPHOSPHATE × 2 ORN L-ornithine × 1 NET TETRAETHYLAMMONIUM ION × 1	X-RAY DIFFRACTION X-ray结晶条件 pH 7.4；0.65M NET4CL 8% PEG 8000 100MM KCL 2.5MM MNCL2 2.5MM ADP 2.5MM ORNITHINE 5MM GLUTAMINE 25MM HEPES PH 7.4 THEN SOAKED INTO: 1.4M NET4CL 8% PEG 8000 250MM KCL 2.5MM MNCL2 2.5MM ADP 2.5MM ORNITHINE 5MM GLUTAMINE 25MM HEPES PH 7.4 7.5% ETHYLENE GLYCOL	分辨率 1.80 Å
1A9X CARBAMOYL PHOSPHATE SYNTHETASE: CAUGHT IN THE ACT OF GLUTAMINE HYDROLYSIS 提交 1998-04-14	构建体不同配体/离子不同实验环境不同结构质量不同	Assembly 3 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 G 1–1072（1072 aa）	未记录	PO4 PHOSPHATE ION × 4 MN MANGANESE (II) ION × 3 K POTASSIUM ION × 8 CL CHLORIDE ION × 7 ADP ADENOSINE-5'-DIPHOSPHATE × 2 ORN L-ornithine × 1 NET TETRAETHYLAMMONIUM ION × 1	X-RAY DIFFRACTION X-ray结晶条件 pH 7.4；0.65M NET4CL 8% PEG 8000 100MM KCL 2.5MM MNCL2 2.5MM ADP 2.5MM ORNITHINE 5MM GLUTAMINE 25MM HEPES PH 7.4 THEN SOAKED INTO: 1.4M NET4CL 8% PEG 8000 250MM KCL 2.5MM MNCL2 2.5MM ADP 2.5MM ORNITHINE 5MM GLUTAMINE 25MM HEPES PH 7.4 7.5% ETHYLENE GLYCOL	分辨率 1.80 Å
1A9X CARBAMOYL PHOSPHATE SYNTHETASE: CAUGHT IN THE ACT OF GLUTAMINE HYDROLYSIS 提交 1998-04-14	构建体不同配体/离子不同实验环境不同结构质量不同	Assembly 4 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 C 1–1072（1072 aa）	未记录	PO4 PHOSPHATE ION × 4 MN MANGANESE (II) ION × 3 K POTASSIUM ION × 8 CL CHLORIDE ION × 7 ADP ADENOSINE-5'-DIPHOSPHATE × 2 ORN L-ornithine × 1 NET TETRAETHYLAMMONIUM ION × 1	X-RAY DIFFRACTION X-ray结晶条件 pH 7.4；0.65M NET4CL 8% PEG 8000 100MM KCL 2.5MM MNCL2 2.5MM ADP 2.5MM ORNITHINE 5MM GLUTAMINE 25MM HEPES PH 7.4 THEN SOAKED INTO: 1.4M NET4CL 8% PEG 8000 250MM KCL 2.5MM MNCL2 2.5MM ADP 2.5MM ORNITHINE 5MM GLUTAMINE 25MM HEPES PH 7.4 7.5% ETHYLENE GLYCOL	分辨率 1.80 Å
1A9X CARBAMOYL PHOSPHATE SYNTHETASE: CAUGHT IN THE ACT OF GLUTAMINE HYDROLYSIS 提交 1998-04-14	构建体不同配体/离子不同实验环境不同结构质量不同	Assembly 5 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 E 1–1072（1072 aa）	未记录	PO4 PHOSPHATE ION × 3 MN MANGANESE (II) ION × 3 K POTASSIUM ION × 8 CL CHLORIDE ION × 7 ADP ADENOSINE-5'-DIPHOSPHATE × 2 ORN L-ornithine × 1 NET TETRAETHYLAMMONIUM ION × 1	X-RAY DIFFRACTION X-ray结晶条件 pH 7.4；0.65M NET4CL 8% PEG 8000 100MM KCL 2.5MM MNCL2 2.5MM ADP 2.5MM ORNITHINE 5MM GLUTAMINE 25MM HEPES PH 7.4 THEN SOAKED INTO: 1.4M NET4CL 8% PEG 8000 250MM KCL 2.5MM MNCL2 2.5MM ADP 2.5MM ORNITHINE 5MM GLUTAMINE 25MM HEPES PH 7.4 7.5% ETHYLENE GLYCOL	分辨率 1.80 Å
1BXR STRUCTURE OF CARBAMOYL PHOSPHATE SYNTHETASE COMPLEXED WITH THE ATP ANALOG AMPPNP 提交 1998-10-08	构建体不同配体/离子不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 A 1–1072（1072 aa）链 C 1–1072（1072 aa）链 E 1–1072（1072 aa）链 G 1–1072（1072 aa）	未记录	MN MANGANESE (II) ION × 13 K POTASSIUM ION × 19 CL CHLORIDE ION × 14 ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 8 ORN L-ornithine × 4 NET TETRAETHYLAMMONIUM ION × 4	X-RAY DIFFRACTION X-ray结晶条件 pH 7.4；pH 7.4	分辨率 2.10 Å
1BXR STRUCTURE OF CARBAMOYL PHOSPHATE SYNTHETASE COMPLEXED WITH THE ATP ANALOG AMPPNP 提交 1998-10-08	构建体不同配体/离子不同结构质量不同	Assembly 2 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 E 1–1072（1072 aa）	未记录	MN MANGANESE (II) ION × 3 K POTASSIUM ION × 5 CL CHLORIDE ION × 2 ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 2 ORN L-ornithine × 1 NET TETRAETHYLAMMONIUM ION × 1	X-RAY DIFFRACTION X-ray结晶条件 pH 7.4；pH 7.4	分辨率 2.10 Å
1BXR STRUCTURE OF CARBAMOYL PHOSPHATE SYNTHETASE COMPLEXED WITH THE ATP ANALOG AMPPNP 提交 1998-10-08	构建体不同配体/离子不同结构质量不同	Assembly 3 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 C 1–1072（1072 aa）	未记录	MN MANGANESE (II) ION × 4 K POTASSIUM ION × 5 CL CHLORIDE ION × 4 ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 2 ORN L-ornithine × 1 NET TETRAETHYLAMMONIUM ION × 1	X-RAY DIFFRACTION X-ray结晶条件 pH 7.4；pH 7.4	分辨率 2.10 Å
1BXR STRUCTURE OF CARBAMOYL PHOSPHATE SYNTHETASE COMPLEXED WITH THE ATP ANALOG AMPPNP 提交 1998-10-08	构建体不同配体/离子不同结构质量不同	Assembly 4 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 A 1–1072（1072 aa）	未记录	MN MANGANESE (II) ION × 3 K POTASSIUM ION × 4 CL CHLORIDE ION × 4 ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 2 ORN L-ornithine × 1 NET TETRAETHYLAMMONIUM ION × 1	X-RAY DIFFRACTION X-ray结晶条件 pH 7.4；pH 7.4	分辨率 2.10 Å
1BXR STRUCTURE OF CARBAMOYL PHOSPHATE SYNTHETASE COMPLEXED WITH THE ATP ANALOG AMPPNP 提交 1998-10-08	构建体不同配体/离子不同结构质量不同	Assembly 5 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 G 1–1072（1072 aa）	未记录	MN MANGANESE (II) ION × 3 K POTASSIUM ION × 5 CL CHLORIDE ION × 4 ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 2 ORN L-ornithine × 1 NET TETRAETHYLAMMONIUM ION × 1	X-RAY DIFFRACTION X-ray结晶条件 pH 7.4；pH 7.4	分辨率 2.10 Å
1C30 CRYSTAL STRUCTURE OF CARBAMOYL PHOSPHATE SYNTHETASE: SMALL SUBUNIT MUTATION C269S 提交 1999-07-24	配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 A 1–1073（1073 aa）链 C 1–1073（1073 aa）链 E 1–1073（1073 aa）链 G 1–1073（1073 aa）	未记录	MN MANGANESE (II) ION × 12 K POTASSIUM ION × 32 CL CHLORIDE ION × 16 PO4 PHOSPHATE ION × 6 ORN L-ornithine × 4 ADP ADENOSINE-5'-DIPHOSPHATE × 8 NET TETRAETHYLAMMONIUM ION × 4	X-RAY DIFFRACTION X-ray结晶条件 BATCH；pH 7.4；277 K；PEG 8000, POTASSIUM CHLORIDE, MANGANESE CHLORIDE, TETRAETHYLAMMONIUM CHLORIDE, L-ORNITHINE, ADP, BERYLLIUM FLUORIDE, HEPPS, pH 7.4, BATCH, temperature 277.0K	分辨率 2.00 Å R-free 0.246
1C30 CRYSTAL STRUCTURE OF CARBAMOYL PHOSPHATE SYNTHETASE: SMALL SUBUNIT MUTATION C269S 提交 1999-07-24	配体/离子不同实验环境不同结构质量不同	Assembly 2 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 G 1–1073（1073 aa）	未记录	MN MANGANESE (II) ION × 3 K POTASSIUM ION × 8 CL CHLORIDE ION × 4 PO4 PHOSPHATE ION × 1 ADP ADENOSINE-5'-DIPHOSPHATE × 2 NET TETRAETHYLAMMONIUM ION × 1	X-RAY DIFFRACTION X-ray结晶条件 BATCH；pH 7.4；277 K；PEG 8000, POTASSIUM CHLORIDE, MANGANESE CHLORIDE, TETRAETHYLAMMONIUM CHLORIDE, L-ORNITHINE, ADP, BERYLLIUM FLUORIDE, HEPPS, pH 7.4, BATCH, temperature 277.0K	分辨率 2.00 Å R-free 0.246
1C30 CRYSTAL STRUCTURE OF CARBAMOYL PHOSPHATE SYNTHETASE: SMALL SUBUNIT MUTATION C269S 提交 1999-07-24	配体/离子不同实验环境不同结构质量不同	Assembly 3 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 A 1–1073（1073 aa）	未记录	MN MANGANESE (II) ION × 3 K POTASSIUM ION × 8 CL CHLORIDE ION × 4 PO4 PHOSPHATE ION × 1 ORN L-ornithine × 4 ADP ADENOSINE-5'-DIPHOSPHATE × 2 NET TETRAETHYLAMMONIUM ION × 1	X-RAY DIFFRACTION X-ray结晶条件 BATCH；pH 7.4；277 K；PEG 8000, POTASSIUM CHLORIDE, MANGANESE CHLORIDE, TETRAETHYLAMMONIUM CHLORIDE, L-ORNITHINE, ADP, BERYLLIUM FLUORIDE, HEPPS, pH 7.4, BATCH, temperature 277.0K	分辨率 2.00 Å R-free 0.246
