1h2i

Human Rad52 protein, N-terminal domain

Method: X-RAY DIFFRACTION

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1. Protein Identity and Related Structures Protein Identity & Related Structures

DNA REPAIR PROTEIN RAD52 HOMOLOG

HOMO SAPIENS

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein homooligomer	Homooligomer	Protein 11	water × 11	Consistent with protein count
2	Protein homooligomer	Homooligomer	Protein 11	water × 11	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RA52_HUMAN
Isoform	—
PDB entities	1
Chains and sequence ranges	Author chain A； PDBConstruct 1–209； UniProt 1–209 Author chain B； PDBConstruct 1–209； UniProt 1–209 Author chain C； PDBConstruct 1–209； UniProt 1–209 Author chain D； PDBConstruct 1–209； UniProt 1–209 Author chain E； PDBConstruct 1–209； UniProt 1–209 Author chain F； PDBConstruct 1–209； UniProt 1–209 Author chain G； PDBConstruct 1–209； UniProt 1–209 Author chain H； PDBConstruct 1–209； UniProt 1–209 Author chain I； PDBConstruct 1–209； UniProt 1–209 Author chain J； PDBConstruct 1–209； UniProt 1–209 Author chain K； PDBConstruct 1–209； UniProt 1–209 Author chain L； PDBConstruct 1–209； UniProt 1–209 Author chain M； PDBConstruct 1–209； UniProt 1–209 Author chain N； PDBConstruct 1–209； UniProt 1–209 Author chain O； PDBConstruct 1–209； UniProt 1–209 Author chain P； PDBConstruct 1–209； UniProt 1–209 Author chain Q； PDBConstruct 1–209； UniProt 1–209 Author chain R； PDBConstruct 1–209； UniProt 1–209 Author chain S； PDBConstruct 1–209； UniProt 1–209 Author chain T； PDBConstruct 1–209； UniProt 1–209 Author chain U； PDBConstruct 1–209； UniProt 1–209 Author chain V； PDBConstruct 1–209； UniProt 1–209

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id	1h2i
Deposition date deposition_date	2002-08-09
Structure title title	Human Rad52 protein, N-terminal domain
Keywords keywords	DNA-BINDING PROTEIN, DNA REPAIR, DNA RECOMBINATION, DNA BINDING PROTEIN; DNA BINDING PROTEIN
Experimental Method method	X-RAY DIFFRACTION

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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

1h2i__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

1h2i__assembly_1__model_1 | I(q)

100 plotted points; both axes use logarithmic scales.

1h2i__assembly_1__model_1 | P(r) · Pending

P(r) will be calculated and displayed separately for the same assembly/model.

Rg（Guinier）	40.64 Å
Rg (electron density)	40.08 Å
Total Rg	40.74 Å
Atom count	16159
Residues	2046
Excluded volume	285740 Å³
Maximum q	0.500 Å⁻¹

Assembly	Model	Structure unit	Oligomeric description	Status	CRYSOL	Actions
1	1	`1h2i__assembly_1__model_1`	undecameric （11）	Success	4.1.3-1-20251215 (887e7ef)	View Download
2	1	`1h2i__assembly_2__model_1`	undecameric （11）	Success	4.1.3-1-20251215 (887e7ef)	View Download

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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (2)

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6. Fold Classification (SCOP + CATH) 44 domains

SCOP 2.08 (22 domains)

Domain ID domain_id	d1h2ia_
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.50 — dsRBD-like
Superfamily Superfamily superfamily	d.50.1 — dsRNA-binding domain-like
Family Family family	d.50.1.3 — The homologous-pairing domain of Rad52 recombinase

Domain ID domain_id	d1h2ib_
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.50 — dsRBD-like
Superfamily Superfamily superfamily	d.50.1 — dsRNA-binding domain-like
Family Family family	d.50.1.3 — The homologous-pairing domain of Rad52 recombinase

Domain ID domain_id	d1h2ic_
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.50 — dsRBD-like
Superfamily Superfamily superfamily	d.50.1 — dsRNA-binding domain-like
Family Family family	d.50.1.3 — The homologous-pairing domain of Rad52 recombinase

