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1iie

HLA-DR ANTIGENS ASSOCIATED INVARIANT CHAIN

Method: SOLUTION NMR
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1. Protein Identity and Related Structures Protein Identity & Related Structures

PROTEIN (HLA-DR ANTIGENS ASSOCIATED INVARIANT CHAIN)

Homo sapiens

UniProt P04233

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein homooligomer Homooligomer Protein 3 No other associated polymer Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1l3h

1 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers
1iie

1 assemblies

Heteromeric or nucleic-acid complex
1a6a 1a6a 1icf 1icf 1icf 3pdo 3pgc 3pgc 3pgd 3pgd 3qxa 3qxa

23 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name HG2A_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–75； UniProt 118–192 Author chain B； PDBConstruct 1–75； UniProt 118–192 Author chain C； PDBConstruct 1–75； UniProt 118–192

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id1iie
Deposition date deposition_date1999-02-02
Structure title titleHLA-DR ANTIGENS ASSOCIATED INVARIANT CHAIN
Keywords keywordsMAJOR HISTOCOMPATIBILITY COMPLEX, ANTIGEN PROCESSING, OLIGOMERIZATION, CHAPERONIN; MAJOR HISTOCOMPATIBILITY COMPLEX
Experimental Method methodSOLUTION NMR
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

1iie__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

1iie__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

1iie__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）19.33 Å
Rg (electron density)18.65 Å
Total Rg19.76 Å
Atom count3726
Residues225
Excluded volume33686 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 1iie__assembly_1__model_1 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 2 1iie__assembly_1__model_2 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 3 1iie__assembly_1__model_3 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 4 1iie__assembly_1__model_4 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 5 1iie__assembly_1__model_5 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 6 1iie__assembly_1__model_6 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 7 1iie__assembly_1__model_7 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 8 1iie__assembly_1__model_8 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 9 1iie__assembly_1__model_9 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 10 1iie__assembly_1__model_10 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 11 1iie__assembly_1__model_11 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 12 1iie__assembly_1__model_12 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 13 1iie__assembly_1__model_13 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 14 1iie__assembly_1__model_14 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 15 1iie__assembly_1__model_15 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 16 1iie__assembly_1__model_16 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 17 1iie__assembly_1__model_17 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 18 1iie__assembly_1__model_18 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 19 1iie__assembly_1__model_19 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 20 1iie__assembly_1__model_20 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (1)

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6. Fold Classification (SCOP + CATH) 6 domains

SCOP 2.08 (3 domains)

Domain ID domain_idd1iiea_
Class classa — All alpha proteins
Fold Fold folda.109 — Class II MHC-associated invariant chain ectoplasmic trimerization domain
Superfamily Superfamily superfamilya.109.1 — Class II MHC-associated invariant chain ectoplasmic trimerization domain
Family Family familya.109.1.1 — Class II MHC-associated invariant chain ectoplasmic trimerization domain
Domain ID domain_idd1iieb_
Class classa — All alpha proteins
Fold Fold folda.109 — Class II MHC-associated invariant chain ectoplasmic trimerization domain
Superfamily Superfamily superfamilya.109.1 — Class II MHC-associated invariant chain ectoplasmic trimerization domain
Family Family familya.109.1.1 — Class II MHC-associated invariant chain ectoplasmic trimerization domain
Domain ID domain_idd1iiec_
Class classa — All alpha proteins
Fold Fold folda.109 — Class II MHC-associated invariant chain ectoplasmic trimerization domain
Superfamily Superfamily superfamilya.109.1 — Class II MHC-associated invariant chain ectoplasmic trimerization domain
Family Family familya.109.1.1 — Class II MHC-associated invariant chain ectoplasmic trimerization domain

CATH v4.4 (3 domains)

Domain ID domain_id1iieA00
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology870 — HLA-dr Antigens Associated Invariant Chain; Chain A
Homologous superfamily homologous superfamily10 — MHC class II-associated invariant chain, trimerisation domain
Domain ID domain_id1iieB00
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology870 — HLA-dr Antigens Associated Invariant Chain; Chain A
Homologous superfamily homologous superfamily10 — MHC class II-associated invariant chain, trimerisation domain
Domain ID domain_id1iieC00
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology870 — HLA-dr Antigens Associated Invariant Chain; Chain A
Homologous superfamily homologous superfamily10 — MHC class II-associated invariant chain, trimerisation domain
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7. Citations (3)