1C30 CRYSTAL STRUCTURE OF CARBAMOYL PHOSPHATE SYNTHETASE: SMALL SUBUNIT MUTATION C269S 提交 1999-07-24	配体/离子不同实验环境不同结构质量不同	Assembly 4 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 C 1–1073（1073 aa）	未记录	MN MANGANESE (II) ION × 3 K POTASSIUM ION × 8 CL CHLORIDE ION × 4 PO4 PHOSPHATE ION × 2 ADP ADENOSINE-5'-DIPHOSPHATE × 2 NET TETRAETHYLAMMONIUM ION × 1	X-RAY DIFFRACTION X-ray结晶条件 BATCH；pH 7.4；277 K；PEG 8000, POTASSIUM CHLORIDE, MANGANESE CHLORIDE, TETRAETHYLAMMONIUM CHLORIDE, L-ORNITHINE, ADP, BERYLLIUM FLUORIDE, HEPPS, pH 7.4, BATCH, temperature 277.0K	分辨率 2.00 Å R-free 0.246
1C30 CRYSTAL STRUCTURE OF CARBAMOYL PHOSPHATE SYNTHETASE: SMALL SUBUNIT MUTATION C269S 提交 1999-07-24	配体/离子不同实验环境不同结构质量不同	Assembly 5 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 E 1–1073（1073 aa）	未记录	MN MANGANESE (II) ION × 3 K POTASSIUM ION × 8 CL CHLORIDE ION × 4 PO4 PHOSPHATE ION × 2 ADP ADENOSINE-5'-DIPHOSPHATE × 2 NET TETRAETHYLAMMONIUM ION × 1	X-RAY DIFFRACTION X-ray结晶条件 BATCH；pH 7.4；277 K；PEG 8000, POTASSIUM CHLORIDE, MANGANESE CHLORIDE, TETRAETHYLAMMONIUM CHLORIDE, L-ORNITHINE, ADP, BERYLLIUM FLUORIDE, HEPPS, pH 7.4, BATCH, temperature 277.0K	分辨率 2.00 Å R-free 0.246
1C3O CRYSTAL STRUCTURE OF THE CARBAMOYL PHOSPHATE SYNTHETASE: SMALL SUBUNIT MUTANT C269S WITH BOUND GLUTAMINE 提交 1999-07-28	配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 A 1–1073（1073 aa）链 C 1–1073（1073 aa）链 E 1–1073（1073 aa）链 G 1–1073（1073 aa）	未记录	MN MANGANESE (II) ION × 12 K POTASSIUM ION × 32 CL CHLORIDE ION × 16 PO4 PHOSPHATE ION × 5 ADP ADENOSINE-5'-DIPHOSPHATE × 8 ORN L-ornithine × 4 GLN GLUTAMINE × 8 NET TETRAETHYLAMMONIUM ION × 4	X-RAY DIFFRACTION X-ray结晶条件 BATCH；pH 7.4；278 K；PEG-8000, MANGANESE CHLORIDE, TETRAETHYLAMMONIUM CHLORIDE, POTASSIUM CHLORIDE, BERYLLIUM FLUORIDE, ADENOSINE 5'-DIPHOSPHATE,L-ORNITHINE, L-GLUTAMINE, HEPPS, pH 7.4, BATCH, temperature 278K	分辨率 2.10 Å R-free 0.258
1CS0 Crystal structure of carbamoyl phosphate synthetase complexed at CYS269 in the small subunit with the tetrahedral mimic l-glutamate gamma-semialdehyde 提交 1999-08-16	配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 A 1–1073（1073 aa）链 C 1–1073（1073 aa）链 E 1–1073（1073 aa）链 G 1–1073（1073 aa）	未记录	MN MANGANESE (II) ION × 12 K POTASSIUM ION × 33 CL CHLORIDE ION × 29 PO4 PHOSPHATE ION × 5 ADP ADENOSINE-5'-DIPHOSPHATE × 8 ORN L-ornithine × 4 NET TETRAETHYLAMMONIUM ION × 4	X-RAY DIFFRACTION X-ray结晶条件 BATCH；pH 7.4；277 K；PEG 8000, TETRAETHYLAMMONIUM CHLORIDE, POTASSIUM CHLORIDE, MANGANESE(II) CHLORIDE, ADENOSINE 5'-DIPHOSPHATE, L-ORNITHINE, L-GLUTAMATE GAMMA-SEMIALDEHYDE, pH 7.4, BATCH, temperature 277K	分辨率 2.00 Å R-free 0.242
1CS0 Crystal structure of carbamoyl phosphate synthetase complexed at CYS269 in the small subunit with the tetrahedral mimic l-glutamate gamma-semialdehyde 提交 1999-08-16	配体/离子不同实验环境不同结构质量不同	Assembly 2 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 C 1–1073（1073 aa）	未记录	MN MANGANESE (II) ION × 3 K POTASSIUM ION × 8 CL CHLORIDE ION × 7 PO4 PHOSPHATE ION × 1 ADP ADENOSINE-5'-DIPHOSPHATE × 2 ORN L-ornithine × 1 NET TETRAETHYLAMMONIUM ION × 1	X-RAY DIFFRACTION X-ray结晶条件 BATCH；pH 7.4；277 K；PEG 8000, TETRAETHYLAMMONIUM CHLORIDE, POTASSIUM CHLORIDE, MANGANESE(II) CHLORIDE, ADENOSINE 5'-DIPHOSPHATE, L-ORNITHINE, L-GLUTAMATE GAMMA-SEMIALDEHYDE, pH 7.4, BATCH, temperature 277K	分辨率 2.00 Å R-free 0.242
1CS0 Crystal structure of carbamoyl phosphate synthetase complexed at CYS269 in the small subunit with the tetrahedral mimic l-glutamate gamma-semialdehyde 提交 1999-08-16	配体/离子不同实验环境不同结构质量不同	Assembly 3 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 G 1–1073（1073 aa）	未记录	MN MANGANESE (II) ION × 3 K POTASSIUM ION × 8 CL CHLORIDE ION × 7 PO4 PHOSPHATE ION × 1 ADP ADENOSINE-5'-DIPHOSPHATE × 2 ORN L-ornithine × 1 NET TETRAETHYLAMMONIUM ION × 1	X-RAY DIFFRACTION X-ray结晶条件 BATCH；pH 7.4；277 K；PEG 8000, TETRAETHYLAMMONIUM CHLORIDE, POTASSIUM CHLORIDE, MANGANESE(II) CHLORIDE, ADENOSINE 5'-DIPHOSPHATE, L-ORNITHINE, L-GLUTAMATE GAMMA-SEMIALDEHYDE, pH 7.4, BATCH, temperature 277K	分辨率 2.00 Å R-free 0.242
1CS0 Crystal structure of carbamoyl phosphate synthetase complexed at CYS269 in the small subunit with the tetrahedral mimic l-glutamate gamma-semialdehyde 提交 1999-08-16	配体/离子不同实验环境不同结构质量不同	Assembly 4 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 A 1–1073（1073 aa）	未记录	MN MANGANESE (II) ION × 3 K POTASSIUM ION × 8 CL CHLORIDE ION × 8 PO4 PHOSPHATE ION × 1 ADP ADENOSINE-5'-DIPHOSPHATE × 2 ORN L-ornithine × 1 NET TETRAETHYLAMMONIUM ION × 1	X-RAY DIFFRACTION X-ray结晶条件 BATCH；pH 7.4；277 K；PEG 8000, TETRAETHYLAMMONIUM CHLORIDE, POTASSIUM CHLORIDE, MANGANESE(II) CHLORIDE, ADENOSINE 5'-DIPHOSPHATE, L-ORNITHINE, L-GLUTAMATE GAMMA-SEMIALDEHYDE, pH 7.4, BATCH, temperature 277K	分辨率 2.00 Å R-free 0.242
1CS0 Crystal structure of carbamoyl phosphate synthetase complexed at CYS269 in the small subunit with the tetrahedral mimic l-glutamate gamma-semialdehyde 提交 1999-08-16	配体/离子不同实验环境不同结构质量不同	Assembly 5 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 E 1–1073（1073 aa）	未记录	MN MANGANESE (II) ION × 3 K POTASSIUM ION × 9 CL CHLORIDE ION × 7 PO4 PHOSPHATE ION × 2 ADP ADENOSINE-5'-DIPHOSPHATE × 2 ORN L-ornithine × 1 NET TETRAETHYLAMMONIUM ION × 1	X-RAY DIFFRACTION X-ray结晶条件 BATCH；pH 7.4；277 K；PEG 8000, TETRAETHYLAMMONIUM CHLORIDE, POTASSIUM CHLORIDE, MANGANESE(II) CHLORIDE, ADENOSINE 5'-DIPHOSPHATE, L-ORNITHINE, L-GLUTAMATE GAMMA-SEMIALDEHYDE, pH 7.4, BATCH, temperature 277K	分辨率 2.00 Å R-free 0.242
1JDB CARBAMOYL PHOSPHATE SYNTHETASE FROM ESCHERICHIA COLI 提交 1997-03-25	构建体不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 B 1–1072（1072 aa）链 E 1–1072（1072 aa）链 H 1–1072（1072 aa）链 K 1–1072（1072 aa）	未记录	MN MANGANESE (II) ION × 16 K POTASSIUM ION × 29 PO4 PHOSPHATE ION × 9 CL CHLORIDE ION × 29 GLN GLUTAMINE × 8 ADP ADENOSINE-5'-DIPHOSPHATE × 8 ORN L-ornithine × 4 NET TETRAETHYLAMMONIUM ION × 4	X-RAY DIFFRACTION X-ray结晶条件 pH 7.4；0.65M TETRAETHYL AMMONIUM CHLORIDE (E4NCL) 8% PEG 8000 100MM KCL 2.5MM MNCL2 2.5MM ADP 2.5MM ORNITHINE 25MM HEPES PH 7.4. THE CRYSTAL WAS SOAKED INTO: 1.4M E4NCL 8% PEG 8000 250MM KCL 2.5MM MNCL2 2.5MM ADP 2.5MM ORNITHINE 25MM GLUTAMINE 25MM HEPES PH 7.4 7.5% ETHYLENE GLYCOL.	分辨率 2.10 Å
1JDB CARBAMOYL PHOSPHATE SYNTHETASE FROM ESCHERICHIA COLI 提交 1997-03-25	构建体不同配体/离子不同实验环境不同结构质量不同	Assembly 2 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 B 1–1072（1072 aa）	未记录	MN MANGANESE (II) ION × 4 K POTASSIUM ION × 7 PO4 PHOSPHATE ION × 2 CL CHLORIDE ION × 7 GLN GLUTAMINE × 2 ADP ADENOSINE-5'-DIPHOSPHATE × 2 ORN L-ornithine × 1 NET TETRAETHYLAMMONIUM ION × 1	X-RAY DIFFRACTION X-ray结晶条件 pH 7.4；0.65M TETRAETHYL AMMONIUM CHLORIDE (E4NCL) 8% PEG 8000 100MM KCL 2.5MM MNCL2 2.5MM ADP 2.5MM ORNITHINE 25MM HEPES PH 7.4. THE CRYSTAL WAS SOAKED INTO: 1.4M E4NCL 8% PEG 8000 250MM KCL 2.5MM MNCL2 2.5MM ADP 2.5MM ORNITHINE 25MM GLUTAMINE 25MM HEPES PH 7.4 7.5% ETHYLENE GLYCOL.	分辨率 2.10 Å
