1g2c

HUMAN RESPIRATORY SYNCYTIAL VIRUS FUSION PROTEIN CORE

Method: X-RAY DIFFRACTION D_max: 103.9 Å Quality: REASONABLE

SAXS 散射曲线 SAXS Profile

P(r) 距离分布 P(r) Distribution

下载 Download SAXS (.dat) P(r) (.pr.out) CIF

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1. 结构基本信息 1. Structure Basics

条目编号 entry_id	1g2c
沉积日期 deposition_date	2000-10-18
结构标题 title	HUMAN RESPIRATORY SYNCYTIAL VIRUS FUSION PROTEIN CORE
关键词 keywords	membrane fusion, pneumovirus, HRSV, Viral protein; VIRAL PROTEIN
实验方法 method	X-RAY DIFFRACTION

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2. SAXS 参数 (CRYSOL 理论计算) 2. SAXS Parameters (CRYSOL)

回转半径 Rg (Guinier) rg_guinier	32.80 Å
回转半径 Rg (电子) rg_electron	32.13 Å
零角强度 I(0) i0	183779000.00
分子量 molecular_weight	114250.0 kDa
排除体积 excluded_volume	145820 Å³
包络体积 envelope_volume	179150 Å³
水化壳体积 shell_volume	46113 Å³
包络直径 envelope_diameter	114.7 Å
壳层 Rg shell_rg	39.50 Å
包络 Rg envelope_rg	32.09 Å
形状 Rg shape_rg	32.12 Å
总 Rg total_rg	32.76 Å
总原子数 total_atoms	8054
残基数 n_residues	1039
球谐函数阶数 n_harmonics	20
q 范围 q_range	— – 0.5000 Å⁻¹
数据点数 n_points	101
壳层类型 shell_type	directional
溶剂电子密度 solvent_density	0.3340 e/Å³
壳层衬度 contrast_shell	0.0300 e/Å³
CRYSOL 版本 crysol_version	4.1.3

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3. P(r) 距离分布 (GNOM 反演) 3. P(r) Analysis (GNOM)

最大尺寸 Dmax dmax	103.9 Å
Rg (实空间) rg_real	32.64 Å
Rg 误差 (实空间) rg_real_error	0.58 Å
I(0) (实空间) i0_real	1.8380e+08
I(0) 误差 (实空间) i0_real_error	3.1580e+06
Rg (倒空间) rg_reciprocal	32.71 Å
I(0) (倒空间) i0_reciprocal	183800000.0000
解质量估计 total_estimate	0.6767
解质量评级 solution_quality	REASONABLE a REASONABLE solution
P(r) 峰数 n_peaks	2
主峰位置 r_peak_primary	43.3 Å
偏度 Skewness skewness	0.207
峰度 Kurtosis kurtosis	-0.386
角度范围 angular_range	— – 0.2400 Å⁻¹
当前正则化参数 α current_alpha	0.0000
最高正则化参数 α highest_alpha	65530000.0000
实空间数据点数 n_real_points	49
GNOM 版本 gnom_version	4.1.3
质量判据 quality_criteria	AN1: 0.000; Oscil: 0.904; Stabil: 1.000; Sysdev: 0.049; Positv: 1.000; Valcen: 0.997; Smooth: 0.936

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4. 晶体学与实验 4. Crystallography & Experiment

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5. 实体与聚合体信息 (3)

Entity 1 polymer

描述 description	FUSION PROTEIN (F)
分子量 formula_weight	5653.7 kDa
来源方法 src_method	man
拷贝数 entity_count	12

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	A,C,E,G,I,K,M,O,Q,S,U,W
原子数 atom_count	8942

LHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTSKVLDLKNYIDKQLLPIVNK

来源 Source

来源生物 organism	Human respiratory syncytial virus
NCBI 分类编号 ncbi_taxonomy_id	11261
宿主生物 host_organism	Escherichia coli

Entity 2 polymer

描述 description	FUSION PROTEIN (F)
分子量 formula_weight	4873.3 kDa
来源方法 src_method	man
拷贝数 entity_count	12

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	B,D,F,H,J,L,N,P,R,T,V,X

FYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLHNVNAG

来源 Source

来源生物 organism	Human respiratory syncytial virus
NCBI 分类编号 ncbi_taxonomy_id	11261
宿主生物 host_organism	Escherichia coli

Entity 3 water

描述 description	water
分子量 formula_weight	18.0 kDa
来源方法 src_method	nat
拷贝数 entity_count	888

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6. 折叠分类 (SCOP + CATH) 26 domains

SCOP 2.08 (12 domains)

