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1e7w

;One active site, two modes of reduction correlate the mechanism of leishmania pteridine reductase with pterin metabolism and antifolate drug resistance in trpanosomes ;

Method: X-RAY DIFFRACTION Dmax: 89.5 Å Quality: GOOD

SAXS Profile

SAXS profile for 1e7w

P(r) Distribution

P(r) distribution for 1e7w
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1. Structure Basics

entry_id1e7w
deposition_date2000-09-11
title;One active site, two modes of reduction correlate the mechanism of leishmania pteridine reductase with pterin metabolism and antifolate drug resistance in trpanosomes ;
keywordsDIHYDROFOLATE REDUCTASE, PTERIDINE REDUCTASE, SHORTCHAIN DEHYDROGENASE, METHOTREXATE RESISTANCE, OXIDOREDUCTASE; OXIDOREDUCTASE
methodX-RAY DIFFRACTION
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Download Data

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2. SAXS Parameters (CRYSOL)

rg_guinier24.89 Å
rg_electron23.94 Å
i059394100.00
molecular_weight58337.0 kDa
excluded_volume72430 ų
envelope_volume86171 ų
shell_volume29497 ų
envelope_diameter86.0 Å
shell_rg31.57 Å
envelope_rg24.25 Å
shape_rg23.96 Å
total_rg24.71 Å
total_atoms4091
n_residues525
n_harmonics20
q_range— – 0.5000 Å−1
n_points101
shell_typedirectional
solvent_density0.3340 e/ų
contrast_shell0.0300 e/ų
crysol_version4.1.3
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3. P(r) Analysis (GNOM)

dmax89.5 Å
rg_real24.84 Å
rg_real_error0.93 Å
i0_real5.9390e+07
i0_real_error9.3770e+05
rg_reciprocal24.85 Å
i0_reciprocal59390000.0000
total_estimate0.7675
solution_quality GOOD a GOOD solution
n_peaks3
r_peak_primary27.0 Å
skewness0.315
kurtosis-0.354
angular_range— – 0.3200 Å−1
current_alpha0.0000
highest_alpha13590000.0000
n_real_points64
gnom_version4.1.3
quality_criteria AN1: 0.000; Oscil: 0.688; Stabil: 0.995; Sysdev: 1.000; Positv: 1.000; Valcen: 0.924; Smooth: 0.000
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4. Crystallography & Experiment

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5. Entities & Polymer Info (5)

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6. Citations (1)

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7. Files & Curves (10)