1JDB CARBAMOYL PHOSPHATE SYNTHETASE FROM ESCHERICHIA COLI 提交 1997-03-25	构建体不同配体/离子不同实验环境不同结构质量不同	Assembly 3 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 H 1–1072（1072 aa）	未记录	MN MANGANESE (II) ION × 4 K POTASSIUM ION × 6 PO4 PHOSPHATE ION × 2 CL CHLORIDE ION × 7 GLN GLUTAMINE × 2 ADP ADENOSINE-5'-DIPHOSPHATE × 2 ORN L-ornithine × 1 NET TETRAETHYLAMMONIUM ION × 1	X-RAY DIFFRACTION X-ray结晶条件 pH 7.4；0.65M TETRAETHYL AMMONIUM CHLORIDE (E4NCL) 8% PEG 8000 100MM KCL 2.5MM MNCL2 2.5MM ADP 2.5MM ORNITHINE 25MM HEPES PH 7.4. THE CRYSTAL WAS SOAKED INTO: 1.4M E4NCL 8% PEG 8000 250MM KCL 2.5MM MNCL2 2.5MM ADP 2.5MM ORNITHINE 25MM GLUTAMINE 25MM HEPES PH 7.4 7.5% ETHYLENE GLYCOL.	分辨率 2.10 Å
1JDB CARBAMOYL PHOSPHATE SYNTHETASE FROM ESCHERICHIA COLI 提交 1997-03-25	构建体不同配体/离子不同实验环境不同结构质量不同	Assembly 4 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 K 1–1072（1072 aa）	未记录	MN MANGANESE (II) ION × 4 K POTASSIUM ION × 8 PO4 PHOSPHATE ION × 3 CL CHLORIDE ION × 7 GLN GLUTAMINE × 2 ADP ADENOSINE-5'-DIPHOSPHATE × 2 ORN L-ornithine × 1 NET TETRAETHYLAMMONIUM ION × 1	X-RAY DIFFRACTION X-ray结晶条件 pH 7.4；0.65M TETRAETHYL AMMONIUM CHLORIDE (E4NCL) 8% PEG 8000 100MM KCL 2.5MM MNCL2 2.5MM ADP 2.5MM ORNITHINE 25MM HEPES PH 7.4. THE CRYSTAL WAS SOAKED INTO: 1.4M E4NCL 8% PEG 8000 250MM KCL 2.5MM MNCL2 2.5MM ADP 2.5MM ORNITHINE 25MM GLUTAMINE 25MM HEPES PH 7.4 7.5% ETHYLENE GLYCOL.	分辨率 2.10 Å
1JDB CARBAMOYL PHOSPHATE SYNTHETASE FROM ESCHERICHIA COLI 提交 1997-03-25	构建体不同配体/离子不同实验环境不同结构质量不同	Assembly 5 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 E 1–1072（1072 aa）	未记录	MN MANGANESE (II) ION × 4 K POTASSIUM ION × 8 PO4 PHOSPHATE ION × 2 CL CHLORIDE ION × 8 GLN GLUTAMINE × 2 ADP ADENOSINE-5'-DIPHOSPHATE × 2 ORN L-ornithine × 1 NET TETRAETHYLAMMONIUM ION × 1	X-RAY DIFFRACTION X-ray结晶条件 pH 7.4；0.65M TETRAETHYL AMMONIUM CHLORIDE (E4NCL) 8% PEG 8000 100MM KCL 2.5MM MNCL2 2.5MM ADP 2.5MM ORNITHINE 25MM HEPES PH 7.4. THE CRYSTAL WAS SOAKED INTO: 1.4M E4NCL 8% PEG 8000 250MM KCL 2.5MM MNCL2 2.5MM ADP 2.5MM ORNITHINE 25MM GLUTAMINE 25MM HEPES PH 7.4 7.5% ETHYLENE GLYCOL.	分辨率 2.10 Å
1KEE Inactivation of the Amidotransferase Activity of Carbamoyl Phosphate Synthetase by the Antibiotic Acivicin 提交 2001-11-15	构建体不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 A 0–1072（1073 aa）链 C 0–1072（1073 aa）链 E 0–1072（1073 aa）链 G 0–1072（1073 aa）	未记录	MN MANGANESE (II) ION × 12 K POTASSIUM ION × 32 CL CHLORIDE ION × 22 PO4 PHOSPHATE ION × 4 ADP ADENOSINE-5'-DIPHOSPHATE × 8 ORN L-ornithine × 4 NET TETRAETHYLAMMONIUM ION × 4	X-RAY DIFFRACTION X-ray结晶条件 batch；pH 7.4；277 K；PEG 8000, Hepes, potassium chloride, manganese chloride, ornithine, tetraethylammonium chloride, HEPPS, pH 7.4, batch, temperature 277K	分辨率 2.10 Å R-free 0.211
1KEE Inactivation of the Amidotransferase Activity of Carbamoyl Phosphate Synthetase by the Antibiotic Acivicin 提交 2001-11-15	构建体不同配体/离子不同实验环境不同结构质量不同	Assembly 2 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 G 0–1072（1073 aa）	未记录	MN MANGANESE (II) ION × 3 K POTASSIUM ION × 8 CL CHLORIDE ION × 5 PO4 PHOSPHATE ION × 1 ADP ADENOSINE-5'-DIPHOSPHATE × 2 ORN L-ornithine × 1 NET TETRAETHYLAMMONIUM ION × 1	X-RAY DIFFRACTION X-ray结晶条件 batch；pH 7.4；277 K；PEG 8000, Hepes, potassium chloride, manganese chloride, ornithine, tetraethylammonium chloride, HEPPS, pH 7.4, batch, temperature 277K	分辨率 2.10 Å R-free 0.211
1KEE Inactivation of the Amidotransferase Activity of Carbamoyl Phosphate Synthetase by the Antibiotic Acivicin 提交 2001-11-15	构建体不同配体/离子不同实验环境不同结构质量不同	Assembly 3 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 E 0–1072（1073 aa）	未记录	MN MANGANESE (II) ION × 3 K POTASSIUM ION × 8 CL CHLORIDE ION × 5 PO4 PHOSPHATE ION × 1 ADP ADENOSINE-5'-DIPHOSPHATE × 2 ORN L-ornithine × 1 NET TETRAETHYLAMMONIUM ION × 1	X-RAY DIFFRACTION X-ray结晶条件 batch；pH 7.4；277 K；PEG 8000, Hepes, potassium chloride, manganese chloride, ornithine, tetraethylammonium chloride, HEPPS, pH 7.4, batch, temperature 277K	分辨率 2.10 Å R-free 0.211
1KEE Inactivation of the Amidotransferase Activity of Carbamoyl Phosphate Synthetase by the Antibiotic Acivicin 提交 2001-11-15	构建体不同配体/离子不同实验环境不同结构质量不同	Assembly 4 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 A 0–1072（1073 aa）	未记录	MN MANGANESE (II) ION × 3 K POTASSIUM ION × 8 CL CHLORIDE ION × 6 PO4 PHOSPHATE ION × 1 ADP ADENOSINE-5'-DIPHOSPHATE × 2 ORN L-ornithine × 1 NET TETRAETHYLAMMONIUM ION × 1	X-RAY DIFFRACTION X-ray结晶条件 batch；pH 7.4；277 K；PEG 8000, Hepes, potassium chloride, manganese chloride, ornithine, tetraethylammonium chloride, HEPPS, pH 7.4, batch, temperature 277K	分辨率 2.10 Å R-free 0.211
1KEE Inactivation of the Amidotransferase Activity of Carbamoyl Phosphate Synthetase by the Antibiotic Acivicin 提交 2001-11-15	构建体不同配体/离子不同实验环境不同结构质量不同	Assembly 5 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 C 0–1072（1073 aa）	未记录	MN MANGANESE (II) ION × 3 K POTASSIUM ION × 8 CL CHLORIDE ION × 6 PO4 PHOSPHATE ION × 1 ADP ADENOSINE-5'-DIPHOSPHATE × 2 ORN L-ornithine × 1 NET TETRAETHYLAMMONIUM ION × 1	X-RAY DIFFRACTION X-ray结晶条件 batch；pH 7.4；277 K；PEG 8000, Hepes, potassium chloride, manganese chloride, ornithine, tetraethylammonium chloride, HEPPS, pH 7.4, batch, temperature 277K	分辨率 2.10 Å R-free 0.211
1M6V Crystal Structure of the G359F (small subunit) Point Mutant of Carbamoyl Phosphate Synthetase 提交 2002-07-17	构建体不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 A 0–1072（1073 aa）链 C 0–1072（1073 aa）链 E 0–1072（1073 aa）链 G 0–1072（1073 aa）	未记录	MN MANGANESE (II) ION × 12 K POTASSIUM ION × 26 CL CHLORIDE ION × 28 PO4 PHOSPHATE ION × 4 ADP ADENOSINE-5'-DIPHOSPHATE × 8 ORN L-ornithine × 4 NET TETRAETHYLAMMONIUM ION × 4	X-RAY DIFFRACTION X-ray结晶条件 batch；pH 7.4；277 K；PEG-8000, manganese chloride, potassium chloride, ADP, ornithine, tetraethylammonium chloride, HEPPS, pH 7.4, batch, temperature 277K	分辨率 2.10 Å R-free 0.245
1T36 Crystal structure of E. coli carbamoyl phosphate synthetase small subunit mutant C248D complexed with uridine 5'-monophosphate 提交 2004-04-24	构建体不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 A 0–1072（1073 aa）链 C 0–1072（1073 aa）链 E 0–1072（1073 aa）链 G 0–1072（1073 aa）	未记录	MN MANGANESE (II) ION × 12 K POTASSIUM ION × 22 PO4 PHOSPHATE ION × 5 CL CHLORIDE ION × 27 ADP ADENOSINE-5'-DIPHOSPHATE × 8 ORN L-ornithine × 4 NET TETRAETHYLAMMONIUM ION × 4 U5P URIDINE-5'-MONOPHOSPHATE × 4	X-RAY DIFFRACTION X-ray结晶条件 batch；pH 7.4；277 K；PEG 8000, tetramethylammonium chloride, potassium chloride, manganese chloride, ornithine, ADP, HEPES, pH 7.4, batch, temperature 277K	分辨率 2.10 Å R-free 0.209