结构域编号 domain_id	d1g2c.1
类 Class class	h — Coiled coil proteins
折叠类型 Fold fold	h.3 — Stalk segment of viral fusion proteins
超家族 Superfamily superfamily	h.3.2 — Virus ectodomain
家族 Family family	h.3.2.1 — Virus ectodomain

结构域编号 domain_id	d1g2c.2
类 Class class	h — Coiled coil proteins
折叠类型 Fold fold	h.3 — Stalk segment of viral fusion proteins
超家族 Superfamily superfamily	h.3.2 — Virus ectodomain
家族 Family family	h.3.2.1 — Virus ectodomain

结构域编号 domain_id	d1g2c.3
类 Class class	h — Coiled coil proteins
折叠类型 Fold fold	h.3 — Stalk segment of viral fusion proteins
超家族 Superfamily superfamily	h.3.2 — Virus ectodomain
家族 Family family	h.3.2.1 — Virus ectodomain

结构域编号 domain_id	d1g2c.4
类 Class class	h — Coiled coil proteins
折叠类型 Fold fold	h.3 — Stalk segment of viral fusion proteins
超家族 Superfamily superfamily	h.3.2 — Virus ectodomain
家族 Family family	h.3.2.1 — Virus ectodomain

结构域编号 domain_id	d1g2c.5
类 Class class	h — Coiled coil proteins
折叠类型 Fold fold	h.3 — Stalk segment of viral fusion proteins
超家族 Superfamily superfamily	h.3.2 — Virus ectodomain
家族 Family family	h.3.2.1 — Virus ectodomain

结构域编号 domain_id	d1g2c.6
类 Class class	h — Coiled coil proteins
折叠类型 Fold fold	h.3 — Stalk segment of viral fusion proteins
超家族 Superfamily superfamily	h.3.2 — Virus ectodomain
家族 Family family	h.3.2.1 — Virus ectodomain

结构域编号 domain_id	d1g2c.7
类 Class class	h — Coiled coil proteins
折叠类型 Fold fold	h.3 — Stalk segment of viral fusion proteins
超家族 Superfamily superfamily	h.3.2 — Virus ectodomain
家族 Family family	h.3.2.1 — Virus ectodomain

结构域编号 domain_id	d1g2c.8
类 Class class	h — Coiled coil proteins
折叠类型 Fold fold	h.3 — Stalk segment of viral fusion proteins
超家族 Superfamily superfamily	h.3.2 — Virus ectodomain
家族 Family family	h.3.2.1 — Virus ectodomain

结构域编号 domain_id	d1g2c.9
类 Class class	h — Coiled coil proteins
折叠类型 Fold fold	h.3 — Stalk segment of viral fusion proteins
超家族 Superfamily superfamily	h.3.2 — Virus ectodomain
家族 Family family	h.3.2.1 — Virus ectodomain

结构域编号 domain_id	d1g2c.a
类 Class class	h — Coiled coil proteins
折叠类型 Fold fold	h.3 — Stalk segment of viral fusion proteins
超家族 Superfamily superfamily	h.3.2 — Virus ectodomain
家族 Family family	h.3.2.1 — Virus ectodomain

结构域编号 domain_id	d1g2c.b
类 Class class	h — Coiled coil proteins
折叠类型 Fold fold	h.3 — Stalk segment of viral fusion proteins
超家族 Superfamily superfamily	h.3.2 — Virus ectodomain
家族 Family family	h.3.2.1 — Virus ectodomain

结构域编号 domain_id	d1g2c.c
类 Class class	h — Coiled coil proteins
折叠类型 Fold fold	h.3 — Stalk segment of viral fusion proteins
超家族 Superfamily superfamily	h.3.2 — Virus ectodomain
家族 Family family	h.3.2.1 — Virus ectodomain

CATH v4.4 (14 domains)

结构域编号 domain_id	1g2cA00
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	20 — Up-down Bundle
拓扑 Topology topology	5 — Single alpha-helices involved in coiled-coils or other helix-helix interfaces
同源超家族 H-superfamily homologous superfamily	300 —

结构域编号 domain_id	1g2cB00
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	20 — Up-down Bundle
拓扑 Topology topology	5 — Single alpha-helices involved in coiled-coils or other helix-helix interfaces
同源超家族 H-superfamily homologous superfamily	170 —

结构域编号 domain_id	1g2cC00
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	20 — Up-down Bundle
拓扑 Topology topology	5 — Single alpha-helices involved in coiled-coils or other helix-helix interfaces
同源超家族 H-superfamily homologous superfamily	300 —

