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1ee2

THE STRUCTURE OF STEROID-ACTIVE ALCOHOL DEHYDROGENASE AT 1.54 A RESOLUTION

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

ALCOHOL DEHYDROGENASE

OrganismNot specified

UniProt P00328

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein homooligomer Homooligomer Protein 2 ZINC ION × 4 NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 2 CHOLIC ACID × 2 water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer
1ee2

1 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex

None

View Construct and Data Evidence
UniProt name ADHS_HORSE
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–373； UniProt 1–373 Author chain B； PDBConstruct 1–373； UniProt 1–373

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id1ee2
Deposition date deposition_date2000-01-30
Structure title titleTHE STRUCTURE OF STEROID-ACTIVE ALCOHOL DEHYDROGENASE AT 1.54 A RESOLUTION
Keywords keywordsDEHYDROGENASE, ALCOHOL, NICOTINAMIDE COENZYME, STEROID BINDING, OXIDOREDUCTASE; OXIDOREDUCTASE
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

1ee2__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

1ee2__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

1ee2__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）29.79 Å
Rg (electron density)29.63 Å
Total Rg30.12 Å
Atom count5676
Residues746
Excluded volume102520 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 1ee2__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (5)

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6. Fold Classification (SCOP + CATH) 8 domains

SCOP 2.08 (4 domains)

Domain ID domain_idd1ee2a1
Class classb — All beta proteins
Fold Fold foldb.35 — GroES-like
Superfamily Superfamily superfamilyb.35.1 — GroES-like
Family Family familyb.35.1.2 — Alcohol dehydrogenase-like, N-terminal domain
Domain ID domain_idd1ee2a2
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.2 — NAD(P)-binding Rossmann-fold domains
Superfamily Superfamily superfamilyc.2.1 — NAD(P)-binding Rossmann-fold domains
Family Family familyc.2.1.1 — Alcohol dehydrogenase-like, C-terminal domain
Domain ID domain_idd1ee2b1
Class classb — All beta proteins
Fold Fold foldb.35 — GroES-like
Superfamily Superfamily superfamilyb.35.1 — GroES-like
Family Family familyb.35.1.2 — Alcohol dehydrogenase-like, N-terminal domain
Domain ID domain_idd1ee2b2
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.2 — NAD(P)-binding Rossmann-fold domains
Superfamily Superfamily superfamilyc.2.1 — NAD(P)-binding Rossmann-fold domains
Family Family familyc.2.1.1 — Alcohol dehydrogenase-like, C-terminal domain

CATH v4.4 (4 domains)

Domain ID domain_id1ee2A01
Class class3 — Alpha Beta
Architecture architecture90 — Alpha-Beta Complex
Topology topology180 — Quinone Oxidoreductase; Chain A, domain 1
Homologous superfamily homologous superfamily10 — Medium-chain alcohol dehydrogenases, catalytic domain
Domain ID domain_id1ee2A02
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily720 — NAD(P)-binding Rossmann-like Domain
Domain ID domain_id1ee2B01
Class class3 — Alpha Beta
Architecture architecture90 — Alpha-Beta Complex
Topology topology180 — Quinone Oxidoreductase; Chain A, domain 1
Homologous superfamily homologous superfamily10 — Medium-chain alcohol dehydrogenases, catalytic domain
Domain ID domain_id1ee2B02
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily720 — NAD(P)-binding Rossmann-like Domain
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7. Citations (4)