共 9 个其他 PDB 条目、33 个 assembly。打开独立比较页并筛选聚集状态

查看构建体与数据证据

UniProt名称	CARB_ECOLI
Isoform	—
PDB实体	1
链与序列区间	作者链 A； PDB构建体 1–1073； UniProt 1–1073 作者链 C； PDB构建体 1–1073； UniProt 1–1073 作者链 E； PDB构建体 1–1073； UniProt 1–1073 作者链 G； PDB构建体 1–1073； UniProt 1–1073

PROTEIN (CARBAMOYL-PHOSPHATE SYNTHASE)

Escherichia coli

UniProt P0A6F1

当前结构中的状态

Assembly	聚集状态	构建体	突变与修饰	配体、离子与共同组分	实验方法与环境	结构质量
1	蛋白异源复合物异源复合物蛋白 × 8 PDB 声明：octameric（8）与蛋白拷贝数一致	链 B； UniProt 1–382 链 D； UniProt 1–382 链 F； UniProt 1–382 链 H； UniProt 1–382	未记录	PROTEIN (CARBAMOYL-PHOSPHATE SYNTHASE) × 4 （P00968） MN MANGANESE (II) ION × 12 K POTASSIUM ION × 28 CL CHLORIDE ION × 12 PO4 PHOSPHATE ION × 4 ADP ADENOSINE-5'-DIPHOSPHATE × 8 ORN L-ornithine × 8 IMP INOSINIC ACID × 4 NET TETRAETHYLAMMONIUM ION × 4	X-RAY DIFFRACTION X-ray结晶条件：pH 7.4；pH 7.4	分辨率 2.10 Å R-free 0.250
2	蛋白异源复合物异源复合物蛋白 × 2 PDB 声明：dimeric（2）与蛋白拷贝数一致	链 B； UniProt 1–382	未记录	PROTEIN (CARBAMOYL-PHOSPHATE SYNTHASE) × 1 （P00968） MN MANGANESE (II) ION × 3 K POTASSIUM ION × 7 CL CHLORIDE ION × 3 PO4 PHOSPHATE ION × 1 ADP ADENOSINE-5'-DIPHOSPHATE × 2 ORN L-ornithine × 2 IMP INOSINIC ACID × 1 NET TETRAETHYLAMMONIUM ION × 1	X-RAY DIFFRACTION X-ray结晶条件：pH 7.4；pH 7.4	分辨率 2.10 Å R-free 0.250
3	蛋白异源复合物异源复合物蛋白 × 2 PDB 声明：dimeric（2）与蛋白拷贝数一致	链 H； UniProt 1–382	未记录	PROTEIN (CARBAMOYL-PHOSPHATE SYNTHASE) × 1 （P00968） MN MANGANESE (II) ION × 3 K POTASSIUM ION × 7 CL CHLORIDE ION × 3 PO4 PHOSPHATE ION × 1 ADP ADENOSINE-5'-DIPHOSPHATE × 2 ORN L-ornithine × 2 IMP INOSINIC ACID × 1 NET TETRAETHYLAMMONIUM ION × 1	X-RAY DIFFRACTION X-ray结晶条件：pH 7.4；pH 7.4	分辨率 2.10 Å R-free 0.250
4	蛋白异源复合物异源复合物蛋白 × 2 PDB 声明：dimeric（2）与蛋白拷贝数一致	链 D； UniProt 1–382	未记录	PROTEIN (CARBAMOYL-PHOSPHATE SYNTHASE) × 1 （P00968） MN MANGANESE (II) ION × 3 K POTASSIUM ION × 7 CL CHLORIDE ION × 3 PO4 PHOSPHATE ION × 1 ADP ADENOSINE-5'-DIPHOSPHATE × 2 ORN L-ornithine × 2 IMP INOSINIC ACID × 1 NET TETRAETHYLAMMONIUM ION × 1	X-RAY DIFFRACTION X-ray结晶条件：pH 7.4；pH 7.4	分辨率 2.10 Å R-free 0.250
5	蛋白异源复合物异源复合物蛋白 × 2 PDB 声明：dimeric（2）与蛋白拷贝数一致	链 F； UniProt 1–382	未记录	PROTEIN (CARBAMOYL-PHOSPHATE SYNTHASE) × 1 （P00968） MN MANGANESE (II) ION × 3 K POTASSIUM ION × 7 CL CHLORIDE ION × 3 PO4 PHOSPHATE ION × 1 ADP ADENOSINE-5'-DIPHOSPHATE × 2 ORN L-ornithine × 2 IMP INOSINIC ACID × 1 NET TETRAETHYLAMMONIUM ION × 1	X-RAY DIFFRACTION X-ray结晶条件：pH 7.4；pH 7.4	分辨率 2.10 Å R-free 0.250