结构域编号 domain_id	1g2cE00
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	20 — Up-down Bundle
拓扑 Topology topology	5 — Single alpha-helices involved in coiled-coils or other helix-helix interfaces
同源超家族 H-superfamily homologous superfamily	300 —

结构域编号 domain_id	1g2cG00
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	20 — Up-down Bundle
拓扑 Topology topology	5 — Single alpha-helices involved in coiled-coils or other helix-helix interfaces
同源超家族 H-superfamily homologous superfamily	300 —

结构域编号 domain_id	1g2cI00
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	20 — Up-down Bundle
拓扑 Topology topology	5 — Single alpha-helices involved in coiled-coils or other helix-helix interfaces
同源超家族 H-superfamily homologous superfamily	300 —

结构域编号 domain_id	1g2cK00
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	20 — Up-down Bundle
拓扑 Topology topology	5 — Single alpha-helices involved in coiled-coils or other helix-helix interfaces
同源超家族 H-superfamily homologous superfamily	300 —

结构域编号 domain_id	1g2cL00
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	20 — Up-down Bundle
拓扑 Topology topology	5 — Single alpha-helices involved in coiled-coils or other helix-helix interfaces
同源超家族 H-superfamily homologous superfamily	170 —

结构域编号 domain_id	1g2cM00
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	20 — Up-down Bundle
拓扑 Topology topology	5 — Single alpha-helices involved in coiled-coils or other helix-helix interfaces
同源超家族 H-superfamily homologous superfamily	300 —

结构域编号 domain_id	1g2cO00
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	20 — Up-down Bundle
拓扑 Topology topology	5 — Single alpha-helices involved in coiled-coils or other helix-helix interfaces
同源超家族 H-superfamily homologous superfamily	300 —

结构域编号 domain_id	1g2cQ00
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	20 — Up-down Bundle
拓扑 Topology topology	5 — Single alpha-helices involved in coiled-coils or other helix-helix interfaces
同源超家族 H-superfamily homologous superfamily	300 —

结构域编号 domain_id	1g2cS00
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	20 — Up-down Bundle
拓扑 Topology topology	5 — Single alpha-helices involved in coiled-coils or other helix-helix interfaces
同源超家族 H-superfamily homologous superfamily	300 —

结构域编号 domain_id	1g2cU00
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	20 — Up-down Bundle
拓扑 Topology topology	5 — Single alpha-helices involved in coiled-coils or other helix-helix interfaces
同源超家族 H-superfamily homologous superfamily	300 —

结构域编号 domain_id	1g2cW00
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	20 — Up-down Bundle
拓扑 Topology topology	5 — Single alpha-helices involved in coiled-coils or other helix-helix interfaces
同源超家族 H-superfamily homologous superfamily	300 —

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7. 引用文献 (1)

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晶胞边长 a length_a	67.904 Å
晶胞边长 b length_b	71.539 Å
晶胞边长 c length_c	76.455 Å
晶胞夹角 α angle_alpha	81.34 °
晶胞夹角 β angle_beta	73.80 °
晶胞夹角 γ angle_gamma	60.72 °
晶胞分子数 Z z_pdb	12

空间群 space_group	P 1
空间群编号 int_tables_number	1
晶系 crystal_system	—

分辨率 resolution	2.300 Å
最低分辨率 resolution_low	10.000 Å
R 因子 r_factor	0.2330
R_work r_work	0.2330
R_free r_free	0.2860

fit	/app/data/saxs_computation/g2/1g2c/1g2c.fit
pddf	/app/data/pr_computation/g2/1g2c/1g2c.pr.out
profile	/app/data/saxs_computation/g2/1g2c/1g2c.dat

HUMAN RESPIRATORY SYNCYTIAL VIRUS FUSION PROTEIN CORE

SAXS 散射曲线 SAXS Profile

P(r) 距离分布 P(r) Distribution

1. 结构基本信息 1. Structure Basics

2. SAXS 参数 (CRYSOL 理论计算) 2. SAXS Parameters (CRYSOL)

3. P(r) 距离分布 (GNOM 反演) 3. P(r) Analysis (GNOM)

4. 晶体学与实验 4. Crystallography & Experiment

晶胞参数 Unit Cell

对称性 Symmetry

精修参数 Refinement

衍射实验 Diffraction

5. 实体与聚合体信息 (3)

Entity 1 polymer

聚合体 Polymer

来源 Source

Entity 2 polymer

聚合体 Polymer

来源 Source

Entity 3 water

6. 折叠分类 (SCOP + CATH) 26 domains

SCOP 2.08 (12 domains)

CATH v4.4 (14 domains)

7. 引用文献 (1)

8. 文件与曲线 (10)

Files (7)

Curves (3)