Domain ID domain_id	d1h2id_
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.50 — dsRBD-like
Superfamily Superfamily superfamily	d.50.1 — dsRNA-binding domain-like
Family Family family	d.50.1.3 — The homologous-pairing domain of Rad52 recombinase

Domain ID domain_id	d1h2ie_
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.50 — dsRBD-like
Superfamily Superfamily superfamily	d.50.1 — dsRNA-binding domain-like
Family Family family	d.50.1.3 — The homologous-pairing domain of Rad52 recombinase

Domain ID domain_id	d1h2if_
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.50 — dsRBD-like
Superfamily Superfamily superfamily	d.50.1 — dsRNA-binding domain-like
Family Family family	d.50.1.3 — The homologous-pairing domain of Rad52 recombinase

Domain ID domain_id	d1h2ig_
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.50 — dsRBD-like
Superfamily Superfamily superfamily	d.50.1 — dsRNA-binding domain-like
Family Family family	d.50.1.3 — The homologous-pairing domain of Rad52 recombinase

Domain ID domain_id	d1h2ih_
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.50 — dsRBD-like
Superfamily Superfamily superfamily	d.50.1 — dsRNA-binding domain-like
Family Family family	d.50.1.3 — The homologous-pairing domain of Rad52 recombinase

Domain ID domain_id	d1h2ii_
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.50 — dsRBD-like
Superfamily Superfamily superfamily	d.50.1 — dsRNA-binding domain-like
Family Family family	d.50.1.3 — The homologous-pairing domain of Rad52 recombinase

Domain ID domain_id	d1h2ij_
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.50 — dsRBD-like
Superfamily Superfamily superfamily	d.50.1 — dsRNA-binding domain-like
Family Family family	d.50.1.3 — The homologous-pairing domain of Rad52 recombinase

Domain ID domain_id	d1h2ik_
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.50 — dsRBD-like
Superfamily Superfamily superfamily	d.50.1 — dsRNA-binding domain-like
Family Family family	d.50.1.3 — The homologous-pairing domain of Rad52 recombinase

Domain ID domain_id	d1h2il_
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.50 — dsRBD-like
Superfamily Superfamily superfamily	d.50.1 — dsRNA-binding domain-like
Family Family family	d.50.1.3 — The homologous-pairing domain of Rad52 recombinase

Domain ID domain_id	d1h2im_
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.50 — dsRBD-like
Superfamily Superfamily superfamily	d.50.1 — dsRNA-binding domain-like
Family Family family	d.50.1.3 — The homologous-pairing domain of Rad52 recombinase

Domain ID domain_id	d1h2in_
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.50 — dsRBD-like
Superfamily Superfamily superfamily	d.50.1 — dsRNA-binding domain-like
Family Family family	d.50.1.3 — The homologous-pairing domain of Rad52 recombinase

Domain ID domain_id	d1h2io_
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.50 — dsRBD-like
Superfamily Superfamily superfamily	d.50.1 — dsRNA-binding domain-like
Family Family family	d.50.1.3 — The homologous-pairing domain of Rad52 recombinase

Domain ID domain_id	d1h2ip_
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.50 — dsRBD-like
Superfamily Superfamily superfamily	d.50.1 — dsRNA-binding domain-like
Family Family family	d.50.1.3 — The homologous-pairing domain of Rad52 recombinase

Domain ID domain_id	d1h2iq_
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.50 — dsRBD-like
Superfamily Superfamily superfamily	d.50.1 — dsRNA-binding domain-like
Family Family family	d.50.1.3 — The homologous-pairing domain of Rad52 recombinase

Domain ID domain_id	d1h2ir_
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.50 — dsRBD-like
Superfamily Superfamily superfamily	d.50.1 — dsRNA-binding domain-like
Family Family family	d.50.1.3 — The homologous-pairing domain of Rad52 recombinase