数据库中的同蛋白其他状态

其他 PDB	相对当前条目 1CE8	Assembly / 聚集状态	构建体	突变与修饰	配体、离子与非聚合物	实验方法与环境	结构质量
1BXR STRUCTURE OF CARBAMOYL PHOSPHATE SYNTHETASE COMPLEXED WITH THE ATP ANALOG AMPPNP 提交 1998-10-08	配体/离子不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 B 1–382（382 aa）链 D 1–382（382 aa）链 F 1–382（382 aa）链 H 1–382（382 aa）	未记录	MN MANGANESE (II) ION × 13 K POTASSIUM ION × 19 CL CHLORIDE ION × 14 ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 8 ORN L-ornithine × 4 NET TETRAETHYLAMMONIUM ION × 4	X-RAY DIFFRACTION X-ray结晶条件 pH 7.4；pH 7.4	分辨率 2.10 Å
1BXR STRUCTURE OF CARBAMOYL PHOSPHATE SYNTHETASE COMPLEXED WITH THE ATP ANALOG AMPPNP 提交 1998-10-08	配体/离子不同结构质量不同	Assembly 2 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 F 1–382（382 aa）	未记录	MN MANGANESE (II) ION × 3 K POTASSIUM ION × 5 CL CHLORIDE ION × 2 ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 2 ORN L-ornithine × 1 NET TETRAETHYLAMMONIUM ION × 1	X-RAY DIFFRACTION X-ray结晶条件 pH 7.4；pH 7.4	分辨率 2.10 Å
1BXR STRUCTURE OF CARBAMOYL PHOSPHATE SYNTHETASE COMPLEXED WITH THE ATP ANALOG AMPPNP 提交 1998-10-08	配体/离子不同结构质量不同	Assembly 3 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 D 1–382（382 aa）	未记录	MN MANGANESE (II) ION × 4 K POTASSIUM ION × 5 CL CHLORIDE ION × 4 ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 2 ORN L-ornithine × 1 NET TETRAETHYLAMMONIUM ION × 1	X-RAY DIFFRACTION X-ray结晶条件 pH 7.4；pH 7.4	分辨率 2.10 Å
1BXR STRUCTURE OF CARBAMOYL PHOSPHATE SYNTHETASE COMPLEXED WITH THE ATP ANALOG AMPPNP 提交 1998-10-08	配体/离子不同结构质量不同	Assembly 4 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 B 1–382（382 aa）	未记录	MN MANGANESE (II) ION × 3 K POTASSIUM ION × 4 CL CHLORIDE ION × 4 ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 2 ORN L-ornithine × 1 NET TETRAETHYLAMMONIUM ION × 1	X-RAY DIFFRACTION X-ray结晶条件 pH 7.4；pH 7.4	分辨率 2.10 Å
1BXR STRUCTURE OF CARBAMOYL PHOSPHATE SYNTHETASE COMPLEXED WITH THE ATP ANALOG AMPPNP 提交 1998-10-08	配体/离子不同结构质量不同	Assembly 5 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 H 1–382（382 aa）	未记录	MN MANGANESE (II) ION × 3 K POTASSIUM ION × 5 CL CHLORIDE ION × 4 ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 2 ORN L-ornithine × 1 NET TETRAETHYLAMMONIUM ION × 1	X-RAY DIFFRACTION X-ray结晶条件 pH 7.4；pH 7.4	分辨率 2.10 Å

共 1 个其他 PDB 条目、5 个 assembly。打开独立比较页并筛选聚集状态

查看构建体与数据证据

UniProt名称	CARA_ECOLI
Isoform	—
PDB实体	2
链与序列区间	作者链 B； PDB构建体 2–380； UniProt 1–382 作者链 D； PDB构建体 2–380； UniProt 1–382 作者链 F； PDB构建体 2–380； UniProt 1–382 作者链 H； PDB构建体 2–380； UniProt 1–382

页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。链映射与序列区间收在“数据证据”中；数据库内部编号、导入时间和 assembly 操作表达式仅用于维护，因此不在读者页面展示。

SAXS 散射曲线 SAXS Profile

P(r) 距离分布 P(r) Distribution

下载 Download SAXS (.dat) P(r) (.pr.out) CIF

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2. 结构基本信息 2. Structure Basics

条目编号 entry_id	1ce8
沉积日期 deposition_date	1999-03-18
结构标题 title	CARBAMOYL PHOSPHATE SYNTHETASE FROM ESCHERICHIS COLI WITH COMPLEXED WITH THE ALLOSTERIC LIGAND IMP
关键词 keywords	IMP, ALLOSTERIC LIGAND, LIGASE IMP; LIGASE IMP
实验方法 method	X-RAY DIFFRACTION

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3. SAXS 参数 (CRYSOL 理论计算) 3. SAXS Parameters (CRYSOL)

回转半径 Rg (Guinier) rg_guinier	71.92 Å
回转半径 Rg (电子) rg_electron	72.04 Å
零角强度 I(0) i0	5776140000.00
分子量 molecular_weight	638370.0 kDa
排除体积 excluded_volume	796160 Å³
包络体积 envelope_volume	1148100 Å³
水化壳体积 shell_volume	131680 Å³
包络直径 envelope_diameter	239.8 Å
壳层 Rg shell_rg	75.44 Å
包络 Rg envelope_rg	68.66 Å
形状 Rg shape_rg	72.07 Å
总 Rg total_rg	71.96 Å
总原子数 total_atoms	44708
残基数 n_residues	5748
球谐函数阶数 n_harmonics	20
q 范围 q_range	— – 0.5000 Å⁻¹
数据点数 n_points	101
壳层类型 shell_type	directional
溶剂电子密度 solvent_density	0.3340 e/Å³
壳层衬度 contrast_shell	0.0300 e/Å³
CRYSOL 版本 crysol_version	4.1.3

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4. P(r) 距离分布 (GNOM 反演) 4. P(r) Analysis (GNOM)

最大尺寸 Dmax dmax	255.6 Å
Rg (实空间) rg_real	71.98 Å
Rg 误差 (实空间) rg_real_error	2.73 Å
I(0) (实空间) i0_real	5.7760e+09
I(0) 误差 (实空间) i0_real_error	1.2750e+08
Rg (倒空间) rg_reciprocal	71.58 Å
I(0) (倒空间) i0_reciprocal	5771000000.0000
解质量估计 total_estimate	0.8560
解质量评级 solution_quality	GOOD a GOOD solution
P(r) 峰数 n_peaks	2
主峰位置 r_peak_primary	92.9 Å
偏度 Skewness skewness	0.249
峰度 Kurtosis kurtosis	-0.562
角度范围 angular_range	— – 0.1100 Å⁻¹
当前正则化参数 α current_alpha	0.0005
最高正则化参数 α highest_alpha	191900000.0000
实空间数据点数 n_real_points	23
GNOM 版本 gnom_version	4.1.3
质量判据 quality_criteria	AN1: 0.000; Oscil: 0.798; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 1.000; Smooth: 0.731

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5. 晶体学与实验 5. Crystallography & Experiment

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6. 实体与聚合物信息 Entities & Polymers (11)

实体 1 Entity 1 polymer

描述 description	PROTEIN (CARBAMOYL-PHOSPHATE SYNTHASE)
分子量 formula_weight	117982.7 kDa
EC 编号 ec_number	6.3.5.5
来源方法 src_method	man
拷贝数 entity_count	4

