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1d5r

Crystal Structure of the PTEN Tumor Suppressor

Method: X-RAY DIFFRACTION D_max: 72.3 Å Quality: EXCELLENT

SAXS Profile

P(r) Distribution

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1. Structure Basics

entry_id	1d5r
deposition_date	1999-10-11
title	Crystal Structure of the PTEN Tumor Suppressor
keywords	C2 DOMAIN, PHOSPHOTIDYLINOSITOL, PHOSPHATASE, HYDROLASE; HYDROLASE
method	X-RAY DIFFRACTION

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Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

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2. SAXS Parameters (CRYSOL)

rg_guinier	22.63 Å
rg_electron	21.58 Å
i0	21889700.00
molecular_weight	36637.0 kDa
excluded_volume	46251 Å³
envelope_volume	54487 Å³
shell_volume	21437 Å³
envelope_diameter	73.8 Å
shell_rg	27.68 Å
envelope_rg	21.73 Å
shape_rg	21.57 Å
total_rg	22.46 Å
total_atoms	2586
n_residues	307
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

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3. P(r) Analysis (GNOM)

dmax	72.3 Å
rg_real	22.63 Å
rg_real_error	0.43 Å
i0_real	2.1890e+07
i0_real_error	2.7170e+05
rg_reciprocal	22.63 Å
i0_reciprocal	21890000.0000
total_estimate	0.9016
solution_quality	EXCELLENT a EXCELLENT solution
n_peaks	2
r_peak_primary	24.1 Å
skewness	0.335
kurtosis	-0.461
angular_range	— – 0.3500 Å⁻¹
current_alpha	0.0000
highest_alpha	4655000.0000
n_real_points	67
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.910; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.993; Smooth: 0.993

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4. Crystallography & Experiment

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5. Entities & Polymer Info (3)

Entity 1 polymer

description	PHOSPHOINOSITIDE PHOSPHATASE PTEN
formula_weight	38496.2 kDa
ec_number	3.1.3.48
mutation	RESIDUES 286-309 ARE REPLACED BY VAL
src_method	man
entity_count	1

Polymer

type	polypeptide(L)
strand_id	A
atom_count	2968

MIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVMICAYLLHRGKFLKAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSYLLKNHLDYRPVALLFHKMMFETIPMFSGGTCNPQFVVCQLKVKIYSSNSGPTRREDKFMYFEFPQPLPVCGDIKVEFFHKQNKMLKKDKMFHFWVNTFFIPGPEEVDNDKEYLVLTLTKNDLDKANKDKANRYFSPNFKVKLYFTKTVEE

Source

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Trichoplusia ni

Entity 2 non-polymer

description	L(+)-TARTARIC ACID
formula_weight	150.1 kDa
src_method	syn
entity_count	1

Entity 3 water

description	water
formula_weight	18.0 kDa
src_method	nat
entity_count	382

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6. Citations (1)

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length_a	113.140 Å
length_b	113.140 Å
length_c	58.550 Å
angle_alpha	90.00 °
angle_beta	90.00 °
angle_gamma	90.00 °
z_pdb	8

space_group	I 4
int_tables_number	79
crystal_system	—

resolution	2.100 Å
resolution_low	15.000 Å
r_factor	0.2260
r_work	0.2240
r_free	0.2760

fit	/app/data/saxs_computation/d5/1d5r/1d5r.fit
pddf	/app/data/pr_computation/d5/1d5r/1d5r.pr.out
profile	/app/data/saxs_computation/d5/1d5r/1d5r.dat

Crystal Structure of the PTEN Tumor Suppressor

SAXS Profile

P(r) Distribution

1. Structure Basics

Download Data

2. SAXS Parameters (CRYSOL)

3. P(r) Analysis (GNOM)

4. Crystallography & Experiment

Unit Cell

Symmetry

Refinement

Diffraction