Domain ID domain_id	d1h2is_
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.50 — dsRBD-like
Superfamily Superfamily superfamily	d.50.1 — dsRNA-binding domain-like
Family Family family	d.50.1.3 — The homologous-pairing domain of Rad52 recombinase

Domain ID domain_id	d1h2it_
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.50 — dsRBD-like
Superfamily Superfamily superfamily	d.50.1 — dsRNA-binding domain-like
Family Family family	d.50.1.3 — The homologous-pairing domain of Rad52 recombinase

Domain ID domain_id	d1h2iu_
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.50 — dsRBD-like
Superfamily Superfamily superfamily	d.50.1 — dsRNA-binding domain-like
Family Family family	d.50.1.3 — The homologous-pairing domain of Rad52 recombinase

Domain ID domain_id	d1h2iv_
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.50 — dsRBD-like
Superfamily Superfamily superfamily	d.50.1 — dsRNA-binding domain-like
Family Family family	d.50.1.3 — The homologous-pairing domain of Rad52 recombinase

CATH v4.4 (22 domains)

Domain ID domain_id	1h2iA01
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	390 — Enolase-like; domain 1
Homologous superfamily homologous superfamily	80 — DNA repair protein Rad52/59/22

Domain ID domain_id	1h2iB01
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	390 — Enolase-like; domain 1
Homologous superfamily homologous superfamily	80 — DNA repair protein Rad52/59/22

Domain ID domain_id	1h2iC01
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	390 — Enolase-like; domain 1
Homologous superfamily homologous superfamily	80 — DNA repair protein Rad52/59/22

Domain ID domain_id	1h2iD01
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	390 — Enolase-like; domain 1
Homologous superfamily homologous superfamily	80 — DNA repair protein Rad52/59/22

Domain ID domain_id	1h2iE01
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	390 — Enolase-like; domain 1
Homologous superfamily homologous superfamily	80 — DNA repair protein Rad52/59/22

Domain ID domain_id	1h2iF01
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	390 — Enolase-like; domain 1
Homologous superfamily homologous superfamily	80 — DNA repair protein Rad52/59/22

Domain ID domain_id	1h2iG01
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	390 — Enolase-like; domain 1
Homologous superfamily homologous superfamily	80 — DNA repair protein Rad52/59/22

Domain ID domain_id	1h2iH01
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	390 — Enolase-like; domain 1
Homologous superfamily homologous superfamily	80 — DNA repair protein Rad52/59/22

Domain ID domain_id	1h2iI01
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	390 — Enolase-like; domain 1
Homologous superfamily homologous superfamily	80 — DNA repair protein Rad52/59/22

Domain ID domain_id	1h2iJ01
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	390 — Enolase-like; domain 1
Homologous superfamily homologous superfamily	80 — DNA repair protein Rad52/59/22

Domain ID domain_id	1h2iK01
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	390 — Enolase-like; domain 1
Homologous superfamily homologous superfamily	80 — DNA repair protein Rad52/59/22

Domain ID domain_id	1h2iL01
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	390 — Enolase-like; domain 1
Homologous superfamily homologous superfamily	80 — DNA repair protein Rad52/59/22

Domain ID domain_id	1h2iM01
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	390 — Enolase-like; domain 1
Homologous superfamily homologous superfamily	80 — DNA repair protein Rad52/59/22

Domain ID domain_id	1h2iN01
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	390 — Enolase-like; domain 1
Homologous superfamily homologous superfamily	80 — DNA repair protein Rad52/59/22

Domain ID domain_id	1h2iO01
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	390 — Enolase-like; domain 1
Homologous superfamily homologous superfamily	80 — DNA repair protein Rad52/59/22

Domain ID domain_id	1h2iP01
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	390 — Enolase-like; domain 1
Homologous superfamily homologous superfamily	80 — DNA repair protein Rad52/59/22

Domain ID domain_id	1h2iQ01
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	390 — Enolase-like; domain 1
Homologous superfamily homologous superfamily	80 — DNA repair protein Rad52/59/22