聚合物 Polymer

聚合物类型 type	polypeptide(L)
链编号 strand_id	A,C,E,G
原子数 atom_count	48888

MPKRTDIKSILILGAGPIVIGQACEFDYSGAQACKALREEGYRVINVNSNPATIMTDPEMADATYIEPIHWEVVRKIIEKERPDAVLPTMGGQTALNCALELERQGVLEEFGVTMIGATADAIDKAEDRRRFDVAMKKIGLETARSGIAHTMEEALAVAADVGFPCIIRPSFTMGGSGGGIAYNREEFEEICARGLDLSPTKELLIDESLIGWKEYEMEVVRDKNDNCIIVCSIENFDAMGIHTGDSITVAPAQTLTDKEYQIMRNASMAVLREIGVETGGSNVQFAVNPKNGRLIVIEMNPRVSRSSALASKATGFPIAKVAAKLAVGYTLDELMNDITGGRTPASFEPSIDYVVTKIPRFNFEKFAGANDRLTTQMKSVGEVMAIGRTQQESLQKALRGLEVGATGFDPKVSLDDPEALTKIRRELKDAGADRIWYIADAFRAGLSVDGVFNLTNIDRWFLVQIEELVRLEEKVAEVGITGLNADFLRQLKRKGFADARLAKLAGVREAEIRKLRDQYDLHPVYKRVDTCAAEFATDTAYMYSTYEEECEANPSTDREKIMVLGGGPNRIGQGIEFDYCCVHASLALREDGYETIMVNCNPETVSTDYDTSDRLYFEPVTLEDVLEIVRIEKPKGVIVQYGGQTPLKLARALEAAGVPVIGTSPDAIDRAEDRERFQHAVERLKLKQPANATVTAIEMAVEKAKEIGYPLVVRPSYVLGGRAMEIVYDEADLRRYFQTAVSVSNDAPVLLDHFLDDAVEVDVDAICDGEMVLIGGIMEHIEQAGVHSGDSACSLPAYTLSQEIQDVMRQQVQKLAFELQVRGLMNVQFAVKNNEVYLIEVNPRAARTVPFVSKATGVPLAKVAARVMAGKSLAEQGVTKEVIPPYYSVKEVVLPFNKFPGVDPLLGPEMRSTGEVMGVGRTFAEAFAKAQLGSNSTMKKHGRALLSVREGDKERVVDLAAKLLKQGFELDATHGTAIVLGEAGINPRLVNKVHEGRPHIQDRIKNGEYTYIINTTSGRRAIEDSRVIRRSALQYKVHYDTTLNGGFATAMALNADATEKVISVQEMHAQIK

来源 Source

来源生物 organism	Escherichia coli
NCBI 分类编号 ncbi_taxonomy_id	562
宿主生物 host_organism	Escherichia coli

实体 2 Entity 2 polymer

描述 description	PROTEIN (CARBAMOYL-PHOSPHATE SYNTHASE)
分子量 formula_weight	41480.9 kDa
EC 编号 ec_number	6.3.5.5
来源方法 src_method	man
拷贝数 entity_count	4

聚合物 Polymer

聚合物类型 type	polypeptide(L)
链编号 strand_id	B,D,F,H

MIKSALLVLEDGTQFHGRAIGATGSAVGEVVFNTSMTGYQEILTDPSYSRQIVTLTYPHIGNVGTNDADEESSQVHAQGLVIRDLPLIASNFRNTEDLSSYLKRHNIVAIADIDTRKLTRLLREKGAQNGCIIAGDNPDAALALEKARAFPGLNGMDLAKEVTTAEAYSWTQGSWTLTGGLPQAKKEDELPFHVVAYDFGAKRNILRMLVDRGCRLTIVPAQTSAEDVLKMNPDGIFLSNGPGDPAPCDYAITAIQKFLETDIPVFGICLGHQLLALASGAKTVKMKFGHHGGNHPVKDVEKNVVMITAQNHGFAVDEATLPANLRVTHKSLFDGTLQGIHRTDKPAFSFQGHPEASPGPHDAAPLFDHFIELIEQYRKTAK

来源 Source

来源生物 organism	Escherichia coli
NCBI 分类编号 ncbi_taxonomy_id	562
宿主生物 host_organism	Escherichia coli

实体 3 Entity 3 non-polymer

描述 description	MANGANESE (II) ION
分子量 formula_weight	54.9 kDa
来源方法 src_method	syn
拷贝数 entity_count	12

实体 4 Entity 4 non-polymer

描述 description	POTASSIUM ION
分子量 formula_weight	39.1 kDa
来源方法 src_method	syn
拷贝数 entity_count	28

实体 5 Entity 5 non-polymer

描述 description	CHLORIDE ION
分子量 formula_weight	35.5 kDa
来源方法 src_method	syn
拷贝数 entity_count	12

实体 6 Entity 6 non-polymer

描述 description	PHOSPHATE ION
分子量 formula_weight	95.0 kDa
来源方法 src_method	syn
拷贝数 entity_count	4

实体 7 Entity 7 non-polymer

描述 description	ADENOSINE-5'-DIPHOSPHATE
分子量 formula_weight	427.2 kDa
来源方法 src_method	syn
拷贝数 entity_count	8

实体 8 Entity 8 non-polymer

描述 description	L-ornithine
分子量 formula_weight	132.2 kDa
来源方法 src_method	syn
拷贝数 entity_count	8

实体 9 Entity 9 non-polymer

描述 description	INOSINIC ACID
分子量 formula_weight	348.2 kDa
来源方法 src_method	syn
拷贝数 entity_count	4

实体 10 Entity 10 non-polymer

描述 description	TETRAETHYLAMMONIUM ION
分子量 formula_weight	130.3 kDa
来源方法 src_method	syn
拷贝数 entity_count	4

实体 11 Entity 11 water

描述 description	water
分子量 formula_weight	18.0 kDa
来源方法 src_method	nat
拷贝数 entity_count	4037

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7. 折叠分类 (SCOP + CATH) 72 domains

SCOP 2.08 (32 domains)

结构域编号 domain_id	d1ce8a1
类 Class class	a — All alpha proteins
折叠类型 Fold fold	a.92 — Carbamoyl phosphate synthetase, large subunit connection domain
超家族 Superfamily superfamily	a.92.1 — Carbamoyl phosphate synthetase, large subunit connection domain
家族 Family family	a.92.1.1 — Carbamoyl phosphate synthetase, large subunit connection domain

结构域编号 domain_id	d1ce8a2
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.24 — Methylglyoxal synthase-like
超家族 Superfamily superfamily	c.24.1 — Methylglyoxal synthase-like
家族 Family family	c.24.1.1 — Carbamoyl phosphate synthetase, large subunit allosteric, C-terminal domain

结构域编号 domain_id	d1ce8a3
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.30 — PreATP-grasp domain
超家族 Superfamily superfamily	c.30.1 — PreATP-grasp domain
家族 Family family	c.30.1.1 — BC N-terminal domain-like

结构域编号 domain_id	d1ce8a4
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.30 — PreATP-grasp domain
超家族 Superfamily superfamily	c.30.1 — PreATP-grasp domain
家族 Family family	c.30.1.1 — BC N-terminal domain-like

结构域编号 domain_id	d1ce8a5
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.142 — ATP-grasp
超家族 Superfamily superfamily	d.142.1 — Glutathione synthetase ATP-binding domain-like
家族 Family family	d.142.1.2 — BC ATP-binding domain-like

结构域编号 domain_id	d1ce8a6
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.142 — ATP-grasp
超家族 Superfamily superfamily	d.142.1 — Glutathione synthetase ATP-binding domain-like
家族 Family family	d.142.1.2 — BC ATP-binding domain-like

结构域编号 domain_id	d1ce8b1
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.8 — The 'swivelling' beta/beta/alpha domain
超家族 Superfamily superfamily	c.8.3 — Carbamoyl phosphate synthetase, small subunit N-terminal domain
家族 Family family	c.8.3.1 — Carbamoyl phosphate synthetase, small subunit N-terminal domain

结构域编号 domain_id	d1ce8b2
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.23 — Flavodoxin-like
超家族 Superfamily superfamily	c.23.16 — Class I glutamine amidotransferase-like
家族 Family family	c.23.16.1 — Class I glutamine amidotransferases (GAT)

结构域编号 domain_id	d1ce8c1
类 Class class	a — All alpha proteins
折叠类型 Fold fold	a.92 — Carbamoyl phosphate synthetase, large subunit connection domain
超家族 Superfamily superfamily	a.92.1 — Carbamoyl phosphate synthetase, large subunit connection domain
家族 Family family	a.92.1.1 — Carbamoyl phosphate synthetase, large subunit connection domain

结构域编号 domain_id	d1ce8c2
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.24 — Methylglyoxal synthase-like
超家族 Superfamily superfamily	c.24.1 — Methylglyoxal synthase-like
家族 Family family	c.24.1.1 — Carbamoyl phosphate synthetase, large subunit allosteric, C-terminal domain

