SUS SCROFA
| Assembly | 物理组成 | 蛋白状态 | 分子拷贝数 | 共同组分 | 数据核对 |
|---|---|---|---|---|---|
| 1 | 蛋白单体 | 单体 | 蛋白 1 | 3,5,7,3',4'-PENTAHYDROXYFLAVONE × 1 | 与蛋白数一致 |
| UniProt名称 | P11G_PIG |
| Isoform | — |
| PDB实体 | 1 |
| 链与序列区间 | 作者链 A； PDB构建体 2–961； UniProt 143–1102 |
页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。 链映射与序列区间收在“数据证据”中；数据库内部编号、导入时间和 assembly 操作表达式仅用于维护，因此不在读者页面展示。
| 条目编号 entry_id | 1e8w |
| 沉积日期 deposition_date | 2000-10-03 |
| 结构标题 title | Structure determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin and staurosporine |
| 关键词 keywords | PHOSPHOINOSITIDE 3-KINASE GAMMA, SECONDARY MESSENGER GENERATION, PI3K, PI 3K, QUERCETIN; PHOSPHOINOSITIDE 3-KINASE GAMMA |
| 实验方法 method | X-RAY DIFFRACTION |
页面只读取最新 assembly 计算结果。每一条曲线都对应明确的 PDB、official biological assembly 和 coordinate model。
Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)
| Rg（Guinier） | 30.09 Å |
| Rg（电子密度） | 29.09 Å |
| 总 Rg | 29.95 Å |
| 原子数 | 6915 |
| 残基数 | 851 |
| 排除体积 | 124360 ų |
| 最大 q | 0.500 Å⁻¹ |
| 结构域编号 domain_id | d1e8wa1 |
| 类 Class class | a — All alpha proteins |
| 折叠类型 Fold fold | a.118 — alpha-alpha superhelix |
| 超家族 Superfamily superfamily | a.118.1 — ARM repeat |
| 家族 Family family | a.118.1.6 — Phoshoinositide 3-kinase (PI3K) helical domain |
| 结构域编号 domain_id | d1e8wa2 |
| 类 Class class | b — All beta proteins |
| 折叠类型 Fold fold | b.7 — C2 domain-like |
| 超家族 Superfamily superfamily | b.7.1 — C2 domain (Calcium/lipid-binding domain, CaLB) |
| 家族 Family family | b.7.1.1 — PLC-like (P variant) |
| 结构域编号 domain_id | d1e8wa3 |
| 类 Class class | d — Alpha and beta proteins (a+b) |
| 折叠类型 Fold fold | d.15 — beta-Grasp (ubiquitin-like) |
| 超家族 Superfamily superfamily | d.15.1 — Ubiquitin-like |
| 家族 Family family | d.15.1.5 — Ras-binding domain, RBD |
| 结构域编号 domain_id | d1e8wa4 |
| 类 Class class | d — Alpha and beta proteins (a+b) |
| 折叠类型 Fold fold | d.144 — Protein kinase-like (PK-like) |
| 超家族 Superfamily superfamily | d.144.1 — Protein kinase-like (PK-like) |
| 家族 Family family | d.144.1.4 — Phoshoinositide 3-kinase (PI3K), catalytic domain |
| 结构域编号 domain_id | d1e8wa5 |
| 类 Class class | l — Artifacts |
| 折叠类型 Fold fold | l.1 — Tags |
| 超家族 Superfamily superfamily | l.1.1 — Tags |
| 家族 Family family | l.1.1.1 — Tags |
| 结构域编号 domain_id | 1e8wA01 |
| 类 Class class | 3 — Alpha Beta |
| 架构 Architecture architecture | 10 — Roll |
| 拓扑 Topology topology | 20 — Ubiquitin-like (UB roll) |
| 同源超家族 H-superfamily homologous superfamily | 90 — Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1 |
| 结构域编号 domain_id | 1e8wA02 |
| 类 Class class | 2 — Mainly Beta |
| 架构 Architecture architecture | 60 — Sandwich |
| 拓扑 Topology topology | 40 — Immunoglobulin-like |
| 同源超家族 H-superfamily homologous superfamily | 150 — C2 domain |
| 结构域编号 domain_id | 1e8wA03 |
| 类 Class class | 1 — Mainly Alpha |
| 架构 Architecture architecture | 25 — Alpha Horseshoe |
| 拓扑 Topology topology | 40 — Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat |
| 同源超家族 H-superfamily homologous superfamily | 70 — Phosphatidylinositol 3-kinase, accessory domain (PIK) |
| 结构域编号 domain_id | 1e8wA04 |
| 类 Class class | 3 — Alpha Beta |
| 架构 Architecture architecture | 30 — 2-Layer Sandwich |
| 拓扑 Topology topology | 1010 — Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 4 |
| 同源超家族 H-superfamily homologous superfamily | 10 — Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 4 |
| 结构域编号 domain_id | 1e8wA05 |
| 类 Class class | 1 — Mainly Alpha |
| 架构 Architecture architecture | 10 — Orthogonal Bundle |
| 拓扑 Topology topology | 1070 — Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, Domain 5 |
| 同源超家族 H-superfamily homologous superfamily | 11 — Phosphatidylinositol 3-/4-kinase, catalytic domain |