Domain ID domain_id	1h2iR01
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	390 — Enolase-like; domain 1
Homologous superfamily homologous superfamily	80 — DNA repair protein Rad52/59/22

Domain ID domain_id	1h2iS01
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	390 — Enolase-like; domain 1
Homologous superfamily homologous superfamily	80 — DNA repair protein Rad52/59/22

Domain ID domain_id	1h2iT01
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	390 — Enolase-like; domain 1
Homologous superfamily homologous superfamily	80 — DNA repair protein Rad52/59/22

Domain ID domain_id	1h2iU01
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	390 — Enolase-like; domain 1
Homologous superfamily homologous superfamily	80 — DNA repair protein Rad52/59/22

Domain ID domain_id	1h2iV01
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	390 — Enolase-like; domain 1
Homologous superfamily homologous superfamily	80 — DNA repair protein Rad52/59/22

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Unit-cell length a length_a	117.259 Å
Unit-cell length b length_b	127.319 Å
Unit-cell length c length_c	191.227 Å
Unit-cell angle α angle_alpha	90.00 °
Unit-cell angle β angle_beta	90.29 °
Unit-cell angle γ angle_gamma	90.00 °
Molecules per unit cell Z z_pdb	44

Space group space_group	P 1 21 1
Space-group number int_tables_number	4
Crystal system crystal_system	—

Resolution resolution	2.700 Å
Low-resolution limit resolution_low	30.000 Å
R factor r_factor	0.2250
R_work r_work	0.2250
R_free r_free	0.2620

Description description	DNA REPAIR PROTEIN RAD52 HOMOLOG
Molecular weight formula_weight	23089.1 kDa
Source method src_method	man
Copy count entity_count	22

Polymer type type	polypeptide(L)
Chain IDs strand_id	A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P,Q,R,S,T,U,V
Atom count atom_count	32802

Human Rad52 protein, N-terminal domain

1. Protein Identity and Related Structures Protein Identity & Related Structures

DNA REPAIR PROTEIN RAD52 HOMOLOG

State in the Current Structure

Other States of the Same Protein in the Database

2. Structure Basics 2. Structure Basics

3. Official assembly/model SAXS Official SAXS Profiles

1h2i__assembly_1__model_1

1h2i__assembly_1__model_1 | I(q)

1h2i__assembly_1__model_1 | P(r) · Pending

4. Crystallography and Experiment 4. Crystallography & Experiment

Unit cell Unit Cell

Symmetry Symmetry

Refinement Refinement

Diffraction experiment Diffraction

5. Entities and Polymers Entities & Polymers (2)

Entity 1 Entity 1 polymer

Polymer Polymer

Source Source

Entity 2 Entity 2 water

6. Fold Classification (SCOP + CATH) 44 domains

SCOP 2.08 (22 domains)

CATH v4.4 (22 domains)

7. Citations (1)

Source organism organism	HOMO SAPIENS
Common name common_name	HUMAN
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	ESCHERICHIA COLI

Description description	water
Molecular weight formula_weight	18.0 kDa
Source method src_method	nat
Copy count entity_count	484

Human Rad52 protein, N-terminal domain

1. Protein Identity and Related Structures Protein Identity & Related Structures

DNA REPAIR PROTEIN RAD52 HOMOLOG

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

2. Structure Basics 2. Structure Basics

3. Official assembly/model SAXS Official SAXS Profiles

1h2i__assembly_1__model_1

1h2i__assembly_1__model_1 | I(q)

1h2i__assembly_1__model_1 | P(r) · Pending

4. Crystallography and Experiment 4. Crystallography & Experiment

Unit cell Unit Cell

Symmetry Symmetry

Refinement Refinement

Diffraction experiment Diffraction

5. Entities and Polymers Entities & Polymers (2)

Entity 1 Entity 1 polymer

Polymer Polymer

Source Source

Entity 2 Entity 2 water

6. Fold Classification (SCOP + CATH) 44 domains

SCOP 2.08 (22 domains)

CATH v4.4 (22 domains)

7. Citations (1)