结构域编号 domain_id	d1ce8c3
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.30 — PreATP-grasp domain
超家族 Superfamily superfamily	c.30.1 — PreATP-grasp domain
家族 Family family	c.30.1.1 — BC N-terminal domain-like

结构域编号 domain_id	d1ce8c4
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.30 — PreATP-grasp domain
超家族 Superfamily superfamily	c.30.1 — PreATP-grasp domain
家族 Family family	c.30.1.1 — BC N-terminal domain-like

结构域编号 domain_id	d1ce8c5
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.142 — ATP-grasp
超家族 Superfamily superfamily	d.142.1 — Glutathione synthetase ATP-binding domain-like
家族 Family family	d.142.1.2 — BC ATP-binding domain-like

结构域编号 domain_id	d1ce8c6
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.142 — ATP-grasp
超家族 Superfamily superfamily	d.142.1 — Glutathione synthetase ATP-binding domain-like
家族 Family family	d.142.1.2 — BC ATP-binding domain-like

结构域编号 domain_id	d1ce8d1
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.8 — The 'swivelling' beta/beta/alpha domain
超家族 Superfamily superfamily	c.8.3 — Carbamoyl phosphate synthetase, small subunit N-terminal domain
家族 Family family	c.8.3.1 — Carbamoyl phosphate synthetase, small subunit N-terminal domain

结构域编号 domain_id	d1ce8d2
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.23 — Flavodoxin-like
超家族 Superfamily superfamily	c.23.16 — Class I glutamine amidotransferase-like
家族 Family family	c.23.16.1 — Class I glutamine amidotransferases (GAT)

结构域编号 domain_id	d1ce8e1
类 Class class	a — All alpha proteins
折叠类型 Fold fold	a.92 — Carbamoyl phosphate synthetase, large subunit connection domain
超家族 Superfamily superfamily	a.92.1 — Carbamoyl phosphate synthetase, large subunit connection domain
家族 Family family	a.92.1.1 — Carbamoyl phosphate synthetase, large subunit connection domain

结构域编号 domain_id	d1ce8e2
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.24 — Methylglyoxal synthase-like
超家族 Superfamily superfamily	c.24.1 — Methylglyoxal synthase-like
家族 Family family	c.24.1.1 — Carbamoyl phosphate synthetase, large subunit allosteric, C-terminal domain

结构域编号 domain_id	d1ce8e3
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.30 — PreATP-grasp domain
超家族 Superfamily superfamily	c.30.1 — PreATP-grasp domain
家族 Family family	c.30.1.1 — BC N-terminal domain-like

结构域编号 domain_id	d1ce8e4
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.30 — PreATP-grasp domain
超家族 Superfamily superfamily	c.30.1 — PreATP-grasp domain
家族 Family family	c.30.1.1 — BC N-terminal domain-like

结构域编号 domain_id	d1ce8e5
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.142 — ATP-grasp
超家族 Superfamily superfamily	d.142.1 — Glutathione synthetase ATP-binding domain-like
家族 Family family	d.142.1.2 — BC ATP-binding domain-like

结构域编号 domain_id	d1ce8e6
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.142 — ATP-grasp
超家族 Superfamily superfamily	d.142.1 — Glutathione synthetase ATP-binding domain-like
家族 Family family	d.142.1.2 — BC ATP-binding domain-like

结构域编号 domain_id	d1ce8f1
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.8 — The 'swivelling' beta/beta/alpha domain
超家族 Superfamily superfamily	c.8.3 — Carbamoyl phosphate synthetase, small subunit N-terminal domain
家族 Family family	c.8.3.1 — Carbamoyl phosphate synthetase, small subunit N-terminal domain

结构域编号 domain_id	d1ce8f2
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.23 — Flavodoxin-like
超家族 Superfamily superfamily	c.23.16 — Class I glutamine amidotransferase-like
家族 Family family	c.23.16.1 — Class I glutamine amidotransferases (GAT)

结构域编号 domain_id	d1ce8g1
类 Class class	a — All alpha proteins
折叠类型 Fold fold	a.92 — Carbamoyl phosphate synthetase, large subunit connection domain
超家族 Superfamily superfamily	a.92.1 — Carbamoyl phosphate synthetase, large subunit connection domain
家族 Family family	a.92.1.1 — Carbamoyl phosphate synthetase, large subunit connection domain

结构域编号 domain_id	d1ce8g2
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.24 — Methylglyoxal synthase-like
超家族 Superfamily superfamily	c.24.1 — Methylglyoxal synthase-like
家族 Family family	c.24.1.1 — Carbamoyl phosphate synthetase, large subunit allosteric, C-terminal domain

结构域编号 domain_id	d1ce8g3
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.30 — PreATP-grasp domain
超家族 Superfamily superfamily	c.30.1 — PreATP-grasp domain
家族 Family family	c.30.1.1 — BC N-terminal domain-like

结构域编号 domain_id	d1ce8g4
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.30 — PreATP-grasp domain
超家族 Superfamily superfamily	c.30.1 — PreATP-grasp domain
家族 Family family	c.30.1.1 — BC N-terminal domain-like

结构域编号 domain_id	d1ce8g5
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.142 — ATP-grasp
超家族 Superfamily superfamily	d.142.1 — Glutathione synthetase ATP-binding domain-like
家族 Family family	d.142.1.2 — BC ATP-binding domain-like

结构域编号 domain_id	d1ce8g6
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.142 — ATP-grasp
超家族 Superfamily superfamily	d.142.1 — Glutathione synthetase ATP-binding domain-like
家族 Family family	d.142.1.2 — BC ATP-binding domain-like

结构域编号 domain_id	d1ce8h1
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.8 — The 'swivelling' beta/beta/alpha domain
超家族 Superfamily superfamily	c.8.3 — Carbamoyl phosphate synthetase, small subunit N-terminal domain
家族 Family family	c.8.3.1 — Carbamoyl phosphate synthetase, small subunit N-terminal domain

结构域编号 domain_id	d1ce8h2
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.23 — Flavodoxin-like
超家族 Superfamily superfamily	c.23.16 — Class I glutamine amidotransferase-like
家族 Family family	c.23.16.1 — Class I glutamine amidotransferases (GAT)

CATH v4.4 (40 domains)

结构域编号 domain_id	1ce8A01
类 Class class	3 — Alpha Beta
架构 Architecture architecture	40 — 3-Layer(aba) Sandwich
拓扑 Topology topology	50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily	20 —

结构域编号 domain_id	1ce8A02
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	470 — D-amino Acid Aminotransferase; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily	20 — ATP-grasp fold, B domain

结构域编号 domain_id	1ce8A03
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	1490 — Dna Ligase; domain 1
同源超家族 H-superfamily homologous superfamily	20 — ATP-grasp fold, A domain

结构域编号 domain_id	1ce8A04
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	1030 — Carbamoyl Phosphate Synthetase; Chain A, domain 4
同源超家族 H-superfamily homologous superfamily	10 — Carbamoyl-phosphate synthetase, large subunit oligomerisation domain

结构域编号 domain_id	1ce8A05
类 Class class	3 — Alpha Beta
架构 Architecture architecture	40 — 3-Layer(aba) Sandwich
拓扑 Topology topology	50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily	20 —

结构域编号 domain_id	1ce8A06
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	470 — D-amino Acid Aminotransferase; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily	20 — ATP-grasp fold, B domain

结构域编号 domain_id	1ce8A07
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	1490 — Dna Ligase; domain 1
同源超家族 H-superfamily homologous superfamily	20 — ATP-grasp fold, A domain

结构域编号 domain_id	1ce8A08
类 Class class	3 — Alpha Beta
架构 Architecture architecture	40 — 3-Layer(aba) Sandwich
拓扑 Topology topology	50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily	1380 — Methylglyoxal synthase-like domain

结构域编号 domain_id	1ce8B01
类 Class class	3 — Alpha Beta
架构 Architecture architecture	50 — 3-Layer(bba) Sandwich
拓扑 Topology topology	30 — Glucose Oxidase; domain 1
同源超家族 H-superfamily homologous superfamily	20 — Carbamoyl-phosphate synthase small subunit, N-terminal domain

结构域编号 domain_id	1ce8B02
类 Class class	3 — Alpha Beta
架构 Architecture architecture	40 — 3-Layer(aba) Sandwich
拓扑 Topology topology	50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily	880 — Class I glutamine amidotransferase (GATase) domain

结构域编号 domain_id	1ce8C01
类 Class class	3 — Alpha Beta
架构 Architecture architecture	40 — 3-Layer(aba) Sandwich
拓扑 Topology topology	50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily	20 —

结构域编号 domain_id	1ce8C02
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	470 — D-amino Acid Aminotransferase; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily	20 — ATP-grasp fold, B domain

结构域编号 domain_id	1ce8C03
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	1490 — Dna Ligase; domain 1
同源超家族 H-superfamily homologous superfamily	20 — ATP-grasp fold, A domain

结构域编号 domain_id	1ce8C04
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	1030 — Carbamoyl Phosphate Synthetase; Chain A, domain 4
同源超家族 H-superfamily homologous superfamily	10 — Carbamoyl-phosphate synthetase, large subunit oligomerisation domain

结构域编号 domain_id	1ce8C05
类 Class class	3 — Alpha Beta
架构 Architecture architecture	40 — 3-Layer(aba) Sandwich
拓扑 Topology topology	50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily	20 —

结构域编号 domain_id	1ce8C06
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	470 — D-amino Acid Aminotransferase; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily	20 — ATP-grasp fold, B domain

结构域编号 domain_id	1ce8C07
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	1490 — Dna Ligase; domain 1
同源超家族 H-superfamily homologous superfamily	20 — ATP-grasp fold, A domain

结构域编号 domain_id	1ce8C08
类 Class class	3 — Alpha Beta
架构 Architecture architecture	40 — 3-Layer(aba) Sandwich
拓扑 Topology topology	50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily	1380 — Methylglyoxal synthase-like domain

结构域编号 domain_id	1ce8D01
类 Class class	3 — Alpha Beta
架构 Architecture architecture	50 — 3-Layer(bba) Sandwich
拓扑 Topology topology	30 — Glucose Oxidase; domain 1
同源超家族 H-superfamily homologous superfamily	20 — Carbamoyl-phosphate synthase small subunit, N-terminal domain

结构域编号 domain_id	1ce8D02
类 Class class	3 — Alpha Beta
架构 Architecture architecture	40 — 3-Layer(aba) Sandwich
拓扑 Topology topology	50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily	880 — Class I glutamine amidotransferase (GATase) domain

结构域编号 domain_id	1ce8E01
类 Class class	3 — Alpha Beta
架构 Architecture architecture	40 — 3-Layer(aba) Sandwich
拓扑 Topology topology	50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily	20 —

结构域编号 domain_id	1ce8E02
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	470 — D-amino Acid Aminotransferase; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily	20 — ATP-grasp fold, B domain

结构域编号 domain_id	1ce8E03
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	1490 — Dna Ligase; domain 1
同源超家族 H-superfamily homologous superfamily	20 — ATP-grasp fold, A domain

结构域编号 domain_id	1ce8E04
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	1030 — Carbamoyl Phosphate Synthetase; Chain A, domain 4
同源超家族 H-superfamily homologous superfamily	10 — Carbamoyl-phosphate synthetase, large subunit oligomerisation domain

结构域编号 domain_id	1ce8E05
类 Class class	3 — Alpha Beta
架构 Architecture architecture	40 — 3-Layer(aba) Sandwich
拓扑 Topology topology	50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily	20 —

结构域编号 domain_id	1ce8E06
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	470 — D-amino Acid Aminotransferase; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily	20 — ATP-grasp fold, B domain

结构域编号 domain_id	1ce8E07
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	1490 — Dna Ligase; domain 1
同源超家族 H-superfamily homologous superfamily	20 — ATP-grasp fold, A domain

结构域编号 domain_id	1ce8E08
类 Class class	3 — Alpha Beta
架构 Architecture architecture	40 — 3-Layer(aba) Sandwich
拓扑 Topology topology	50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily	1380 — Methylglyoxal synthase-like domain

结构域编号 domain_id	1ce8F01
类 Class class	3 — Alpha Beta
架构 Architecture architecture	50 — 3-Layer(bba) Sandwich
拓扑 Topology topology	30 — Glucose Oxidase; domain 1
同源超家族 H-superfamily homologous superfamily	20 — Carbamoyl-phosphate synthase small subunit, N-terminal domain

结构域编号 domain_id	1ce8F02
类 Class class	3 — Alpha Beta
架构 Architecture architecture	40 — 3-Layer(aba) Sandwich
拓扑 Topology topology	50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily	880 — Class I glutamine amidotransferase (GATase) domain

结构域编号 domain_id	1ce8G01
类 Class class	3 — Alpha Beta
架构 Architecture architecture	40 — 3-Layer(aba) Sandwich
拓扑 Topology topology	50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily	20 —

结构域编号 domain_id	1ce8G02
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	470 — D-amino Acid Aminotransferase; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily	20 — ATP-grasp fold, B domain

结构域编号 domain_id	1ce8G03
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	1490 — Dna Ligase; domain 1
同源超家族 H-superfamily homologous superfamily	20 — ATP-grasp fold, A domain

结构域编号 domain_id	1ce8G04
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	1030 — Carbamoyl Phosphate Synthetase; Chain A, domain 4
同源超家族 H-superfamily homologous superfamily	10 — Carbamoyl-phosphate synthetase, large subunit oligomerisation domain

结构域编号 domain_id	1ce8G05
类 Class class	3 — Alpha Beta
架构 Architecture architecture	40 — 3-Layer(aba) Sandwich
拓扑 Topology topology	50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily	20 —

结构域编号 domain_id	1ce8G06
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	470 — D-amino Acid Aminotransferase; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily	20 — ATP-grasp fold, B domain

结构域编号 domain_id	1ce8G07
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	1490 — Dna Ligase; domain 1
同源超家族 H-superfamily homologous superfamily	20 — ATP-grasp fold, A domain

结构域编号 domain_id	1ce8G08
类 Class class	3 — Alpha Beta
架构 Architecture architecture	40 — 3-Layer(aba) Sandwich
拓扑 Topology topology	50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily	1380 — Methylglyoxal synthase-like domain

结构域编号 domain_id	1ce8H01
类 Class class	3 — Alpha Beta
架构 Architecture architecture	50 — 3-Layer(bba) Sandwich
拓扑 Topology topology	30 — Glucose Oxidase; domain 1
同源超家族 H-superfamily homologous superfamily	20 — Carbamoyl-phosphate synthase small subunit, N-terminal domain

结构域编号 domain_id	1ce8H02
类 Class class	3 — Alpha Beta
架构 Architecture architecture	40 — 3-Layer(aba) Sandwich
拓扑 Topology topology	50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily	880 — Class I glutamine amidotransferase (GATase) domain

▶

8. 引用文献 (1)

▶

晶胞边长 a length_a	152.100 Å
晶胞边长 b length_b	163.900 Å
晶胞边长 c length_c	331.200 Å
晶胞夹角 α angle_alpha	90.00 °
晶胞夹角 β angle_beta	90.00 °
晶胞夹角 γ angle_gamma	90.00 °
晶胞分子数 Z z_pdb	16

空间群 space_group	P 21 21 21
空间群编号 int_tables_number	19
晶系 crystal_system	—

分辨率 resolution	2.100 Å
最低分辨率 resolution_low	30.000 Å
R 因子 r_factor	0.1920
R_work r_work	0.1930
R_free r_free	0.2500

fit	/app/data/saxs_computation/ce/1ce8/1ce8.fit
pddf	/app/data/pr_computation/ce/1ce8/1ce8.pr.out
profile	/app/data/saxs_computation/ce/1ce8/1ce8.dat

CARBAMOYL PHOSPHATE SYNTHETASE FROM ESCHERICHIS COLI WITH COMPLEXED WITH THE ALLOSTERIC LIGAND IMP

1. 蛋白身份与相关结构 Protein Identity & Related Structures

PROTEIN (CARBAMOYL-PHOSPHATE SYNTHASE)

当前结构中的状态

数据库中的同蛋白其他状态

PROTEIN (CARBAMOYL-PHOSPHATE SYNTHASE)

当前结构中的状态

数据库中的同蛋白其他状态

SAXS 散射曲线 SAXS Profile

P(r) 距离分布 P(r) Distribution

2. 结构基本信息 2. Structure Basics

3. SAXS 参数 (CRYSOL 理论计算) 3. SAXS Parameters (CRYSOL)

4. P(r) 距离分布 (GNOM 反演) 4. P(r) Analysis (GNOM)

5. 晶体学与实验 5. Crystallography & Experiment

晶胞参数 Unit Cell

对称性 Symmetry

精修参数 Refinement

衍射实验 Diffraction

6. 实体与聚合物信息 Entities & Polymers (11)

实体 1 Entity 1 polymer

聚合物 Polymer

来源 Source

实体 2 Entity 2 polymer

聚合物 Polymer

来源 Source

实体 3 Entity 3 non-polymer

实体 4 Entity 4 non-polymer

实体 5 Entity 5 non-polymer

实体 6 Entity 6 non-polymer

实体 7 Entity 7 non-polymer

实体 8 Entity 8 non-polymer

实体 9 Entity 9 non-polymer

实体 10 Entity 10 non-polymer

实体 11 Entity 11 water

7. 折叠分类 (SCOP + CATH) 72 domains

SCOP 2.08 (32 domains)

CATH v4.4 (40 domains)

8. 引用文献 (1)

9. 文件与曲线 (10)

Files (7)

Curves (3)